Heng Yu Fan
Affiliation: Zhejiang University
- Zhang Y, Yu C, Ji S, Li X, Zhang Y, Zhang D, et al. TOP2? is essential for ovarian follicles that are hypersensitive to chemotherapeutic drugs. Mol Endocrinol. 2013;27:1678-91 pubmed publisher..We also newly identified TOP2? as a factor involved in regulating GC genomic integrity and follicle atresia. This study has clinical implications for ovarian functional defects both for premenopausal cancer survivors and healthy women. ..
- Zhang Y, Xia Y, Yu C, Richards J, Liu J, Fan H. CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation. Mol Hum Reprod. 2014;20:850-60 pubmed publisher..These results support the proposition that LH induces rapid, significant gene expression in pre-ovulatory follicles by modulating histone acetylation status. ..
- Yu C, Fan X, Sha Q, Wang H, Li B, Dai X, et al. CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep. 2017;20:1161-1172 pubmed publisher..Our study highlights the importance of H3K4me3 in continuous histone replacement for transcriptional regulation, chromatin remodeling, and normal developmental progression in a non-replicative system. ..
- Xu Y, Cao L, Wang M, Xu Y, Wu X, Liu J, et al. Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice. J Cell Sci. 2017;130:3297-3307 pubmed publisher..Maternal DCAF2 protein is crucial for prevention of DNA re-replication in the first and unique mitotic cell cycle of the zygote.This article has an associated First Person interview with the first author of the paper. ..