Changyou Gao


Affiliation: Zhejiang University
Country: China


  1. Wu S, Du W, Duan Y, Zhang D, Liu Y, Wu B, et al. Regulating the migration of smooth muscle cells by a vertically distributed poly(2-hydroxyethyl methacrylate) gradient on polymer brushes covalently immobilized with RGD peptides. Acta Biomater. 2018;75:75-92 pubmed publisher
  2. Yu S, Duan Y, Zuo X, Chen X, Mao Z, Gao C. Mediating the invasion of smooth muscle cells into a cell-responsive hydrogel under the existence of immune cells. Biomaterials. 2018;180:193-205 pubmed publisher
    ..Further mechanism investigation revealed that the expressions of cell migration-related genes and proteins were significantly up-regulated in the MMP-sensitive hydrogels compared to those in the MMP-insensitive hydrogels. ..
  3. Zhang D, Wu S, Feng J, Duan Y, Xing D, Gao C. Micropatterned biodegradable polyesters clicked with CQAASIKVAV promote cell alignment, directional migration, and neurite outgrowth. Acta Biomater. 2018;: pubmed publisher
    ..Hence, the integration of physical micropatterns and bioactive molecules is an effective way to obtain featured biomaterials for the regeneration of nerves and other types of tissues. ..
  4. Sun M, Deng J, Gao C. The correlation between fibronectin adsorption and attachment of vascular cells on heparinized polycaprolactone membrane. J Colloid Interface Sci. 2015;448:231-7 pubmed publisher
    ..Therefore, the adsorbed Fn takes a decisive role on the selective adhesion of ECs and the suppression of SMCs attachment. ..
  5. Ren T, Yu S, Mao Z, Gao C. A complementary density gradient of zwitterionic polymer brushes and NCAM peptides for selectively controlling directional migration of Schwann cells. Biomaterials. 2015;56:58-67 pubmed publisher
    ..The success of the complementary gradient relies on the appropriate interplay between the PDMAPS brushes and the cell-specific ligands, enabling the selective guidance of SCs migration. ..
  6. Yu S, Zuo X, Shen T, Duan Y, Mao Z, Gao C. A density gradient of VAPG peptides on a cell-resisting surface achieves selective adhesion and directional migration of smooth muscle cells over fibroblasts. Acta Biomater. 2018;72:70-81 pubmed publisher
  7. Jin K, Ye X, Li S, Li B, Zhang C, Gao C, et al. A biomimetic collagen/heparin multi-layered porous hydroxyapatite orbital implant for in vivo vascularization studies on the chicken chorioallantoic membrane. Graefes Arch Clin Exp Ophthalmol. 2016;254:83-9 pubmed publisher
  8. Zhang K, Zheng H, Liang S, Gao C. Aligned PLLA nanofibrous scaffolds coated with graphene oxide for promoting neural cell growth. Acta Biomater. 2016;37:131-42 pubmed publisher
    ..The design of this type of structure is of both scientific and technical importance, and possesses broad interest in the fields of biomaterials, tissue engineering and regenerative medicine. ..
  9. Liang S, Yu S, Gao C. Preparation of complementary glycosylated hyperbranched polymer/poly(ethylene glycol) brushes and their selective interactions with hepatocytes. Colloids Surf B Biointerfaces. 2016;145:309-318 pubmed publisher
    ..Therefore, the specific interactions of carbohydrate-protein can be used to modulate cell behaviors in vitro, for example the selective adhesion and migration of HepG2 cells. ..

More Information


  1. Jiang P, Zhang Y, Zhu C, Zhang W, Mao Z, Gao C. Fe3O4/BSA particles induce osteogenic differentiation of mesenchymal stem cells under static magnetic field. Acta Biomater. 2016;46:141-150 pubmed publisher
    ..The results demonstrate a potential magnetic manipulation method for stem cell differentiation, and also convey the significance of careful evaluation of the safety issue of magnetic particles in real an application situation. ..
  2. Zhang W, Jiang P, Chen J, Zhu C, Mao Z, Gao C. Application of melatonin-loaded poly(N-isopropylacrylamide) hydrogel particles to reduce the toxicity of airborne pollutes to RAW264.7 cells. J Colloid Interface Sci. 2017;490:181-189 pubmed publisher
    ..This concept-proving study demonstrates the potential to use the thermo-responsive PNIPAM/MLT particles to suppress the toxicity of airborne PM2.5 pollutes, which is a paramount requirement for human health. ..
  3. Liang S, Yu S, Zhou N, Deng J, Gao C. Controlling the selective and directional migration of hepatocytes by a complementary density gradient of glycosylated hyperbranched polymers and poly(ethylene glycol) molecules. Acta Biomater. 2017;56:161-170 pubmed publisher
    ..The success of the complementary gradient relies on the specific interaction between galactose and asialoglycoprotein receptor (ASGPR) expressed on HepG2 cells. STATEMENT OF SIGNIFICANCE. ..
  4. Deng J, Yao M, Gao C. Cytotoxicity of gold nanoparticles with different structures and surface-anchored chiral polymers. Acta Biomater. 2017;53:610-618 pubmed publisher
    ..The structure and surface chirality at the nanoscale can influence cytotoxicity and genotoxicity. • A new perspective on designing nanoparticles for drug delivery, bioimaging and diagnosis. ..
  5. Liu X, Zheng H, Li G, Li H, Zhang P, Tong W, et al. Fabrication of polyurethane microcapsules with different shapes and their influence on cellular internalization. Colloids Surf B Biointerfaces. 2017;158:675-681 pubmed publisher
    ..Both types of capsules did not show significant cytotoxicity even after co-incubation for 72h at a high ratio of capsule to cell. ..
  6. Chen X, Gao C. Influences of size and surface coating of gold nanoparticles on inflammatory activation of macrophages. Colloids Surf B Biointerfaces. 2017;160:372-380 pubmed publisher
    ..Comparatively, smaller GNPs induced stronger inflammatory responses regardless of their surface-conjugated molecules. ..