Adriano Chio

Summary

Publications

  1. doi request reprint Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study
    Adriano Chio
    Department of Neuroscience, University of Torino, AOU San Giovanni Battista, Via Cherasco 15, 10126 Torino, Italy
    J Neurol Neurosurg Psychiatry 82:740-6. 2011
  2. doi request reprint ATXN2 polyQ intermediate repeats are a modifier of ALS survival
    Adriano Chio
    From the ALS Center A Chiò, A Calvo, C M, A Canosa, M Brunetti, M Barberis, Rita Levi Montalcini Department of Neuroscience, University of Torino the Laboratory of Molecular Genetics M Brunetti, M Barberis, G R, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino A Chiò, A Calvo the Neuroscience Institute of Torino NIT A Chiò, A Calvo the Departments of Neurosciences, Ophthalmology, Genetics, Rehabilitation, and Child Health A Canosa, University of Genoa the Neurological Institute A Conte, G B, M S and the Institute of Medical Genetics G Marangi, A M, S L, M Z, Catholic University of the Sacred Heart, Rome the Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases IRCAD M Bagarotti, L C, S D, and the Department of Neurology E B, L M, Amedeo Avogadro University of Eastern Piedmont, Novara the Salvatore Maugeri Foundation A B, Communicable Disease Surveillance Centre
    Neurology 84:251-8. 2015
  3. doi request reprint Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes
    Adriano Chio
    ALS Center, Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy Electronic address
    Lancet Neurol 13:1228-40. 2014
  4. pmc Extensive genetics of ALS: a population-based study in Italy
    Adriano Chio
    ALS Center, Department of Neurosciences, University of Torino and AOU San Giovanni Battista of Torino, Torino, Italy
    Neurology 79:1983-9. 2012
  5. pmc UNC13A influences survival in Italian amyotrophic lateral sclerosis patients: a population-based study
    Adriano Chio
    ALS Center, Department of Neuroscience, University of Torino, and Azienda Ospedale Università San Giovanni Battista, Torino, Italy
    Neurobiol Aging 34:357.e1-5. 2013
  6. doi request reprint ALS/FTD phenotype in two Sardinian families carrying both C9ORF72 and TARDBP mutations
    Adriano Chio
    Department of Neuroscience, University of Torino, Torino, Italy
    J Neurol Neurosurg Psychiatry 83:730-3. 2012
  7. doi request reprint Pain in amyotrophic lateral sclerosis: a population-based controlled study
    A Chio
    ALS Centre, Department of Neuroscience, University of Torino, Torino, Italy
    Eur J Neurol 19:551-5. 2012
  8. pmc Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72
    Adriano Chio
    Department of Neuroscience, University of Turin and Azienda Ospedale Università San Giovanni Battista of Turin, I 10126 Turin, Italy
    Brain 135:784-93. 2012
  9. doi request reprint Neurobehavioral dysfunction in ALS has a negative effect on outcome and use of PEG and NIV
    A Chio
    ALS Center, Department of Neuroscience, University of Torino, Torino, Italy
    Neurology 78:1085-9. 2012
  10. doi request reprint Non-invasive ventilation in amyotrophic lateral sclerosis: a 10 year population based study
    Adriano Chio
    ALS Centre, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy
    J Neurol Neurosurg Psychiatry 83:377-81. 2012

Detail Information

Publications76

  1. doi request reprint Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study
    Adriano Chio
    Department of Neuroscience, University of Torino, AOU San Giovanni Battista, Via Cherasco 15, 10126 Torino, Italy
    J Neurol Neurosurg Psychiatry 82:740-6. 2011
    ..However, the differential characteristics of these phenotypes are still largely unknown...
  2. doi request reprint ATXN2 polyQ intermediate repeats are a modifier of ALS survival
    Adriano Chio
    From the ALS Center A Chiò, A Calvo, C M, A Canosa, M Brunetti, M Barberis, Rita Levi Montalcini Department of Neuroscience, University of Torino the Laboratory of Molecular Genetics M Brunetti, M Barberis, G R, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino A Chiò, A Calvo the Neuroscience Institute of Torino NIT A Chiò, A Calvo the Departments of Neurosciences, Ophthalmology, Genetics, Rehabilitation, and Child Health A Canosa, University of Genoa the Neurological Institute A Conte, G B, M S and the Institute of Medical Genetics G Marangi, A M, S L, M Z, Catholic University of the Sacred Heart, Rome the Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases IRCAD M Bagarotti, L C, S D, and the Department of Neurology E B, L M, Amedeo Avogadro University of Eastern Piedmont, Novara the Salvatore Maugeri Foundation A B, Communicable Disease Surveillance Centre
    Neurology 84:251-8. 2015
    ....
