Shiun Kwei Chiou

Summary

Publications

  1. ncbi Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyond
    Shiun Kwei Chiou
    Department of Medicine, Veterans Affairs Medical Center, Long Beach, CA, USA University of California, Irvine, CA, USA
    Med Sci Monit 9:PI25-9. 2003
  2. ncbi Survivin: a novel target for indomethacin-induced gastric injury
    Shiun Kwei Chiou
    Department of Medicine, Gastroenterology Section, Veterans Affairs Medical Center, 5901 East 7th Street, Long Beach, CA 90822, USA
    Gastroenterology 128:63-73. 2005
  3. ncbi NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis
    S K Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Biochem Pharmacol 74:1485-95. 2007
  4. ncbi Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Apoptosis 14:1341-51. 2009
  5. ncbi Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, 5901 E 7th St, Long Beach, CA 90822 5201, USA
    J Pharmacol Exp Ther 334:693-702. 2010
  6. ncbi Sulindac sulfide induces autophagic death in gastric epithelial cells via survivin down-regulation: a mechanism of NSAIDs-induced gastric injury
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Biochem Pharmacol 81:1317-23. 2011
  7. ncbi Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells
    Sarathy Mandayam
    Division of Gastroenterology, VA Medical Center, 5901 E Seventh Street 111, Long Beach, CA 90822, USA
    Apoptosis 12:1109-16. 2007
  8. ncbi Selective cyclooxygenase (COX) inhibition causes damage to portal hypertensive gastric mucosa: roles of nitric oxide and NF-kappaB
    Tomohiko Akahoshi
    Department of Medicine, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    FASEB J 19:1163-5. 2005
  9. ncbi Survivin expression in the stomach: implications for mucosal integrity and protection
    Shiun-Kwei Chiou
    Department of Medicine, Veterans Affairs Medical Center, Long Beach, 5901 East Seventh Street, Long Beach, CA 90822, USA
    Biochem Biophys Res Commun 305:374-9. 2003

Collaborators

  • A Tarnawski
  • M K Jones
  • Sarathy Mandayam
  • Tomohiko Akahoshi
  • Richard Huang
  • Tetsuya Tanigawa
  • Makoto Hashizume
  • I James Sarfeh
  • Yoshihiko Maehara

Detail Information

Publications9

  1. ncbi Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyond
    Shiun Kwei Chiou
    Department of Medicine, Veterans Affairs Medical Center, Long Beach, CA, USA University of California, Irvine, CA, USA
    Med Sci Monit 9:PI25-9. 2003
    ..Understanding the mechanism of survivin function can potentially allow for the development of therapeutic strategies for cancer and other diseases...
  2. ncbi Survivin: a novel target for indomethacin-induced gastric injury
    Shiun Kwei Chiou
    Department of Medicine, Gastroenterology Section, Veterans Affairs Medical Center, 5901 East 7th Street, Long Beach, CA 90822, USA
    Gastroenterology 128:63-73. 2005
    ..Apoptosis is one of the mechanisms. The role of survivin, an antiapoptosis protein, in NSAID-induced gastric injury is unknown. We examined the role of survivin in NSAID-induced gastric mucosal and gastric cell injury...
  3. ncbi NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis
    S K Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Biochem Pharmacol 74:1485-95. 2007
    ..In conclusion, indomethacin treatment enhances degradation of survivin via the ubiquitin proteasome machinery in RGM-1 cells, and maintenance of survivin levels is important for prevention of gastric epithelial cell injury and apoptosis...
  4. ncbi Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Apoptosis 14:1341-51. 2009
    ..These findings confirm a role for GADD45alpha in NSAID-induced cytotoxicity, a mechanism for the anti-neoplastic effect of NSAIDs in colon tumorigenesis and cancer growth...
  5. ncbi Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, 5901 E 7th St, Long Beach, CA 90822 5201, USA
    J Pharmacol Exp Ther 334:693-702. 2010
    ....
  6. ncbi Sulindac sulfide induces autophagic death in gastric epithelial cells via survivin down-regulation: a mechanism of NSAIDs-induced gastric injury
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Biochem Pharmacol 81:1317-23. 2011
    ..Induction of Survivin-dependent autophagic cell death is a novel mechanism by which sulindac sulfide induces gastric mucosal injury...
  7. ncbi Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells
    Sarathy Mandayam
    Division of Gastroenterology, VA Medical Center, 5901 E Seventh Street 111, Long Beach, CA 90822, USA
    Apoptosis 12:1109-16. 2007
    ..These data support a role for survivin isoforms in colon cancer cell apoptosis, and thus in prevention of colon cancer growth by NSAIDs...
  8. ncbi Selective cyclooxygenase (COX) inhibition causes damage to portal hypertensive gastric mucosa: roles of nitric oxide and NF-kappaB
    Tomohiko Akahoshi
    Department of Medicine, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    FASEB J 19:1163-5. 2005
    ....
  9. ncbi Survivin expression in the stomach: implications for mucosal integrity and protection
    Shiun-Kwei Chiou
    Department of Medicine, Veterans Affairs Medical Center, Long Beach, 5901 East Seventh Street, Long Beach, CA 90822, USA
    Biochem Biophys Res Commun 305:374-9. 2003
    ..Based on these expression studies, and the known role of survivin as an anti-apoptosis protein, survivin may play a role in maintaining gastric mucosal integrity and regulating cell renewal in the gastric mucosa...