Megan Chircop

Summary

Publications

  1. ncbi Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells
    Charlotte M Smith
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Mol Cancer 12:4. 2013
  2. ncbi Phosphorylation of dynamin II at serine-764 is associated with cytokinesis
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia
    Biochim Biophys Acta 1813:1689-99. 2011
  3. ncbi Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Mol Cancer Ther 10:1553-62. 2011
  4. ncbi The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells
    Sanket Joshi
    Children s Medical Research Institute, The University of Sydney, Westmead, New South Wales, Australia
    Mol Cancer Ther 9:1995-2006. 2010
  5. ncbi Calcineurin activity is required for the completion of cytokinesis
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Cell Mol Life Sci 67:3725-37. 2010
  6. ncbi Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression
    Sanket Joshi
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
    Mol Cancer 10:78. 2011
  7. ncbi SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis
    Maggie P C Ma
    Children s Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia
    J Cell Sci 125:4372-82. 2012
  8. ncbi Clathrin-mediated endocytic proteins are involved in regulating mitotic progression and completion
    Charlotte M Smith
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Traffic 13:1628-41. 2012

Collaborators

Detail Information

Publications8

  1. ncbi Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells
    Charlotte M Smith
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Mol Cancer 12:4. 2013
    ..abstract:..
  2. ncbi Phosphorylation of dynamin II at serine-764 is associated with cytokinesis
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia
    Biochim Biophys Acta 1813:1689-99. 2011
    ..Therefore, phosphorylation of dynamin II primarily occurs on a single site that regulates cytokinesis downstream of calcineurin, rather than regulating endocytosis or centrosome function...
  3. ncbi Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Mol Cancer Ther 10:1553-62. 2011
    ..Thus, the dynoles are a second class of dynamin GTPase inhibitors, with dynole 34-2 as the lead compound, that are novel antimitotic compounds acting specifically at the abscission stage...
  4. ncbi The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells
    Sanket Joshi
    Children s Medical Research Institute, The University of Sydney, Westmead, New South Wales, Australia
    Mol Cancer Ther 9:1995-2006. 2010
    ..Thus, MiTMABs have toxicity and antiproliferative properties that preferentially target cancer cells. This suggests that dynII may be a novel target for pharmacologic intervention for the treatment of cancer...
  5. ncbi Calcineurin activity is required for the completion of cytokinesis
    Megan Chircop
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Cell Mol Life Sci 67:3725-37. 2010
    ..CaN activity and disassembly of the FMRs coincide with abscission. Thus, CaN activity at the midbody plays a key role in regulating the completion of cytokinesis in mammalian cells...
  6. ncbi Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression
    Sanket Joshi
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
    Mol Cancer 10:78. 2011
    ..The cellular response following cytokinesis failure and the mechanistic pathway involved is unknown...
  7. ncbi SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis
    Maggie P C Ma
    Children s Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia
    J Cell Sci 125:4372-82. 2012
    ..We conclude that SNX9 subfamily members are required for mitosis through both endocytosis-dependent and -independent processes...
  8. ncbi Clathrin-mediated endocytic proteins are involved in regulating mitotic progression and completion
    Charlotte M Smith
    Children s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW, 2145, Australia
    Traffic 13:1628-41. 2012
    ..Therefore, the role of endocytic proteins in mitosis is much broader than previously recognized...