  3. doi request reprint Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes
    Adriano Chio
    ALS Center, Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy Electronic address
    Lancet Neurol 13:1228-40. 2014
    ..Studies involving international collaborations, standardised assessments, and large patient cohorts will overcome these shortcomings and provide further insight into the pathogenesis of ALS. ..
  4. pmc Extensive genetics of ALS: a population-based study in Italy
    Adriano Chio
    ALS Center, Department of Neurosciences, University of Torino and AOU San Giovanni Battista of Torino, Torino, Italy
    Neurology 79:1983-9. 2012
    ..To assess the frequency and clinical characteristics of patients with mutations of major amyotrophic lateral sclerosis (ALS) genes in a prospectively ascertained, population-based epidemiologic series of cases...
  5. pmc UNC13A influences survival in Italian amyotrophic lateral sclerosis patients: a population-based study
    Adriano Chio
    ALS Center, Department of Neuroscience, University of Torino, and Azienda Ospedale Università San Giovanni Battista, Torino, Italy
    Neurobiol Aging 34:357.e1-5. 2013
    ..The identification of UNC13A as a modifier of prognosis among sporadic ALS patients potentially provides a new therapeutic target aimed at slowing disease progression...
  6. doi request reprint ALS/FTD phenotype in two Sardinian families carrying both C9ORF72 and TARDBP mutations
    Adriano Chio
    Department of Neuroscience, University of Torino, Torino, Italy
    J Neurol Neurosurg Psychiatry 83:730-3. 2012
    ..In the isolated population of Sardinia, a Mediterranean island, ∼25% of ALS cases carry either a p.A382T mutation of the TARDBP gene or a GGGGCC hexanucleotide repeat expansion in the first intron of the C9ORF72 gene...
  7. doi request reprint Pain in amyotrophic lateral sclerosis: a population-based controlled study
    A Chio
    ALS Centre, Department of Neuroscience, University of Torino, Torino, Italy
    Eur J Neurol 19:551-5. 2012
    ..To assess the prevalence and characteristics of pain in an epidemiological series of patients with amyotrophic lateral sclerosis (ALS) compared to population-based controls...
  8. pmc Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72
    Adriano Chio
    Department of Neuroscience, University of Turin and Azienda Ospedale Università San Giovanni Battista of Turin, I 10126 Turin, Italy
    Brain 135:784-93. 2012
    ..Their pedigrees typically display a high frequency of cases with pure frontotemporal dementia, widening the concept of familial amyotrophic lateral sclerosis...
  9. doi request reprint Neurobehavioral dysfunction in ALS has a negative effect on outcome and use of PEG and NIV
    A Chio
    ALS Center, Department of Neuroscience, University of Torino, Torino, Italy
    Neurology 78:1085-9. 2012
    ..To assess the effect of neurobehavioral dysfunction on amyotrophic lateral sclerosis (ALS) survival and on the use of life-prolonging therapies in a population-based setting...
  10. doi request reprint Non-invasive ventilation in amyotrophic lateral sclerosis: a 10 year population based study
    Adriano Chio
    ALS Centre, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy
    J Neurol Neurosurg Psychiatry 83:377-81. 2012
    ..To evaluate the clinical characteristics and outcome of non-invasive ventilation (NIV) in an epidemiological based series of amyotrophic lateral sclerosis (ALS) patients...
  11. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
    ..A new locus for amyotrophic lateral sclerosis--frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p...
  12. pmc Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation
    Adriano Chio
    ALS Center, Department of Neuroscience, University of Turin, Turin, Italy
    Neurobiol Aging 30:1272-5. 2009
    ..R514S mutation and bulbar onset, with very young age and a rapid course in the family carrying the p.P525L mutation...
