Jun Zhou

Summary

Country: China

Publications

  1. pmc Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1
    Jun Zhou
    Department of Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, 17 Changlexilu, Xi an 710032, Shaanxi, P R China
    BMC Cell Biol 6:25. 2005
  2. pmc CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes
    Ping Zhu
    Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, PR China
    Arthritis Res Ther 8:R44. 2006
  3. ncbi [Quantitative expression of voltage-dependent calcium channels in prostate smooth muscle cells of rats with estradiol-induced chronic nonbacterial prostatitis]
    Liang Zhang
    Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China
    Zhonghua Nan Ke Xue 16:295-9. 2010
  4. ncbi Preparation of gold-labeled antibody probe and its use in immunochromatography assay for detection of aflatoxin B1
    Sun Xiulan
    School of Food Science, Southern Yangtze University, 170, Huihe Road, Wuxi, Jiangsu 214036, PR China
    Int J Food Microbiol 99:185-94. 2005
  5. ncbi Analytical vectorial structure of hollow Gaussian beams in the far field
    Guohua Wu
    Shanghai Institute of Optics and Fine Mechanics, CAS, Shanghai 201800
    Opt Express 16:6417-24. 2008
  6. ncbi Expression of CD147 as a significantly unfavorable prognostic factor in hepatocellular carcinoma
    Qing Zhang
    Department of Cell Biology and Cell Engineering Research Centre, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Eur J Cancer Prev 16:196-202. 2007
  7. ncbi Poly (ethylenimine)-grafted-poly [(aspartic acid)-co-lysine], a potential non-viral vector for DNA delivery
    Gu Ping Tang
    Institute of Bioengineering and Nanotechnology, Singapore
    J Biomater Sci Polym Ed 17:461-80. 2006
  8. ncbi [Surgery therapy of Crohn disease complicated with fistula]
    Jian Ping Wang
    Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Wei Chang Wai Ke Za Zhi 9:281-3. 2006
  9. doi Gene-carried chitosan-linked-PEI induced high gene transfection efficiency with low toxicity and significant tumor-suppressive activity
    Jian Qing Gao
    Institute of Pharmaceutics, Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, PR China
    Int J Pharm 387:286-94. 2010
  10. doi Fabrication of low-loss, single-mode-channel waveguide with DNA-CTMA biopolymer by multistep processing technology
    Jun Zhou
    Institute of Photonics, Faculty of Science, Ningbo University, Ningbo 315211, Zhejiang, China
    Opt Lett 35:1512-4. 2010

Collaborators

Detail Information

Publications67

  1. pmc Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1
    Jun Zhou
    Department of Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, 17 Changlexilu, Xi an 710032, Shaanxi, P R China
    BMC Cell Biol 6:25. 2005
    ..We found in our study that CD147 played a very important role in this process...
  2. pmc CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes
    Ping Zhu
    Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, PR China
    Arthritis Res Ther 8:R44. 2006
    ..These findings suggest that CD147 may be one of the important factors in progressive joint destruction of RA and that CD147 may be a potential therapeutic target in RA treatment...
  3. ncbi [Quantitative expression of voltage-dependent calcium channels in prostate smooth muscle cells of rats with estradiol-induced chronic nonbacterial prostatitis]
    Liang Zhang
    Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China
    Zhonghua Nan Ke Xue 16:295-9. 2010
    ..To construct a rat model of chronic nonbacterial prostatitis (CP) and investigate the difference in the quantitative expression of voltage-dependent calcium channels of prostate smooth muscle cells (PSMCs) between the models and controls...
  4. ncbi Preparation of gold-labeled antibody probe and its use in immunochromatography assay for detection of aflatoxin B1
    Sun Xiulan
    School of Food Science, Southern Yangtze University, 170, Huihe Road, Wuxi, Jiangsu 214036, PR China
    Int J Food Microbiol 99:185-94. 2005
    ..Detection time was reduced 6-10 times comparative with ELISA. With visual observation, lower test limit was found to be around 2.5 ng/ml aflatoxin B1 standard solution, which was increased to two times of ELISA...
  5. ncbi Analytical vectorial structure of hollow Gaussian beams in the far field
    Guohua Wu
    Shanghai Institute of Optics and Fine Mechanics, CAS, Shanghai 201800
    Opt Express 16:6417-24. 2008
    ..The physics pictures of HGB is illustrated from the vectorial structure, which is important to understand the theoretical aspects of both scalar and vector HGB propagation...
