Research Topics
Genomes and Genes | Shiwu ZhangSummaryCountry: China Publications
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Publications
[The influence of different microenvironments on melanoma invasiveness and microcirculation patterns]Shi Wu Zhang
Department of Pathology, Tianjin Medical University Cancer Hospital, Tianjin, China
Zhonghua Bing Li Xue Za Zhi 36:832-7. 2007..To investigate the influence of different microenvironments on tumor microcirculation patterns and invasive capability...
Thalidomide influences growth and vasculogenic mimicry channel formation in melanomaShiwu Zhang
Department of Pathology, Tianjin Cancer Hospital, Tianjin, Medical University, Tianjin, 300060, PR China
J Exp Clin Cancer Res 27:60. 2008..To observe the effects of thalidomide on melanoma tumor growth and blood supply patterns in C57 mice...- Vasculogenic mimicry: current status and future prospectsShiwu Zhang
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China
Cancer Lett 254:157-64. 2007.... - Clusterin expression and univariate analysis of overall survival in human breast cancerShiwu Zhang
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China
Technol Cancer Res Treat 5:573-8. 2006..The CLU expression staining coefficient of cancer tissues with lymph node metastasis was higher than those without lymph node metastasis (P=0.000). Cytoplasmic CLU expression was found to be a prognostic factor for human breast cancer... - Hypoxia influences vasculogenic mimicry channel formation and tumor invasion-related protein expression in melanomaBaocun Sun
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, PR China
Cancer Lett 249:188-97. 2007..Hypoxia can enhance tumor cell invasion and metastasis. The cause and the molecular mechanism are still not clear... - Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancerShiwu Zhang
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, PR China
J Exp Clin Cancer Res 27:62. 2008..To identify the roles of CXCL12 and CXCR4 and the associated mechanism involved in perineural invasion of prostate cancer... - Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancerBin Zhang
National Key Laboratory of Breast Cancer Prevention and Treatment, Tianjin Medical University Cancer Institute and Hospital TJMUCIH, Tianjin, PR China
BMC Cancer 8:83. 2008.... - Microcirculation patterns in different stages of melanoma growthShiwu Zhang
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, PR China
Oncol Rep 15:15-20. 2006..718, P=0.009), while the number of vasculogenic mimicry was inversely correlated (r=0.77, P=0.003). In conclusion, the number of vasculogenic mimicry decreased and the number of endothelial-dependent vessels increased during tumor growth... 
Hypoxia influences linearly patterned programmed cell necrosis and tumor blood supply patterns formation in melanomaShiwu Zhang
Department of Pathology, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin, PR China
Lab Invest 89:575-86. 2009..We speculated that under hypoxic conditions, some melanoma cells might undergo LPPCN, thus providing a spatial foundation for VM channel formation...- The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse modelBaocun Sun
Department of Pathology, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin 300060, People s Republic of China
J Cancer Res Clin Oncol 133:979-85. 2007..To investigate the influence of different microenvironments on tumor microcirculation patterns and invasiveness capability... - Prognostic implication of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in synovial sarcomaYan Sun
Department of Pathology, Cancer Institute and Hospital, Tianjin, China
Cancer Sci 100:1018-25. 2009..In addition, histological grade and tumor size were also important prognostic factors for SS... - Role and mechanism of vasculogenic mimicry in gastrointestinal stromal tumorsBaocun Sun
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, People s Republic of China
Hum Pathol 39:444-51. 2008..033, respectively). We conclude that VM in GISTs is an unfavorable prognostic sign and that patients with VM-positive tumors are prone to suffer liver metastasis. Both MMP-2 and MMP-9 play an important role in VM formation in GISTs... - The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 casesBaocun Sun
Department of Pathology, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China
Cancer Sci 99:1355-61. 2008..It is indicated that the efficiency of FISH is comparable to or even higher than that of RT-PCR for SYT-SSX detection. The detection of SYT-SSX by RT-PCR or FISH is very useful for the final diagnosis of potential synovial sarcomas... - Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinomaBaocun Sun
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, P.R. China