  13. doi request reprint Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter study
    Adriano Chio
    Dipartimento di Neuroscienze, Centro per la Sclerosi Laterale Amiotrofica, Torino, Italy
    Muscle Nerve 43:189-95. 2011
    ..G-CSF treatment was safe and feasible in a multicenter series of ALS patients. A decrease in the CSF levels of proinflammatory cytokines MCP-1 and IL-17 was found, indicating a G-CSF-induced central anti-inflammatory response...
  14. doi request reprint Epidemiology of ALS in Italy: a 10-year prospective population-based study
    A Chio
    Department of Neuroscience, University of Torino, Italy
    Neurology 72:725-31. 2009
    ..To describe the temporal patterns of incidence and demographic characteristics of amyotrophic lateral sclerosis (ALS) in Piemonte and Valle d'Aosta, Italy, in the 10-year period 1995 through 2004...
  15. ncbi request reprint Comorbidity between CIDP and diabetes mellitus: only a matter of chance?
    A Chio
    Department of Neuroscience, Via Cherasco 15, 10126 Torino, Italy
    Eur J Neurol 16:752-4. 2009
    ..It is well known that chronic inflammatory demyelinating polyneuropathy (CIDP) and diabetes mellitus (DM) are often associated, but it is not clear if these two disorders are patogenetically correlated...
  16. doi request reprint Prevalence of SOD1 mutations in the Italian ALS population
    A Chio
    ALS Center, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy
    Neurology 70:533-7. 2008
    ..However, estimates of SOD1 mutation prevalence have been exclusively based on case series and clinic referral cohorts...
  17. doi request reprint ALS in Italian professional soccer players: the risk is still present and could be soccer-specific
    Adriano Chio
    Department of Neuroscience, University of Turin, Turin, Italy
    Amyotroph Lateral Scler 10:205-9. 2009
    ..The absence of ALS cases in professional road cyclists and basketball players indicates that ALS is not related to physical activity per se...
  18. doi request reprint Lower serum lipid levels are related to respiratory impairment in patients with ALS
    A Chio
    Department of Neuroscience, University of Torino, ALS Center, Torino, Italy
    Neurology 73:1681-5. 2009
    ..To investigate this, we evaluated the status of blood lipids in a large Italian series of patients with ALS, and assessed the effect of hyperlipidemia on patients' survival...
  19. doi request reprint ALS clinical trials: do enrolled patients accurately represent the ALS population?
    A Chio
    ALS Centre, Department of Neuroscience, University of Turin, Turin
    Neurology 77:1432-7. 2011
    ..To assess the effect of eligibility criteria in amyotrophic lateral sclerosis (ALS) clinical trials on the representativeness of the enrolled population...
  20. pmc A de novo missense mutation of the FUS gene in a "true" sporadic ALS case
    Adriano Chio
    ALS Center, Department of Neuroscience, University of Torino, Torino, Italy
    Neurobiol Aging 32:553.e23-6. 2011
    ..R521C). This report highlights the importance of screening ALS patients, both familial and sporadic, for FUS mutations and also suggests that de novo mutations is a relevant mechanism underlying sporadic neurodegenerative disease...
  21. pmc Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene
    Adriano Chio
    Department of Neuroscience, University of Torino, Via Cherasco 15, Turin, Italy
    Arch Neurol 68:594-8. 2011
    ..To perform an extensive screening for mutations of amyotrophic lateral sclerosis (ALS)-related genes in a consecutive cohort of Sardinian patients, a genetic isolate phylogenically distinct from other European populations...
  22. doi request reprint Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial
    A Chio
    Department of Neuroscience, Via Cherasco 15, 10126 Torino, Italy
    Neurology 75:619-25. 2010
    ..4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG])...
  23. pmc Amyotrophic lateral sclerosis-frontotemporal lobar dementia in 3 families with p.Ala382Thr TARDBP mutations
    Adriano Chio
    Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy
    Arch Neurol 67:1002-9. 2010
    ..However, to our knowledge, there is only 1 description of 2 patients with FTLD and TARDBP gene mutations who later developed motor neuron disease...
  24. doi request reprint Tracheostomy in amyotrophic lateral sclerosis: a 10-year population-based study in Italy
    A Chio
    ALS Centre, Department of Neuroscience, University of Torino, Torino, Italy
    J Neurol Neurosurg Psychiatry 81:1141-3. 2010
    ..In conclusion, in an epidemiological setting, ALS survival after tracheostomy was <1 year. Sociocultural factors influence the probability of choice to be tracheostomised, even in a highly socialized health system as Italian one...