  6. ncbi Expression of CD147 as a significantly unfavorable prognostic factor in hepatocellular carcinoma
    Qing Zhang
    Department of Cell Biology and Cell Engineering Research Centre, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Eur J Cancer Prev 16:196-202. 2007
    ..0001). The findings suggest that CD147 may be a significant independent predictor of poor survival in patients with hepatocellular carcinoma, and may be involved in tumor growth, invasion and angiogenesis in hepatocellular carcinoma...
  7. ncbi Poly (ethylenimine)-grafted-poly [(aspartic acid)-co-lysine], a potential non-viral vector for DNA delivery
    Gu Ping Tang
    Institute of Bioengineering and Nanotechnology, Singapore
    J Biomater Sci Polym Ed 17:461-80. 2006
    ..This means that the PEI600-PSL co-polymer is a promising candidate for gene delivery...
  8. ncbi [Surgery therapy of Crohn disease complicated with fistula]
    Jian Ping Wang
    Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Wei Chang Wai Ke Za Zhi 9:281-3. 2006
    ..To investigate the surgical treatment of Crohn disease(CD) complicated with perforation or fistula...
  9. doi Gene-carried chitosan-linked-PEI induced high gene transfection efficiency with low toxicity and significant tumor-suppressive activity
    Jian Qing Gao
    Institute of Pharmaceutics, Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, PR China
    Int J Pharm 387:286-94. 2010
    ..When these gene-altered cells were inoculated in mice, the tumor growth rate was significantly decreased, indicating the CP copolymer was a promising vector for the therapeutic gene delivery...
  10. doi Fabrication of low-loss, single-mode-channel waveguide with DNA-CTMA biopolymer by multistep processing technology
    Jun Zhou
    Institute of Photonics, Faculty of Science, Ningbo University, Ningbo 315211, Zhejiang, China
    Opt Lett 35:1512-4. 2010
    ..The measurement results show that these channel waveguides have low propagation losses and small polarization dependent losses at 633, 1310, and 1550 nm wavelengths...
  11. pmc Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production
    Ping Zhu
    Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Arthritis Res Ther 7:R1023-33. 2005
    ..These findings, together with a better understanding of CD147, CyPA and RA, will help in the development of innovative therapeutic interventions for RA...
  12. doi Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production
    Wen Bo Liu
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xiing Hospital, Fourth Military Medical University, Xi an 710032, China
    Neurochem Int 57:206-15. 2010
    ....
  13. ncbi Minimally invasive treatment combined with cytokine-induced killer cells therapy lower the short-term recurrence rates of hepatocellular carcinomas
    De sheng Weng
    State Key Laboratory of Oncology in Southern China, Biotherapy Center, Department of Imaging and Interventional Radiology, Sun Yat Sen University, Guangzhou, Guangdong, P R China
    J Immunother 31:63-71. 2008
    ..05). The data suggest that CIK cell transfusion is an effective treatment. It can boost the immunologic function in HCC patients and plays an important role in reducing the recurrence rate of HCC...
  14. ncbi Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma
    Hui Wang
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Yuexiu District, Guangzhou, Guangdong Province 510060, People s Republic of China
    J Cancer Res Clin Oncol 134:535-41. 2008
    ....
  15. ncbi Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism
    Huazhang An
    Institute of Immunology, Second Military Medical University, Shanghai, People s Republic of China
    Blood 105:4685-92. 2005
    ....
  16. ncbi Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line
    Guiqin Sun
    Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, P R China
    Int J Oncol 32:1065-71. 2008
    ..The results suggested that ZNF217 might play a crucial role in the proliferation and invasion of ovarian cancer...
  17. ncbi [Effect of Ca2+ mobilization on release and activation of matrix metalloproteinases in hepatocellular carcinoma cells]
    Jian Li Jiang
    Cell Engineering Research Center, The Fourth Military Medical University, Xi an 710032, China
    Zhonghua Zhong Liu Za Zhi 26:525-7. 2004
    ..To investigate the effect of Ca(2+) mobilization on release and activation of matrix metalloproteinases (MMPs) in human hepatocellular carcinoma cells...
