Shi Hong Zhang

Summary

Affiliation: Zhejiang University
Country: China

Publications

  1. ncbi request reprint Paracrine-like excitation of low-threshold mechanoceptive C-fibers innervating rat hairy skin is mediated by substance P via NK-1 receptors
    Shi Hong Zhang
    Faculty of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, PR China
    Brain Res Bull 75:138-45. 2008
  2. doi request reprint Therapeutic time window of low-frequency stimulation at entorhinal cortex for amygdaloid-kindling seizures in rats
    Zheng Hao Xu
    Institute of Neuroscience, Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    Epilepsia 51:1861-4. 2010
  3. doi request reprint Mode-dependent effect of low-frequency stimulation targeting the hippocampal CA3 subfield on amygdala-kindled seizures in rats
    Hong Liu Sun
    Institute of Neuroscience, School of Medicine, Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    Epilepsy Res 90:83-90. 2010
  4. ncbi request reprint Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice
    Guo Liang Yu
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China
    Pharmacology 73:31-40. 2005
  5. doi request reprint Histamine modulation of acute nociception involves regulation of Nav 1.8 in primary afferent neurons in mice
    Jie Yu
    Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, China
    CNS Neurosci Ther 19:649-58. 2013
  6. ncbi request reprint Focal cerebral ischemia alters the spatio-temporal properties, but not the amount of activity in mice
    Qi Zhang
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, PR China
    Behav Brain Res 169:66-74. 2006
  7. ncbi request reprint Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague-Dawley rats
    Shuang Wang
    Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 China
    Neurobiol Dis 29:52-8. 2008
  8. doi request reprint Effects of histamine on spontaneous neuropathic pain induced by peripheral axotomy
    Jie Yu
    Department of Pharmacology, School of Basic Medical Sciences College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China
    Neurosci Bull 29:261-9. 2013
  9. ncbi request reprint Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice
    Guo Liang Yu
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou Zhejiang 310031, China
    Brain Res 1053:116-25. 2005
  10. ncbi request reprint Time-dependent effect of low-frequency stimulation on amygdaloid-kindling seizures in rats
    Deng Chang Wu
    Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, 388 Yuhang Tang Road, Hangzhou 310058, PR China
    Neurobiol Dis 31:74-9. 2008

