Min Xin Guan

Summary

Affiliation: Zhejiang University
Country: China

Publications

  1. Xue L, Chen Y, Tang X, Yao J, Huang H, Wang M, et al. A deafness-associated mitochondrial DNA mutation altered the tRNASer(UCN) metabolism and mitochondrial function. Mitochondrion. 2019;46:370-379 pubmed publisher
    ..Our findings highlighted critical insights into the pathophysiology of maternally inherited deafness, which is manifested by the aberrant tRNA metabolism. ..
  2. Zhang J, Jiang P, Jin X, Liu X, Zhang M, Xie S, et al. Leber's hereditary optic neuropathy caused by the homoplasmic ND1 m.3635G>A mutation in nine Han Chinese families. Mitochondrion. 2014;18:18-26 pubmed publisher
    ..The data provide the direct evidence for the m.3635G>A mutation leading to LHON. Our findings may provide new insights into the understanding of pathophysiology of LHON. ..
  3. Liu H, Li R, Li W, Wang M, Ji J, Zheng J, et al. Maternally inherited diabetes is associated with a homoplasmic T10003C mutation in the mitochondrial tRNA(Gly) gene. Mitochondrion. 2015;21:49-57 pubmed publisher
    ..These data provide the first direct evidence that the tRNA(Gly) mutation might be associated with diabetes. Thus, our findings may provide new insights into the understanding of pathophysiology of maternally inherited diabetes. ..
  4. Liu Y, Li Y, Wang X, Ma Q, Zhu C, Li Z, et al. Mitochondrial tRNA mutations in Chinese hypertensive individuals. Mitochondrion. 2016;28:1-7 pubmed publisher
    ..A lot of work still should be done for the mechanism and functional effect of the mtDNA mutation on hypertension. ..
  5. Wang M, Peng Y, Zheng J, Zheng B, Jin X, Liu H, et al. A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function. Nucleic Acids Res. 2016;44:10974-10985 pubmed
    ..7551A > G mutation are associated with deafness. Our findings may provide new insights into the pathophysiology of maternally transmitted deafness that was manifested by altered nucleotide modification of mitochondrial tRNA. ..
  6. request reprint
    Zhang J, Zhang Z, Fu R, Ji Y, Jiang P, Tong Y, et al. [The role of MT-ND1 m.3635G>A mutation in Leber's hereditary optic neuropathy]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016;33:747-751 pubmed
    ..05), ATP-linked OCR (P<0.05) and the maximum OCR (P<0.05) have all reduced to some extent compared with the controls. These results showed that m.3635G>A, as a LHON-associated mutation, can lead to mitochondrial dysfunction. ..
  7. Meng F, He Z, Tang X, Zheng J, Jin X, Zhu Y, et al. Contribution of the tRNAIle 4317A→G mutation to the phenotypic manifestation of the deafness-associated mitochondrial 12S rRNA 1555A→G mutation. J Biol Chem. 2018;293:3321-3334 pubmed publisher
    ..1555A→G mutation. Our findings provide new insights into the pathophysiology of maternally inherited deafness arising from the synergy between mitochondrial 12S rRNA and tRNA mutations. ..
  8. Zhou M, Xue L, Chen Y, Li H, He Q, Wang B, et al. A hypertension-associated mitochondrial DNA mutation introduces an m1G37 modification into tRNAMet, altering its structure and function. J Biol Chem. 2018;293:1425-1438 pubmed publisher
    ..Our findings provide critical insights into the pathophysiology of maternally inherited hypertension, which is manifested by the deficient tRNA nucleotide modification. ..
  9. Su X, Wang W, Ruan G, Liang M, Zheng J, Chen Y, et al. A Comprehensive Characterization of Mitochondrial Genome in Papillary Thyroid Cancer. Int J Mol Sci. 2016;17: pubmed
    ..This can help to clarify the molecular mechanisms underlying PTC and offer potential biomarkers or therapeutic targets for future clinical practice. ..

