Y Christen

Summary

Publications

  1. ncbi Oxidative stress and Alzheimer disease
    Y Christen
    Fondation Ipsen, 24 rue Erlanger, 75016 Paris, France
    Am J Clin Nutr 71:621S-629S. 2000
  2. ncbi Egb 761 in the postgenomic era: new tools from molecular biology for the study of complex products such as Ginkgo biloba extract
    Yves Christen
    Beaufour Ipsen, Paris, France
    Cell Mol Biol (Noisy-le-grand) 48:593-9. 2002
  3. ncbi The Ginkgo biloba extract EGb 761 increases viability of hnt human neurons in culture and affectsthe expression of genes implicated in the stress response
    C Soulie
    INSERM U383, Hĵpital Necker, Paris, France
    Cell Mol Biol (Noisy-le-grand) 48:641-6. 2002
  4. ncbi Ginkgo biloba and neurodegenerative disorders
    Yves Christen
    IPSEN, 24 rue Erlanger, 75016 Paris, France
    Front Biosci 9:3091-104. 2004
  5. ncbi Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, MD 21201, USA
    Eur J Neurosci 26:2931-9. 2007
  6. ncbi Ginkgo biloba extract (EGb 761) in Alzheimer's disease: is there any evidence?
    Charles Ramassamy
    Institut National de la Recherche Scientifique, Institut Armand Frappier, Pointe Claire, Quebec, Canada
    Curr Alzheimer Res 4:253-62. 2007
  7. ncbi EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    FASEB J 21:2400-8. 2007
  8. ncbi Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:13102-13. 2006
  9. ncbi Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
    Fanny Longpre
    INRS, Institut Armand Frappier, Universite du Quebec, 245 boulevard Hymus, Pointe Claire, H9R1G6 INAF, Univ Laval, Quebec, Canada
    Free Radic Biol Med 41:1781-94. 2006
  10. ncbi Amyloid precursor protein metabolism is regulated toward alpha-secretase pathway by Ginkgo biloba extracts
    Francesca Colciaghi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Neurobiol Dis 16:454-60. 2004

Collaborators

  • Lester Packer
  • Yuan Luo
  • CHRISTOPHER LINK
  • Lourdes Massieu
  • Charles Ramassamy
  • Yanjue Wu
  • Yanan Xu
  • Zhixin Wu
  • Flaubert Tchantchou
  • Zhiming Cao
  • Fanny Longpre
  • Francesca Colciaghi
  • Amy Strayer
  • Hean Zhuang
  • C Soulie
  • Changhai Cui
  • Kenneth Curry
  • Cheuk Pang
  • Peter Butko
  • William L Klein
  • Philippe Garneau
  • Mary P Lambert
  • Annalisa Longhi
  • Martina Zimmermann
  • Barbara Borroni
  • Flaminio Cattabeni
  • Camilla Bellone
  • Monica Di Luca
  • Alessandro Padovani
  • A Nicole
  • I Ceballos-Picot
  • SYLVAIN DORE
  • Sokhon Pin

Detail Information

Publications15

  1. ncbi Oxidative stress and Alzheimer disease
    Y Christen
    Fondation Ipsen, 24 rue Erlanger, 75016 Paris, France
    Am J Clin Nutr 71:621S-629S. 2000
    ....
  2. ncbi Egb 761 in the postgenomic era: new tools from molecular biology for the study of complex products such as Ginkgo biloba extract
    Yves Christen
    Beaufour Ipsen, Paris, France
    Cell Mol Biol (Noisy-le-grand) 48:593-9. 2002
    ..Instead of studying a simple gene or protein, a global investigation of all genes or proteins at once can give insights of the complexity of biological systems...
  3. ncbi The Ginkgo biloba extract EGb 761 increases viability of hnt human neurons in culture and affectsthe expression of genes implicated in the stress response
    C Soulie
    INSERM U383, Hĵpital Necker, Paris, France
    Cell Mol Biol (Noisy-le-grand) 48:641-6. 2002
    ..These results support the idea that modulation of target genes and transcription factors may be involved in the neuroprotective action of EGb 761...
  4. ncbi Ginkgo biloba and neurodegenerative disorders
    Yves Christen
    IPSEN, 24 rue Erlanger, 75016 Paris, France
    Front Biosci 9:3091-104. 2004
    ..Positive findings would be particularly interesting since this drug is very safe to use...
  5. ncbi Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, MD 21201, USA
    Eur J Neurosci 26:2931-9. 2007
    ..Actions of individual EGb 761 components provide further insights into direct mechanisms underlying the effect of EGb 761 on enhancing the cognitive performance of patients with AD...
  6. ncbi Ginkgo biloba extract (EGb 761) in Alzheimer's disease: is there any evidence?
    Charles Ramassamy
    Institut National de la Recherche Scientifique, Institut Armand Frappier, Pointe Claire, Quebec, Canada
    Curr Alzheimer Res 4:253-62. 2007
    ..Moreover we will discuss the complexity of the cellular and molecular mechanisms of EGb 761 and the significance of the synergic effect of different constituents of EGb 761...
  7. ncbi EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    FASEB J 21:2400-8. 2007
    ....
  8. ncbi Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:13102-13. 2006
    ....
  9. ncbi Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
    Fanny Longpre
    INRS, Institut Armand Frappier, Universite du Quebec, 245 boulevard Hymus, Pointe Claire, H9R1G6 INAF, Univ Laval, Quebec, Canada
    Free Radic Biol Med 41:1781-94. 2006
    ....
  10. ncbi Amyloid precursor protein metabolism is regulated toward alpha-secretase pathway by Ginkgo biloba extracts
    Francesca Colciaghi
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Neurobiol Dis 16:454-60. 2004
    ..Additional research will be needed to clearly define the effective clinical relevance, thus considering EGb761 as a possible supplementary treatment in dementing diseases...
  11. ncbi Effect of Ginkgo biloba (EGb 761) on staurosporine-induced neuronal death and caspase activity in cortical cultured neurons
    Lourdes Massieu
    Departamento de Neurociencias, Instituto de Fisiologia Celular, AP 70 253, UNAM, Mexico DF, CP 04510, Mexico
    Brain Res 1002:76-85. 2004
    ..Inhibition of capase-3 induced by EGb 761 and vitamin E does not seem to contribute to their observed protective action...
  12. ncbi Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761
    Amy Strayer
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406 5018, USA
    FASEB J 17:2305-7. 2003
    ..These results support the hypothesis that EGb 761 augments the natural antistress system of C. elegans, thus increasing stress resistance and life span...
  13. ncbi Induction of heme oxygenase 1 by Ginkgo biloba in neuronal cultures and potential implications in ischemia
    Hean Zhuang
    Cell Mol Biol (Noisy-le-grand) 48:647-53. 2002
    ..We are proposing that several of the protective effects of EGb 761 in ischemia could be mediated through beneficial actions of heme degradation and its metabolites...
  14. ncbi What is Ginkgo biloba extract EGb 761? An overview--from molecular biology to clinical medicine
    Yves Christen
    Beaufour Ipsen, Paris, France
    Cell Mol Biol (Noisy-le-grand) 48:601-11. 2002
    ....
  15. ncbi Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans
    Zhiming Cao
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 62:1337-45. 2007
    ..elegans is a valid model system for testing therapeutic intervention for delaying the progress of sarcopenia...