E L Chung

Summary

Publications

  1. ncbi Detection of cyclic 1,N2-propanodeoxyguanosine adducts in DNA of rats treated with N-nitrosopyrrolidine and mice treated with crotonaldehyde
    F L Chung
    Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, NY 10595
    Carcinogenesis 10:1291-7. 1989
  2. ncbi Tea and cancer prevention: studies in animals and humans
    Fung Lung Chung
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
    J Nutr 133:3268S-3274S. 2003
  3. ncbi Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mouse
    E L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Exp Lung Res 27:319-30. 2001
  4. ncbi Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, NY 10595, USA
    Carcinogenesis 21:2287-91. 2000
  5. ncbi Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 60:1507-11. 2000
  6. ncbi The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Proc Soc Exp Biol Med 220:244-8. 1999
  7. ncbi Endogenous formation and significance of 1,N2-propanodeoxyguanosine adducts
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 424:71-81. 1999
  8. ncbi Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent
    F L Chung
    Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 58:4096-101. 1998
  9. ncbi DNA adducts of 2,3-epoxy-4-hydroxynonanal: detection of 7-(1', 2'-dihydroxyheptyl)-3H-imidazo[2,1-i]purine and 1,N6-ethenoadenine by gas chromatography/negative ion chemical ionization/mass spectrometry
    H J Chen
    American Health Foundation, Valhalla, New York 10595, USA
    Chem Res Toxicol 11:1474-80. 1998
  10. ncbi Formation of 7-(4-oxobutyl)guanine in hepatic DNA of rats treated with N-nitrosopyrrolidine
    M Wang
    Section of Nucleic Acid Chemistry, American Health Foundation, Valhalla, New York 10595
    Carcinogenesis 13:1909-11. 1992

