Sung Jin Cho



  1. Le T, Lee E, Lee J, Hong A, Yim C, Yang I, et al. Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp. Mar Drugs. 2019;17: pubmed publisher
    ..Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition. ..
  2. Jeong S, Byun J, Cho S, Chin J, Lee I, Choi Y, et al. Transcription Factor Eb Is Required for Macropinocytosis-Mediated Growth Recovery of Nutrient-Deprived Kras-Mutant Cells. Nutrients. 2018;10: pubmed publisher
    ..Collectively, our results show that TFEB plays a role in macropinocytosis-mediated KRAS-mutant cell growth under nutrient deprivation by promoting lysosomal degradation of extracellular proteins. ..
  3. Kim D, Lee E, Lee J, Leutou A, Shin Y, Choi B, et al. Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment. Mar Drugs. 2018;16: pubmed publisher
    ..Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase. ..
  4. Kim D, Lee J, Londhe A, Kadayat T, Joo J, Hwang H, et al. Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist. Bioorg Med Chem. 2018;26:4382-4389 pubmed publisher
    ..Our overall results clearly demonstrate that this orally administrable PPARδ agonist 3a is a viable drug candidate for the treatment of various PPARδ-related disorders. ..
  5. Kim J, Im C, Yoo E, Ma M, Kim S, Hong E, et al. Identification of Selective ERRγ Inverse Agonists. Molecules. 2016;21:80 pubmed publisher
    ..This novel class of ERRγ inverse agonists shows promise in the development of drugs targeting ERRγ-related diseases. ..
  6. Kim J, Chin J, Im C, Yoo E, Woo S, Hwang H, et al. Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists. Eur J Med Chem. 2016;120:338-52 pubmed publisher
    ..Thus, the newly synthesized class of ERR? inverse agonists could be lead candidates for developing clinical therapies for ERR?-related disorders. ..