  18. ncbi Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells
    Ceshi Chen
    Winship Cancer Institute and Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:41553-61. 2005
    ..These findings not only established WWP1 as an E3 ubiquitin ligase for KLF5, they also further implicated the KLF5 pathway in human carcinogenesis...
  19. ncbi CD147, MMP-2, MMP-9 and MVD-CD34 are significant predictors of recurrence after liver transplantation in hepatocellular carcinoma patients
    Qing Zhang
    Departerment of Cell Biology and Cell Engineering Research Centre, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an, China
    Cancer Biol Ther 5:808-14. 2006
    ....
  20. doi Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells
    Jinhong Zeng
    Department of Chemistry, Huazhong University of Science and Technology, 1037 Luoyu Lu, Hongshan, Wuhan, Hubei 430074, People s Republic of China
    Arch Biochem Biophys 478:1-6. 2008
    ....
  21. ncbi SiC-shell nanostructures fabricated by replicating ZnO nano-objects: a technique for producing hollow nanostructures of desired shape
    Jun Zhou
    School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0245, USA
    Small 2:1344-7. 2006
  22. ncbi Hyperthermia differentially regulates TLR4 and TLR2-mediated innate immune response
    Wei Zhao
    Institute of Immunology and State Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai 200433, PR China
    Immunol Lett 108:137-42. 2007
    ....
  23. ncbi Puerarin facilitates Ca(2+)-induced Ca(2+) release triggered by KCl-depolarization in primary cultured rat hippocampal neurons
    Fankai Lin
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Eur J Pharmacol 570:43-9. 2007
    ..However, U-73122, the inhibitor of phospholipase C (PLC) had no effect, indicating that the cyclic AMP/PKA signaling pathway was involved in the activation of CICR by puerarin...
  24. ncbi Economic assessment of the health effects related to particulate matter pollution in 111 Chinese cities by using economic burden of disease analysis
    Minsi Zhang
    Department of Environmental Science, Peking University, Beijing 100871, China
    J Environ Manage 88:947-54. 2008
    ..The results will help policy makers in formulating more effective countermeasures and increasing public awareness to enhance environmental protection...
  25. ncbi PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-terminal kinase pathway
    Min Liu
    Department of Genetics and Cell Biology, Key Laboratory of Bioactive Materials Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
    J Biol Chem 282:17581-6. 2007
    ....
  26. ncbi Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma
    Hua kun Zhang
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Yuexiu District, Guangzhou, Guangdong Province 510060, PR China
    Cancer Lett 261:183-92. 2008
    ..Our data suggest that ING2 is involved in the progression of HCC, therefore it is considered to be a candidate tumor suppressor gene and its significantly decreased expression in HCC may lead to an unfavorable prognosis...
  27. ncbi Preparation, characterization and in vivo distribution of solid lipid nanoparticles loaded with cisplatin
    Jie Tian
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR China
    Pharmazie 63:593-7. 2008
    ..CDDP-SLN prepared by this method was proved to be a targeted and less toxic drug delivery system...
  28. doi Detachment of colloids from a solid surface by a moving air-water interface
    Prabhakar Sharma
    Section for Environmental Engineering, Aalborg University, Aalborg 9000, Denmark
    J Colloid Interface Sci 326:143-50. 2008
    ..The force balances, calculated from theory, supported the experimental findings, and highlight the dominance of detachment forces (surface tension forces) over the attachment forces (DLVO forces)...
  29. pmc Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease
    Jun Zhou
    Department of Molecular Biology and Biochemistry, Institute for Brain Aging and Dementia, Center for Immunology, University of California, Irvine, California 92697 3900, USA
    J Neurochem 106:2080-92. 2008
    ..Finally, induced expression of C3 in a subset of astrocytes suggests the existence of differential activation states of these cells...
  30. doi Study on the interaction of porphyrin with G-quadruplex DNAs
    Chunying Wei
    Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
    Biophys Chem 137:19-23. 2008
    ..TPrPyP4 presents two lifetimes of about 5.8 and 12.0 ns in the complexes of G-quadruplexes-TPrPyP4. The primary results suggest that two TPrPyP4 molecules bind to both G-quadruplexes by terminal stacking and outside binding mode...