Collaborators

Detail Information

Publications39

  1. ncbi Detection of cyclic 1,N2-propanodeoxyguanosine adducts in DNA of rats treated with N-nitrosopyrrolidine and mice treated with crotonaldehyde
    F L Chung
    Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, NY 10595
    Carcinogenesis 10:1291-7. 1989
    ..However, no such background adduct was detected in skin DNA of mice. This method demonstrated for the first time the in vivo formation of the cyclic 1,N2-propanodeoxyguanosine adducts...
  2. ncbi Tea and cancer prevention: studies in animals and humans
    Fung Lung Chung
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
    J Nutr 133:3268S-3274S. 2003
    ..Finally, a recent small pilot intervention study with green tea in smokers is presented...
  3. ncbi Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mouse
    E L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Exp Lung Res 27:319-30. 2001
    ..These findings are of importance, considering the potential of these agents as chemopreventive agents for lung cancer in smokers and ex-smokers...
  4. ncbi Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, NY 10595, USA
    Carcinogenesis 21:2287-91. 2000
    ..05). The NAC conjugates were inactive as anti-initiators against AOM-induced ACF. These findings provide important laboratory evidence for a potential role of SFN and PEITC in the protection against colon cancer...
  5. ncbi Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 60:1507-11. 2000
    ..Our studies in vitro further indicate that omega-6 polyunsaturated fatty acids are likely a unique class of fatty acids involved in HNE-dG adduct formation...
  6. ncbi The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Proc Soc Exp Biol Med 220:244-8. 1999
    ....
  7. ncbi Endogenous formation and significance of 1,N2-propanodeoxyguanosine adducts
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 424:71-81. 1999
    ..The involvement of these adducts in tumor promotion is speculated on the basis that oxidative condition in tissues is believed to be associated with this process...
  8. ncbi Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent
    F L Chung
    Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 58:4096-101. 1998
    ....
  9. ncbi DNA adducts of 2,3-epoxy-4-hydroxynonanal: detection of 7-(1', 2'-dihydroxyheptyl)-3H-imidazo[2,1-i]purine and 1,N6-ethenoadenine by gas chromatography/negative ion chemical ionization/mass spectrometry
    H J Chen
    American Health Foundation, Valhalla, New York 10595, USA
    Chem Res Toxicol 11:1474-80. 1998
    ..The high sensitivity of the assay suggests that it may be used in the analysis of ethenoadenine adducts in vivo...
  10. ncbi Formation of 7-(4-oxobutyl)guanine in hepatic DNA of rats treated with N-nitrosopyrrolidine
    M Wang
    Section of Nucleic Acid Chemistry, American Health Foundation, Valhalla, New York 10595
    Carcinogenesis 13:1909-11. 1992
    ..p. administration was 643 +/- 9 mumol/mol guanine, approximately one-third of the level of adduct 1. This study is the first to demonstrate the in vivo formation of a formylalkyl-substituted guanine adduct by a nitrosamine...
  11. ncbi Formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts in the reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with DNA
    M Wang
    American Health Foundation, Valhalla, New York 10595, USA
    Chem Res Toxicol 8:617-24. 1995
    ..abstract truncated at 250 words)..
  12. ncbi Reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts
    R Young Sciame
    American Health Foundation, Valhalla, New York 10595, USA
    Chem Res Toxicol 8:607-16. 1995
    ..Adducts formed from enal products of the two nitrosamines were also different. Adduct formation as characterized in this study may account for some of the contrasting carcinogenic properties of NPYR and NPIP...
  13. ncbi Identification of crotonaldehyde as a hepatic microsomal metabolite formed by alpha-hydroxylation of the carcinogen N-nitrosopyrrolidine
    M Y Wang
    Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, New York 10595
    Chem Res Toxicol 1:28-31. 1988
    ..These results demonstrate that crotonaldehyde is formed upon metabolic alpha-hydroxylation of N-nitrosopyrrolidine and suggest that it may be involved in N-nitrosopyrrolidine-macromolecule interactions...
  14. ncbi Detection of exocyclic guanine adducts in hydrolysates of hepatic DNA of rats treated with N-nitrosopyrrolidine and in calf thymus DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine
    F L Chung
    Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, New York 10595
    Cancer Res 49:2034-41. 1989
    ..The results of this study provide the first example of a structurally characterized DNA adduct formed in vivo from a cyclic nitrosamine and support the alpha-hydroxylation hypothesis of cyclic nitrosamine metabolic activation...
  15. ncbi Formation of acyclic and cyclic guanine adducts in DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine
    M Wang
    Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, New York 10595
    Chem Res Toxicol 2:423-8. 1989
    ..The concentrations of adducts 11-13, which were formed by reaction with DNA of crotonaldehyde (10), increased gradually over the 36-h time period studied.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. ncbi Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes
    C C Conaway
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, One Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 14:1170-6. 2001
    ....
  17. ncbi Differential effects of thiols on DNA modifications via alkylation and Michael addition by alpha-acetoxy-N-nitrosopyrrolidine
    M Wang
    Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, New York 10595
    Chem Res Toxicol 5:528-31. 1992
    ..However, unlike mesna, Glu inhibited the formation of adduct 1, while it did not inhibit the formation of adduct 2, although both adducts are presumably derived from the 4-oxobutylating agent.(ABSTRACT TRUNCATED AT 250 WORDS)..
  18. ncbi Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest
    Jen Wei Chiao
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Carcinogenesis 25:1403-8. 2004
    ..PEITC-NAC may prevent initiation of carcinogenesis and modulate the post-initiation phase by targeting cell cycle regulators and apoptosis induction...
  19. ncbi Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention
    Longgui Wang
    Division of Medical Oncology, Mount Sinai Medical Center, New York, NY 10029, USA
    Int J Oncol 24:187-92. 2004
    ..The potential of SFN, as an active dietary factor to inhibit initiation and post-initiation of prostate cancer carcinogenesis is discussed...
  20. ncbi Molecular and cellular effects of green tea on oral cells of smokers: a pilot study
    Joel L Schwartz
    University of Illinois, College of Dentistry, Chicago, IL 60612 7211, USA
    Mol Nutr Food Res 49:43-51. 2005