  25. doi request reprint Neurobehavioral symptoms in ALS are negatively related to caregivers' burden and quality of life
    A Chio
    ALS Center, Department of Neuroscience, University of Torino, San Giovanni Battista Hospital, Torino, Italy
    Eur J Neurol 17:1298-303. 2010
    ..To evaluate the frequency of neurobehavioral symptoms related to FTLD in a consecutive series of amyotrophic lateral sclerosis (ALS) patients and to assess their influence on patients' and caregivers' mood, burden, and quality of life...
  26. ncbi request reprint ALS patients and caregivers communication preferences and information seeking behaviour
    A Chio
    ALS Centre, Department of Neuroscience, University of Torino, Torino, Italy
    Eur J Neurol 15:55-60. 2008
    ..Health professionals should be aware that ALS patients and caregivers often use internet to obtain information and should help them to better sort-out and interpret the news they found...
  27. pmc Idiopathic chronic inflammatory demyelinating polyneuropathy: an epidemiological study in Italy
    A Chio
    Department of Neuroscience, University of Torino, Italy
    J Neurol Neurosurg Psychiatry 78:1349-53. 2007
    ..The clinical and epidemiological characteristics of chronic inflammatory demyelinating polyneuropathy (CIDP) in an Italian population were assessed...
  28. ncbi request reprint Cesare Lombroso, cortical dysplasia, and epilepsy: keen findings and odd theories
    A Chio
    Section of Neurology, Department of Neuroscience, University of Turin, Italy
    Neurology 61:1412-6. 2003
    ..Cesare Lombroso supported a common origin of criminality, genius, and epilepsy as caused by factors impairing the embryonic development of the CNS, mainly affecting the hierarchically superior neural centers...
  29. pmc Percutaneous radiological gastrostomy: a safe and effective method of nutritional tube placement in advanced ALS
    A Chio
    Second Division of Neurology, Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy
    J Neurol Neurosurg Psychiatry 75:645-7. 2004
    ..As PEG is not indicated in patients with severe respiratory impairment, an alternative is percutaneous radiological gastrostomy (PRG), involving air insufflation into the stomach under fluoroscopic guidance for tube insertion...
  30. pmc A cross sectional study on determinants of quality of life in ALS
    A Chio
    Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Torino, Italy
    J Neurol Neurosurg Psychiatry 75:1597-601. 2004
    ..Understanding the determinants of quality of life (QoL) in amyotrophic lateral sclerosis (ALS) has become increasingly important with the recent emphasis on the comprehensive management of patients...
  31. ncbi request reprint Guillain-Barré syndrome: a prospective, population-based incidence and outcome survey
    A Chio
    Department of Neuroscience, University of Turin, San Giovanni Battista Hospital, Italy
    Neurology 60:1146-50. 2003
    ..The authors evaluated the incidence and long-term prognostic factors of Guillain-Barré syndrome (GBS) in a prospective, population-based study...
  32. ncbi request reprint Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players
    Adriano Chio
    Dipartimento di Scienze Fisiologiche Farmacologiche, Cellulari Molecolari, Sezione di Farmacologia e Biotecnologie Farmacologiche, Universita di Pavia, Italy
    Brain 128:472-6. 2005
    ..2, 95% CI, 3.1-44.4; < or =5 years, 3.5, 95% CI, 0.4-12.7). Our findings seem to indicate that playing professional football is a strong risk factor for ALS...
  33. ncbi request reprint Breaking the news in amyotrophic lateral sclerosis
    Adriano Chio
    Second Division of Neurology, Department of Neuroscience, University of Turin, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:195-201. 2004
    ..Written material may increase satisfaction of patients and their relatives, but should never substitute for face-to-face discussion...
  34. ncbi request reprint Validity of hospital morbidity records for amyotrophic lateral sclerosis. A population-based study
    Adriano Chio
    2nd Division of Neurology, Department of Neuroscience, University of Turin and S Giovanni Battista Hospital, Via Cherasco 15, 10126 Torino, Italy
    J Clin Epidemiol 55:723-7. 2002
    ..In conclusion, hospital discharge records appear to poorly reflect the incidence of ALS, and can be used only after clinical verification of the diagnosis...
