Shusen Zheng

Summary

Affiliation: Zhejiang University
Country: China

Publications

  1. ncbi request reprint A modified protocol with rituximab and intravenous immunoglobulin in emergent ABO-incompatible liver transplantation for acute liver failure
    Tian Shen
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 13:395-401. 2014
  2. ncbi request reprint Impact of intra-operative cholangiography and parenchymal resection to donor liver function in living donor liver transplantation
    Feng Gao
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 13:259-63. 2014
  3. pmc ZIP4, a novel determinant of tumor invasion in hepatocellular carcinoma, contributes to tumor recurrence after liver transplantation
    Xiao Xu
    1 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated, Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China 3 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
    Int J Biol Sci 10:245-56. 2014
  4. pmc Pulmonary lymphangitic carcinomatosis in liver carcinoma: a rare case report and literature review
    Li Zhuang
    Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, 310003 Hangzhou, Zhejiang, China
    World J Surg Oncol 12:66. 2014
  5. ncbi request reprint FBW7 increases chemosensitivity in hepatocellular carcinoma cells through suppression of epithelial-mesenchymal transition
    Jun Yu
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine Key Laboratory of Multi Organ Transplantation of Ministry of Public Health, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 13:184-91. 2014
  6. ncbi request reprint The diversity between pancreatic head and body/tail cancers: clinical parameters and in vitro models
    Qi Ling
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Hangzhou, 310003, China
    Hepatobiliary Pancreat Dis Int 12:480-7. 2013
  7. ncbi request reprint Perioperative antiviral therapy for chronic hepatitis B-related hepatocellular carcinoma
    Qiang Wei
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 12:251-5. 2013
  8. pmc Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing
    Sheng Gao
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Hangzhou, China
    World J Surg Oncol 11:57. 2013
  9. doi request reprint Liver transplantation for hepatocellular carcinoma: Hangzhou experiences
    Shu Sen Zheng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    Transplantation 85:1726-32. 2008
  10. ncbi request reprint [Recurrence and metastasis of hepatocellular carcinoma after liver transplantation: single center experiences]
    Shu Sen Zheng
    Liver Transplantation Center, First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China
    Zhonghua Wai Ke Za Zhi 46:1609-13. 2008

Collaborators

  • Lin Zhou
  • Jian Wu
  • Xiao Xu
  • Min Zhang
  • Sheng Yan
  • Qi Ling
  • Yan Shen
  • Yan Wang
  • Zhiwei Li
  • Wu Zhang
  • Jun Yu
  • Xinhua Chen
  • Feng Gao
  • Changku Jia
  • Qiang Wei
  • Feng Zhu
  • Sushen Zhen
  • Jian Zhang
  • Haiyang Xie
  • WeiLin Wang
  • Zhenhua Hu
  • Guoping Jiang
  • Lei Geng
  • Chunyang Xing
  • Aibin Zhang
  • Shengyong Yin
  • Xiaobo Yu
  • Junfang Deng
  • Jianfeng Wei
  • Zhijun Jiang
  • Liming Wu
  • Songming Ding
  • Jun Cheng
  • Bajin Wei
  • Yigang Qian
  • Chen Hu
  • Yufu Ye
  • Songfeng Yu
  • Fenqiang Xiao
  • Zhe Yang
  • Zhen Lv
  • Kangjie Chen
  • Jie Zhou
  • Chaofeng Ding
  • Heng Xiao
  • Li Zhuang
  • Jia Yao
  • Qiang Sun
  • Rong Su
  • Xiaofei Cheng
  • Lanjuan Li
  • Xiaowen Feng
  • Shaobing Cheng
  • Chengli Du
  • Jun Chen
  • Di Lu
  • Qiyi Zhang
  • Tian Shen
  • Haijun Guo
  • Sheng Gao
  • Zhigang Ren
  • Zehui Wu
  • Yu Gu
  • Wuhua Zhou
  • Feng Zhang
  • Yifan Dai
  • Dongkai Zhou
  • Qing Xie
  • Tianxiang Chen
  • Qianqian Zhu
  • Lelin Pan
  • Penghong Song
  • Baohong Wang
  • Hai Yang Xie
  • Baiye Jin
  • Yuanbiao Zhang
  • Jianju Lu
  • Jennifer Meintjes
  • Dong Zhang
  • Guanghou Fu
  • Miaoda Shen
  • Xiaojun Xie
  • Weidong Li
  • Yuling Sun
  • Haiyong Chen
  • Zhou Ye
  • Shu Wan
  • Shenyong Yin
  • Junwei Liu
  • Donglin Li

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint A modified protocol with rituximab and intravenous immunoglobulin in emergent ABO-incompatible liver transplantation for acute liver failure
    Tian Shen
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 13:395-401. 2014
    ..We developed a protocol consisting of rituximab and intravenous immunoglobulin (IVIG) for ABO-I LT in patients with acute liver failure (ALF)...
  2. ncbi request reprint Impact of intra-operative cholangiography and parenchymal resection to donor liver function in living donor liver transplantation
    Feng Gao
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 13:259-63. 2014
    ....
