Kejun Zhang

Summary

Country: China

Publications

  1. doi request reprint Slug regulates proliferation and invasiveness of esophageal adenocarcinoma cells in vitro and in vivo
    Kejun Zhang
    General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, 266003, People s Republic of China
    Med Oncol 28:1089-100. 2011
  2. doi request reprint Slug inhibition upregulates radiation-induced PUMA activity leading to apoptosis in cholangiocarcinomas
    Kejun Zhang
    Department of General Surgery, the Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, Shan Dong Province, People s Republic of China
    Med Oncol 28:S301-9. 2011
  3. pmc RNA Interference Targeting Slug Increases Cholangiocarcinoma Cell Sensitivity to Cisplatin via Upregulating PUMA
    Kejun Zhang
    General Surgery of the Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shan Dong Province 266003, China E Mails K Z X W B Y
    Int J Mol Sci 12:385-400. 2011
  4. pmc Clusterin confers gemcitabine resistance in pancreatic cancer
    Qingfeng Chen
    Affiliated Hospital of Medical College, Qingdao University, RP China
    World J Surg Oncol 9:59. 2011
  5. pmc The E-cadherin repressor slug and progression of human extrahepatic hilar cholangiocarcinoma
    Ke Jun Zhang
    General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qing Dao, Shandong Province, 266003, China
    J Exp Clin Cancer Res 29:88. 2010
  6. ncbi request reprint Activation of NF-B upregulates Snail and consequent repression of E-cadherin in cholangiocarcinoma cell invasion
    Kejun Zhang
    General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Shan Dong Province, PR China
    Hepatogastroenterology 58:1-7. 2011
  7. pmc Slug down-regulation by RNA interference inhibits invasion growth in human esophageal squamous cell carcinoma
    Peng Tang
    Department of Surgery, Qingdao University, Qingdao, Shan Dong Province, People s Republic of China
    BMC Gastroenterol 11:60. 2011
  8. doi request reprint Transcriptional repressor snail and metastasis in hepatocellular carcinoma
    Dong Chen
    Department of General Surgery, Qingdao University, Qingdao, China
    Hepatogastroenterology 59:1359-65. 2012
  9. pmc Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling
    Kejun Zhang
    Department of General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, PR China
    Lab Invest 91:426-38. 2011
  10. doi request reprint Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma
    Dong Chen
    Department of General Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong Province, People s Republic of China
    Med Princ Pract 21:68-73. 2012