  35. ncbi request reprint Caregiver burden and patients' perception of being a burden in ALS
    A Chio
    Department of Neuroscience, University of Turin, Italy
    Neurology 64:1780-2. 2005
    ..ALS patients have a good objective perception of their impact on caregivers...
  36. ncbi request reprint Amyotrophic lateral sclerosis associated with pregnancy: report of four new cases and review of the literature
    Adriano Chio
    Second Division of Neurology, Department of Neurosciences, University of Torino, Turin, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:45-8. 2003
    ..Generally, ALS does not have deleterious effects on fetal development. However, pregnancy in a woman with severe respiratory failure may precipitate the disease...
  37. ncbi request reprint Motor neuron disease and optic neuropathy after acute exposure to a methanol-containing solvent mixture
    Adriano Chio
    Neuroscience, University of Turin, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:188-91. 2004
    ..The temporal onset of the clinical symptoms, biological plausibility, young age of the patient and absence of neurological disorders in the family history raises suspicion of a possible causative relationship...
  38. ncbi request reprint Amyotrophic lateral sclerosis care in Italy: a nationwide study in neurological centers
    A Chio
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    J Neurol Sci 191:145-50. 2001
    ..Therefore, there are considerable opportunities to improve the care of ALS patients in Italy, primarily through the education of neurologists on AAN standards of care for ALS...
  39. ncbi request reprint Caregiver time use in ALS
    A Chio
    Department of Neuroscience, University of Turin, Torino, Italy
    Neurology 67:902-4. 2006
    ..With worsening of patients' disability, families relied increasingly on paid caregivers. Caregiver time is a hidden cost of ALS care and is a major burden for caregivers...
  40. pmc Positive effects of tertiary centres for amyotrophic lateral sclerosis on outcome and use of hospital facilities
    A Chio
    Divisione di Neurologia 1, Dipartimento di Neuroscienze, Universita di Torino, Torino, Italy
    J Neurol Neurosurg Psychiatry 77:948-50. 2006
    ..To evaluate the effects of tertiary centres for amyotrophic lateral sclerosis (ALS) on ALS outcome and the use of hospital facilities...
  41. ncbi request reprint Early symptom progression rate is related to ALS outcome: a prospective population-based study
    A Chio
    Division of Neurology, Department of Neuroscience, University of Torino and Azienda Ospedaliera S Giovanni Battista, Torino, Italy
    Neurology 59:99-103. 2002
    ..To define the factors related to ALS outcome in a population-based, prospective survey...
  42. doi request reprint An ALS case with a novel D90N-SOD1 heterozygous missense mutation
    Andrea Calvo
    Department of Neuroscience, University of Turin, Turin, Italy
    Amyotroph Lateral Scler 13:393-5. 2012
    ..D90N). Our report confirms that ALS patients with D90 codon heterozygous mutations may be associated with rapid progression and a prominent pain syndrome...
  43. doi request reprint Genetic counselling in ALS: facts, uncertainties and clinical suggestions
    Adriano Chio
    Department of Neuroscience, ALS Center, Rita Levi Montalcini, University of Torino, Torino, and Azienda Ospedaliera Città della Salute e della Scienza, Torino, Italy
    J Neurol Neurosurg Psychiatry 85:478-85. 2014
    ....
  44. doi request reprint Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS
    Ettore Beghi
    Dipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, Milan, Italy
    Amyotroph Lateral Scler Frontotemporal Degener 14:397-405. 2013
    ..Median survival was 45 months (ALC) and 22 months (placebo) (p = 0.0176). MRC, QoL and adverse events were similar. In conclusion, ALC may be effective, well-tolerated and safe in ALS. A pivotal phase III trial is needed...
  45. doi request reprint The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients
    Angelina Cistaro
    Positron Emission Tomography Center IRMET S p A, Torino, Italy
    Eur J Nucl Med Mol Imaging 41:844-52. 2014
    ..Relatively little is known about the brain metabolism profile of patients carrying the expansion. Our aim was to identify the [(18)F]FDG PET profile in ALS patients with the C9ORF72 expansion (C9ORF72-ALS)...
