Zheng Wei Mao


Affiliation: Zhejiang University
Country: China


  1. Zhang W, Jiang P, Chen Y, Luo P, Li G, Zheng B, et al. Suppressing the cytotoxicity of CuO nanoparticles by uptake of curcumin/BSA particles. Nanoscale. 2016;8:9572-82 pubmed publisher
    ..The concept-proving study demonstrates the potential of the CUR/BSA particles in suppressing cytotoxicity of metal-based nanomaterials, which is a paramount requirement for the safe application of nanotechnology. ..
  2. Wu L, Lin B, Yang H, Chen J, Mao Z, Wang W, et al. Enzyme-responsive multifunctional peptide coating of gold nanorods improves tumor targeting and photothermal therapy efficacy. Acta Biomater. 2019;: pubmed publisher
  3. Yu G, Yu S, Saha M, Zhou J, Cook T, Yung B, et al. A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy. Nat Commun. 2018;9:4335 pubmed publisher
    ..Gene chip analyses confirmed the contribution of different therapeutic modalities to the tumor abrogation. This supramolecular platform holds potential in precise cancer theranostics. ..
  4. Jiang T, Zhao J, Yu S, Mao Z, Gao C, Zhu Y, et al. Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels. Biomaterials. 2019;188:130-143 pubmed publisher
    ..This study might provide new insights into rational design of scaffolds for generating in vitro tumor models to test anticancer therapeutics and for regenerating tissue to repair defects. ..
  5. Yu S, Zuo X, Shen T, Duan Y, Mao Z, Gao C. A density gradient of VAPG peptides on a cell-resisting surface achieves selective adhesion and directional migration of smooth muscle cells over fibroblasts. Acta Biomater. 2018;72:70-81 pubmed publisher
  6. Zhang H, Yu S, Zhao X, Mao Z, Gao C. Stromal cell-derived factor-1α-encapsulated albumin/heparin nanoparticles for induced stem cell migration and intervertebral disc regeneration in vivo. Acta Biomater. 2018;72:217-227 pubmed publisher
    ..This study provides a simple nanoplatform to load SDF-1α and protect it from degradation, with potential application in inductive tissue regeneration in vivo. ..
  7. Jiang P, Mao Z, Gao C. Combinational effect of matrix elasticity and alendronate density on differentiation of rat mesenchymal stem cells. Acta Biomater. 2015;19:76-84 pubmed publisher
    ..Their osteo-inductive effects are comparable to some extent, and high Aln density could be more effective than the stiffness. ..
  8. Yu S, Duan Y, Zuo X, Chen X, Mao Z, Gao C. Mediating the invasion of smooth muscle cells into a cell-responsive hydrogel under the existence of immune cells. Biomaterials. 2018;180:193-205 pubmed publisher
    ..Further mechanism investigation revealed that the expressions of cell migration-related genes and proteins were significantly up-regulated in the MMP-sensitive hydrogels compared to those in the MMP-insensitive hydrogels. ..
  9. Li X, Zhao X, Pardhi D, Wu Q, Zheng Y, Zhu H, et al. Folic acid modified cell membrane capsules encapsulating doxorubicin and indocyanine green for highly effective combinational therapy in vivo. Acta Biomater. 2018;74:374-384 pubmed publisher
    ..This study provides a simple and robust strategy to develop biocompatible therapeutic cell membrane capsules, holds strong translational potential in precise cancer treatment. ..

More Information


  1. Ren T, Yu S, Mao Z, Gao C. A complementary density gradient of zwitterionic polymer brushes and NCAM peptides for selectively controlling directional migration of Schwann cells. Biomaterials. 2015;56:58-67 pubmed publisher
    ..The success of the complementary gradient relies on the appropriate interplay between the PDMAPS brushes and the cell-specific ligands, enabling the selective guidance of SCs migration. ..
  2. Yu S, Mao Z, Gao C. Preparation of gelatin density gradient on poly(ε-caprolactone) membrane and its influence on adhesion and migration of endothelial cells. J Colloid Interface Sci. 2015;451:177-83 pubmed publisher
  3. Zhang W, Mao Z, Gao C. Preparation of TAT peptide-modified poly(N-isopropylacrylamide) microgel particles and their cellular uptake, intracellular distribution, and influence on cytoviability in response to temperature change. J Colloid Interface Sci. 2014;434:122-9 pubmed publisher
    ..Doxorubicin loaded PNIPAM microgel particles showed the strongest cytotoxicity when being cultured at 25°C for 4 h, suggesting the combinational effect of intracellular volume expansion and drug release on cells. ..
  4. Yu G, Yang Z, Fu X, Yung B, Yang J, Mao Z, et al. Polyrotaxane-based supramolecular theranostics. Nat Commun. 2018;9:766 pubmed publisher
    ..These supramolecular nanomedicines also exhibit excellent anti-tumour performance against orthotopic breast cancer and prevent lung metastasis with negligible systemic toxicity. ..
  5. Chen Y, Xu Z, Zhu D, Tao X, Gao Y, Zhu H, et al. Gold nanoparticles coated with polysarcosine brushes to enhance their colloidal stability and circulation time in vivo. J Colloid Interface Sci. 2016;483:201-210 pubmed publisher
    ..The Au@PS did not cause obvious toxicity in vivo, suggesting potential applications in disease diagnosis and therapy. ..
  6. Sheng G, Chen Y, Han L, Huang Y, Liu X, Li L, et al. Encapsulation of indocyanine green into cell membrane capsules for photothermal cancer therapy. Acta Biomater. 2016;43:251-261 pubmed publisher
    ..The system provides a better photothermal effect against tumors, an important step forward in the practical application of ICG in cancer therapy. ..
  7. Yu W, Zhang W, Chen Y, Song X, Tong W, Mao Z, et al. Cellular uptake of poly(allylamine hydrochloride) microcapsules with different deformability and its influence on cell functions. J Colloid Interface Sci. 2016;465:149-57 pubmed publisher
    ..The results pointed out that the deformability of microcapsules is an important factor governing the biological performance of microcapsules, which requires careful adjustment for further biomedical applications. ..
  8. Jiang P, Zhang Y, Zhu C, Zhang W, Mao Z, Gao C. Fe3O4/BSA particles induce osteogenic differentiation of mesenchymal stem cells under static magnetic field. Acta Biomater. 2016;46:141-150 pubmed publisher
    ..The results demonstrate a potential magnetic manipulation method for stem cell differentiation, and also convey the significance of careful evaluation of the safety issue of magnetic particles in real an application situation. ..
  9. Zhu H, Chen Y, Yan F, Chen J, Tao X, Ling J, et al. Polysarcosine brush stabilized gold nanorods for in vivo near-infrared photothermal tumor therapy. Acta Biomater. 2017;50:534-545 pubmed publisher
    ..In vivo photothermal therapy showed that tumors were completely cured without reoccurrence by one-time irradiation of NIR laser after a single injection of the polysarcosine modified AuNRs. ..
  10. Zhang W, Jiang P, Chen J, Zhu C, Mao Z, Gao C. Application of melatonin-loaded poly(N-isopropylacrylamide) hydrogel particles to reduce the toxicity of airborne pollutes to RAW264.7 cells. J Colloid Interface Sci. 2017;490:181-189 pubmed publisher
    ..This concept-proving study demonstrates the potential to use the thermo-responsive PNIPAM/MLT particles to suppress the toxicity of airborne PM2.5 pollutes, which is a paramount requirement for human health. ..
  11. Peng L, Huang Y, Zhang C, Niu J, Chen Y, Chu Y, et al. Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity. Biomaterials. 2016;103:137-149 pubmed publisher