Collaborators

Detail Information

Publications17

  1. doi request reprint Slug regulates proliferation and invasiveness of esophageal adenocarcinoma cells in vitro and in vivo
    Kejun Zhang
    General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, 266003, People s Republic of China
    Med Oncol 28:1089-100. 2011
    ..Slug is an important modulator of apoptosis, growth and invasion in EA in vitro and in vivo. Slug inhibition may represent a novel strategy for treatment of EA...
  2. doi request reprint Slug inhibition upregulates radiation-induced PUMA activity leading to apoptosis in cholangiocarcinomas
    Kejun Zhang
    Department of General Surgery, the Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, Shan Dong Province, People s Republic of China
    Med Oncol 28:S301-9. 2011
    ..In summary, integrating gene therapy with radiotherapy could have a synergistic effect, thereby improving the survival of patients with cholangiocarcinomas...
  3. pmc RNA Interference Targeting Slug Increases Cholangiocarcinoma Cell Sensitivity to Cisplatin via Upregulating PUMA
    Kejun Zhang
    General Surgery of the Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shan Dong Province 266003, China E Mails K Z X W B Y
    Int J Mol Sci 12:385-400. 2011
    ..One of the mechanisms is the regulation of PUMA by Slug...
  4. pmc Clusterin confers gemcitabine resistance in pancreatic cancer
    Qingfeng Chen
    Affiliated Hospital of Medical College, Qingdao University, RP China
    World J Surg Oncol 9:59. 2011
    ..To measure clusterin expression in pancreatic cancer tissues and cell lines and to evaluate whether clusterin confers resistance to gmcitabine in pancreatic cancer cells...
  5. pmc The E-cadherin repressor slug and progression of human extrahepatic hilar cholangiocarcinoma
    Ke Jun Zhang
    General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qing Dao, Shandong Province, 266003, China
    J Exp Clin Cancer Res 29:88. 2010
    ..This study explored the expression and function of Slug in human extrahepatic hilar cholangiocarcinoma (EHC) to identify its role in tumor progression...
  6. ncbi request reprint Activation of NF-B upregulates Snail and consequent repression of E-cadherin in cholangiocarcinoma cell invasion
    Kejun Zhang
    General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Shan Dong Province, PR China
    Hepatogastroenterology 58:1-7. 2011
    ..In the present study, we reported that activation of NF-kappaB promotes migration and invasion in cholangiocarcinoma cell through upregulating Snail and consequent repression of E-cadherin...
  7. pmc Slug down-regulation by RNA interference inhibits invasion growth in human esophageal squamous cell carcinoma
    Peng Tang
    Department of Surgery, Qingdao University, Qingdao, Shan Dong Province, People s Republic of China
    BMC Gastroenterol 11:60. 2011
    ..We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice...
  8. doi request reprint Transcriptional repressor snail and metastasis in hepatocellular carcinoma
    Dong Chen
    Department of General Surgery, Qingdao University, Qingdao, China
    Hepatogastroenterology 59:1359-65. 2012
    ..We aimed to elucidate the effect of Snail transcriptional factor on invasion and metastasis and related molecular mechanisms in HCC...
  9. pmc Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling
    Kejun Zhang
    Department of General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, PR China
    Lab Invest 91:426-38. 2011
    ..These results suggest that Slug promotes migration and invasion of PANC-1 cells, which may correlate with the reorganization of MMP-9 and remodeling of the F-actin cytoskeleton, but not with E-cadherin expression...
  10. doi request reprint Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma
    Dong Chen
    Department of General Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong Province, People s Republic of China
    Med Princ Pract 21:68-73. 2012
    ..The purpose of this study was to clarify the association between P53 and the Bcl-2 family (Bcl-2, Bax, Bcl-xL, Bcl-xS) expression and apoptosis in pancreatic ductal adenocarcinoma (PDAC)...
  11. pmc Correction: liang, j., et Al. Antisense oligonucleotide against clusterin regulates human hepatocellular carcinoma invasion through transcriptional regulation of matrix metalloproteinase-2 and e-cadherin. Int. J. Mol. Sci. 2012, 13, 10594-10607
    Dong Chen
    Department of General Surgery, The Affiliated Hospital of Qingdao Medical College, Qingdao University, Qingdao 266003, China
    Int J Mol Sci 14:6516-7. 2013
    ..The authors would like to apologize for any inconvenience this may have caused to the readers of this journal...
  12. pmc Knockdown of snail sensitizes pancreatic cancer cells to chemotherapeutic agents and irradiation
    Kejun Zhang
    Department of General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qing Dao, Shan Dong Province 266003, China E Mails X J X L Q W D Z
    Int J Mol Sci 11:4891-2. 2010
    ..In conclusion, our findings indicate that Snail is an important modulator of therapeutic responses of pancreatic cancer cells and is potentially useful as a sensitizer in pancreatic cancer therapy...
  13. doi request reprint Short interfering RNA directed against Slug blocks tumor growth, metastasis formation, and vascular leakage in bladder cancer
    Xinsheng Wang
    Department of Urology Surgery, the Affiliated Hospital of Medical College, Qingdao University, No 16 Jiangsu Road, Qingdao, Shan Dong Province 266003, People s Republic of China
    Med Oncol 28:S413-22. 2011
    ..Blocking Slug signaling in bladder cancer may represent a novel strategy in the future to reduce metastatic disease burden in bladder cancer patients...
  14. pmc Antisense oligonucleotide against clusterin regulates human hepatocellular carcinoma invasion through transcriptional regulation of matrix metalloproteinase-2 and e-cadherin
    Dong Chen
    Department of General Surgery, The Affiliated Hospital of Qingdao Medical College, Qingdao University, Qingdao 266003, China E Mails D C K Z X J
    Int J Mol Sci 13:10594-607. 2012
    ..Thus, OGX-011 could be an effective therapeutic agent for HCC...
  15. pmc Expression of transcription factors snail, slug, and twist in human bladder carcinoma
    Qinchao Yu
    Department of Urology Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shan Dong Province, 266403, China
    J Exp Clin Cancer Res 29:119. 2010
    ..Slug, snail, and twist are transcription factors that regulate the expression of tumor suppressors such as E-cadherin. In this study, we aimed to examine the expression of these transcription factors in human bladder carcinoma...
  16. pmc S100A7 enhances invasion of human breast cancer MDA-MB-468 cells through activation of nuclear factor-κB signaling
    Huamin Liu
    Department of Oncology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong 266003, R P China
    World J Surg Oncol 11:93. 2013
    ....
  17. pmc Inhibition of AKT2 Enhances Sensitivity to Gemcitabine via Regulating PUMA and NF-κB Signaling Pathway in Human Pancreatic Ductal Adenocarcinoma
    Dong Chen
    Department of General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China
    Int J Mol Sci 13:1186-208. 2012
    ....