  46. pmc De novo nonsense mutation of the FUS gene in an apparently familial amyotrophic lateral sclerosis case
    Andrea Calvo
    Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy
    Neurobiol Aging 35:1513.e7-11. 2014
    ..De novo mutations could account for a sizable number of apparently sporadic ALS patients carrying mutations of ALS-related genes. ..
  47. doi request reprint Religiousness is positively associated with quality of life of ALS caregivers
    Andrea Calvo
    ALS Centre, Department of Neuroscience, University of Turin, Italy
    Amyotroph Lateral Scler 12:168-71. 2011
    ..Health care professionals caring for ALS patients should consider that the needs of the caregivers include religious/spiritual concerns...
  48. doi request reprint Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis
    Marco Pagani
    From the Institute of Cognitive Sciences and Technologies M P, A Cistaro, CNR, Rome, Italy Departments of Nuclear Medicine M P and Hospital Physics J O, Karolinska Hospital, Stockholm, Sweden ALS Center A Chiò, A Calvo, C M, D B, Rita Levi Montalcini Department of Neuroscience, University of Turin, Italy Neuroscience Institute of Turin A Chiò, Italy Department of Neuroradiology M C V, CTO Hospital, Turin, Italy Clinical Neurology Unit F N, Department of Neurosciences, Ophthalmology and Genetics DINOGMI and Department of Health Sciences S M, Nuclear Medicine Unit, Department of Internal Medicine, University of Genoa, Italy Institute of Molecular Bioimaging and Physiology F D, CNR Genoa Unit, Italy and Positron Emission Tomography Center IRMET S p A P F, A Cistaro, Euromedic Inc, Turin, Italy
    Neurology 83:1067-74. 2014
    ..We investigated a large sample of patients with amyotrophic lateral sclerosis (ALS) at rest in order to assess the value of (18)F-2-fluoro-2-deoxy-d-glucose ((18)F-FDG) PET as a biomarker to discriminate patients from controls...
  49. doi request reprint Monomelic amyotrophy is not always benign: a case report
    Cristina Moglia
    ALS Centre, Department of Neuroscience, University of Turin, San Giovanni Hospital, Torino, Italy
    Amyotroph Lateral Scler 12:307-8. 2011
    ..This case demonstrates that monomelic amyotrophy may rarely evolve to a diffuse fatal MND, even after more than a decade of clinical stability. Our findings support the idea that MA is part of the clinical continuum of MND...
  50. ncbi request reprint A longitudinal study on quality of life and depression in ALS patient-caregiver couples
    A Gauthier
    Dipartimento di Neuroscienze, University of Torino, Torino, Italy
    Neurology 68:923-6. 2007
    ....
  51. doi request reprint Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy
    Anna Montuschi
    Rita Levi Montalcini Department of Neuroscience, the ALS Center, University of Torino, Italy
    J Neurol Neurosurg Psychiatry 86:168-73. 2015
    ..There is less data available regarding the characteristics of cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) in a population-based series...
  52. doi request reprint Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases
    Giovanni De Marco
    Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy Department of Oncology, University of Turin, Turin, Italy
    Biochim Biophys Acta 1843:725-34. 2014
    ..This outcome should be considered when murine models are used to investigate TDP-43 proteinopathies. ..
  53. doi request reprint Amyotrophic lateral sclerosis in Piedmont (Italy): a Bayesian spatial analysis of the incident cases
    Giuseppe Migliaretti
    Department of Public Health and Microbiology, University of Turin, Turin, Italy
    Amyotroph Lateral Scler Frontotemporal Degener 14:58-65. 2013
    ..Despite some limits of the spatial analysis in the study of rare diseases, results appear coherent with literature data, stimulating other in-depth analysis in this field of research...
  54. doi request reprint Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset
    Angelina Cistaro
    Positron Emission Tomography Center IRMET S p A, Turin, Italy
    Eur J Nucl Med Mol Imaging 39:251-9. 2012
    ..To identify the neurobiological traits of amyotrophic lateral sclerosis (ALS) and to elucidate functional differences between ALS of spinal and bulbar onset. We hypothesized that glucose metabolism distribution might vary between groups...
