Has the role of calcium channel blockers in treating hypertension finally been defined?George S Chrysant
Oklahoma Cardiovascular and Hypertension Center, and the University of Oklahoma College of Medicine, 5850 W Wilshire Boulevard, Oklahoma City, OK 73132 4904, USA
Curr Hypertens Rep 5:295-300. 2003
..They can also be used as first-line therapy for older, stroke-prone hypertensive patients. In addition, when a calcium channel blocker is indicated for better blood pressure control, its use should not be withheld for safety concerns...
- Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis
Steven G Chrysant
University of Oklahoma, Oklahoma City, OK 73132, USA
Curr Med Res Opin 24:1039-47. 2008
..Here we report the results of a pre-planned 6-month interim analysis of a long-term, open-label study examining the safety, tolerability and efficacy of the aliskiren/valsartan 300/320-mg combination in patients with hypertension...
New insights into the true nature of the obesity paradox and the lower cardiovascular riskSteven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and The University of Oklahoma, OK 73132, USA
J Am Soc Hypertens 7:85-94. 2013
..Therefore, based on recent studies using other indices of body fat distribution, such as WC and WHR, besides BMI, the true existence of OP has been questioned and needs to be confirmed by future studies...
- Olmesartan medoxomil-based antihypertensive therapy evaluated by ambulatory blood pressure monitoring: efficacy in high-risk patient subgroups
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma School of Medicine, Oklahoma City, OK 73132, USA
Am J Cardiovasc Drugs 12:375-89. 2012
....
- The pleiotropic effects of phosphodiesterase 5 inhibitors on function and safety in patients with cardiovascular disease and hypertension
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and The University of Oklahoma, Oklahoma City, OK, USA
J Clin Hypertens (Greenwich) 14:644-9. 2012
..These beneficial pleiotropic and safe cardiovascular effects of PDE-5 inhibitors will be discussed in this concise review...
- Triple-Combination therapy with olmesartan, amlodipine, and hydrochlorothiazide in black and non-black study participants with hypertension: the TRINITY randomized, double-blind, 12-week, parallel-group study
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma College of Medicine, Oklahoma City, OK, USA
Am J Cardiovasc Drugs 12:233-43. 2012
..Although awareness of hypertension in Black patients has increased, blood pressure (BP) is frequently inadequately controlled...
- Blood pressure effects of high-dose amlodipine-benazepril combination in Black and White hypertensive patients not controlled on monotherapy
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma Health and Sciences Center, Oklahoma City, OK, USA
Drugs R D 12:57-64. 2012
..This resistance can be overcome with the combination of ACE inhibitors with diuretics or calcium-channel blockers (CCBs)...
- Clinical implications of cardiovascular preventing pleiotropic effects of dipeptidyl peptidase-4 inhibitors
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma College oh Medicine, Oklahoma City, Oklahoma, USA
Am J Cardiol 109:1681-5. 2012
..All these actions are discussed in this concise review. In conclusion, DPP-4 inhibitors are novel antidiabetic agents with pleiotropic cardiovascular protective effects in addition to their antidiabetic action...
- The role of angiotensin II receptors in stroke protection
Steven G Chrysant
University of Oklahoma College of Medicine, 5850 West Wilshire Boulevard, Oklahoma City, OK 73132, USA
Curr Hypertens Rep 14:202-8. 2012
..In this review, the role of the Ang II receptors and their mechanism of action regarding stroke prevention are discussed in view of the evidence from experimental and clinical studies...
- Current status of β-blockers for the treatment of hypertension: an update
S G Chrysant
University of Oklahoma, Oklahoma City, OK, USA
Drugs Today (Barc) 48:353-66. 2012
....
- Efficacy and safety of triple-combination therapy with olmesartan, amlodipine, and hydrochlorothiazide in study participants with hypertension and diabetes: a subpopulation analysis of the TRINITY study
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma College of Medicine, Oklahoma City, OK, USA
J Am Soc Hypertens 6:132-41. 2012
....