  3. pmc ZIP4, a novel determinant of tumor invasion in hepatocellular carcinoma, contributes to tumor recurrence after liver transplantation
    Xiao Xu
    1 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated, Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China 3 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
    Int J Biol Sci 10:245-56. 2014
    ..Our aim was to assess the role of ZIP4 in invasiveness, migration and apoptosis of hepatocellular carcinoma (HCC). The prognostic value of ZIP4 in HCC after liver transplantation was evaluated...
  4. pmc Pulmonary lymphangitic carcinomatosis in liver carcinoma: a rare case report and literature review
    Li Zhuang
    Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, 310003 Hangzhou, Zhejiang, China
    World J Surg Oncol 12:66. 2014
    ..Herein we report the case of a patient with PLC after liver transplantation due to liver carcinoma. PLC was confirmed by clinical manifestations, imaging studies and cytologic examination of exfoliated cells in the pleural effusion. ..
  5. ncbi request reprint FBW7 increases chemosensitivity in hepatocellular carcinoma cells through suppression of epithelial-mesenchymal transition
    Jun Yu
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine Key Laboratory of Multi Organ Transplantation of Ministry of Public Health, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 13:184-91. 2014
    ..This study aimed to evaluate the role of FBW7 in chemosensitivity and epithelial-mesenchymal transition (EMT) in different hepatocellular carcinoma (HCC) cell lines and to investigate the relevant underlying mechanisms...
  6. ncbi request reprint The diversity between pancreatic head and body/tail cancers: clinical parameters and in vitro models
    Qi Ling
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Hangzhou, 310003, China
    Hepatobiliary Pancreat Dis Int 12:480-7. 2013
    ..To understand the postulated genotype difference, we present comprehensive information on two PDAC cell lines as typical representatives originating from pancreatic head and body/tail cancers, respectively...
  7. ncbi request reprint Perioperative antiviral therapy for chronic hepatitis B-related hepatocellular carcinoma
    Qiang Wei
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 12:251-5. 2013
    ..The present analysis is trying to develop a perioperative anti-HBV treatment protocol...
  8. pmc Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing
    Sheng Gao
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Hangzhou, China
    World J Surg Oncol 11:57. 2013
    ..Many advances have been made to understand the pathogenesis of HCC; however, the molecular mechanisms that lead to hepatocarcinogenesis and progression are still not clearly understood...
  9. doi request reprint Liver transplantation for hepatocellular carcinoma: Hangzhou experiences
    Shu Sen Zheng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    Transplantation 85:1726-32. 2008
    ..This study was designed to summarize our experience in LT for HCC patients and establish a new set of criteria for patient selection and prognosis prediction...
  10. ncbi request reprint [Recurrence and metastasis of hepatocellular carcinoma after liver transplantation: single center experiences]
    Shu Sen Zheng
    Liver Transplantation Center, First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China
    Zhonghua Wai Ke Za Zhi 46:1609-13. 2008
    ..To study the clinical features and treatment of recurrent hepatocellular carcinoma after liver transplantation...
  11. ncbi request reprint [Actuality and progression of pancreas-kidney transplantation]
    Shu Sen Zheng
    Zhonghua Wai Ke Za Zhi 45:298-300. 2007
  12. ncbi request reprint [Liver transplantation for hepatocellular carcinoma: prognostic analysis of 89 cases]
    Shu Sen Zheng
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Key Lab of Combined Multi Organ Transplantation, Ministry of Health, Zhejiang University, Hangzhou 310003, China
    Zhonghua Wai Ke Za Zhi 43:450-4. 2005
    ..To summarize the experience of liver transplantation (LT) for hepatocellular carcinoma (HCC) in one center and identify prognostic factors for survival...
  13. doi request reprint Reversing effect of ring finger protein 43 inhibition on malignant phenotypes of human hepatocellular carcinoma
    Chunyang Xing
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang, China
    Mol Cancer Ther 12:94-103. 2013
    ..These results suggest that RNF43 is involved in tumorigenesis and progression of HCCs and that antagonism of RNF43 may be beneficial for HCC treatment...
  14. doi request reprint Pro-apoptotic and anti-proliferative effects of mitofusin-2 via Bax signaling in hepatocellular carcinoma cells
    WeiLin Wang
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Hangzhou, People s Republic of China
    Med Oncol 29:70-6. 2012
    ..This gene may be an important therapeutic target for the treatment of tumors or hyperproliferative diseases...
  15. doi request reprint Regulation of TLR4-induced IL-6 response in bladder cancer cells by opposing actions of MAPK and PI3K signaling
    Yigang Qian
    Department of Hepatobiliary Pancreatic Surgery, Key Lab of Organ Transplantation of Zhejiang Province, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China
    J Cancer Res Clin Oncol 135:379-86. 2009
    ..In this study, we manage to find out whether TLR4 signaling is involved in the production of IL-6 by human bladder cancer cells, and the detailed molecule mechanisms by which IL-6 is up-regulated...