More Information

Publications22

  1. Xue L, Wang M, Li H, Wang H, Jiang F, Hou L, et al. Mitochondrial tRNA mutations in 2070 Chinese Han subjects with hypertension. Mitochondrion. 2016;30:208-21 pubmed publisher
    ..9% cases of 2070 Han Chinese hypertensive subjects. Our findings may provide new insights into the pathophysiology of hypertension that were manifested by mitochondrial dysfunction. ..
  2. Wang M, Liu H, Zheng J, Chen B, Zhou M, Fan W, et al. A Deafness- and Diabetes-associated tRNA Mutation Causes Deficient Pseudouridinylation at Position 55 in tRNAGlu and Mitochondrial Dysfunction. J Biol Chem. 2016;291:21029-21041 pubmed
    ..Our findings may provide new insights into the pathophysiology of maternally inherited diabetes and deafness, which is primarily manifested by the deficient nucleotide modification of mitochondrial tRNAGlu. ..
  3. Jiang P, Wang M, Xue L, Xiao Y, Yu J, Wang H, et al. A Hypertension-Associated tRNAAla Mutation Alters tRNA Metabolism and Mitochondrial Function. Mol Cell Biol. 2016;36:1920-30 pubmed publisher
    ..These caused increases in the production of reactive oxygen species in the mutant cybrids. The data provide evidence for the association of the tRNA(Ala) 5655A ? G mutation with hypertension. ..
  4. Chen X, Nie Z, Wang F, Wang J, Liu X, Zheng J, et al. Late onset nonsyndromic hearing loss in a Dongxiang Chinese family is associated with the 593T>C variant in the mitochondrial tRNAPhe gene. Mitochondrion. 2017;35:111-118 pubmed publisher
    ..Thus, our findings may provide the new insights into the understanding of pathophysiology and valuable information for management and treatment of maternally inherited hearing loss. ..
  5. Jiang P, Liang M, Zhang C, Zhao X, He Q, Cui L, et al. Biochemical evidence for a mitochondrial genetic modifier in the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation. Hum Mol Genet. 2016;25:3613-3625 pubmed publisher
    ..11778G > A mutation than those carrying only 11778G > A mutation. Our findings provided new insights into the pathophysiology of LHON that were manifested by interaction between primary and secondary mtDNA mutations. ..
  6. Jiang P, Jin X, Peng Y, Wang M, Liu H, Liu X, et al. The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation. Hum Mol Genet. 2016;25:584-96 pubmed publisher
    ..Our findings provided new insights into the pathophysiology of LHON that were manifested by interaction between mtDNA mutation and mutated nuclear-modifier YARS2. ..
  7. Meng F, Cang X, Peng Y, Li R, Zhang Z, Li F, et al. Biochemical Evidence for a Nuclear Modifier Allele (A10S) in TRMU (Methylaminomethyl-2-thiouridylate-methyltransferase) Related to Mitochondrial tRNA Modification in the Phenotypic Manifestation of Deafness-associated 12S rRNA Mutation. J Biol Chem. 2017;292:2881-2892 pubmed publisher
    ..Our findings provided new insights into the pathophysiology of maternally inherited deafness that was manifested by interaction between mtDNA mutation and nuclear modifier gene. ..
  8. Liu Y, Li Y, Zhu C, Tian L, Guan M, Chen Y. Mitochondrial biogenesis dysfunction and metabolic dysfunction from a novel mitochondrial tRNAMet 4467 C>A mutation in a Han Chinese family with maternally inherited hypertension. Sci Rep. 2017;7:3034 pubmed publisher
    ..Therefore, this mutation contributes to oxidative stress and mitochondrial biogenesis dysfunction, which may be involved in the pathogenesis of hypertension. ..
  9. Zhou M, Wang M, Xue L, Lin Z, He Q, Shi W, et al. A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNALeu(UUR). J Biol Chem. 2017;292:13934-13946 pubmed publisher
    ..In conclusion, our findings may provide new insights into the pathophysiology of maternally inherited hypertension. ..
  10. Zhang J, Liu X, Liang X, Lu Y, Zhu L, Fu R, et al. A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis. Sci Rep. 2017;7:5704 pubmed publisher
    ..These data provided the direct evidence for c.1198C > G mutation leading to ADOA. Our findings may provide new insights into the understanding of pathophysiology of ADOA. ..
  11. Chen D, Li F, Yang Q, Tian M, Zhang Z, Zhang Q, et al. The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish. Int J Biochem Cell Biol. 2016;77:1-9 pubmed publisher
    ..In addition, this zebrafish model of mitochondrial disease may provide unique opportunities for studying defective tRNA modification, mitochondrial biogenesis, and pathophysiology of mitochondrial disorders. ..
  12. Zhang J, Ji Y, Liu X, Chen J, Wang B, Zhang M, et al. Leber's hereditary optic neuropathy caused by a mutation in mitochondrial tRNAThr in eight Chinese pedigrees. Mitochondrion. 2018;42:84-91 pubmed publisher
    ..Our data demonstrated the first mitochondrial tRNA mutation leading to LHON. Our findings may provide new insights into the understanding of pathophysiology of LHON. ..
  13. Tang X, Zheng J, Ying Z, Cai Z, Gao Y, He Z, et al. Mitochondrial tRNA(Ser(UCN)) variants in 2651 Han Chinese subjects with hearing loss. Mitochondrion. 2015;23:17-24 pubmed publisher
    ..Thus, our findings may provide valuable information for the further understanding of pathophysiology and management of hearing loss. ..