- Efficacy and safety of long-term treatment with the combination of amlodipine besylate and olmesartan medoxomil in patients with hypertension
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma College of Medicine, Oklahoma City, OK, USA
J Clin Hypertens (Greenwich) 11:475-82. 2009
..5 mg/d, and 46.3% for AML+OM+HCTZ 10+40+25 mg/d. Study medication was safe and well tolerated. Combination antihypertensive therapy with AML+OM+/-HTCZ, up-titrated as necessary, allowed a majority of patients to achieve BP goal...
- Amlodipine besylate/olmesartan medoximil fixed combination for the treatment of hypertension
Steven G Chrysant
Clinical Professor, Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma School of Medicine, 5850 W Wilshire Blvd, Oklahoma City, OK 73132 4904, USA
Expert Rev Cardiovasc Ther 7:887-95. 2009
..001) and resulted in 54% of patients achieving blood pressure goals. It also decreased the pedal edema induced by amlodipine monotherapy 10 mg/day by 36.1%. This drug combination, besides being effective, is also safe and well tolerated...
- Combination therapy with olmesartan medoxomil and hydrochlorothiazide: secondary analysis of the proportion of patients achieving recommended blood pressure goals from a randomized, double-blind, factorial study
Steven G Chrysant
University of Oklahoma, School of Medicine, Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, Oklahoma 73132, USA
Am J Cardiovasc Drugs 9:241-51. 2009
....
- Irbesartan/hydrochlorothiazide for the treatment of isolated systolic hypertension: a subgroup analysis of the INCLUSIVE trial
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma School of Medicine, 5850 W Wilshire Blvd, Oklahoma City, OK 73132, USA
J Natl Med Assoc 101:300-7. 2009
..Fixed-dose irbesartan/HCTZ combination treatment provided effective and well-tolerated BP lowering in a diverse population of patients with isolated systolic hypertension...
- Angiotensin II receptor blockers in the treatment of the cardiovascular disease continuum
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma School of Medicine, Oklahoma City, Oklahoma, USA
Clin Ther 30:2181-90. 2008
..Initiation of treatment, at any stage in its course, might prevent or delay its further progression...
- Proactive compared with passive adverse event recognition: calcium channel blocker-associated edema
Steven G Chrysant
University of Oklahoma and the Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK, USA
J Clin Hypertens (Greenwich) 10:716-22. 2008
..The incidence of dihydropyridine CCB-induced edema appears to be dependent on the method of edema assessment...
- Using fixed-dose combination therapies to achieve blood pressure goals
Steven G Chrysant
University of Oklahoma College of Medicine, Oklahoma Cardiovascular Hypertension Center, Oklahoma City, Oklahoma 73132 4904, USA
Clin Drug Investig 28:713-34. 2008
..This approach would improve BP control rates in the US and worldwide...
- Clinical experience with the use of angiotensin receptor blockers in patients with cardiovascular, cerebrovascular and renal diseases
Steven G Chrysant
University of Oklahoma, Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK 73132 4904, USA
Curr Clin Pharmacol 1:139-46. 2006
..All these actions of the ARBs will be discussed in this comprehensive review...
- Amlodipine/ARB fixed-dose combinations for the treatment of hypertension: focus on amlodipine/olmesartan combination
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma School of Medicine, Oklahoma City, OK, USA
Drugs Today (Barc) 44:443-53. 2008
..In addition, due to the metabolic neutrality of both component drugs, these preparations are preferable for the treatment of hypertensive patients with diabetes or the metabolic syndrome, in addition to other cardiovascular risk factors...
- Current and future status of beta-blockers in the treatment of hypertension
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, Oklahoma 73132 4704, USA
Clin Cardiol 31:249-52. 2008
..There are reservations regarding their administration to diabetic and older hypertensive patients. However, when compelling indications for their use exist, they should not be withheld...