  55. pmc Prognostic factors in ALS: A critical review
    Adriano Chio
    Department of Neuroscience, University of Torino and San Giovanni Battista Hospital, Turin, Italy
    Amyotroph Lateral Scler 10:310-23. 2009
    ..Alternative trial designs can include the use of natural history controls, the so-called minimization method for treatment allocation, and the futility approach...
  56. ncbi request reprint Deregulation of the p14ARF/Mdm2/p53 pathway and G1/S transition in two glioblastoma sets
    Chiara Ghimenti
    Department of Neuroscience, University of Turin, Turin, Italy
    J Neurooncol 61:95-102. 2003
    ..All glioblastomas with gemistocytic areas showed p14ARF inactivation. Immunohistochemistry showed higher percentages of positivity in comparison with molecular genetics, but with similar variations...
  57. ncbi request reprint The sinister side of Italian soccer
    Simone Beretta
    Department of Neuroscience, University of Milano Bicocca, Milan, Italy
    Lancet Neurol 2:656-7. 2003
  58. ncbi request reprint Cogwheel rigidity
    Paolo Ghiglione
    Department of Neuroscience, University of Turin, Turin, Italy
    Arch Neurol 62:828-30. 2005
  59. ncbi request reprint Follow-up of patients affected by manganese-induced Parkinsonism after treatment with CaNa2EDTA
    Elena Herrero Hernandez
    Department of Traumatology, Orthopaedics and Occupational Health, Neurotoxicology Unit, University of Turin, Via Zuretti 29, 10126 Turin, Italy
    Neurotoxicology 27:333-9. 2006
    ..Therefore, chelating treatment can be a great aid in overt manganism, but particular attention must be paid to primary prevention, as this disease should now be totally preventable and definitely merits eradication...
  60. pmc A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
    Adriano Chio
    Department of Neuroscience, University of Turin, Turin, Italy
    Hum Mol Genet 18:1524-32. 2009
    ..Our findings suggest that ALS is more genetically and clinically heterogeneous than previously recognized. Genotype data from our study have been made available online to facilitate such future endeavors...
  61. doi request reprint Anxiety undermines quality of life in ALS patients and caregivers
    A Vignola
    Department of Neuroscience, ALS Center, University of Torino, Torino, Italy
    Eur J Neurol 15:1231-6. 2008
    ..Although depression has been widely studied in amyotrophic lateral sclerosis (ALS), there is little information on anxiety...
  62. ncbi request reprint Epidemiology of adult medulloblastoma
    M T Giordana
    Department of Neuroscience, University of Turin, Italy
    Int J Cancer 80:689-92. 1999
    ..The figure is higher than that generally assumed, and indicates that the occurrence of this embryonal tumor in adult age is relevant. Our epidemiological data are consistent with an embryonal origin of medulloblastoma...
  63. doi request reprint Multiple sclerosis relapses: a multivariable analysis of residual disability determinants
    M Vercellino
    Department of Neuroscience, University of Turin, Italy
    Acta Neurol Scand 119:126-30. 2009
    ..Recovery from multiple sclerosis (MS) relapses is variable. The factors influencing persistence of residual disability (RD) after a relapse are still to be thoroughly elucidated...
  64. doi request reprint NADPH oxidase (NOX2) activity is a modifier of survival in ALS
    Giuseppe Marrali
    Rita Levi Montalcini Department of Neuroscience, ALS Centre, University of Torino, Via Cherasco 15, 10126, Turin, Italy
    J Neurol 261:2178-83. 2014
    ..A proper modulation of NOX2 activity might hold therapeutic potential for ALS. ..
  65. doi request reprint Amyotrophic lateral sclerosis outcome measures and the role of albumin and creatinine: a population-based study
    Adriano Chio
    Amyotrophic Lateral Sclerosis Center, Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy2Città della Salute e della Scienza, Azienda Ospedaliero Universitaria, Turin, Italy3Neuroscience Institute of Torino, Turin, Italy
    JAMA Neurol 71:1134-42. 2014
    ..There is an urgent need to identify reliable biomarkers of amyotrophic lateral sclerosis (ALS) progression for clinical practice and pharmacological trials...
  66. pmc SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Elisa Rubino
    Neurology II, Department of Internal Medicine, University of Torino, Torino, Italy
    Neurology 79:1556-62. 2012
    ..The purpose of our study was to evaluate the frequency of SQSTM1 mutations in a dataset of unrelated patients with FTLD or ALS, in comparison with healthy controls and patients with Paget disease of bone (PDB)...
