Teratogen update: evaluation of the reproductive and developmental risks of caffeineM S Christian
Argus International and Argus Research Laboratories, Horsham, Pennsylvania 19044, USA
Teratology 64:51-78. 2001
..Proven human teratogens have an identifiable syndrome. The malformations described in the animal studies at very high doses fit the description of vascular disruptive types of malformations. (ABSTRACT TRUNCATED)..
- Developmental toxicity studies of four fragrances in rats
M S Christian
Argus Research Laboratories Inc, Horsham, PA 19044, USA
Toxicol Lett 111:169-74. 1999
..The results of this study indicate that under conditions of normal use, the tested fragrances do not pose a risk to human conceptuses...
- Introduction/overview: gender-based differences in pharmacologic and toxicologic responses
M S Christian
Primedica Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 20:145-8. 2001
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- Biodisposition of dibromoacetic acid (DBA) and bromodichloromethane (BDCM) administered to rats and rabbits in drinking water during range-finding reproduction and developmental toxicity studies
M S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 20:239-53. 2001
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- Oral (drinking water) two-generation reproductive toxicity study of dibromoacetic acid (DBA) in rats
M S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 21:237-76. 2002
..Based on the high multiples of human exposure required to produce effects in male rats, DBA should not be identified as a human reproductive or developmental risk...
- Oral (drinking water) developmental toxicity studies of bromodichloromethane (BDCM) in rats and rabbits
M S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 20:225-37. 2001
..3 mg/kg/day). These NOAELs are 56,250 and 69,120 times the human adult exposure level of 0.0008 mg/kg/day, respectively. Based on the results of these studies, BDCM should not be identified as a risk to development of human conceptuses...
- Lack of effects of nose-only inhalation exposure on testicular toxicity in male rats
S J Rothenberg
Primedica Argus, Horsham, Pennsylvania 19044, USA
Toxicol Sci 53:127-34. 2000
..Thus, nose-only exposure for up to 2 h per day for a total of 42 days did not cause adverse effects on the reproductive organs, fertility, or reproductive performance of male rats under the conditions of this study...
- Developmental (embryo-fetal toxicity/teratogenicity) toxicity studies of synthetic crystalline lycopene in rats and rabbits
M S Christian
Argus International Inc 933 Horsham Road, Horsham, PA 19044, USA
Food Chem Toxicol 41:773-83. 2003
..Neither Lycopene 10 CWD nor LycoVit 10% caused direct maternal or developmental toxicity in rats or rabbits at dosages as high as 3000 or 2000 mg/kg/day, respectively...
- Lack of developmental neurotoxicity of MN rgp 120/HIV-1 administered subcutaneously to neonatal rats
J L Bussiere
Department of Toxicology, Genentech, Inc, South San Francisco, CA 94080, USA
Toxicol Sci 48:90-9. 1999
..Thus, MN rgp120/HIV-1 alone or formulated as a vaccine does not cause neurotoxicity or developmental toxicity in neonatal rats after exposure in utero and/or during the neonatal period...
- Embryo-fetal toxicity signals for 17alpha-hydroxyprogesterone caproate in high-risk pregnancies: a review of the non-clinical literature for embryo-fetal toxicity with progestins
M S Christian
Argus International, Horsham, PA 19044, USA
J Matern Fetal Neonatal Med 20:89-112. 2007
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- Oral (drinking water) two-generation reproductive toxicity study of bromodichloromethane (BDCM) in rats
M S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania, USA
Int J Toxicol 21:115-46. 2002
..5 to 109.0 mg/kg/day), or 36,875 to 136,250 times the human adult exposure level. Regardless, these data indicate that BDCM should not be identified as a risk to human reproductive performance or development of human conceptuses...
