Qiaoming Zhi


Country: China


  1. Liu F, Li W, Hua S, Han Y, Xu Z, Wan D, et al. Nigericin Exerts Anticancer Effects on Human Colorectal Cancer Cells by Inhibiting Wnt/β-catenin Signaling Pathway. Mol Cancer Ther. 2018;17:952-965 pubmed publisher
    ..i>Mol Cancer Ther; 17(5); 952-65. ©2018 AACR. ..
  2. Xu M, Liu L, Wu M, Jiang M, Shou L, Wang W, et al. The combination of cantharidin and antiangiogenic therapeutics presents additive antitumor effects against pancreatic cancer. Oncogenesis. 2018;7:94 pubmed publisher
    ..We recommend that the clinical application of cantharidin should be performed on the premise of antivascularization therapy. ..
  3. Zhi Q, Sun H, Qian X, Yang L. Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?. Int Immunopharmacol. 2011;11:96-102 pubmed publisher
    ..In addition, the mRNA expression of TGF-?1, MMP-2, and TIMP-1 down-regulated. Histological examination showed that edaravone decreased interstitial edema, inflammatory cell infiltration and prevented the process of pulmonary fibrosis. ..
  4. Han Y, Xue X, Jiang M, Guo X, Li P, Liu F, et al. LGR5, a relevant marker of cancer stem cells, indicates a poor prognosis in colorectal cancer patients: a meta-analysis. Clin Res Hepatol Gastroenterol. 2015;39:267-73 pubmed publisher
    ..These findings suggested that Lgr5 might serve as an efficient biomarker for prognostic indicator, and could be a new molecular target in colorectal cancer therapy. ..
  5. Wang X, Hu B, Shen H, Zhou H, Xue X, Chen Y, et al. Clinical and prognostic relevance of EZH2 in breast cancer: A meta-analysis. Biomed Pharmacother. 2015;75:218-25 pubmed publisher
    ..In conclusion, EZH2 participated in the progression of BC as a putative factor, and over-expression of EZH2 was distinctly correlated with a poor patient survival. EZH2 may serve as a prognostic biomarker and target in BC patients. ..
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    Hu Y, Yi B, He S, Gao L, Liu P, Wang L, et al. Clinical Significance of miR-1826 as a Novel Prognostic Biomarker in Colorectal Cancer. Anticancer Agents Med Chem. 2016;16:1109-16 pubmed
    ..Up-regulation of miR-1826 might serve as a novel prognostic marker of CRC and could be a potential target for CRC therapies. ..
  7. Shen X, Han Y, Xue X, Li W, Guo X, Li P, et al. Epidermal growth factor-like domain 7 promotes cell invasion and angiogenesis in pancreatic carcinoma. Biomed Pharmacother. 2016;77:167-75 pubmed publisher
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    Shi H, Zhang W, Zhi Q, Jiang M. Lapatinib resistance in HER2+ cancers: latest findings and new concepts on molecular mechanisms. Tumour Biol. 2016;: pubmed
    ..The present review, in the hope of providing further scientific support for molecular targeted therapies in HER2+ cancers, discusses about the latest findings and new concepts on molecular mechanisms underlying lapatinib resistance. ..
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    Han Y, Xue X, Shen H, Guo X, Wang X, Yuan B, et al. Prognostic significance of Beclin-1 expression in colorectal cancer: a meta-analysis. Asian Pac J Cancer Prev. 2014;15:4583-7 pubmed
    ..Beclin-1 might serve as an efficient prognostic indicator in CRC, and could be a new molecular target in CRC therapy. ..

More Information


  1. Xue X, Zhang Y, Zhi Q, Tu M, Xu Y, Sun J, et al. MiR200-upregulated Vasohibin 2 promotes the malignant transformation of tumors by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. Cell Commun Signal. 2014;12:62 pubmed publisher
    ..VASH2 promoted invasion, reduced apoptosis and increased the proportion of stem cells in vitro and in vivo. These results indicated that VASH2 expression in HCC cells promotes the malignant transformation of tumors by inducing EMT. ..
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    Jiang W, Gu W, Qiu R, He S, Shen C, Wu Y, et al. miRNA-101 Suppresses Epithelial-to-Mesenchymal Transition by Targeting HMGA2 in Pancreatic Cancer Cells. Anticancer Agents Med Chem. 2016;16:432-9 pubmed
    ..05). Taken together, our findings speculated that miR-101 might act as an inhibiting factor in EMT process in PC and up-regulation of miR-101 might be considered as a potentially key molecular treatment strategy for PC patients. ..
  3. Chen P, Wan D, Zheng D, Zheng Q, Wu F, Zhi Q. Long non-coding RNA UCA1 promotes the tumorigenesis in pancreatic cancer. Biomed Pharmacother. 2016;83:1220-1226 pubmed publisher
    ..05). Our results raised the possibility of using UCA1 as a potential prognostic biomarker and therapy target of PC, and down-regulation of UCA1 might be considered to be a novel molecular treatment strategy for patients with PC. ..
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    Zhi Q, Yang L, Sun H. Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. Intern Med. 2011;50:1879-87 pubmed
    ..To evaluate the possible therapeutic effect of ambroxol on pulmonary fibrosis induced by paraquat...
  5. Xue X, Liu F, Han Y, Li P, Yuan B, Wang X, et al. Silencing NPAS2 promotes cell growth and invasion in DLD-1 cells and correlated with poor prognosis of colorectal cancer. Biochem Biophys Res Commun. 2014;450:1058-62 pubmed publisher
    ..05). In conclusion, our study suggested that NPAS2, functioned as a potential tumor suppressor gene, could serve as a promising target and potential prognostic indicator for colorectal cancer. ..