- The treatment of cardiovascular disease continuum: focus on prevention and RAS blockade
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK 73132 4904, USA
Curr Clin Pharmacol 5:89-95. 2010
..This concise review will focus on prevention and the aggressive treatment of the existing cardiovascular risk factors with emphasis on the blockers of RAS, and demonstrate that RAS blockers are the best drugs for its treatment...
Efficacy and tolerability of amlodipine plus olmesartan medoxomil in patients with difficult-to-treat hypertensionS G Chrysant
Department of Cardiology and Hypertension, Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma School of Medicine, Oklahoma City, OK, USA
J Hum Hypertens 24:730-8. 2010
..These results suggest that the combination of amlodipine+olmesartan medoxomil provides a safe and effective option for the treatment of hypertension in challenging patient populations...
- Single-pill triple-combination therapy: an alternative to multiple-drug treatment of hypertension
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK 73132, USA
Postgrad Med 123:21-31. 2011
..In patients with essential HTN for whom dual therapy is inadequate, single-pill triple-drug therapy can offer a simplified and effective treatment strategy...
- Triple-drug, fixed-dose combinations for the treatment of hypertension: focus on olmesartan/amlodipine/hydrochlorothiazide combination
S G Chrysant
The Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, Oklahoma, USA
Drugs Today (Barc) 47:197-206. 2011
..These studies with collateral literature will be discussed in this concise review...
- Current status of aggressive blood glucose and blood pressure control in diabetic hypertensive subjects
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and The University of Oklahoma, Oklahoma City, Oklahoma, USA
Am J Cardiol 107:1856-61. 2011
..In conclusion, a review of recent research findings suggests less aggressive control of glucose and BP, and "the lower the better" may not be defensible at present, until new data become available...
- Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension
Steven G Chrysant
University of Oklahoma, Oklahoma City, OK, USA
Curr Med Res Opin 26:2841-9. 2010
..To assess the long-term safety and antihypertensive efficacy of aliskiren/valsartan 300/320 mg combination...
- Current evidence on the hemodynamic and blood pressure effects of isometric exercise in normotensive and hypertensive persons
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and The University of Oklahoma, Oklahoma City, OK 73132 4904, USA
J Clin Hypertens (Greenwich) 12:721-6. 2010
..Based on these changes, the authors believe that isometric exercise, whether alone or in combination with dynamic exercise, should be recommended to hypertensive patients and be part of a comprehensive treatment regimen...
- The role of Angiotensin receptor blocker and calcium channel blocker combination therapy in treating hypertension: focus on recent studies
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma, USA
Am J Cardiovasc Drugs 10:315-20. 2010
..A MEDLINE search of the English literature from 2006 to 2009 of amlodipine in combination with ARBs revealed six publications, which are included in this review...
- Effectiveness of lowering blood pressure to prevent stroke versus to prevent coronary events
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and The University of Oklahoma, Oklahoma City, Oklahoma, USA
Am J Cardiol 106:825-9. 2010
..In conclusion, most of the reviewed publications suggest a J-curve effect with low diastolic and systolic BP for cardiovascular disease complications but not stroke complications...
- Safety and tolerability of an olmesartan medoxomil-based regimen in patients with stage 1 hypertension: a randomized, double-blind, placebo-controlled study
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma School of Medicine, Oklahoma City, Oklahoma, USA
Clin Drug Investig 30:473-82. 2010
..Therefore, it is crucial for an antihypertensive agent to provide a high level of efficacy without compromising tolerability...
- The antihypertensive effectiveness and safety of dual RAAS blockade with aliskiren and valsartan
Steven G Chrysant
University of Oklahoma and the Oklahoma Cardiovascular and Hypertension Center, 5850 W Eilshire Boulevard, Oklahoma City, OK 73132 4904, USA
Drugs Today (Barc) 46:151-62. 2010
..The combination of aliskiren with valsartan, and with other antihypertensive drugs is discussed...
