Xu P, Bailey Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, et al. Innate antiviral host defense attenuates TGF-Î² function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014;56:723-37 pubmed publisher
..WeÂ present a mechanism of regulation of TGF-Î² signaling by the antiviral defense, with evidence for its role in immune tolerance and cancer cell behavior. ..
Liu S, Chen S, Li X, Wu S, Zhang Q, Jin Q, et al. Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses. Cell Host Microbe. 2017;21:754-768.e5 pubmed publisher
..These findings unveil the negative regulation of TBK1 via tyrosine phosphorylation and the functional integration of SFKs into innate antiviral immunity. ..