  16. ncbi request reprint NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma
    Jun Cheng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Cancer Lett 310:35-45. 2011
    ..Taken together, these results suggested that NDRG1 was an important molecule in controlling HCC metastasis and thus suggested as a novel biomarker for predicting HCC recurrence after LT...
  17. doi request reprint O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation
    Qianqian Zhu
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, 310003 Hangzhou, Zhejiang, China
    Med Oncol 29:985-93. 2012
    ..Altogether, these results suggest that O-GlcNAcylation might play important roles in HCC formation and progression and may be a potential marker to predict patient risk of recurrence after LT and a valuable target for therapy...
  18. ncbi request reprint Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2)
    Junfang Deng
    Key Laboratory of Combined Multi organ Transplantation, Department of Hepatobiliary Pancreatic Surgery, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Liver Int 28:1458-64. 2008
    ..Honokiol has been known to have antitumour activity. This study was conducted to evaluate the antiproliferative potential of honokiol against the hepG2 heptocellular cell line and its mechanism of action...
  19. ncbi request reprint Antitumor efficacy of C-X-C motif chemokine ligand 14 in hepatocellular carcinoma in vitro and in vivo
    WeiLin Wang
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Key Laboratory of Organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Cancer Sci 104:1523-31. 2013
    ..In conclusion, CXCL14 plays a pivotal role as a potential tumor suppressor in HCC. The re-expression or upregulation of this gene may provide a novel strategy in HCC therapy in the future. ..
  20. doi request reprint A novel model for evaluating the risk of hepatitis B recurrence after liver transplantation
    Xiao Xu
    Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Liver Int 31:1477-84. 2011
    ..Hepatitis B virus (HBV) recurrence is a major risk factor affecting the long-term survival of recipients for liver transplantation (LTx). Therefore, a model that can assess this risk before transplantation is highly desirable...
  21. ncbi request reprint Recipient cytotoxic T lymphocyte antigen-4 +49 G/G genotype is associated with reduced incidence of hepatitis B virus recurrence after liver transplantation among Chinese patients
    Zhijun Jiang
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China
    Liver Int 27:1202-8. 2007
    ....
  22. pmc A case report of de novo hepatocellular carcinoma after living donor liver transplantation
    Songfeng Yu
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    World J Surg Oncol 11:176. 2013
    ..Moreover, the de novo cancer first presented as a lung mass with minimal liver involvement and was obscured by a pulmonary fungal infection...
  23. doi request reprint Impacts of TCF7L2 gene polymorphisms on the susceptibility of hepatogenous diabetes and hepatocellular carcinoma in cirrhotic patients
    Qi Ling
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Gene 522:214-8. 2013
    ..TCF7L2 gene has been reported to be associated with type 2 diabetes and also cancer risks. We aim to evaluate the impact of TCF7L2 gene on the susceptibility of HD and hepatocellular carcinoma (HCC) in a Chinese Han population...
  24. pmc Association of MDR1 gene SNPs and haplotypes with the tacrolimus dose requirements in Han Chinese liver transplant recipients
    Xiaobo Yu
    Key Lab of Combined Multi Organ Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Ministry of Public Health, Hangzhou, Zhejiang, China
    PLoS ONE 6:e25933. 2011
    ....
  25. ncbi request reprint Involvement of Th17 and Th1 effector responses in patients with Hepatitis B
    Yufu Ye
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People s Republic of China
    J Clin Immunol 30:546-55. 2010
    ....
  26. ncbi request reprint HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo
    WeiLin Wang
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, PR China
    Oncol Rep 24:183-8. 2010
    ....
  27. ncbi request reprint Long-term outcome of combined liver-kidney transplantation: a single-center experience in China
    Jian Wu
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, PR China
    Hepatogastroenterology 55:334-7. 2008
    ..To evaluate patient survival with combined liver-kidney transplantation (CLKT) and to identify factors of death in these patients...
  28. ncbi request reprint Ischemic preconditioning improves liver tolerance to congestion-reperfusion injury in mice
    Qiyi Zhang
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang Province, China Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang Province, China Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
    J Surg Res 189:152-8. 2014
    ..Ischemic preconditioning (IPC) has been endowed with powerful protective properties toward IRI. This study aimed to investigate whether IPC also has a protective effect against CRI and potential underlying mechanisms...
  29. ncbi request reprint Nanosecond pulsed electric field (nsPEF) treatment for hepatocellular carcinoma: a novel locoregional ablation decreasing lung metastasis
    Shengyong Yin
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China
    Cancer Lett 346:285-91. 2014
    ..NsPEF treatment may elicit a host immune response against tumor cells. This study suggests nsPEF therapy could be used as a potential locoregional therapy for hepatocellular carcinoma. ..
  30. doi request reprint Association of family history of HBV with resectability of hepatocellular carcinoma
    Zhenhua Hu
    Ministry of Public Health, Hangzhou, China
    Hepatogastroenterology 59:485-91. 2012
    ..This study aims to address the relationship between a positive family history of liver cancer or hepatitis B virus (HBV) infection and the operative resectability of hepatocellular carcinoma (HCC) in the Chinese population...
