Shusen Zheng


Affiliation: Zhejiang University
Country: China


  1. Lu D, Zhuo J, Yang M, Wang C, Pan L, Xie H, et al. The association between donor genetic variations in one-carbon metabolism pathway genes and hepatitis B recurrence after liver transplantation. Gene. 2018;663:121-125 pubmed publisher
    ..05). Hepatitis B recurrence impaired post-transplant survival. Donor liver genetic variations in one-carbon metabolism pathway genes were significantly associated with post-transplant hepatitis B recurrence. ..
  2. Ke Q, Huang H, Ling Q, Liu J, Dong S, He X, et al. New-onset hyperglycemia immediately after liver transplantation: A national survey from China Liver Transplant Registry. Hepatobiliary Pancreat Dis Int. 2018;: pubmed publisher
    ..Strategic targeting graft ischemic injury may help maintain glucose homeostasis. ..
  3. Chen T, Huang H, Zhou Y, Geng L, Shen T, Yin S, et al. HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3? signaling pathways. J Exp Clin Cancer Res. 2018;37:193 pubmed publisher
    ..Our data revealed that HJURP is an oncogene that drives cell cycle progression upstream of p21 in HCC. These findings may provide a potential therapeutic and prognostic target for HCC. ..
  4. Wei Q, Wang K, He Z, Ke Q, Xu X, Zheng S. Acute Liver Allograft Rejection After Living Donor Liver Transplantation: Risk Factors and Patient Survival. Am J Med Sci. 2018;356:23-29 pubmed publisher
    ..Higher posttransplant model for predicting mortality score was associated with AR after living donor liver transplantation. ABO-incompatibility and patient age ?50 years were independent prognostic factors for overall survival. ..
  5. Ling Q, Liu J, Zhuo J, Zhuang R, Huang H, He X, et al. Development of models to predict early post-transplant recurrence of hepatocellular carcinoma that also integrate the quality and characteristics of the liver graft: A national registry study in China. Surgery. 2018;: pubmed publisher
    ..The identification of donor risks can further help understand the mechanism of different patterns of recurrence. ..
  6. Wang W, Xie Q, Zhou X, Yao J, Zhu X, Huang P, et al. Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells. Cancer Lett. 2015;358:47-58 pubmed publisher
    ..Thus, we confirmed that Mfn2 induced apoptosis in HCC cells by triggering influx of Ca(2+) into the mitochondria from the ER. ..
  7. Xu X, Liu Z, Zhou L, Xie H, Cheng J, Ling Q, et al. Characterization of genome-wide TFCP2 targets in hepatocellular carcinoma: implication of targets FN1 and TJP1 in metastasis. J Exp Clin Cancer Res. 2015;34:6 pubmed publisher
  8. Zhang Q, Tian Y, Duan J, Wu J, Yan S, Chen H, et al. Chelerythrine ameliorates acute cardiac allograft rejection in mice. Transpl Immunol. 2016;38:78-83 pubmed publisher
    ..Meanwhile, chelerythrine was also found to inhibit the dephosphorylation of phosphorylated nuclear factor of activated T cells (NFAT) protein 1 and 4. ..
  9. Lu D, Wang W, Liu J, Qi L, Zhuang R, Zhuo J, et al. Peroxiredoxins in inflammatory liver diseases and ischemic/reperfusion injury in liver transplantation. Food Chem Toxicol. 2018;113:83-89 pubmed publisher
    ..Alcohol administration increases oxidization and inactivation of Prxs in mice because of oxidative stress. In conclusion, Prxs are essential mediators and biomarkers in inflammatory liver diseases and I/R injury. ..