- Current status of dual Renin Angiotensin aldosterone system blockade for the treatment of cardiovascular diseases
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma, Oklahoma City, Oklahoma, USA
Am J Cardiol 105:849-52. 2010
....
- The combination of olmesartan medoxomil and amlodipine besylate in controlling high blood pressure: COACH, a randomized, double-blind, placebo-controlled, 8-week factorial efficacy and safety study
Steven G Chrysant
Oklahoma Cardiovascular Hypertension Center, Oklahoma City, Oklahoma 73132 4904, USA
Clin Ther 30:587-604. 2008
..Hypertension guidelines recommend the use of 2 agents having complementary mechanisms of action when >1 agent is needed to achieve blood pressure (BP) goals...
- Aliskiren-hydrochlorothiazide combination for the treatment of hypertension
Steven G Chrysant
University of Oklahoma School of Medicine, Oklahoma City, OK 73132 4904 USA
Expert Rev Cardiovasc Ther 6:305-14. 2008
..In this article, the pharmacokinetic and pharmacodynamic profile and the clinical application of aliskiren alone and in combination with HCTZ will be discussed...
- Current status of angiotensin receptor blockers for the treatment of cardiovascular diseases: focus on telmisartan
S G Chrysant
University of Oklahoma, Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK 73132 4904, USA
J Hum Hypertens 19:173-83. 2005
..With respect to the angiotensin receptor blockers, telmisartan has been demonstrated by several studies to be the longest acting among its class of drugs and to effectively prevent the early morning rise of blood pressure...
- Stroke prevention with losartan in the context of other antihypertensive drugs
Steven G Chrysant
University of Oklahoma School of Medicine and Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, Oklahoma 73132, USA
Drugs Today (Barc) 40:791-801. 2004
..These include the prevention of platelet adhesiveness and aggregation and the decrease of serum uric acid levels, which both lead to reduction in cardiovascular and cerebrovascular events. (..
- Pharmacological and clinical profile of moexipril: a concise review
Steven G Chrysant
University of Oklahoma and the Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, USA
J Clin Pharmacol 44:827-36. 2004
..In this review, the pharmacological profile of this drug and its clinical usefulness are discussed...
- Amlodipine/benazepril combination therapy for hypertensive patients nonresponsive to benazepril monotherapy
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma School of Medicine, Oklahoma City, Oklahoma 73132, USA
Am J Hypertens 17:590-6. 2004
....
- Pharmacological profile and clinical use of moexipril
Steven G Chrysant
University of Oklahoma, Oklahoma Cardiovascular and Hypertension Center, 5850 W Wilshire Blvd, Oklahoma City, OK 73132 4904, USA
Expert Rev Cardiovasc Ther 1:345-52. 2003
..In this review, the pharmacological profile of this drug and its clinical usefulness will be discussed...
- Fixed combination therapy of hypertension: focus on valsartan/hydrochlorothiazide combination (Diovan/HCT)
Steven G Chrysant
University of Oklahoma, Oklahoma Cardiovascular and Hypertension Center, 5850 W Wilshire Blvd, Oklahoma City, OK 73132 4904, USA
Expert Rev Cardiovasc Ther 1:335-43. 2003
..Its fixed combination with hydrochlorothiazide (HCT) is even more effective in controlling blood pressure in 70% of the cases. The most commonly used combinations are valsartan/HCT (Diovan/HCT), 80/12.5 and 160/12.5 mg given once-daily...
- Antihypertensive efficacy of olmesartan medoxomil alone and in combination with hydrochlorothiazide
Steven G Chrysant
University of Oklahoma School of Medicine and Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK, USA
Expert Opin Pharmacother 5:657-67. 2004
....
- Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazide
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma, 5850 W Wilshire Boulevard, Oklahoma City, OK 73132, USA
Am J Hypertens 17:252-9. 2004
..The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ)...