  31. doi request reprint Mitofusin-2 is a novel direct target of p53
    WeiLin Wang
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Key Lab of Organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
    Biochem Biophys Res Commun 400:587-92. 2010
    ....
  32. pmc Salvage liver transplantation is a reasonable option for selected patients who have recurrent hepatocellular carcinoma after liver resection
    Zhenhua Hu
    Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    PLoS ONE 7:e36587. 2012
    ..We retrospectively studied the clinical characteristics of SLT recipients and conducted a comparison between SLT recipients and primary liver transplantation (PLT) recipients...
  33. ncbi request reprint Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling
    Chen Hu
    Department of General Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
    Carcinogenesis 29:2289-97. 2008
    ..Our results indicate the protective role of intrinsic ABCG2 expression in HCC cells and suggest that suppressing Akt signaling could help overcome the drug efflux by ABCG2 transporter...
  34. doi request reprint Reconstruction of middle hepatic vein in living donor liver transplantation with modified right lobe graft: a single center experience
    Jian Wu
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Transpl Int 21:843-9. 2008
    ..The recipient's portal vein is an optimal choice for the interpositional vein and hepatic venoplasty in living donor liver transplantation can simplify the operation and ensure excellent venous drainage...
  35. ncbi request reprint B7-H1 up-regulated expression in human pancreatic carcinoma tissue associates with tumor progression
    Lei Geng
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health and Department of Hepato Biliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    J Cancer Res Clin Oncol 134:1021-7. 2008
    ..This study was designed to investigate the expression of B7-H1 and IL-10 in normal pancreas tissues and pancreatic carcinoma samples, and to evaluate clinical significance of B7-H1 expression in pancreatic carcinoma...
  36. ncbi request reprint MDR1 gene polymorphisms and risk of recurrence in patients with hepatocellular carcinoma after liver transplantation
    Liming Wu
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    J Surg Oncol 96:62-8. 2007
    ..This study was undertaken to evaluate the association between three polymorphisms (C1236T, G2677A/T, C3435T) of Multidrug resistance 1 (MDR1) gene and the risk of recurrence after LT...
  37. doi request reprint Impact of preexisting diabetes mellitus on outcome after liver transplantation in patients with hepatitis B virus-related liver disease
    Qi Ling
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, China
    Dig Dis Sci 56:889-93. 2011
    ..So far, there are few reports on the effect of preexisting DM on outcome of liver transplant recipients with HBV infection...
  38. doi request reprint The influence of a contemporaneous portal and hepatic artery revascularization protocol on biliary complications after liver transplantation
    Di Lu
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Surgery 155:190-5. 2014
    ..We sought to compare the impact of sequential and contemporaneous revascularizations of portal vein and hepatic artery on biliary complications in patients undergoing liver transplantation...
  39. ncbi request reprint Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma
    Xueli Bai
    Key Laboratory of Multi Organ Transplantation of Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, People s Republic of China
    J Cancer Res Clin Oncol 134:83-91. 2008
    ..It has been indicated that activated hepatic stellate cells (HSCs) play key roles on the pathogenesis of hepatocellular carcinoma (HCC). The purpose of the study was to investigate the potential mechanism in it...
  40. doi request reprint Cyclin-dependent kinase inhibitor 3 is overexpressed in hepatocellular carcinoma and promotes tumor cell proliferation
    Chunyang Xing
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
    Biochem Biophys Res Commun 420:29-35. 2012
    ..These results suggest that CDKN3 acts as an oncogene in human hepatocellular carcinoma and antagonism of CDKN3 may be of interest for the treatment of HCC...
  41. doi request reprint Involvement of ERK and JNK pathways in IFN-γ-induced B7-DC expression on tumor cells
    Junfang Deng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    J Cancer Res Clin Oncol 137:243-50. 2011
    ..This study was designed to investigate the relationship of IFN-γ and B7-DC on tumor cells and further explored the signal transduction pathways involved...
  42. doi request reprint A pathogenic role of IL- 17 at the early stage of corneal allograft rejection
    Haiyong Chen
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China
    Transpl Immunol 21:155-61. 2009
    ..However, the role of these cells in organ allograft rejection remains largely unknown. In this study, we investigate whether Th17 cells participate in allogeneic corneal rejection in a mouse model...
  43. doi request reprint microRNA-200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6
    Fenqiang Xiao
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang, P R China
    Oncol Rep 30:2203-10. 2013
    ..Furthermore, CDK6 was identified as a novel functional target of miR‑200a. Our data indicate that miR‑200a functions as a potential tumor suppressor in HCC. ..
  44. pmc MicroRNA-503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma
    Fenqiang Xiao
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, Zhejiang, P R China
    J Transl Med 11:195. 2013
    ..However, the biological function of miR-503 in hepatocellular carcinoma (HCC) is still largely unknown. In this study we aimed to elucidate the prognostic implications of miR-503 in HCC and its pathophysiologic role...
