Affiliation: Zhejiang University
Chen C, Chen Y, Guan M. A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene modulation. Protein Cell. 2015;6:862-70 pubmed publisher
..Here we review selected examples of modifier genes and mitochondrial retrograde signaling in mitochondrial disorders, which refine our understanding and will guide the rational design of clinical therapies. ..
Hui L, Chen Y. Tumor microenvironment: Sanctuary of the devil. Cancer Lett. 2015;368:7-13 pubmed publisher
..We believe that this rapidly moving field promises many more to come, and they will guide the rational design of combinational therapies for success in cancer eradication. ..
Hu X, Mei S, Meng W, Xue S, Jiang L, Yang Y, et al
. CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance. Cancer Lett. 2018;425:1-12 pubmed publisher
..Targeting the SDF-1Î±-CXCR4-autophagy signaling may contribute to an enhanced efficacy of active treatments. ..
Chen D, Li F, Yang Q, Tian M, Zhang Z, Zhang Q, et al
. The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish. Int J Biochem Cell Biol. 2016;77:1-9 pubmed publisher
..In addition, this zebrafish model of mitochondrial disease may provide unique opportunities for studying defective tRNA modification, mitochondrial biogenesis, and pathophysiology of mitochondrial disorders. ..
Su X, Wang W, Ruan G, Liang M, Zheng J, Chen Y, et al
. A Comprehensive Characterization of Mitochondrial Genome in Papillary Thyroid Cancer. Int J Mol Sci. 2016;17: pubmed
..This can help to clarify the molecular mechanisms underlying PTC and offer potential biomarkers or therapeutic targets for future clinical practice. ..
Li Q, Gao Z, Chen Y, Guan M. The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells. Protein Cell. 2017;8:439-445 pubmed publisher
Meng W, Xue S, Chen Y. The role of CXCL12 in tumor microenvironment. Gene. 2018;641:105-110 pubmed publisher
..Our review focuses on these roles of CXCL12 and summarizes strategies for treating cancer by disrupting this interaction with special emphasis on the CXCR4/CXCL12 axis...