- The ALLHAT study: results and clinical implications
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma, 5850 W. Wilshire Boulevard, Oklahoma City, OK 73132, USA
QJM 96:771-3. 2003
- Possible pathophysiologic mechanisms supporting the superior stroke protection of angiotensin receptor blockers compared to angiotensin-converting enzyme inhibitors: clinical and experimental evidence
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK 73132 4904, USA
J Hum Hypertens 19:923-31. 2005
..These include antiplatelet aggregating, hypouricemic, antidiabetic and atrial antifibrillatory effects. However, the most critical factor in stroke prevention is good blood pressure control irrespective of drug used...
- Clinical experience with angiotensin receptor blockers with particular reference to valsartan
Steven G Chrysant
The University of Oklahoma School of Medicine, 5850 W Wilshire Boulevard, Oklahoma City, OK 73132, USA
J Clin Hypertens (Greenwich) 6:445-51. 2004
..The role of this system in cardiovascular remodeling and its blockade will be discussed in this review, which will specifically summarize data with the ARB, valsartan...
- The effects of high-dose amlodipine/benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma School of Medicine, Oklahoma City 73132, USA
Blood Press Suppl 1:10-7. 2007
..This study compared the efficacy and safety of amlodipine/benazepril (10/40 mg/day and 10/20 mg/day) with amlodipine 10 mg/day in patients whose blood pressure (BP) was not adequately controlled with amlodipine monotherapy...
- Treatment of hypertension with olmesartan medoxomil, alone and in combination with a diuretic: an update
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma School of Medicine, Oklahoma City, OK, USA
J Hum Hypertens 21:699-708. 2007
..In addition, the BP lowering effect of olmesartan, like the other members of its class, is greatly enhanced in combination with a diuretic. Its safety profile is similar to the other ARBs and no different than placebo...
- The pathophysiologic role of the brain renin-angiotensin system in stroke protection: clinical implications
Steven G Chrysant
University of Oklahoma School of Medicine and the Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK 73132 4904, USA
J Clin Hypertens (Greenwich) 9:454-9. 2007
..The evidence for this effect of ARBs compared with ACE inhibitors, however, is only indirect. Ongoing clinical trials with head-to-head comparisons of ARBs and ACE inhibitors will hopefully provide the needed information...
- The effects of high-dose amlodipine/benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma 73132, USA
Blood Press Suppl 16:10-7. 2007
..CONCLUSION: Amlodipine/benazepril combinations were well tolerated and resulted in significant BP reductions and better BP responder rates than amlodipine monotherapy...
- Niacin-ER/statin combination for the treatment of dyslipidemia: focus on low high-density lipoprotein cholesterol
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma School of Medicine, Oklahoma City, 73132 4904, USA
J Clin Hypertens (Greenwich) 8:493-9; quiz 500-1. 2006
..Thus, the long-term treatment of dyslipidemias with these two agents may help to modify risk and reduce cardiovascular morbidity and mortality in these patients over and above benefits achieved by lowering blood pressure...
- Use of 24-h ambulatory blood pressure monitoring to assess blood pressure control: a comparison of olmesartan medoxomil and amlodipine besylate
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension and the University of Oklahoma School of Medicine, Oklahoma City 73132, USA
Blood Press Monit 11:135-41. 2006
..This secondary analysis of a randomized, double-blind study compared the efficacy of olmesartan medoxomil with that of amlodipine besylate in achieving ambulatory blood pressure goals among patients with mild-to-moderate hypertension...
- The pleiotropic effects of angiotensin receptor blockers
Steven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma School of Medicine, 5850 West Wilshire Boulevard, Oklahoma City, OK 73132 4904, USA
J Clin Hypertens (Greenwich) 8:261-8. 2006
..All these actions make the ARBs a true pleiotropic class of drugs. Each of the foregoing effects will be discussed briefly in this concise review...
- Fixed low-dose drug combination for the treatment of hypertension
S G Chrysant
Department of Medicine, University of Oklahoma, Oklahoma City, USA
Arch Fam Med 7:370-6. 1998
....