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Paracrine-like excitation of low-threshold mechanoceptive C-fibers innervating rat hairy skin is mediated by substance P via NK-1 receptors
    Shi Hong Zhang
    Faculty of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, PR China
    Brain Res Bull 75:138-45. 2008
    ..We propose that this cross-talk has evolved as a mechanism regulating the mechanoceptive characteristics of LTM C-fibers, presumably contributing to pain sensation elicited by tactile stimuli ('allodynia')...
  2. doi request reprint Therapeutic time window of low-frequency stimulation at entorhinal cortex for amygdaloid-kindling seizures in rats
    Zheng Hao Xu
    Institute of Neuroscience, Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    Epilepsia 51:1861-4. 2010
    ..Our findings suggest that even in the duration of afterdischarge, there exists a "time window" for LFS treatment, indicating that the time delay of closed-loop stimulation is crucial for LFS treatment...
  3. doi request reprint Mode-dependent effect of low-frequency stimulation targeting the hippocampal CA3 subfield on amygdala-kindled seizures in rats
    Hong Liu Sun
    Institute of Neuroscience, School of Medicine, Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    Epilepsy Res 90:83-90. 2010
    ..The hippocampal CA3 subfield could be considered as a potential target for epilepsy treatment using LFS, and should be delivered in an appropriate stimulation mode...
  4. ncbi request reprint Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice
    Guo Liang Yu
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China
    Pharmacology 73:31-40. 2005
    ..1-1.0 mg/kg and a therapeutic window of 30 min. These findings further support the therapeutic potential of CysLT1 receptor antagonists in the treatment of cerebral ischemia at earlier phases...
  5. doi request reprint Histamine modulation of acute nociception involves regulation of Nav 1.8 in primary afferent neurons in mice
    Jie Yu
    Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, China
    CNS Neurosci Ther 19:649-58. 2013
    ..To explore the role of histamine in acute pain perception and its possible mechanisms...
  6. ncbi request reprint Focal cerebral ischemia alters the spatio-temporal properties, but not the amount of activity in mice
    Qi Zhang
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, PR China
    Behav Brain Res 169:66-74. 2006
    ....
  7. ncbi request reprint Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague-Dawley rats
    Shuang Wang
    Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 China
    Neurobiol Dis 29:52-8. 2008
    ..Our study suggests that LFS of targets outside the limbic system, such as the FN, may have a significant anti-epileptogenic action, and the effects of LFS depend on the frequency and timing of stimulation...
  8. doi request reprint Effects of histamine on spontaneous neuropathic pain induced by peripheral axotomy
    Jie Yu
    Department of Pharmacology, School of Basic Medical Sciences College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China
    Neurosci Bull 29:261-9. 2013
    ..This study justifies the avoidance of a histamine-rich diet and the use of peripherally-acting H1 receptor antagonists as well as agents that improve histamine action in the central nervous system in patients with spontaneous NP...
  9. ncbi request reprint Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice
    Guo Liang Yu
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou Zhejiang 310031, China
    Brain Res 1053:116-25. 2005
    ....
  10. ncbi request reprint Time-dependent effect of low-frequency stimulation on amygdaloid-kindling seizures in rats
    Deng Chang Wu
    Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, 388 Yuhang Tang Road, Hangzhou 310058, PR China
    Neurobiol Dis 31:74-9. 2008
    ..However, delayed LFS prolonged the cumulative GSD and afterdischarge duration. Our study indicates that there is a time-dependent aspect of LFS treatment, and immediate LFS has anti-epileptogenic action...
  11. doi request reprint Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats
    Kai Zhong
    Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou 310058, China
    Neurobiol Dis 48:20-6. 2012
    ..Thus, these results demonstrated that LFS of the subiculum has a wide therapeutic time-window for temporal lobe epilepsy treatment in rats, suggesting that the subiculum may be a promising and suitable target for clinical application...
  12. doi request reprint Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury
    Qi Fang
    Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China Department of Biochemistry and Molecular Cell Biology, Institute of Medical Sciences, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
    Neuropharmacology 77:156-66. 2014
    ..In summary, our results suggest that histamine up-regulates GLT-1 expression and function via astrocytic H1 receptors, thus resulting in neuroprotection against excitotoxicity and ischemic injury. ..
  13. pmc Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors
    Hua Hu
    Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    J Zhejiang Univ Sci B 6:33-7. 2005
    ..To characterize the expression of aquaporin-4 (AQP4), one of the aquaporins (AQPs), in human brain specimens from patients with traumatic brain injury or brain tumors...
  14. ncbi request reprint [Advances in application of deep brain stimulation in treatment of neuropsychological diseases]
    Zhong Chen
    1Institute of Neuroscience, 2 Departmemt of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 38:549-58. 2009
    ..Deep brain stimulation is now emerging as a promising approach for the treatment of resistant neuropsychological diseases...
  15. ncbi request reprint Carnosine ameliorates morphine-induced conditioned place preference in rats
    Ying Xia Gong
    Department of Pharmacology and Neurobiology, School of Medicine, Zhejiang University, Hangzhou 310058, China
    Neurosci Lett 422:34-8. 2007
    ..The study suggests that carnosine has potential as a new anti-addictive drug...
  16. doi request reprint Low-frequency stimulation of the tuberomammillary nucleus facilitates electrical amygdaloid-kindling acquisition in Sprague-Dawley rats
    Deng Chang Wu
    Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058, China
    Neurobiol Dis 32:151-6. 2008
    ..These results suggest that specific negative sites for DBS exist in the brain, such as the TM. This study indicates that it is crucial to choose a suitable target for DBS in the clinical treatment of epilepsy...
  17. doi request reprint Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat
    Shi Hong Zhang
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, PR China
    Pain 139:293-305. 2008
    ..3, Nav1.7, Nav1.8, and Cav2.2 channels in rat DRG neurons, inhibition of substance P release from spinal cord synaptosomes, NMDA receptor antagonism and neuroprotection...