  45. pmc Nanosecond pulsed electric field inhibits cancer growth followed by alteration in expressions of NF-κB and Wnt/β-catenin signaling molecules
    Zhigang Ren
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
    PLoS ONE 8:e74322. 2013
    ..These findings may provide a creative and effective therapeutic strategy for cancers. ..
  46. doi request reprint The role of liver cancer stem cells in donor liver allocation for patients with hepatocellular carcinoma
    Jie Zhou
    Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Postgrad Med 125:24-30. 2013
    ..We provide reliable evidence supporting this hypothesis, and offer proposals for future applications in transplant practice. ..
  47. pmc Induction of an EMT-like transformation and MET in vitro
    Songming Ding
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang, China
    J Transl Med 11:164. 2013
    ..TM is characterized by its complexity and flexibility. The purpose of this study was to ascertain the exact effect of each distinct TM component on the evolution hepatocellular carcinoma (HCC) metastasis...
  48. pmc Survival in liver transplant recipients with hepatitis B- or hepatitis C-associated hepatocellular carcinoma: the Chinese experience from 1999 to 2010
    Zhenhua Hu
    Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    PLoS ONE 8:e61620. 2013
    ..Hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) and hepatitis C virus (HCV)-HCC are the main indications for liver transplantation. We compared differences in survival outcomes between these two conditions...
  49. doi request reprint Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population
    Qi Ling
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    J Hepatol 58:271-7. 2013
    ..In addition, the donor liver plays a vital role in regulating blood glucose levels. In this study, we aim at evaluating the association between donor and recipient TCF7L2 gene polymorphisms with NODM after LT...
  50. doi request reprint Hepatitis B virus X protein inhibits p53-mediated upregulation of mitofusin-2 in hepatocellular carcinoma cells
    WeiLin Wang
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, PR China
    Biochem Biophys Res Commun 421:355-60. 2012
    ..These results indicate that HBx impacts p53-mediated transcription of Mfn2, providing insight into the negative effect of HBx against p53-dependent chemotherapeutic agents, such as doxorubicin, used in the treatment of HCC...
  51. doi request reprint The analysis of CD45 isoforms expression on HBV-specific T cells after liver transplantation
    Lelin Pan
    Key Lab of Multi Organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang Province 310003, China
    Med Oncol 29:899-908. 2012
    ..Therefore, the switch from CD45RA to CD45RO probably depended on IL-7, without being stimulated by hepatitis B virus (HBV) and proliferated by IL-15. IL-7 could aid in maintaining HBV-specific T cells effectively during 3 years...
  52. doi request reprint Inaccurate preoperative imaging assessment on biliary anatomy not increases biliary complications after living donor liver transplantation
    Xiao Xu
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China
    Eur J Radiol 81:e457-60. 2012
    ....
  53. doi request reprint TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells
    Yigang Qian
    Department of Hepatobiliary Pancreatic Surgery, Key Lab of Organ Transplantation of Zhejiang Province, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Cancer Invest 26:816-21. 2008
    ..Our results elucidated the molecule mechanism of regulation of B7-H1 expression through TLR4 signaling and may suggest new strategies of down-regulating the cancer-associated B7-H1 expression for bladder cancer treatment...
  54. ncbi request reprint MHC-mismatched mice liver transplantation promotes tumor growth in liver graft
    Sheng Yan
    Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, PR China Key Laboratory of Combined Multi Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, PR China Key Laboratory of Organ Transplantation Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, PR China
    Cancer Lett 351:162-71. 2014
    ..For the first time, we demonstrated that susceptibility to tumor development in liver graft is due to the down-regulation of effector T cells' function mediated by the regulatory T cells. ..
  55. pmc BAG3 and HIF-1 α coexpression detected by immunohistochemistry correlated with prognosis in hepatocellular carcinoma after liver transplantation
    Heng Xiao
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Hangzhou 310003, China
    Biomed Res Int 2014:516518. 2014
    ..The objective is to determine the effects of BAG3 and HIF-1 α expression on the prognosis of HCC patients after liver transplantation...
  56. doi request reprint Reduction of intestinal electrogenic glucose absorption after duodenojejunal bypass in a mouse model
    Sheng Yan
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang University, Hangzhou, Zhejiang Province 310003, China
    Obes Surg 23:1361-9. 2013
    ..Six groups of C57/BL6 mice were studied (n = 6 each) 2 weeks, 1 month, and 2 months after DJB or sham surgery...
  57. pmc The stratifying value of Hangzhou criteria in liver transplantation for hepatocellular carcinoma
    Jun Chen
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    PLoS ONE 9:e93128. 2014
    ..In this era of limited deceased donor organs, the value of living donor liver transplantation (LDLT) for HCC remains controversial. The aim of the present study was to verify the stratification value of the Hangzhou criteria for LDLT...
  58. ncbi request reprint Calcitriol inhibits hepatocyte apoptosis in rat allograft by regulating apoptosis-associated genes
    Aibin Zhang
    Key Lab of Combined Multi Organ Transplantation, Chinese Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, China
    Int Immunopharmacol 7:1122-8. 2007
    ..These effects may be related to its suppression of the Fas/Fas ligand pathway and its inhibition of cytotoxic T lymphocyte products...