- Antihypertensive efficacy and safety of olmesartan medoxomil compared with amlodipine for mild-to-moderate hypertension
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma, Oklahoma City, OK 73132 4904, USA
J Hum Hypertens 17:425-32. 2003
....
- Comparison of moexipril, a new ACE inhibitor, to verapamil-SR as add-on therapy to low dose hydrochlorothiazide in hypertensive patients
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma, Oklahoma City 73132-4904, USA
Am J Hypertens 8:418-21. 1995
..001). This study demonstrated that the addition of moexipril and verapamil-SR to low dose HCTZ is effective for the treatment of moderate to severe hypertension...
- Effects of isradipine or enalapril on blood pressure in salt-sensitive hypertensives during low and high dietary salt intake. MIST II Trial Investigators
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center and The University of Oklahoma, Oklahoma City, USA
Am J Hypertens 13:1180-8. 2000
..6 v 4.8 +/- 0.9 mm Hg for SDBP, P < .001), but enalapril exerted a similar effect during both diets. Because salt restriction lowered both SSBP and SDBP, the lowest BP achieved with both drugs were during the salt restriction phase...
- Antihypertensive effectiveness of amlodipine in combination with hydrochlorothiazide
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, Oklahoma City
Am J Hypertens 2:537-41. 1989
..We conclude: (1) the addition of amlodipine to HCTZ enhanced its antihypertensive action; (2) amlodipine was safe and well tolerated; and (3) amlodipine, perhaps, has a favorable effect on lipids...
- Antihypertensive and metabolic effects of single and combined atenolol regimens
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, The University of Oklahoma, Oklahoma City 73132
J Clin Pharmacol 32:61-5. 1992
..01). Mild, but statistically significant, increases in BUN, glucose, triglycerides, and uric acid were noted in groups 2, 5, and 6 (P less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)..
- Sustained blood pressure control with controlled-release isradipine
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma, Oklahoma City 73132-4904, USA
Am J Hypertens 8:87-9. 1995
..001). The most common clinical side effect was mild ankle edema, which was dose dependent, occurring in 35.5% of the patients taking the 20-mg ICR dose. This study showed that ICR is long acting, effective, and well tolerated...
- Treatment of white coat hypertension
S G Chrysant
Oklahoma Cardiovascular and Hypertension Center, University of Oklahoma, 5850 W Wilshire Boulevard, Oklahoma City, OK 73132 4904, USA
Curr Hypertens Rep 2:412-7. 2000
..In addition, semiannual or annual follow-up with ambulatory blood pressure monitoring is advised...
- Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
Alberto Villamil
Fundapres, Las Heras 2910 Piso 1A, Buenos Aires, Argentina
J Hypertens 25:217-26. 2007
..The effects of these treatments on plasma renin activity (PRA) were also assessed...
- Effects of the angiotensin II receptor blockers telmisartan versus valsartan in combination with hydrochlorothiazide: a large, confirmatory trial
William B White
Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Blood Press Monit 13:21-7. 2008
..Both studies support the strategy of using angiotensin receptor blockers with a higher dose of a thazide diuretic (25 mg) for enhancing the control of hypertension...
- Telmisartan/Hydrochlorothiazide in comparison with losartan/hydrochlorothiazide in managing patients with mild-to-moderate hypertension
Joel M Neutel
Orange County Research Center, Tustin, USA
Hypertens Res 28:555-63. 2005
..5 during the last 6 h of the 24-h dosing interval, which corresponds to the high-risk early-morning hours, and that T80/H12.5 provided additional blood pressure reductions...
- Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial
Ralph M Vicari
MIMA Century Research Associates, Melbourne, Florida 32901, USA
J Am Coll Cardiol 46:1803-11. 2005
..This study sought to evaluate the efficacy and safety of fasudil, an orally available rho kinase inhibitor, in patients with stable angina...