  67. doi request reprint Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutations
    Giovanni De Marco
    Department of Medicine and Experimental Oncology, Section of Biochemistry, University of Turin, Turin, Italy
    Acta Neuropathol 121:611-22. 2011
    ..Were these findings further confirmed, circulating lymphomonocytes could be informative of TDP-43 mislocalisation in nervous tissue and used as a biomarker for future disease risk...
  68. ncbi request reprint The IVS1 +319 t>a of SOD1 gene is not an ALS causing mutation
    G Restagno
    S C Molecolare, Dipartmento di Patalogia Clinica, A O O I R M S Anna, Torino, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:45-9. 2005
    ..These results strongly support the idea that the IVS1 +319 t>a alone is not an ALS causing mutation, and that special care must be taken in the interpretation of data from mutations databases for correct genetic counselling...
  69. doi request reprint Consistent bone marrow-derived cell mobilization following repeated short courses of granulocyte-colony-stimulating factor in patients with amyotrophic lateral sclerosis: results from a multicenter prospective trial
    Corrado Tarella
    Dip Medicina Oncologia Sperimentale, SC Universitaria di Ematologia and Molecular Biotechnology Center, Torino, Italy
    Cytotherapy 12:50-9. 2010
    ....
  70. ncbi request reprint Anaplasia is rare and does not influence prognosis in adult medulloblastoma
    Maria Teresa Giordana
    Department of Neuroscience, University of Torino, Torino, Italy
    J Neuropathol Exp Neurol 64:869-74. 2005
    ..Histopathologic factors have no clinical use for stratification of patients in risk groups. The histologic spectrum of medulloblastoma in adults is different from that in children...
  71. doi request reprint The last months of life of people with amyotrophic lateral sclerosis in mechanical invasive ventilation: A qualitative study
    Simone Veronese
    Fondazione F A R O onlus, Palliative Care, Turin, Italy
    Amyotroph Lateral Scler Frontotemporal Degener 15:499-504. 2014
    ..The study shows that tracheostomy is often undertaken with little discussion. The end-of-life phase can be defined, with several indicators of deterioration, which could be triggers for the involvement of palliative care. ..
  72. doi request reprint Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis
    Adriano Chio
    Rita Levi Montalcini Department of Neuroscience, University of Torino, Torino, Italy
    J Neurol Neurosurg Psychiatry 86:38-44. 2015
    ..Our purpose was to develop an ALS staging system (ALS Milano-Torino Staging) that captures the observed progressive loss of independence and function...
  73. ncbi request reprint Risk of cancer in patients with Guillain-Barré syndrome (GBS). A population-based study
    Maria Claudia Vigliani
    2nd Division of Neurology, Dept of Neuroscience, University of Turin, Turin, Italy
    J Neurol 251:321-6. 2004
    ..These results suggest a possible correlation between some cases of GBS and cancer. However, GBS in cancer patients does not meet all the criteria for paraneoplastic diseases...
  74. ncbi request reprint MGMT promoter hypermethylation in a series of 104 glioblastomas
    Marta Mellai
    Neuro bio oncology Center of Policlinico di Monza Foundation, University of Turin, Via Pietro Micca, 29 13100 Vercelli, Italy
    Cancer Genomics Proteomics 6:219-27. 2009
    ..To evaluate MGMT promoter hypermethylation as prognostic factor in a retrospective study of 104 cases of glioblastoma multiforme (GBM)...
  75. ncbi request reprint Involvement of immune response in the pathogenesis of amyotrophic lateral sclerosis: a therapeutic opportunity?
    A Calvo
    ALS Center, Department of Neuroscience, University of Torino, Italy
    CNS Neurol Disord Drug Targets 9:325-30. 2010
    ..The multiple aspects of the immune response in ALS are beginning to be appreciated, and their potential as pharmacologic targets in neurologic disease is being explored...
  76. ncbi request reprint Morphophenotype of medulloblastoma in children and adults. The size of nuclei
    C Dagostino
    Department of Neuroscience, University of Torino, Italy
    Clin Neuropathol 25:227-31. 2006
    ..The aim of the present study was to compare the size of nuclei between pediatric and adult medulloblastomas by a morphometric analysis...