Zaijun Zhang


Country: China


  1. Fang F, Zhao J, Ding L, Huang C, Naman C, He S, et al. 5-Hydroxycyclopenicillone, a New ?-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. Mar Drugs. 2017;15: pubmed publisher
    ..These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-A? fibrillization properties and neuroprotective effects, and might be a good free radical scavenger. ..
  2. Huang C, Zhang Z, Cui W. Marine-Derived Natural Compounds for the Treatment of Parkinson's Disease. Mar Drugs. 2019;17: pubmed publisher
    ..Moreover, marine-derived natural compounds currently evaluated in the clinical trials for the treatment of PD are also discussed. ..
  3. Li N, Song X, Wu L, Zhang T, Zhao C, Yang X, et al. Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats. Neurosci Lett. 2018;687:94-98 pubmed publisher
    ..Taken together, miconazole promoted functional recovery on ischemic stroke model via stimulating post-ischemic neurogenesis. ..
  4. Sa F, Zhang L, Chong C, Guo B, Li S, Zhang Z, et al. Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo. Neurosci Lett. 2015;593:7-12 pubmed publisher
  5. Zhao Y, Law H, Zhang Z, Lam H, Quan Q, Li G, et al. Online coupling of hydrophilic interaction/strong cation exchange/reversed-phase liquid chromatography with porous graphitic carbon liquid chromatography for simultaneous proteomics and N-glycomics analysis. J Chromatogr A. 2015;1415:57-66 pubmed publisher
  6. Zhang Z, Jiang J, Yu P, Zeng X, Larrick J, Wang Y. Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. J Transl Med. 2009;7:62 pubmed publisher
    ..We have demonstrated that AL-1 had both hypoglycemic and beta cell protective effects which translated into antioxidant and NF-kappaB inhibitory activity. AL-1 is a potential new anti-diabetic agent. ..
  7. Chen H, Xu D, Tan G, Cai W, Zhang G, Cui W, et al. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. J Mol Neurosci. 2015;56:977-987 pubmed publisher
    ..These multiple functions of a single molecule suggest that T-006 is a promising novel neuroprotective agent for treating various neurodegenerative disorders, including and in particular Alzheimer's disease. ..
  8. request reprint
    Zhang G, Zhang F, Zhang T, Gu J, Li C, Sun Y, et al. Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury. Neurochem Res. 2016;41:2948-2957 pubmed
    ..In conclusion, TBN improves neurobehavioral functions and protects neurons against TBI. This protective effect may be achieved by anti-neuronal apoptosis, alleviating oxidative stress damage and up-regulating Nrf-2 and HO-1 expression. ..
  9. Zhang G, Zhang T, Wu L, Zhou X, Gu J, Li C, et al. Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy. Neuromolecular Med. 2018;20:97-111 pubmed publisher

More Information


  1. Xu D, Zhang K, Zhang Z, Sun Y, Guo B, Wang Y, et al. A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways. Neurochem Int. 2014;78:76-85 pubmed publisher
    ..These results suggest that TN-2 protected against 6-OHDA-induced neurotoxicity via modulating the NF-κB-medicated neuroinflammation and PKCα/PI3-K/Akt pathways. ..
  2. Liu Z, Cai W, Lang M, Yan R, Li Z, Zhang G, et al. Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson's Disease Model. J Mol Neurosci. 2017;61:498-510 pubmed publisher
    ..These findings suggest that MT-20R may be a novel therapeutic candidate for treatment of PD. ..
  3. Guo B, Hu S, Zheng C, Wang H, Luo F, Li H, et al. Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. Neuropharmacology. 2017;126:12-24 pubmed publisher
    ..SU4312 thus may be an effective drug candidate for the prevention or even modification of the pathological processes of PD. ..
  4. Zhang T, Gu J, Wu L, Li N, Sun Y, Yu P, et al. Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology. 2017;118:137-147 pubmed publisher
  5. Xu B, Deng H, Zhang X, Luo J, Zhang G, Zhang Z, et al. A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. Eur J Pharmacol. 2018;818:158-166 pubmed publisher
    ..Taken together, the vasorelaxation of ADTM may be possibly involved in its cardioprotection. ADTM may serve as a promising candidate for the treatment of ischemic heart diseases. ..