    ..These results warrant a large-scale intervention trial to further verify the role of green tea in the prevention of oral cancer in smokers...
  21. ncbi Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver
    Fung Lung Chung
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 18:24-7. 2005
    ..These results further support the endogenous origin of HNE-dG adducts and, more importantly, indicate a critical role that GSH plays in protecting against in vivo formation of the promutagenic cyclic DNA adducts derived from HNE...
  22. ncbi Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers
    Joel L Schwartz
    Institute for Cancer Prevention, One Dana Road, Valhalla, NY 10595, USA
    Oral Oncol 39:842-54. 2003
    ..Flow cytometric evaluation of oral cytology harvested keratinocytes can be used to measure exposure to tobacco carcinogens, and possibly establish a link to premalignant and malignant transformation before a lesion is noted...
  23. ncbi Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    C Clifford Conaway
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, New York, USA
    Cancer Res 65:8548-57. 2005
    ..The results of the study provide a basis for future evaluation of the potential of phenethyl isothiocyanate and sulforaphane and their conjugates as chemopreventive agents in smokers and ex-smokers with early lung lesions...
  24. ncbi The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma
    Wenwei Hu
    Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Carcinogenesis 23:1781-9. 2002
    ..These results suggest that 4-HNE may be an important etiological agent for human cancers that have a mutation at codon 249 of the p53 gene...
  25. ncbi Deoxyguanosine adducts of tert-4-hydroxy-2-nonenal as markers of endogenous DNA lesions
    Fung Lung Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Methods Enzymol 353:523-36. 2002
  26. ncbi N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells
    Yang Ming Yang
    Division of Carcinogenesis, American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, New York, USA
    Cancer Res 65:8538-47. 2005
    ..The observation that PEITC-NAC induces apoptosis predominantly in growth-promoted cells, such as neoplastic cells, suggests a selective mechanism by which PEITC-NAC inhibits lung carcinogenesis...
  27. ncbi A solid-phase extraction/high-performance liquid chromatography-based (32)P-postlabeling method for detection of cyclic 1,N(2)-propanodeoxyguanosine adducts derived from enals
    Jishen Pan
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Anal Biochem 348:15-23. 2006
    ..The detection limit was determined to be as low as 0.5 fmol in 80 microg DNA, corresponding to 9 adducts/10(9) dG...
  28. ncbi The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 67:6409-16. 2007
    ..Because PEITC is a stronger inducer of apoptosis than SFN, these results indicate that direct covalent binding to cellular proteins is an important early event in the induction of apoptosis by the ITCs...
  29. pmc Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts
    Sujata Choudhury
    DNA Repair Laboratory, Valhalla, New York 10595, USA
    Biochemistry 43:7514-21. 2004
    ..The repair kinetics indicated that the excision rate is faster than the rate of gap-filling/DNA synthesis. Furthermore, the HNE-dG adduct isomers 2 and 4 appeared to be repaired more efficiently at early time points than isomers 1 and 3...
  30. pmc Detection of the acrolein-derived cyclic DNA adduct by a quantitative 32P-postlabeling/solid-phase extraction/HPLC method: blocking its artifact formation with glutathione
    Armaghan Emami
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Anal Biochem 374:163-72. 2008
    ..Finally, this method was used to detect Acr-dG in calf thymus and human colon HT29 cell DNA with an excellent linear quantitative relationship...
  31. ncbi Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China
    Jay H Fowke
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 12:1536-9. 2003
    ..In conclusion, a single urinary ITC measure, in conjunction with markers of Phase II enzyme activity, provides a complementary measure of habitual Brassica intake among Shanghai women...
  32. ncbi Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation
    Fung Lung Chung
    Division of Carcinogenesis and Molecular Epidemiology, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY 10595, USA
    Mutat Res 531:25-36. 2003
    ..Together, results of these studies provide a better understanding of the involvement of different PUFAs in DNA damage and their possible roles in tumorigenesis...
  33. ncbi Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats
    Sujata Choudhury
    DNA Repair Laboratory, Mechanism of Carcinogenesis Program, American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Cancer Res 63:7704-7. 2003
    ....
  34. ncbi Urinary isothiocyanate levels, brassica, and human breast cancer
    Jay H Fowke
    Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
    Cancer Res 63:3980-6. 2003
    ..In conclusion, greater Brassica vegetable consumption, as measured by the urinary ITC biomarker, was associated with significantly reduced breast cancer risk among Chinese women...
  35. ncbi Effects of garage employment and tobacco smoking on breathing-zone concentrations of carbonyl compounds
    Lin Zhang
    Environmental and Occupational Health Sciences Institute, UMDNJ Robert Wood Johnson Medical School, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    AIHA J (Fairfax, Va) 64:388-93. 2003
    ..In general, within-subject variations were smaller than between-subject variations on 48-hour averaged breathing-zone concentrations of carbonyl compounds...
  36. ncbi Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans
    C Clifford Conaway
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, NY 10595, USA
    Curr Drug Metab 3:233-55. 2002
    ..Finally, based on recent epidemiological studies, the role of dietary consumption of vegetables containing ITCs in prevention of human cancers and human cancer susceptibility is discussed...
  37. ncbi Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions
    Jishen Pan
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:367-72. 2002
    ..These results may be important for the understanding of the specific roles of different types of fatty acids in tumorigenesis...
  38. ncbi Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 a
    Yang Ming Yang
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 62:2-7. 2002
    ....
  39. pmc Urinary total isothiocyanates and colorectal cancer: a prospective study of men in Shanghai, China
    Kristin A Moy
    The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Epidemiol Biomarkers Prev 17:1354-9. 2008
    ..25-0.83), respectively, for risk of colorectal cancer (P for trend = 0.006). The present study suggests that dietary ITCs may exert tumor inhibitory effects, especially during earlier stages of the multistage process of carcinogenesis...