Jinghua Jin

Summary

Affiliation: Zhejiang University
Country: China

Publications

  1. pmc Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    BMC Neurosci 8:67. 2007
  2. ncbi request reprint Oligomeric alpha-synuclein inhibits tubulin polymerization
    Leo Chen
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Biochem Biophys Res Commun 356:548-53. 2007
  3. ncbi request reprint Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 5:1193-204. 2006
  4. ncbi request reprint Identification of novel proteins associated with both alpha-synuclein and DJ-1
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 6:845-59. 2007
  5. doi request reprint Mortalin: a protein associated with progression of Parkinson disease?
    Min Shi
    Department of Pathology, University of Washington, School of Medicine, Seattle, Washington, USA
    J Neuropathol Exp Neurol 67:117-24. 2008
  6. ncbi request reprint Proteomic identification of novel proteins in cortical lewy bodies
    James B Leverenz
    Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 17:139-45. 2007
  7. pmc Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    J Neuroinflammation 4:2. 2007
  8. ncbi request reprint Proteomics identification of proteins in human cortex using multidimensional separations and MALDI tandem mass spectrometer
    Sheng Pan
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 6:1818-23. 2007
  9. pmc Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion
    Robert C Rostomily
    Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Proteome Res 9:2610-8. 2010
  10. ncbi request reprint Identification of glycoproteins in human cerebrospinal fluid with a complementary proteomic approach
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Proteome Res 5:2769-79. 2006

Collaborators

Detail Information

Publications17

  1. pmc Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    BMC Neurosci 8:67. 2007
    ..A comprehensive analysis of the mitochondrial protein expression profile affected by rotenone can provide important insight into the role of mitochondrial dysfunction in PD...
  2. ncbi request reprint Oligomeric alpha-synuclein inhibits tubulin polymerization
    Leo Chen
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Biochem Biophys Res Commun 356:548-53. 2007
    ..Finally, we demonstrated that neurotoxicity induced by oligomeric alpha-synuclein was largely prevented by overexpressing the neuroprotective protein, DJ-1...
  3. ncbi request reprint Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 5:1193-204. 2006
    ..Manipulations of mortalin level in dopaminergic neurons resulted in significant changes in sensitivity to PD phenotypes via pathways involving mitochondrial and proteasomal function as well as oxidative stress...
  4. ncbi request reprint Identification of novel proteins associated with both alpha-synuclein and DJ-1
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 6:845-59. 2007
    ..Further characterization of these docking proteins will likely shed more light on the mechanisms by which DJ-1 modulates the function of alpha-synuclein, and vice versa, in the setting of PD...
  5. doi request reprint Mortalin: a protein associated with progression of Parkinson disease?
    Min Shi
    Department of Pathology, University of Washington, School of Medicine, Seattle, Washington, USA
    J Neuropathol Exp Neurol 67:117-24. 2008
    ..Of those, mortalin, a mitochondrial protein, was decreased in the advanced PD cases and was further validated to be decreased using independent techniques. These results suggest a role for mortalin in PD progression...
  6. ncbi request reprint Proteomic identification of novel proteins in cortical lewy bodies
    James B Leverenz
    Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 17:139-45. 2007
    ..Further investigation of these novel candidates is also necessary to ensure that the potential proteins in cortical LBs are not identified incorrectly because of incomplete current human protein database...
  7. pmc Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    J Neuroinflammation 4:2. 2007
    ..It has been demonstrated that aggregated alpha-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated alpha-synuclein activates microglia are not understood fully...
  8. ncbi request reprint Proteomics identification of proteins in human cortex using multidimensional separations and MALDI tandem mass spectrometer
    Sheng Pan
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 6:1818-23. 2007
    ..Finally 140 proteins found in the cortical proteome were present in the proteome of cerebrospinal fluid, providing tissue-specific candidates for biomarker discovery in body fluid...
  9. pmc Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion
    Robert C Rostomily
    Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Proteome Res 9:2610-8. 2010
    ..Future analysis of larger patient samples are warranted to further refine biomarker panels to predict biological behavior and assist in the identification of deleted gene products that define the 1p/19q phenotype...
  10. ncbi request reprint Identification of glycoproteins in human cerebrospinal fluid with a complementary proteomic approach
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Proteome Res 5:2769-79. 2006
    ..This investigation, for the first time, not only categorized many glycoproteins in human CSF but also expanded the existing overall CSF protein database...
  11. ncbi request reprint Characterization of proteome of human cerebrospinal fluid
    Jing Xu
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Int Rev Neurobiol 73:29-98. 2006
  12. ncbi request reprint Microglial activation induced by neurodegeneration: a proteomic analysis
    Yong Zhou
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 4:1471-9. 2005
    ..The search revealed numerous novel proteins that are potentially important in neurodegeneration-mediated microglial activation, a process believed to be critical in Parkinson disease progression...
  13. ncbi request reprint Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease
    Jinghua Jin
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Res Mol Brain Res 134:119-38. 2005
    ..In addition, DJ-1 was present in the halo but not in the core of classical LBs in patients with PD. Our findings suggested that DJ-1 might play an important role in mitochondrial dysfunction, as well as LB formation in PD...
  14. ncbi request reprint Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders
    Fadi Abdi
    Applied Biosystems, Framingham, MA, USA
    J Alzheimers Dis 9:293-348. 2006
    ....
  15. ncbi request reprint Zinc finger proteins and other transcription regulators as response proteins in benzo[a]pyrene exposed cells
    Zhihua Gao
    Department of Pathology and Pathophysiology, Center for Environmental Genomics, Zhejiang University School of Medicine, 353 Yan An Road, Hangzhou, Zhejiang 310031, China
    Mutat Res 550:11-24. 2004
    ..These data may provide new clues to further understand the implication of these proteins in cellular responses to carcinogen exposure as well as the molecular mechanisms of B[a]P-induced mutagenesis and carcinogenesis...
  16. ncbi request reprint Proteomic analysis of cellular responses to low concentration N-methyl-N'-nitro-N-nitrosoguanidine in human amnion FL cells
    Jinghua Jin
    Department of Pathophysiology, Center for Environmental Genomics, Zhejiang University School of Medicine, Hangzhou, China
    Environ Mol Mutagen 43:93-9. 2004
    ..Furthermore, some of these proteins may serve as biomarkers for detecting exposure of human populations to environmental carcinogens...
  17. ncbi request reprint Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N'-nitro-N-nitrosoguanidine
    Jinghua Jin
    Department of Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China
    Environ Mol Mutagen 41:344-52. 2003
    ....