A Churg

Summary

Publications

  1. ncbi request reprint The separation of benign and malignant mesothelial proliferations
    Andrew Churg
    Department of Pathology, G227, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Arch Pathol Lab Med 136:1217-26. 2012
  2. doi request reprint Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in COPD
    A Churg
    Dept of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Eur Respir J 39:197-209. 2012
  3. ncbi request reprint Mineral dusts directly induce epithelial and interstitial fibrogenic mediators and matrix components in the airway wall
    J Dai
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 158:1907-13. 1998
  4. ncbi request reprint Active oxygen species mediate asbestos fiber uptake by tracheal epithelial cells
    J Hobson
    Department of Pathology, University of British Columbia, Vancouver, Canada
    FASEB J 4:3135-9. 1990
  5. pmc Effects of cigarette smoke on the clearance of short asbestos fibres from the lung and a comparison with the clearance of long asbestos fibres
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Int J Exp Pathol 73:287-97. 1992
  6. ncbi request reprint Induction of fibrogenic mediators by fine and ultrafine titanium dioxide in rat tracheal explants
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol 277:L975-82. 1999
  7. ncbi request reprint Iron enhances uptake of mineral particles and increases lipid peroxidation in tracheal epithelial cells
    B Keeling
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 10:683-8. 1994
  8. ncbi request reprint Cigarette smoke increases amosite asbestos fiber binding to the surface of tracheal epithelial cells
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol 275:L502-8. 1998
  9. pmc Effects of cigarette smoke and asbestos on airway, vascular and mesothelial cell proliferation
    H Sekhon
    Department of Pathology, University of British Columbia, Canada
    Int J Exp Pathol 76:411-8. 1995
  10. ncbi request reprint Rapid short-term clearance of chrysotile compared with amosite asbestos in the guinea pig
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am Rev Respir Dis 139:885-90. 1989