  31. doi The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions
    Jun Zhou
    State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Biophys Chem 136:124-7. 2008
    ..This work also demonstrates that ht-quadruplex can be well assembled without cations and the structure of ht-quadruplex is actually very complex in vivo...
  32. doi Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity
    Taylor Sittler
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Clin Cancer Res 14:3896-905. 2008
    ..We sought to identify targets of responses from this vaccination strategy...
  33. doi The effect of trophoblasts on T lymphocytes: possible regulatory effector molecules--a proteomic analysis
    Minyue Dong
    Women s Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    Cell Physiol Biochem 21:463-72. 2008
    ..The present investigation aimed to observe the regulatory effects on T lymphocytes by human trophoblasts and to explore possible effector molecules...
  34. doi Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway
    Valérie Lallemand-Breitenbach
    Université de Paris 7 CNRS UMR 7151, Equipe Labellisée N11 Ligue Nationale Contre le Cancer, Hopital St Louis, 1, Av C Vellefaux 75475 Paris CEDEX 10 France
    Nat Cell Biol 10:547-55. 2008
    ..As PML SUMOylation recruits not only RNF4, ubiquitin and proteasomes, but also many SUMOylated proteins onto PML nuclear bodies, these domains could physically integrate the SUMOylation, ubiquitination and degradation pathways...
  35. ncbi Comparison of membrane fouling during short-term filtration of aerobic granular sludge and activated sludge
    Jun Zhou
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China
    J Environ Sci (China) 19:1281-6. 2007
    ..The major components of the foulants were identified as comprising of proteins and polysaccharide materials...
  36. doi The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration
    Jinmin Gao
    Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, China
    J Biol Chem 283:8802-9. 2008
    ..Thus CYLD joins a growing list of CAP-Gly domain-containing proteins that regulate microtubule dynamics and function...
  37. doi Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells
    Lei Sun
    Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    Biochem Pharmacol 75:1027-34. 2008
    ..These results suggest that Aurora inhibitors might be effective in spindle checkpoint-defective cancer cells and a combination of Aurora inhibitors with the vinca alkaloids is a promising approach for cancer chemotherapy...
  38. ncbi Production of epsilon-poly-L-lysine by newly isolated Kitasatospora sp. PL6-3
    Jia Ouyang
    College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing, PR China
    Biotechnol J 1:1459-63. 2006
    ..As a result, epsilon-PL from Kitasatospora sp. PL6-3, which contains more lysine residues than that from other strains, is more promising in the field of food preservatives...
  39. ncbi Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma
    Xundi Xu
    Department of Surgery, Xiangya 2nd Hospital, Central South University, Renming Zhong Road 139, Changsha City, Hunan Province, China
    Cancer Genet Cytogenet 171:31-8. 2006
    ..010 and 0.037, respectively). Our results indicate that CB1 and CB2 have potential as prognostic indicators and suggest possible beneficial effects of cannabinoids on prognosis of patients with HCC...
  40. ncbi [Association of abnormal cyclooxygenase-2 gene expression with colorectal carcinoma metastasis]
    Zu Guo Li
    Key Laboratory of Functional Proteomics and Transcriptomics of Main Human Diseases of Guangdong Province and Ministry of Education, Department of Pathology, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1408-11. 2006
    ..To investigate cyclooxygenase-2 (COX-2) expression of in colorectal carcinoma cell lines and tissues and its clinical implications...
  41. ncbi Tissue responses to thermally-responsive hydrogel nanoparticles
    Hong Weng
    Biomedical Engineering Program, University of Texas at Arlington, PO Box 19138, Arlington, TX 76019, USA
    J Biomater Sci Polym Ed 15:1167-80. 2004
    ..It is likely that these hydrogel nanoparticles may be suitable for tissue augmentation or drug-delivery devices...
  42. ncbi Autocrine expression of hepatocyte growth factor and its cytoprotective effect on hepatocyte poisoning
    Yong He
    Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, 127 ChangLe West Road, Xi an 710032, Shaanxi Province, China
    World J Gastroenterol 10:2827-30. 2004
    ....
  43. ncbi Expression levels of genes likely involved in glucose-sensing in the obese Zucker rat brain
    Iwona Bogacka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Nutr Neurosci 7:67-74. 2004
    ..Furthermore, the hindbrain may be an important site for glucose-sensing where major phenotypic changes occur for glucose-sensing genes expression...