  59. ncbi request reprint Prevention of hepatitis B recurrence after liver transplantation using lamivudine or lamivudine combined with hepatitis B Immunoglobulin prophylaxis
    Shusen Zheng
    Department of Hepatobiliary Pancreatic Surgery, Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, First Affiliated Hospital of Medical College, Zhejiang University, Hang Zhou, PR China
    Liver Transpl 12:253-8. 2006
    ....
  60. doi request reprint Identification of two portal vein tumor thrombosis associated proteins in hepatocellular carcinoma: protein disulfide-isomerase A6 and apolipoprotein A-I
    Xiao Xu
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    J Gastroenterol Hepatol 26:1787-94. 2011
    ..In the present study, we aimed to find out some biomarkers associated with vascular invasion features of HCC with the method of comparative proteomic analysis...
  61. ncbi request reprint Inhibitory effect of tea polyphenols on renal cell apoptosis in rat test subjects suffering from cyclosporine-induced chronic nephrotoxicity
    Shaohua Shi
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, China
    Chin Med J (Engl) 116:1345-50. 2003
    ..To investigate the inhibitory effect of tea polyphenols on renal cell apoptosis in rat test subjects suffering from cyclosporine A (CsA)-induced chronic nephrotoxicity...
  62. ncbi request reprint [Lamivudine as prophylaxis against hepatitis B virus reinfection following orthotopic liver transplantation]
    Shusen Zheng
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College of Zhejiang University, Hangzhou 310003, China
    Zhonghua Yi Xue Za Zhi 82:445-8. 2002
    ..To discuss the effect of lamivudine as prophylaxis against hepatitis B virus (HBV) reinfection following orthotopic liver transplantation (OLT)...
  63. doi request reprint Outcome of patients with hepatorenal syndrome type 1 after liver transplantation: Hangzhou experience
    Xiao Xu
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Transplantation 87:1514-9. 2009
    ..Liver transplantation (LT) is the only treatment that can cure terminal stage liver disease and reverse HRS. However, the data showing the impact of LT on patients with HRS type 1 are limited...
  64. ncbi request reprint B7-H1 up-regulated expression in human hepatocellular carcinoma tissue: correlation with tumor interleukin-10 levels
    Lei Geng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Zhejiang Province, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Hepatogastroenterology 58:960-4. 2011
    ..This study was designed to investigate the expression of B7-H1 and IL-10 in normal liver tissues and HCC samples, and further to evaluate the correlation between B7-H1 expression and IL-10 levels...
  65. pmc Genetic polymorphism of interferon regulatory factor 5 (IRF5) correlates with allograft acute rejection of liver transplantation
    Xiaobo Yu
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    PLoS ONE 9:e94426. 2014
    ..Although TLR4 has been proved to contribute to acute allograft rejection, including after liver transplantation, the correlation between IRF5 gene and acute rejection has not been elucidated yet...
  66. pmc Downgrading MELD improves the outcomes after liver transplantation in patients with acute-on-chronic hepatitis B liver failure
    Qi Ling
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    PLoS ONE 7:e30322. 2012
    ..Artificial liver support system (ALSS) has been proved to effectively improve liver and kidney functions, and thus reduce the MELD score. We aim to evaluate whether downgrading MELD score could improve patient survival after LT...
  67. pmc Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells
    Chaofeng Ding
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China
    Int J Mol Sci 15:4060-76. 2014
    ..Taken together, HOTAIR could promote migration and invasion of HCC cells by inhibiting RBM38, which indicated critical roles of HOTAIR and RBM38 in HCC progression. ..
  68. ncbi request reprint Mitochondrial dysfunction-related genes in hepatocellular carcinoma
    WeiLin Wang
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
    Front Biosci (Landmark Ed) 18:1141-9. 2013
    ..Investigation of mitochondrial dysfunction-related genes could potentially provide evidence for novel therapies that target HCC...
  69. ncbi request reprint A novel model of portal vein transplantation in mice using two-cuff technique
    Sheng Yan
    Department of Hepato biliary pancreatic Surgery and Liver Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People s Republic of China
    Microsurgery 27:569-74. 2007
    ..In conclusion, the PV transplantation model in mice using two-cuff technique is a feasible procedure with a high survival rate. The PV allografts responded well to the CTLA4-Ig therapy in our preliminary research by the model...
  70. pmc Artificial liver support system combined with liver transplantation in the treatment of patients with acute-on-chronic liver failure
    Xiao Xu
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    PLoS ONE 8:e58738. 2013
    ..This study was designed to evaluate the experience in artificial liver support system (ALSS) combined with liver transplantation (LT) in the treatment of ACLF...