More Information


  1. request reprint
    Geng L, Lin B, Shen T, Guo H, Ye Y, Zheng S. Anti-virus prophylaxis withdrawal may be feasible in liver transplant recipients whose serum HBeAg and HBV DNA are negative. Hepatobiliary Pancreat Dis Int. 2016;15:316-8 pubmed
    ..Our data suggested that complete withdrawal of anti-virus prophylaxis was safe and feasible for patients whose serum HBeAg and HBV DNA were negative at the time of LT. ..
  2. request reprint
    Wei Q, Nemdharry R, Zhuang R, Li J, Ling Q, Wu J, et al. A good prognostic predictor for liver transplantation recipients with benign end-stage liver cirrhosis. Hepatobiliary Pancreat Dis Int. 2017;16:164-168 pubmed
    ..05). PMPM score is a simple and effective tool to predict short-term mortality after liver transplantation in patients with benign liver diseases, and an indicator for prompt salvaging treatment as well. ..
  3. request reprint
    Gao F, Zhu H, Zhu Y, Shan Q, Ling Q, Wei X, et al. Predictive value of tumor markers in patients with recurrent hepatocellular carcinoma in different vascular invasion pattern. Hepatobiliary Pancreat Dis Int. 2016;15:371-7 pubmed
    ..In the MaVI- patients, DCP >445 mAu/mL and tumor size >8 cm were predictive factors for postoperative recurrence. ..
  4. request reprint
    Ling Q, Xu X, Zheng S, Kalthoff H. The diversity between pancreatic head and body/tail cancers: clinical parameters and in vitro models. Hepatobiliary Pancreat Dis Int. 2013;12:480-7 pubmed
    ..They present different chemo- and/or radio-resistance, extracellular matrix adhesion and invasiveness, as well as genetic profiles. Genetic and tumor biological diversity exists in PDAC according to the tumor localization. ..
  5. Wang J, Xie H, Ling Q, Lu D, Lv Z, Zhuang R, et al. Coding-noncoding gene expression in intrahepatic cholangiocarcinoma. Transl Res. 2016;168:107-121 pubmed publisher
    ..Thus, lncRNA may be a potential diagnostic and prognostic biomarker for ICC. Furthermore, the combined assessment of lncRNA and mRNA expressions might predict the survival of patients with ICC. ..
  6. request reprint
    Gao F, Xu X, Zhu Y, Wei Q, Zhou B, Shen X, et al. Impact of intra-operative cholangiography and parenchymal resection to donor liver function in living donor liver transplantation. Hepatobiliary Pancreat Dis Int. 2014;13:259-63 pubmed
  7. Wei X, Li J, Xie H, Ling Q, Wang J, Lu D, et al. Proteomics-based identification of the tumor suppressor role of aminoacylase 1 in hepatocellular carcinoma. Cancer Lett. 2014;351:117-25 pubmed publisher
    ..The study's results indicated that ACY1 acts as a tumor suppressor in HCC. ..
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    Yu J, Zhang W, Gao F, Liu Y, Chen Z, Cheng L, et al. FBW7 increases chemosensitivity in hepatocellular carcinoma cells through suppression of epithelial-mesenchymal transition. Hepatobiliary Pancreat Dis Int. 2014;13:184-91 pubmed
    ..This study aimed to evaluate the role of FBW7 in chemosensitivity and epithelial-mesenchymal transition (EMT) in different hepatocellular carcinoma (HCC) cell lines and to investigate the relevant underlying mechanisms...
  9. Lu D, Xu X, Wang J, Ling Q, Xie H, Zhou L, et al. The influence of a contemporaneous portal and hepatic artery revascularization protocol on biliary complications after liver transplantation. Surgery. 2014;155:190-5 pubmed publisher
    ..We sought to compare the impact of sequential and contemporaneous revascularizations of portal vein and hepatic artery on biliary complications in patients undergoing liver transplantation...
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    Shen T, Lin B, Jia J, Wang Z, Wang L, Ling Q, et al. A modified protocol with rituximab and intravenous immunoglobulin in emergent ABO-incompatible liver transplantation for acute liver failure. Hepatobiliary Pancreat Dis Int. 2014;13:395-401 pubmed
    ..We developed a protocol consisting of rituximab and intravenous immunoglobulin (IVIG) for ABO-I LT in patients with acute liver failure (ALF)...