Oncol Rep 16:693-8. 2006..In conclusion, VM is a marker of poor clinical prognosis in HCC: Its presence may be associated with a high tumor grade, invasion and metastasis, and short survival... - Vasculogenic mimicry: a new prognostic sign of gastric adenocarcinomaMan Li
Department of Pathology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, 300060, People s Republic of China
Pathol Oncol Res 16:259-66. 2010..039 and 0.004) for GAC. In conclusion, VM exists in GAC, especially in poorly differentiated GAC. Additionally, it is an unfavorable prognostic indictor for GAC. Hypoxia may play a role in VM formation in GAC... - Doxycycline influences microcirculation patterns in B16 melanomaBaocun Sun
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, PRChina
Exp Biol Med (Maywood) 232:1300-7. 2007..01). MMP-2 and MMP-9 mRNA levels in the treatment group were also lower than those in the control group were. Doxycycline inhibits the growth of engrafted melanoma and results in reduced expression of MMP-2, MMP-9, and VM formations... - Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancerYanjun Gu
Department of Pathology, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin 300060, China
J Exp Clin Cancer Res 29:6. 2010..In this study, we investigate differential gene expression, especially the expression of decorin, EGFR and cyclin D1, during mammary gland epithelial cell carcinogenesis in TA2 mice... - Correlation between melanoma angiogenesis and the mesenchymal stem cells and endothelial progenitor cells derived from bone marrowBaocun Sun
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China
Stem Cells Dev 14:292-8. 2005..Thus, we demonstrate that both differentiated endothelial cells from tissue peripheral to that of a tumor as well as progeny of human MSC have similar capacities to participate in angiogenesis... - Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancerBaocun Sun
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin, People s Republic of China
Clin Cancer Res 14:7050-9. 2008..Currently, there are no definite biomarkers of triple-negative breast cancer. The study aims to identify the metastasis-associated proteins of triple-negative breast tumors... - Vasculogenic mimicry is associated with poor survival in patients with mesothelial sarcomas and alveolar rhabdomyosarcomasBaocun Sun
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, PR China
Int J Oncol 25:1609-14. 2004..Our findings also suggested that a subpopulation of tumor cells possess features of both endothelial cells that line the vessels and mesenchymal cells that secrete the extracellular matrix required for the vascular infrastructure... - Clusterin is associated with spontaneous breast cancer in TA2 miceBaocun Sun
Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin, PR China
FEBS Lett 581:3277-82. 2007..n-CLU may play an important role in tientsin albinao 2 spontaneous breast cancer initiation and development... - High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survivalWenfeng Cao
The Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Am J Clin Pathol 128:430-6. 2007..More important, lymph node metastasis, HER-2/neu-positive expression, and high-level SLP-2 expression were associated with significantly decreased survival... - The effect of high gravidity on the carcinogenesis of mammary gland in TA2 miceXuan Wang
Department of Pathology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, He Xi District, China
Am J Reprod Immunol 63:396-409. 2010..We hypothesized that the dysfunction of cellular immunity caused by the increase of 17beta-estradiol (E2) and progesterone (P) might be one of the reasons for carcinogenesis of mammary gland... - [Microarray study of vasculogenic mimicry in bi-directional differentiation malignant tumor]Xishan Hao
Cancer Hospital, Tianjin Medical University, Tianjin 300060, China
Zhonghua Yi Xue Za Zhi 82:1298-302. 2002..05). CONCLUSION: VM exists in bi-directional differentiation malignant tumors... - Critical role for c-FLIP(L) on Fas resistance in colon carcinoma cell line HT-29Fenglin Zang
Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, PR China
Cell Biol Int 32:329-36. 2008..In conclusion, our study indicated that c-FLIP(L) might be a suppressor of Fas-mediated apoptosis in Fas antigen expressing colon carcinoma and therefore a potential target for novel anticancer therapies... - Combined treatment with exogenous estradiol and progesterone increases the incidence of breast cancer in TA2 mice without ovariesYu Yin
Department of Pathology, Anhui Medical University, Hefei, Anhui Province, PR China
Cancer Lett 311:171-6. 2011..Various members of the Wnt gene family may play specific roles in different stages of carcinogenesis in TA2 mice...