Shiun Kwei Chiou

Summary

Publications

  1. ncbi request reprint Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyond
    Shiun Kwei Chiou
    Department of Medicine, Veterans Affairs Medical Center, Long Beach, CA, USA University of California, Irvine, CA, USA
    Med Sci Monit 9:PI25-9. 2003
  2. ncbi request reprint Indomethacin promotes apoptosis in gastric cancer cells through concomitant degradation of Survivin and Aurora B kinase proteins
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, 5901 E 7th St, Long Beach, CA, 90822 5201, USA
    Apoptosis 19:1378-88. 2014
  3. doi request reprint Sulindac sulfide induces autophagic death in gastric epithelial cells via survivin down-regulation: a mechanism of NSAIDs-induced gastric injury
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Biochem Pharmacol 81:1317-23. 2011
  4. doi request reprint Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, 5901 E 7th St, Long Beach, CA 90822 5201, USA
    J Pharmacol Exp Ther 334:693-702. 2010
  5. doi request reprint Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Apoptosis 14:1341-51. 2009
  6. ncbi request reprint NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis
    S K Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Biochem Pharmacol 74:1485-95. 2007
  7. ncbi request reprint Survivin: a novel target for indomethacin-induced gastric injury
    Shiun Kwei Chiou
    Department of Medicine, Gastroenterology Section, Veterans Affairs Medical Center, 5901 East 7th Street, Long Beach, CA 90822, USA
    Gastroenterology 128:63-73. 2005
  8. pmc Differential glioma-associated tumor antigen expression profiles of human glioma cells grown in hypoxia
    Lisheng Ge
    Diagnostic and Molecular Health Care Group, Veterans Affairs Medical Center, Long Beach, California, United States of America
    PLoS ONE 7:e42661. 2012
  9. ncbi request reprint Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells
    Sarathy Mandayam
    Division of Gastroenterology, VA Medical Center, 5901 E Seventh Street 111, Long Beach, CA 90822, USA
    Apoptosis 12:1109-16. 2007
  10. ncbi request reprint Selective cyclooxygenase (COX) inhibition causes damage to portal hypertensive gastric mucosa: roles of nitric oxide and NF-kappaB
    Tomohiko Akahoshi
    Department of Medicine, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    FASEB J 19:1163-5. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyond
    Shiun Kwei Chiou
    Department of Medicine, Veterans Affairs Medical Center, Long Beach, CA, USA University of California, Irvine, CA, USA
    Med Sci Monit 9:PI25-9. 2003
    ..Understanding the mechanism of survivin function can potentially allow for the development of therapeutic strategies for cancer and other diseases...
  2. ncbi request reprint Indomethacin promotes apoptosis in gastric cancer cells through concomitant degradation of Survivin and Aurora B kinase proteins
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, 5901 E 7th St, Long Beach, CA, 90822 5201, USA
    Apoptosis 19:1378-88. 2014
    ..Thus this report provides better understanding of the molecular mechanisms underlying the anti-cancer effect of NSAIDs by elucidating a significant role for Aurora B kinase in indomethacin-induced apoptosis. ..
  3. doi request reprint Sulindac sulfide induces autophagic death in gastric epithelial cells via survivin down-regulation: a mechanism of NSAIDs-induced gastric injury
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Biochem Pharmacol 81:1317-23. 2011
    ..Induction of Survivin-dependent autophagic cell death is a novel mechanism by which sulindac sulfide induces gastric mucosal injury...
  4. doi request reprint Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, 5901 E 7th St, Long Beach, CA 90822 5201, USA
    J Pharmacol Exp Ther 334:693-702. 2010
    ....
  5. doi request reprint Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths
    Shiun Kwei Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Apoptosis 14:1341-51. 2009
    ..These findings confirm a role for GADD45alpha in NSAID-induced cytotoxicity, a mechanism for the anti-neoplastic effect of NSAIDs in colon tumorigenesis and cancer growth...
  6. ncbi request reprint NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis
    S K Chiou
    Department of Veterans Affairs Medical Center, Long Beach, CA 90822 5201, USA
    Biochem Pharmacol 74:1485-95. 2007
    ..In conclusion, indomethacin treatment enhances degradation of survivin via the ubiquitin proteasome machinery in RGM-1 cells, and maintenance of survivin levels is important for prevention of gastric epithelial cell injury and apoptosis...
  7. ncbi request reprint Survivin: a novel target for indomethacin-induced gastric injury
    Shiun Kwei Chiou
    Department of Medicine, Gastroenterology Section, Veterans Affairs Medical Center, 5901 East 7th Street, Long Beach, CA 90822, USA
    Gastroenterology 128:63-73. 2005
    ..Apoptosis is one of the mechanisms. The role of survivin, an antiapoptosis protein, in NSAID-induced gastric injury is unknown. We examined the role of survivin in NSAID-induced gastric mucosal and gastric cell injury...
  8. pmc Differential glioma-associated tumor antigen expression profiles of human glioma cells grown in hypoxia
    Lisheng Ge
    Diagnostic and Molecular Health Care Group, Veterans Affairs Medical Center, Long Beach, California, United States of America
    PLoS ONE 7:e42661. 2012
    ..The antigens expressed by hypoxic tumor cells may be a better source of starting tumor material for loading dendritic cells for novel immunotherapy of glioma using tumor-associated antigens...
  9. ncbi request reprint Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells
    Sarathy Mandayam
    Division of Gastroenterology, VA Medical Center, 5901 E Seventh Street 111, Long Beach, CA 90822, USA
    Apoptosis 12:1109-16. 2007
    ..These data support a role for survivin isoforms in colon cancer cell apoptosis, and thus in prevention of colon cancer growth by NSAIDs...
  10. ncbi request reprint Selective cyclooxygenase (COX) inhibition causes damage to portal hypertensive gastric mucosa: roles of nitric oxide and NF-kappaB
    Tomohiko Akahoshi
    Department of Medicine, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    FASEB J 19:1163-5. 2005
    ....
  11. ncbi request reprint Survivin expression in the stomach: implications for mucosal integrity and protection
    Shiun Kwei Chiou
    Department of Medicine, Veterans Affairs Medical Center, Long Beach, 5901 East Seventh Street, Long Beach, CA 90822, USA
    Biochem Biophys Res Commun 305:374-9. 2003
    ..Based on these expression studies, and the known role of survivin as an anti-apoptosis protein, survivin may play a role in maintaining gastric mucosal integrity and regulating cell renewal in the gastric mucosa...
  12. pmc Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis
    Shiun Kwei Chiou
    Research Division, Veterans Affairs Medical Center, 5901 E 7th Street, Long Beach, CA 90822, USA Department of Medicine, University of California, 101 The City Drive, Irvine, Orange, CA 92868, USA
    Gastroenterol Res Pract 2012:897678. 2012
    ..These results suggest that whether a cell lives or dies due to autophagy induction depends on the balance of factors that regulate both autophagic and apoptotic processes...
  13. pmc Glioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy
    Lisheng Ge
    Diagnostic and Molecular Health Care Group, Long Beach, CA 90822, USA
    J Immunol 189:2625-34. 2012
    ..This study shows that peptides derived from cancer-associated ion channels maybe useful targets for T cell-mediated immunotherapy...