Heng Yu Fan


Affiliation: Zhejiang University
Country: China


  1. Zhang Y, Guo K, Ji S, Liu X, Wang P, Wu J, et al. Development and characterization of a novel long-acting recombinant follicle stimulating hormone agonist by fusing Fc to an FSH-β subunit. Hum Reprod. 2016;31:169-82 pubmed publisher
    ..This study was supported by National Basic Research Program of China (2011|CB944504, 2012CB944403) and National Natural Science Foundation of China (81172473, 31371449). The authors have no conflicts of interest to declare. ..
  2. Sha Q, Dai X, Dang Y, Tang F, Liu J, Zhang Y, et al. A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes. Development. 2017;144:452-463 pubmed publisher
    ..Taken together, ERK1/2-mediated CPEB1 phosphorylation/degradation is a major mechanism of maternal mRNA translational activation, and is crucial for mouse oocyte maturation and MZT. ..
  3. Sha Q, Yu J, Guo J, Dai X, Jiang J, Zhang Y, et al. CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte. EMBO J. 2018;37: pubmed publisher
  4. Zhang J, Zhang Y, Zhao L, Guo J, Yu J, Ji S, et al. Mammalian nucleolar protein DCAF13 is essential for ovarian follicle maintenance and oocyte growth by mediating rRNA processing. Cell Death Differ. 2018;: pubmed publisher
    ..Taken together, these results elucidated the in vivo function of novel nucleolar protein DCAF13 in maintaining mammalian oogenesis. ..
  5. Zhang Y, Zhao L, Zhang J, Le R, Ji S, Chen C, et al. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO J. 2018;37: pubmed publisher
    ..Taken together, CRL4-DCAF13-mediated SUV39H1 degradation is an essential step for progressive genome reprogramming during preimplantation embryonic development. ..
  6. Sha Q, Dai X, Jiang J, Yu C, Jiang Y, Liu J, et al. CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes. Nat Commun. 2018;9:3477 pubmed publisher
    ..Dual inhibition of CFP1 removes the SETD1-CFP1 complex from chromatin and ensures appropriate chromosome configuration changes during meiosis and mitosis. ..
  7. Yu C, Xu Y, Sha Q, Fan H. CRL4DCAF1 is required in activated oocytes for follicle maintenance and ovulation. Mol Hum Reprod. 2015;21:195-205 pubmed publisher
    ..These results suggested that CRL4 in oocytes also regulated granulosa cell functions in a cell non-autonomous manner. ..
  8. Zhang Y, Liu X, Ji S, Sha Q, Zhang J, Fan H. ERK1/2 activities are dispensable for oocyte growth but are required for meiotic maturation and pronuclear formation in mouse. J Genet Genomics. 2015;42:477-85 pubmed publisher
    ..In conclusion, these results indicate that ERK1/2 activities are required for not only MII-arrest maintenance, but also efficient pronuclear formation in mouse oocytes. ..
  9. Yu C, Zhou J, Fan H. Studying the Functions of TGF-β Signaling in the Ovary. Methods Mol Biol. 2016;1344:301-11 pubmed publisher
    ..These mouse models are also described. ..

More Information


  1. Zhang Y, Yu C, Ji S, Li X, Zhang Y, Zhang D, et al. TOP2? is essential for ovarian follicles that are hypersensitive to chemotherapeutic drugs. Mol Endocrinol. 2013;27:1678-91 pubmed publisher
    ..We also newly identified TOP2? as a factor involved in regulating GC genomic integrity and follicle atresia. This study has clinical implications for ovarian functional defects both for premenopausal cancer survivors and healthy women. ..
  2. Zhang Y, Xia Y, Yu C, Richards J, Liu J, Fan H. CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation. Mol Hum Reprod. 2014;20:850-60 pubmed publisher
    ..These results support the proposition that LH induces rapid, significant gene expression in pre-ovulatory follicles by modulating histone acetylation status. ..
  3. Yu C, Fan X, Sha Q, Wang H, Li B, Dai X, et al. CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep. 2017;20:1161-1172 pubmed publisher
    ..Our study highlights the importance of H3K4me3 in continuous histone replacement for transcriptional regulation, chromatin remodeling, and normal developmental progression in a non-replicative system. ..
  4. Xu Y, Cao L, Wang M, Xu Y, Wu X, Liu J, et al. Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice. J Cell Sci. 2017;130:3297-3307 pubmed publisher
    ..Maternal DCAF2 protein is crucial for prevention of DNA re-replication in the first and unique mitotic cell cycle of the zygote.This article has an associated First Person interview with the first author of the paper. ..