Li Xin Xiang
Affiliation: Zhejiang University
Zhu L, Shao T, Nie L, Zhu L, Xiang L, Shao J. Evolutionary implication of B-1 lineage cells from innate to adaptive immunity. Mol Immunol. 2016;69:123-30 pubmed publisher
..Our discussion would contribute to the understanding on the origination of B cells specialized in adaptive immunity from innate immunity. The results might provide further insight into the evolution of the immune system as a whole. ..
Xiang L, Guo F, Zhang H, LaCoste L, Rollins D, Bruno A, et al
. Gene discovery, evolutionary affinity and molecular detection of Oxyspirura petrowi, an eye worm parasite of game birds. BMC Microbiol. 2013;13:233 pubmed publisher
Nie L, Xiong R, Zhang Y, Zhu L, Shao J, Xiang L. Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways. Dev Comp Immunol. 2014;43:23-9 pubmed publisher
..This study demonstrates the conserved negative regulatory role of teleost SOCS-1s in IFN signaling pathways, providing perspective into the functional conservation of SOCS-1 proteins during evolution. ..
Nie L, Zhang Y, Dong W, Xiang L, Shao J. Involvement of zebrafish RIG-I in NF-ÎºB and IFN signaling pathways: insights into functional conservation of RIG-I in antiviral innate immunity. Dev Comp Immunol. 2015;48:95-101 pubmed publisher
Shao T, Zhu L, Nie L, Shi W, Dong W, Xiang L, et al
. Characterization of surface phenotypic molecules of teleost dendritic cells. Dev Comp Immunol. 2015;49:38-43 pubmed publisher
..Our findings contributed to the current understanding of the evolutionary history of DCs and the DC-regulatory mechanisms of adaptive immunity. ..
Xu X, Wan H, Nie L, Shao T, Xiang L, Shao J. RIG-I: a multifunctional protein beyond a pattern recognition receptor. Protein Cell. 2018;9:246-253 pubmed publisher
..Taken together, the function of RIG-I exceeds far beyond that of a pattern recognition receptor. ..
Jiang X, Liu Z, Lin A, Xiang L, Shao J. Coordination of Bactericidal and Iron Regulatory Functions of Hepcidin in Innate Antimicrobial Immunity in a Zebrafish Model. Sci Rep. 2017;7:4265 pubmed publisher
..Results indicate that the induction of hepcidin leads to the decrease of iron in circulation, which eventually limits iron availability to invading microorganisms, thus contributing to host defence. ..