Genomes and Genes


Qiang Shu


Affiliation: Zhejiang University
Country: China


  1. Tong F, Chen T, Jiang P, Yang R, Zhao Z, Shu Q. [Analysis of ACADVL gene variations among nine neonates with very long chain acyl-coA dehydrogenase deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019;36:310-313 pubmed publisher
    ..Carriers of null variations of the ACADVL gene may have relatively poorer clinical outcome. Above results will provide valuable information for the diagnosis and management of VLCADD. ..
  2. Xu J, Luo Y, Wang J, Xu W, Shi Z, Fu J, et al. Patient-specific three-dimensional printed heart models benefit preoperative planning for complex congenital heart disease. World J Pediatr. 2019;: pubmed publisher
    ..3D printed heart models are beneficial and promising in preoperative planning for complex congenital heart diseases, and are able to help conform or even improve the surgery options. ..
  3. Xu B, Wu L, Jin Z, Chen X, Chen C, Liu J, et al. Residual airway foreign bodies in children who underwent rigid bronchoscopy. Int J Pediatr Otorhinolaryngol. 2019;118:170-176 pubmed publisher
    ..Surgeons with sufficient experience are important for the success of the procedure, which is supported by chest CT and flexible bronchoscopy. ..
  4. request reprint
    Tong F, Jiang P, Yang R, Huang X, Zhou X, Hong F, et al. [Medium-chain acyl-CoA dehydrogenase deficiency: neonatal screening and follow-uP]. Zhongguo Dang Dai Er Ke Za Zhi. 2019;21:52-57 pubmed
    ..MCADD is relatively rare in southern China, and p.T150Rfs*4 is a common mutation in the Chinese population. Cases with positive screening results should be evaluated by octanoylcarnitine C8 value and gene detection. ..
  5. Chen T, Xu W, Wu D, Han J, Zhu L, Tong F, et al. Mutational and phenotypic spectrum of phenylalanine hydroxylase deficiency in Zhejiang Province, China. Sci Rep. 2018;8:17137 pubmed publisher
    ..The data presented here will provide a valuable tool for improved genetic counseling and management of future cases of PAHD in China. ..
  6. Qiu G, Zheng G, Ge M, Wang J, Huang R, Shu Q, et al. Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs. Stem Cell Res Ther. 2018;9:320 pubmed publisher
    ..In conclusion, EV-mediated miRNA transfer plays an important role in disease-modulating capacity of MSCs. ..
  7. Wang J, Li M, Tang D, Xu S, Mao J, Cai J, et al. Neoadjuvant transcatheter arterial chemoembolization and systemic chemotherapy for treatment of clear cell sarcoma of the kidney in children. J Pediatr Surg. 2019;54:550-556 pubmed publisher
    ..Neoadjuvant TACE and systemic chemotherapy appeared to be feasible in the treatment of advanced CCSK in this pilot study. A case series with no comparison group. Level IV. ..
  8. Lai D, Tang J, Chen L, Fan E, Scott M, Li Y, et al. Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis. Cell Death Dis. 2018;9:369 pubmed publisher
    ..These findings suggest a previously unidentified innate pathway that negatively regulates lung inflammation following sepsis. ..
  9. Liu X, Chen Q, Luo Y, Hu Y, Lai D, Zhang X, et al. Plasma levels of alarmin HNPs 1-3 associate with lung dysfunction after cardiac surgery in children. BMC Pulm Med. 2017;17:218 pubmed publisher

More Information


  1. Meng F, He Z, Tang X, Zheng J, Jin X, Zhu Y, et al. Contribution of the tRNAIle 4317A→G mutation to the phenotypic manifestation of the deafness-associated mitochondrial 12S rRNA 1555A→G mutation. J Biol Chem. 2018;293:3321-3334 pubmed publisher
    ..1555A→G mutation. Our findings provide new insights into the pathophysiology of maternally inherited deafness arising from the synergy between mitochondrial 12S rRNA and tRNA mutations. ..
  2. Shi S, Yue X, Zhao D, Fan J, Xu J, Liu X, et al. Plasma gelsolin level predicts acute kidney injury after cardiopulmonary bypass in infants and young children. World J Pediatr. 2018;14:143-150 pubmed publisher
    ..The findings suggest that circulating GSN in post-CPB patients may have beneficial effects on diminishing inflammatory responses. ..
  3. Xie P, Zang L, Li X, Shu Q. An epigenetic view of developmental diseases: new targets, new therapies. World J Pediatr. 2016;12:291-297 pubmed publisher
    ..DNA and RNA modifications play important roles in development and diseases through regulating gene expression. Epigenetic components could serve as novel targets for the treatment of developmental diseases. ..
  4. Zheng G, Qiu G, Ge M, He J, Huang L, Chen P, et al. Human adipose-derived mesenchymal stem cells alleviate obliterative bronchiolitis in a murine model via IDO. Respir Res. 2017;18:119 pubmed publisher
    ..Repeated doses of ASCs are capable of ameliorating OB. ASCs act at least in part via elevating IDO expression. ASCs promote the generation of Treg and suppress T cell infiltration via an IDO-dependent mechanism. ..
  5. Yue X, Zhao X, Dai Y, Shu Q. Episode of Kasabach-Merritt phenomenon following Japanese encephalitis vaccination: Case report. Vaccine. 2017;35:6594-6597 pubmed publisher
    ..The episode of KMP was treated successfully by steroid. KMP is a rare complication of vaccination that physicians should be aware of. Giving up the following vaccination to provide the recurrence of KMP is not recommended. ..
  6. Jin Z, Yang M, Lin R, Huang W, Wang J, Hu Z, et al. Application of end-tidal carbon dioxide monitoring via distal gas samples in ventilated neonates. Pediatr neonatol. 2017;58:370-375 pubmed publisher
    ..Thus, the PETCO2 value was closer to that of PaCO2. PETCO2 detected via modified carbon dioxide monitoring had a better accuracy and correlation with PaCO2 in neonates. ..
  7. Hou J, Chen Q, Wu X, Zhao D, Reuveni H, Licht T, et al. S1PR3 Signaling Drives Bacterial Killing and Is Required for Survival in Bacterial Sepsis. Am J Respir Crit Care Med. 2017;196:1559-1570 pubmed publisher
    ..S1PR3 signaling drives bacterial killing and is essential for survival in bacterial sepsis. Interventions targeting S1PR3 signaling could have translational implications for manipulating the innate immune response to combat pathogens. ..