Li Zheng


Country: China


  1. Jiang X, Liu J, Liu Q, Lu Z, Zheng L, Zhao J, et al. Therapy for cartilage defects: functional ectopic cartilage constructed by cartilage-simulating collagen, chondroitin sulfate and hyaluronic acid (CCH) hybrid hydrogel with allogeneic chondrocytes. Biomater Sci. 2018;6:1616-1626 pubmed publisher
    ..This study may provide a new insight for cartilage repair using ectopic cartilage reconstructed from functional materials and allogeneic cells. ..
  2. Jiang X, Huang X, Jiang T, Zheng L, Zhao J, Zhang X. The role of Sox9 in collagen hydrogel-mediated chondrogenic differentiation of adult mesenchymal stem cells (MSCs). Biomater Sci. 2018;6:1556-1568 pubmed publisher
    ..Thus, interventions targeting Sox9 may help improve articular cartilage repair. ..
  3. Jiang T, Liu J, OuYang Y, Wu H, Zheng L, Zhao J, et al. Intra-hydrogel culture prevents transformation of mesenchymal stem cells induced by monolayer expansion. Biomater Sci. 2018;6:1168-1176 pubmed publisher
    ..This study indicates that intra-hydrogel culture can mitigate the monolayer expansion induced transformation of MSCs and maintain the uniformity of the stem cells, which is a viable in vitro culture system for stem cell therapy. ..
  4. Jiang T, Zhao J, Yu S, Mao Z, Gao C, Zhu Y, et al. Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels. Biomaterials. 2019;188:130-143 pubmed publisher
    ..This study might provide new insights into rational design of scaffolds for generating in vitro tumor models to test anticancer therapeutics and for regenerating tissue to repair defects. ..
  5. Lu Z, Wei S, Wu H, Lin X, Lin C, Liu B, et al. A novel synthesized sulfonamido-based gallic acid--LDQN-C: effects on chondrocytes growth and phenotype maintenance. Bioorg Chem. 2014;57:99-107 pubmed publisher
    ..36×10(-8)M. GA at concentration of 0.125μg/mL was compared. This study might provide a basis for the development of a novel agent for the treatment of articular cartilage defect. ..
  6. Jin P, Liao L, Lin X, Guo Q, Lin C, Wu H, et al. Stimulating effect of a novel synthesized sulfonamido-based gallate ZXHA-TC on primary osteoblasts. Yonsei Med J. 2015;56:760-71 pubmed publisher
    ..25×10⁻² μg/mL showed the best performance. This study may hold promise for the development of a novel agent for the treatment of osteoporosis. ..
  7. Jiang T, Kai D, Liu S, Huang X, Heng S, Zhao J, et al. Mechanically cartilage-mimicking poly(PCL-PTHF urethane)/collagen nanofibers induce chondrogenesis by blocking NF-kappa B signaling pathway. Biomaterials. 2018;178:281-292 pubmed publisher
    ..Our work shows that the PC nanofibers can serve as building blocks of new scaffolds for cartilage regeneration and provides new insights on the effect of the mechanical properties of the nanofibers on the cartilage regeneration. ..
  8. Zhu S, Zhou B, Liu Q, Wu H, Zheng L. Effect of Longan polysaccharides on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro. Med Biol Eng Comput. 2016;54:607-17 pubmed publisher
    ..38 μg/ml. All the evidences revealed that LP may replace the growth factors to be applied in ACI therapy. This study might provide a basis for development of a novel agent in the treatment of articular cartilage defect. ..
  9. Xu F, Wu H, Zhang K, Lv P, Zheng L, Zhao J. Pro-neurogenic effect of β-asarone on RSC96 Schwann cells in vitro. In Vitro Cell Dev Biol Anim. 2016;52:278-86 pubmed publisher
    ..The results indicate that β-asarone can accelerate proliferation of RSC96 cells in vitro and meanwhile maintain the phenotype, which may provide valuable references for further exploration on peripheral nerve diseases. ..

More Information


  1. Zuo W, Xu F, Zhang K, Zheng L, Zhao J. Proliferation-enhancing effects of gastrodin on RSC96 Schwann cells by regulating ERK1/2 and PI3K signaling pathways. Biomed Pharmacother. 2016;84:747-753 pubmed publisher
    ..This study may provide reference for its application in treatment of peripheral nerve injuries. ..
  2. Xu F, Zhang K, Lv P, Lu R, Zheng L, Zhao J. NECL1 coated PLGA as favorable conduits for repair of injured peripheral nerve. Mater Sci Eng C Mater Biol Appl. 2017;70:1132-1140 pubmed publisher
    ..Therefore, the novel blend of PLGA/NECL1 conduits proved to be promising candidate for tissue engineering scaffold. ..
  3. Huang L, Zhou B, Wu H, Zheng L, Zhao J. Effect of apatite formation of biphasic calcium phosphate ceramic (BCP) on osteoblastogenesis using simulated body fluid (SBF) with or without bovine serum albumin (BSA). Mater Sci Eng C Mater Biol Appl. 2017;70:955-961 pubmed publisher
    ..Especially, BSA-SBF enhanced the cell growth significantly. This study indicated that treatment by BSA-SBF is of importance for BCP before clinical application. ..
  4. Wu Y, Zhou B, Xu F, Wang X, Liu G, Zheng L, et al. Functional quantum dot-siRNA nanoplexes to regulate chondrogenic differentiation of mesenchymal stem cells. Acta Biomater. 2016;46:165-176 pubmed publisher
    ..Moreover, QD-SMCC has an intrinsic signal for noninvasive imaging of siRNA transport. The results indicate that SOX9 is imperative for the chondrogenesis of MSCs and QD-SMCC has great potential for real-time tracking of transfection. ..
  5. Lin X, Chai L, Liu B, Chen H, Zheng L, Liu Q, et al. Synthesis, Biological Evaluation, and Docking Studies of a Novel Sulfonamido-Based Gallate as Pro-Chondrogenic Agent for the Treatment of Cartilage. Molecules. 2016;22: pubmed publisher
    ..Furthermore, a docking study showed that HAMDC fits into the core of the active site of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), which provides an explanation for its activity and selectivity. ..
  6. Li Y, Jiang T, Zheng L, Zhao J. Osteogenic differentiation of mesenchymal stem cells (MSCs) induced by three calcium phosphate ceramic (CaP) powders: A comparative study. Mater Sci Eng C Mater Biol Appl. 2017;80:296-300 pubmed publisher
    ..For the three CaPs, BCP powders showed the most prominent effect on osteoinduction. Next to BCP is TCP. Thus, this study supported that BCP may have better application prospects for repairing of bone defects in clinic. ..
  7. Yang X, Lu Z, Wu H, Li W, Zheng L, Zhao J. Collagen-alginate as bioink for three-dimensional (3D) cell printing based cartilage tissue engineering. Mater Sci Eng C Mater Biol Appl. 2018;83:195-201 pubmed publisher
    ..In summary, 3D bioprinted SA/COL with favorable mechanical strength and biological functionality is promising in cartilage tissue engineering. ..