  44. ncbi Isotopomeric polymorphism
    Jun Zhou
    Department of Chemistry, University of Nebraska at Lincoln, Lincoln, Nebraska 68588, USA
    J Am Chem Soc 126:8392-3. 2004
    ..The phenomenon is apparently due to very different hydrogen bond strengths between the two polymorphs...
  45. ncbi [Gene expression profile of yolk sac and fetal liver in mouse]
    Jun Zhou
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Xue Ye Xue Za Zhi 25:266-8. 2004
    ..To better understand the mechanisms of the fetal hematopoiesis turn over from primitive to definitive hematopoiesis through the expression level of c-kit(+) and sca-1(+), and major characters of gene expression profile of these cells...
  46. ncbi Short-term food restriction and refeeding alter expression of genes likely involved in brain glucosensing
    Jun Zhou
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Exp Biol Med (Maywood) 228:943-50. 2003
    ..The results indicate that putative glucosensing (GK, Glut-2, and Glp-1R) gene expression in the hypothalamus and brainstem is reduced in response to food intake, depending on prior nutritional status...
  47. ncbi Brugia malayi microfilariae induce cell death in human dendritic cells, inhibit their ability to make IL-12 and IL-10, and reduce their capacity to activate CD4+ T cells
    Roshanak Tolouei Semnani
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:1950-60. 2003
    ..These data further suggest that MF induce an orchestrated response in APC that leads to a diminished capacity to function appropriately, which in turn has significant consequences for CD4(+) T cells...
  48. ncbi Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine
    Jun Zhou
    Graduate Program in Biochemistry, Cell and Developmental Biology, Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 277:39777-85. 2002
    ..In addition, our results suggest that the JNK pathway plays an essential role in microtubule inhibitor-induced apoptosis...
  49. ncbi Isolation and characterization of Brachystemidines A-E, novel alkaloids from Brachystemma calycinum
    Yong Xian Cheng
    Laboratory of Phytochemistry, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, People s Republic of China
    J Nat Prod 65:750-2. 2002
    ..Their structures were established by spectral data, especially by 1D and 2D NMR techniques. The crystal structure of brachystemidine D was determined via X-ray diffraction analysis...
  50. ncbi [Construction of hepatocyte growth factor expression vector and detection of expression in human hepatocytes]
    Yong He
    Department of Hepatobilliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Zhonghua Gan Zang Bing Za Zhi 10:119. 2002
  51. ncbi Two new ring A-rearranged clerodane diterpenes, dunniana acids A and B, from Clausena dunniana
    Hong Ping He
    Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, People s Republic of China
    J Nat Prod 65:392-4. 2002
    ..Two ring A-rearranged clerodane diterpenes named dunniana acids A (1) and B (2) were isolated from the aerial parts of Clausena dunniana. The structures of 1 and 2 were determined using spectral methods...
  52. ncbi Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint
    Jun Zhou
    Graduate Program in Biochemistry, Cell and Developmental Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 277:17200-8. 2002
    ..Our data also support the idea that Mad2 and Bub1/BubR1 respond to kinetochore-microtubule attachment and/or tension to different degrees...
  53. ncbi Survivin deregulation in beta-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to taxol
    Jun Zhou
    Winship Cancer Institute and Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 64:8708-14. 2004
    ..Our results show the importance of survivin for the mitotic response in the context of Taxol resistance and provide novel insights into the mechanisms of mitotic arrest and apoptosis induced by microtubule-targeting agents...
  54. ncbi A sumoylation site in PML/RARA is essential for leukemic transformation
    Jun Zhu
    CNRS UPR 9051, laboratoire associé N11 du comité de Paris de la Ligue contre le Cancer, affilié à l Université de Paris VII, Hopital St Louis, 1 avenue Claude Vellefaux, 75475 Paris, Cedex 10, France
    Cancer Cell 7:143-53. 2005
    ..Thus, transcriptional repression dependent on a specific sumoylation site in PML is critical for the APL phenotype, while forced RARA dimerization could control expansion of the myeloid compartment...