  71. doi request reprint Hepatic venous occlusion causes more impairment after reperfusion compared with portal clamping in a murine model
    Sheng Yan
    Key Laboratory of Combined Multiorgan Transplantation, Ministry of Public Health, Zhejiang Province, Hangzhou, China
    J Surg Res 169:117-24. 2011
    ..Congestion/reperfusion (CR) is not uncommon with the development of partial liver transplantation and liver resection. The purpose of this study was to compare the impairments caused by acute hepatic CR or IR using a murine model...
  72. doi request reprint Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma
    Baiye Jin
    Department of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, People s Republic of China
    Med Oncol 28:S373-80. 2011
    ..Mfn2 may become an important therapeutic target for treating UBCC...
  73. ncbi request reprint A new serum cystatin C-based equation for assessing glomerular filtration rate in liver transplantation
    Qi Ling
    Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Clin Chem Lab Med 46:405-10. 2008
    ..Cystatin C (CysC) has been identified to be an alternative marker of glomerular filtration rate (GFR), but no CysC-based equation has been developed for patients receiving liver transplantation...
  74. doi request reprint Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma
    Aibin Zhang
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Stem Cells Dev 19:1277-84. 2010
    ..The phenotypic similarities between the LPCs and the HLECs suggest that a precursor-product relationship may exist between the 2 cell types...
  75. ncbi request reprint [Orthotopic liver transplantation with no veno-venous bypass]
    Shusen Zheng
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China
    Zhonghua Wai Ke Za Zhi 40:326-8. 2002
    ..To assess the feasibility and outcome of orthotopic liver transplantation (OLT) with no veno-venous bypass (VVB) in adult patients...
  76. doi request reprint Hepatitis B virus reactivation is a risk factor for development of post-transplant lymphoproliferative disease after liver transplantation
    Aibin Zhang
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Clin Transplant 23:756-60. 2009
    ..05 for all). These data suggest that PTLD may be more prevalent in patients who experience HBV reactivation after liver transplantation. HBV reactivation may be a risk factor for development of PTLD...
  77. ncbi request reprint Immunophenotypic shift of memory CD8 T cells identifies the changes of immune status in the patients after liver transplantation
    Yuling Sun
    Institute of Hepatic Vascular Disease, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhengzhou University, School of Medicine, Zhengzhou
    Scand J Clin Lab Invest 69:789-96. 2009
    ..The purpose of this study was to investigate the correlation between immunophenotypic shift of memory CD8+ T cells and immune status in the patients after liver transplantation...
  78. doi request reprint The value of serum alpha-fetoprotein in predicting tumor recurrence after liver transplantation for hepatocellular carcinoma
    Xiao Xu
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Key Lab of Combined Muti Organ Transplantation, Ministry of Health, Zhejiang University, Hangzhou, 310003, China
    Dig Dis Sci 54:385-8. 2009
    ..Factors associated with tumor recurrence should be determined to improve the outcome of LT. The purpose of the study was to evaluate the value of alpha-fetoprotein (AFP) in forecasting tumor recurrence after LT for patients with HCC...
  79. pmc Recipient cytotoxic T lymphocyte antigen 4 +49 single-nucleotide polymorphism is not associated with acute rejection after liver transplantation in Chinese population
    Zhijun Jiang
    Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou Zhejiang 310003, P R China
    Int J Med Sci 10:250-4. 2013
    ..Therefore we sought to clarify whether CTLA-4 +49 SNP influences the incidence of acute rejection after liver transplantation in Chinese population...
  80. ncbi request reprint Prohibitin-2 promotes hepatocellular carcinoma malignancy progression in hypoxia based on a label-free quantitative proteomics strategy
    Jun Cheng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P R, China Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Zhejiang University, Hangzhou, P R, China
    Mol Carcinog . 2013
    ..Thus, PHB2 in HCC supports the development and progression of hepatocellular malignancy to hypoxia, and implicates the potential antagonist function of PHB2 in transarterial chemoembolization treatment. © 2013 Wiley Periodicals, Inc...
  81. ncbi request reprint Anticancer effects of Huaier are associated with down-regulation of P53
    Xiao Xu
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Asian Pac J Cancer Prev 12:2251-4. 2011
    ..Longer term survival rates between group D and E were not significantly different. Huaier can protect liver from chemical injury and furthermore HCC development, possibly with involvement of down-regulation of P53...
  82. doi request reprint Histopathological follow-up by tissue micro-array in a survival study after melanoma treated by nanosecond pulsed electric fields (nsPEF)
    Xinhua Chen
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    J Dermatolog Treat 22:153-61. 2011
    ..Thus, nsPEF could be applied in a non-ionizing therapeutic approach, without other agents, to locally treat tumors within a defined boundary...
  83. ncbi request reprint Calcitriol prolongs recipient survival by inducing expression of zinc-finger protein A20 and inhibiting its downstream gene following rat orthotopic liver transplantation
    Aibin Zhang
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Immunopharmacol Immunotoxicol 28:591-600. 2006
    ..The results suggest that calcitriol exerts its immunosuppression action in part through inducement of the A20, IkB, inhibition of NF-kB, and resultant proinflammatory expression pathway...