Collaborators

Detail Information

Publications35

  1. ncbi request reprint The separation of benign and malignant mesothelial proliferations
    Andrew Churg
    Department of Pathology, G227, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Arch Pathol Lab Med 136:1217-26. 2012
    ..The separation of benign from malignant mesothelial proliferations is crucial to patient management but is often a difficult problem for the pathologist...
  2. doi request reprint Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in COPD
    A Churg
    Dept of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Eur Respir J 39:197-209. 2012
    ..Whether inhibition of other MMPs might be useful is unclear...
  3. ncbi request reprint Mineral dusts directly induce epithelial and interstitial fibrogenic mediators and matrix components in the airway wall
    J Dai
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 158:1907-13. 1998
    ..Different mineral dusts produce different patterns of reaction...
  4. ncbi request reprint Active oxygen species mediate asbestos fiber uptake by tracheal epithelial cells
    J Hobson
    Department of Pathology, University of British Columbia, Vancouver, Canada
    FASEB J 4:3135-9. 1990
    ..We conclude that uptake of amosite asbestos fibers is mediated in part by active oxygen species (most likely OH.), but that other mechanisms of fiber uptake must also exist...
  5. pmc Effects of cigarette smoke on the clearance of short asbestos fibres from the lung and a comparison with the clearance of long asbestos fibres
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Int J Exp Pathol 73:287-97. 1992
    ..These observations suggest that short asbestos fibres could play an important role in the pathogenesis of some types of asbestos-related disease in cigarette smokers...
  6. ncbi request reprint Induction of fibrogenic mediators by fine and ultrafine titanium dioxide in rat tracheal explants
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol 277:L975-82. 1999
    ..Differential upregulation of PDGF receptors does not appear to explain dust-induced fibrosis in this model...
  7. ncbi request reprint Iron enhances uptake of mineral particles and increases lipid peroxidation in tracheal epithelial cells
    B Keeling
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 10:683-8. 1994
    ..These observations suggest that cationic iron may play a major role in particle uptake by tracheobronchial epithelia, and that particle uptake is also related to iron-mediated lipid peroxidation...
  8. ncbi request reprint Cigarette smoke increases amosite asbestos fiber binding to the surface of tracheal epithelial cells
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol 275:L502-8. 1998
    ....
  9. pmc Effects of cigarette smoke and asbestos on airway, vascular and mesothelial cell proliferation
    H Sekhon
    Department of Pathology, University of British Columbia, Canada
    Int J Exp Pathol 76:411-8. 1995
    ..However, the latter process does not correlate with local accumulation of asbestos fibres...
  10. ncbi request reprint Rapid short-term clearance of chrysotile compared with amosite asbestos in the guinea pig
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am Rev Respir Dis 139:885-90. 1989
    ....
  11. pmc Antioxidant gene expression in rat lung after exposure to cigarette smoke
    C B Gilks
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Am J Pathol 152:269-78. 1998
    ..MT expression is also transiently increased by smoke whereas GPX expression increases after prolonged (7 to 14 days) exposure to cigarette smoke...
  12. pmc Effects of cigarette smoke exposure on retention of asbestos fibers in various morphologic compartments of the guinea pig lung
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Pathol 129:385-93. 1987
    ....
  13. doi request reprint Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices
    J L Wright
    Department of Pathology, University of British Columbia, University Hospital, 2211 Wesbrook Mall, Vancouver, BC, Canada
    J Appl Physiol 104:1462-9. 2008
    ..These changes may be important in the development of pulmonary hypertension...
  14. ncbi request reprint Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNF-alpha signaling
    J L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5, USA
    Am J Physiol Lung Cell Mol Physiol 292:L125-33. 2007
    ..MMP production is largely TNF-alpha dependent, further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke-induced lung disease...
  15. pmc The distribution of amosite asbestos in the periphery of the normal human lung
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Br J Ind Med 47:677-81. 1990
    ....
  16. ncbi request reprint Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Exp Lung Res 17:997-1009. 1991
    ..The etiology of this process may be smoke-induced inflammation with release of vasoactive substances as well as proteolytic enzymes...
  17. ncbi request reprint TNF-alpha increases tracheal epithelial asbestos and fiberglass binding via a NF-kappaB-dependent mechanism
    C Xie
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol Lung Cell Mol Physiol 279:L608-14. 2000
    ....
  18. pmc Mechanisms of mineral dust-induced emphysema
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Environ Health Perspect 105:1215-8. 1997
    ..These observations support our theory that dust-induced emphysema and smoke-induced emphysema occur through similar mechanisms...
  19. pmc Absence of amosite asbestos in airway mucosa of non-smoking long term workers with occupational exposure to asbestos
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Br J Ind Med 50:355-9. 1993
    ..These findings also call into question the idea that asbestos acts as a direct airway carcinogen in humans...
  20. ncbi request reprint Fiber burden and patterns of asbestos-related disease in workers with heavy mixed amosite and chrysotile exposure
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 150:663-9. 1994
    ..abstract truncated at 250 words)..
  21. ncbi request reprint Current concepts in mechanisms of emphysema
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Toxicol Pathol 35:111-5. 2007
    ..Over the last 10 years, there has been a remarkable degree of progress in our understanding of the pathophysiological mechanisms involved in the genesis of emphysema. This review attempts to summarize these data...
  22. ncbi request reprint Airway remodeling in the smoke exposed guinea pig model
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Inhal Toxicol 19:915-23. 2007
    ..This model should prove useful in further investigations into the mechanisms of airway remodeling...
  23. ncbi request reprint The distribution of amosite asbestos fibers in the lungs of workers with mesothelioma or carcinoma
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Exp Lung Res 15:771-83. 1989
    ..These differences may be a manifestation of individual handling of mineral particles because of structural variations in individual lungs...
  24. ncbi request reprint Mineralogic parameters related to amosite asbestos-induced fibrosis in humans
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am Rev Respir Dis 142:1331-6. 1990
    ..Last, the concentration comparison data indicate that, fiber for fiber, amosite is more fibrogenic than is chrysotile or tremolite, and indirectly suggest that tremolite is more fibrogenic than is chrysotile...
  25. ncbi request reprint Effects of cigarette smoke on nitric oxide synthase expression in the rat lung
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Lab Invest 79:975-83. 1999
    ..These findings indicate that cigarette smoke can directly and rapidly affect NOS expression, and thus potentially affect the function of the pulmonary vasculature...
  26. ncbi request reprint Advances in the pathology of COPD
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Histopathology 49:1-9. 2006
    ..This review is designed to help surgical pathologists evaluate the lungs of subjects who have clinical manifestations of airflow obstruction so that appropriate clinical-pathological correlations can be performed...
  27. doi request reprint Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS(-/-) mice and human smokers
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, B C Canada
    Inhal Toxicol 24:732-40. 2012
    ..Most likely the source of reactive nitrogen species is the cigarette smoke itself...
  28. pmc Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment
    J L Wright
    Department of Pathology, University of Columbia, Vancouver, BC, Canada
    Thorax 60:605-9. 2005
    ..These changes are in many ways similar to those seen in other forms of pulmonary hypertension and suggest that the treatments used for primary pulmonary hypertension may be beneficial in patients with COPD...
  29. ncbi request reprint The separation of benign and malignant mesothelial proliferations
    A Churg
    University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 24:1183-200. 2000
    ..Although both p53 and EMA staining have been proposed as markers of mesothelial malignancy, in our experience they are not helpful for the individual case...
  30. ncbi request reprint A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels
    J L Wright
    Dept of Pathology, University of British Columbia, Vancouver, Canada
    Eur Respir J 22:77-81. 2003
    ..These data suggest that smoke-induced cell proliferation leads to pulmonary arterial muscularisation. Serine-elastase inhibitors appear to be able to reduce cell proliferation and vascular remodelling...
  31. ncbi request reprint Enhanced retention of asbestos fibers in the airways of human smokers
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 151:1409-13. 1995
    ..These findings indicate that cigarette smoking causes enhanced accumulation of both amosite and chrysotile in the airway mucosa. This process may play a role in potentiating the pathologic effects of asbestos...
  32. ncbi request reprint Site of methacholine reactivity in the peripheral airways: analysis using lung explants
    J L Wright
    University of British Columbia, Vancouver, Canada
    Am J Physiol 272:L68-72. 1997
    ..They do not, however, completely rule out the possibility of in vivo species-dependent differences in airway-parenchymal interactions...
  33. ncbi request reprint Relationship of fiber surface iron and active oxygen species to expression of procollagen, PDGF-A, and TGF-beta(1) in tracheal explants exposed to amosite asbestos
    J Dai
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 24:427-35. 2001
    ..Surface iron and AOS also play a role in PDGF-A and TGF-beta gene expression, but through an ERK-dependent mechanism...
  34. ncbi request reprint Ambient atmospheric particles in the airways of human lungs
    A Churg
    Department of Pathology and School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, Canada
    Ultrastruct Pathol 24:353-61. 2000
    ....
  35. ncbi request reprint Smoking cessation decreases the number of metaplastic secretory cells in the small airways of the Guinea pig
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Inhal Toxicol 14:1153-9. 2002
    ..We conclude that, in a guinea pig model, smoking produces secretory-cell metaplasia in the airways and that smoking cessation allows partial recovery of normal structure...