  55. pmc Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization
    Jun Zhou
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7151, Universite de Paris 7, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Hopital St Louis, 1 avenue C Vellefaux, 75475 Paris Cedex 10, France
    Proc Natl Acad Sci U S A 103:9238-43. 2006
    ..Our studies exemplify how dimerization-induced gain of functions converts an unessential transcription factor into a dominant oncogenic protein...
  56. ncbi Peptide YY and proglucagon mRNA expression patterns and regulation in the gut
    Jun Zhou
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:683-9. 2006
    ..We further examined the regulation of PYY and proglucagon mRNA by a diet containing fermentation-resistant starch (in vivo) and butyrate (in vitro)...
  57. ncbi Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells
    Min Liu
    Department of Genetics and Cell Biology and Key Laboratory of Bioactive Materials Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    J Biol Chem 281:18090-7. 2006
    ..In addition, these findings suggest that a combination of Eg5 inhibitors with agents abrogating Hsp70 induction would be useful for myeloma therapy in the clinic...
  58. ncbi [Process of human platelets loaded with rehalose before lyophilization]
    Fa Qiang Lu
    Department of Blood Transfusion, General Hospital of PLA, Center for Clinical Blood Transfusion of PLA, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:156-61. 2006
    ..The processing of loading with trehalose before platelet lyophilization has no significant effects on response of platelets to agonists and activation...
  59. ncbi Preliminary DNA identification for the tsunami victims in Thailand
    Ya Jun Deng
    The Key Laboratory of the Ministry of Health for Forensic Sciences, Xi an Jiaotong University, Xi an 710061, China
    Genomics Proteomics Bioinformatics 3:143-57. 2005
    ..Our results provide valuable evidence and protocols for the future forensic practice...
  60. ncbi [The assessment of curative effect after total mesorectal excision with autonomic nerve preservation for rectal cancer]
    Jian Ping Wang
    Department of Gastrointestinal and Pancreatic Surgery, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, China
    Zhonghua Wai Ke Za Zhi 43:1500-2. 2005
    ..To evaluate the impact on sexual function, local recurrence and survival after total mesorectal excision (TME) with autonomic nerve preservation (PANP) of rectal cancer...
  61. ncbi Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase
    Jun Zhou
    Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, China
    Cancer Res 66:445-52. 2006
    ..Our study provides the first direct evidence that enhancement of the JNK pathway down-regulates P-glycoprotein and reverses P-glycoprotein-mediated MDR in cancer cells...
  62. pmc Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011
    Ritu Aneja
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 107:2486-92. 2006
    ..These findings suggest that EM011 may be a safe and effective chemotherapeutic agent for oral treatment of drug-resistant human lymphomas...
  63. ncbi Compound representatives of a new type of triterpenoid from Aglaia odorata
    Xiang Hai Cai
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
    Org Lett 7:2877-9. 2005
    ....
  64. pmc The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase
    Adam I Marcus
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 65:3883-93. 2005
    ..Taken together, these data suggest a relationship between FT inhibition, HDAC6 function, and cell death, providing insight into the putative molecular basis of the lonafarnib/taxane synergistic antiproliferative combination...
  65. pmc Heat shock up-regulates expression of Toll-like receptor-2 and Toll-like receptor-4 in human monocytes via p38 kinase signal pathway
    Jun Zhou
    Institute of Immunology, Zhejiang University, Hangzhou, People s Republic of China
    Immunology 114:522-30. 2005
    ..These results suggest that the p38 kinase-mediated up-regulation of TLR2 and TLR4 might be involved in the enhanced response to PAMP in human monocytes induced by heat shock...
  66. ncbi Heat shock up-regulates TLR9 expression in human B cells through activation of ERK and NF-kappaB signal pathways
    Weilin Chen
    Institute of Immunology, Zhejiang University, 353 Yanan Road, Hangzhou 310031, PR China
    Immunol Lett 98:153-9. 2005
    ....
  67. ncbi Regulation of tubulin synthesis and cell cycle progression in mammalian cells by gamma-tubulin-mediated microtubule nucleation
    Jun Zhou
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Department of Cell Biology, Emory University School of Medicine, 1648 Pierce Dtive, Atlanta, GA 30322, USA
    J Cell Biochem 84:472-83. 2002
    ..These results thus suggest that the number of microtubule nucleation sites, or even gamma-tubulin itself, might play an important role in the regulation of tubulin synthesis as well as cell cycle progression...