  84. doi request reprint The association of frequent allelic loss on 17p13.1 with early metastatic recurrence of hepatocellular carcinoma after liver transplantation
    Lin Zhou
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
    J Surg Oncol 102:802-8. 2010
    ..This study aimed to investigate LOH status on chromosomes 4q, 6q, 8p, 9p, and 17p, and to explore their clinical significances in HCC post-liver transplantation...
  85. ncbi request reprint Cyclosporin a Up-regulates B7-DC expression on dendritic cells in an IL-4-dependent manner in vitro, which is associated with decreased allostimulatory capacity of dendritic cells
    Lei Geng
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Department of Hepato Biliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Immunopharmacol Immunotoxicol 30:399-409. 2008
    ..Thus, up-regulated expression of B7-DC may be responsible for Cyclosporin A-mediated inhibitory effects on allostimulatory capacity of DC...
  86. ncbi request reprint Clinical utility of an automated pupillometer for assessing and monitoring recipients of liver transplantation
    Sheng Yan
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Zhejiang University, Hangzhou, People s Republic of China
    Liver Transpl 15:1718-27. 2009
    ..An automated pupillometer is potentially a supplementary device for pretransplant screening and posttransplant monitoring in patients undergoing LT, but further prospective studies are required...
  87. pmc Perioperative dynamic alterations in peripheral regulatory T and B cells in patients with hepatocellular carcinoma
    Tianxiang Chen
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    J Transl Med 10:14. 2012
    ..We here investigated perioperative dynamic alterations of peripheral circulating Tregs and Bregs in HCC patients to reveal the relationship between regulatory lymphocytes and its clinical implications...
  88. ncbi request reprint Intrathymic inoculation of liver specific antigen alleviates liver transplant rejection
    Changku Jia
    Department of Hepatobiliary Pancreatic Surgery, Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou 310003
    Chin Med Sci J 19:38-43. 2004
    ..To study the effects of liver specific antigen (LSA) on liver allotransplantation rejection...
  89. pmc Recipient outcomes after ABO-incompatible liver transplantation: a systematic review and meta-analysis
    Jian Wu
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    PLoS ONE 6:e16521. 2011
    ..We systematically reviewed studies containing outcomes after ILT compared to that after ABO-compatible liver transplantation (CLT)...
  90. ncbi request reprint Interaction of B7-H1 on intrahepatic cholangiocarcinoma cells with PD-1 on tumor-infiltrating T cells as a mechanism of immune evasion
    Yufu Ye
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
    J Surg Oncol 100:500-4. 2009
    ..This study aimed to investigate the expression of B7-H1 and its receptor PD-1 and to explore their significance in the progression of intraheptic cholangiocarcinoma (ICC)...
  91. doi request reprint Non-classical MHC-Ι genes in chronic hepatitis B and hepatocellular carcinoma
    Jian Zhang
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine Zhejiang University, 310003, Hangzhou, Zhejiang Province, People s Republic of China
    Immunogenetics 64:251-8. 2012
    ..Our study provides healthy reference and detailed analyses of non-classical HLA class Ι polymorphisms that provide insight into immune mechanisms involved in susceptibility to hepatitis B and HCC...
  92. pmc Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c
    Qi Ling
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    J Exp Clin Cancer Res 30:66. 2011
    ..The present study was to investigate the anti-cancer effect of oxymatrine on human pancreatic cancer PANC-1 cells, and its possible molecular mechanism...
  93. pmc Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population
    Liming Wu
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Hangzhou, China
    Hepat Mon 11:469-74. 2011
    ..There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production...
  94. ncbi request reprint Involvement of endoplasmic reticulum in hepatitis B virus replication
    Weiliang Xia
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Department of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China
    Virus Res 121:116-21. 2006
    ....
  95. ncbi request reprint A proteomic analysis of allograft rejection in rats after liver transplantation
    Chunchao Zhang
    Department of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China
    Sci China C Life Sci 50:312-9. 2007
    ..The results of the present paper could be helpful for our better understanding of allograft rejection in organ transplantation...
  96. ncbi request reprint [Orthotopic liver transplantation for end-stage liver diseases in 71 cases]
    Shusen Zheng
    Department of Hepatobiliary Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhonghua Gan Zang Bing Za Zhi 10:7-9. 2002
    ..To assess the role of orthotopic liver transplantation (OLT) in the treatment of end-stage liver diseases and to discuss the experience of the operation...
  97. pmc Pretreatment of cisplatin in recipients attenuates post-transplantation pancreatitis in murine model
    Sheng Yan
    Division of Hepatobiliary and Pancreatic Surgery, Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
    Int J Biol Sci 8:298-309. 2012
    ..In short, our study demonstrated that pretreatment of Cis in recipients may reduce the onset of PTP in pancreas transplantation...
  98. doi request reprint Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry
    Baohong Wang
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qing Chun Road, Hangzhou 310003, PR China
    J Proteome Res 11:1217-27. 2012
    ..UPLC-MS signatures, alone or in combination with AFP levels, could be an efficient and convenient tool for early diagnosis and screening of HCC in high-risk populations...