Luo C, Zhou S, Zhou Z, Liu Y, Yang L, Liu J, et al
. Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells. J Am Soc Nephrol. 2018;29:1238-1256 pubmed publisher
..Furthermore, the Wnt9a-TGF-β pathway appears to create a reciprocal activation loop between senescent tubular cells and activated fibroblasts that promotes and accelerates the pathogenesis of renal fibrosis. ..
Zhou L, Chen X, Lu M, Wu Q, Yuan Q, Hu C, et al
. Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria. Kidney Int. 2019;95:830-845 pubmed publisher
..These studies uncover a novel mechanistic linkage of oxidative stress, Wnt/β-catenin activation, and podocyte dysfunction. ..
Chen S, Fu H, Wu S, Zhu W, Liao J, Hong X, et al
. Tenascin-C protects against acute kidney injury by recruiting Wnt ligands. Kidney Int. 2019;95:62-74 pubmed publisher
..These studies indicate that TNC is specifically induced at sites of injury and recruits Wnt ligands, thereby creating a favorable microenvironment for tubular repair and regeneration after AKI. ..
Zhou L, Zhou S, Yang P, Tian Y, Feng Z, Xie X, et al
. Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal fibrosis. Kidney Int. 2018;94:756-772 pubmed publisher
..Thus, CB2 is a pathogenic mediator in kidney fibrosis and targeted inhibition with the novel inverse agonist XL-001 may provide a strategy in the fight against fibrotic kidney diseases. ..
Lin X, Wu Q, Yu Y, Liang Z, Liu Y, Zhou L, et al
. Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities. Sci Rep. 2017;7:10757 pubmed publisher