Research Topics

Genomes and Genes


Jinming Yu


Country: China


  1. Zhu W, Zhang Y, Kong L, Huang Y, Zheng J, Wang R, et al. 18F-fluorodeoxyglucose positron emission tomography predicts lymph node responses to definitive chemoradiotherapy in esophageal squamous cell carcinoma patients. Onco Targets Ther. 2018;11:4345-4353 pubmed publisher
    ..7 Gy) improved the CR rate of lymph node in MTV-Groups 3 and 4. Pretreatment metabolic parameters can predict the response of mLNs to dCRT for patients with ESCC. The parameters could also be used to guide personalized dose to mLNs. ..
  2. Wang Z, Li M, Teng F, Kong L, Yu J. Primary tumor location is an important predictor of survival in pulmonary adenocarcinoma. Cancer Manag Res. 2019;11:2269-2280 pubmed publisher
    ..Tumor location of pulmonary ADC plays a critical role in predicting prognosis and choosing therapeutic strategies. ..
  3. Zhang D, Dong Y, Sun X, Yuan S, Yu J. Surgery of primary tumor improves the survival of newly diagnosed metastatic melanoma: a population-based, propensity-matched study. Cancer Manag Res. 2019;11:339-346 pubmed publisher
    ..IRB approval is not required because the SEER data are freely accessible. ..
  4. Li B, Li C, Guo M, Shang S, Li X, Xie P, et al. Predictive value of LDH kinetics in bevacizumab treatment and survival of patients with advanced NSCLC. Onco Targets Ther. 2018;11:6287-6294 pubmed publisher
    ..Serum level of LDH reducing over time was a potential biomarker for patients to achieve good clinical response (CR/PR) to bevacizumab. ..
  5. Lu H, Wu Y, Liu X, Jiang H, Pang Q, Peng L, et al. A prospective study on neoadjuvant chemoradiotherapy plus anti-EGFR monoclonal antibody followed by surgery for locally advanced cervical cancer. Onco Targets Ther. 2018;11:3785-3792 pubmed publisher
    ..No severe late toxicities were observed. Concurrent chemoradiotherapy plus nimotuzumab followed by surgery is highly effective and safe in LACC. Further studies are warranted to confirm the findings. ..
  6. Guo M, Li W, Li B, Zou B, Wang S, Meng X, et al. Prognostic value of delta inflammatory biomarker-based nomograms in patients with inoperable locally advanced NSCLC. Int Immunopharmacol. 2019;72:395-401 pubmed publisher
    ..The proposed nomograms based on the dynamic inflammatory biomarkers and clinicopathological factors may be practical and widely available for evaluating the prognosis of patients with inoperable LA-NSCLC. ..
  7. Liu C, Hu Q, Hu K, Su H, Shi F, Kong L, et al. Increased CD8+CD28+ T cells independently predict better early response to stereotactic ablative radiotherapy in patients with lung metastases from non-small cell lung cancer. J Transl Med. 2019;17:120 pubmed publisher
    ..01-0.85; P = 0.039). A pre-SABR CD8+CD28+ T-cell count could predict early tumor response to SABR in patients with lung metastases from NSCLC. Larger, independently prospective analyses are warranted to verify our findings. ..
  8. Cong B, Yu J, Wang Y. Axillary management still needed for patients with sentinel node micrometastases. Cancer Manag Res. 2019;11:2097-2100 pubmed publisher
    ..At present, axillary management should still be required for patients with SLN micrometastases. ..
  9. Min Q, Molina L, Li J, Adebayo Michael A, Russell J, Preziosi M, et al. β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis. Am J Pathol. 2019;189:1091-1104 pubmed publisher
    ..Thus, we demonstrate that β-catenin point mutants can also collaborate with YAP1 in HB development, albeit with a distinct molecular profile from the deletion mutant, which may have implications in both biology and therapy. ..

More Information


  1. Wang X, Guo G, Guan H, Yu Y, Lu J, Yu J. Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma. J Exp Clin Cancer Res. 2019;38:87 pubmed publisher
  2. Wang L, Dong T, Xin B, Xu C, Guo M, Zhang H, et al. Integrative nomogram of CT imaging, clinical, and hematological features for survival prediction of patients with locally advanced non-small cell lung cancer. Eur Radiol. 2019;: pubmed publisher
    ..This nomogram has value to permit non-invasive, comprehensive, and dynamical evaluation of the phenotypes of LA-NSCLC and can provide a feasible and practical reference for individualized management of LA-NSCLC patients. ..
  3. Hu M, Jiang L, Cui X, Zhang J, Yu J. Proton beam therapy for cancer in the era of precision medicine. J Hematol Oncol. 2018;11:136 pubmed publisher
    ..We systematically review the latest advances of PBT and the challenges for patient treatment in the era of precision medicine. ..
  4. Xu Y, Liu Z, Pan C, Yang X, Ning S, Liu H, et al. HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium. Oncogene. 2019;38:868-880 pubmed publisher
    ..High expression of HMGB1 was associated with MVD and poor prognosis in clinical analyzation. Postoperative serum HMGB1 and cholangitis could predict high recurrence and unfavorable prognosis. ..
  5. Liu Y, Dong Y, Kong L, Shi F, Zhu H, Yu J. Abscopal effect of radiotherapy combined with immune checkpoint inhibitors. J Hematol Oncol. 2018;11:104 pubmed publisher
    ..Finally, the most significant purpose of this review is to identify the potential predictors of the abscopal effect to help identify the most appropriate patients who would most likely benefit from the combination treatment modality. ..
  6. Zhu H, Guo H, Shi F, Zhu K, Luo J, Liu X, et al. Prophylactic cranial irradiation improved the overall survival of patients with surgically resected small cell lung cancer, but not for stage I disease. Lung Cancer. 2014;86:334-8 pubmed publisher
    ..Multivariate analysis revealed that PCI (HR = 2.339; p = 0.001) was an independent prognostic factor of the overall survival. PCI could improve the OS of patients with surgically resected SCLC, but not for p-stage I patients. ..
  7. Li X, Lian Z, Wang S, Xing L, Yu J. Interactions between EGFR and PD-1/PD-L1 pathway: Implications for treatment of NSCLC. Cancer Lett. 2018;418:1-9 pubmed publisher
  8. Guo H, Liu S, Guo J, Li B, Li W, Lu Z, et al. Rapid on-site evaluation during endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of hilar and mediastinal lymphadenopathy in patients with lung cancer. Cancer Lett. 2016;371:182-6 pubmed publisher
  9. Xue S, Song G, Yu J. The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis. Sci Rep. 2017;7:4231 pubmed publisher
    ..However, because of our limited sample size, further prospective or retrospective multi-centre, well-designed studies should be performed to verify this result. ..
  10. Zhang J, Kong L, Jiao Q, Li M, Yu J. Stereotactic ablative radiotherapy in treatment of early-stage non-small cell lung cancer: Unsolved questions and frontiers ahead. Cancer Lett. 2017;401:46-52 pubmed publisher
    ..Finally, witnessing the emergence of proton therapy and immunotherapy, we believe that the future of SABR lay behind these novel forms of treatment. ..
  11. Teng F, Meng X, Kong L, Yu J. Progress and challenges of predictive biomarkers of anti PD-1/PD-L1 immunotherapy: A systematic review. Cancer Lett. 2018;414:166-173 pubmed publisher
    ..As current evidence of those potential predictors, a consensus and standardization is needed to establish to widely applied in future studies. Multiplex detecting methods and combined biomarkers may provide new strategies. ..
  12. Wen Q, Zhu J, Meng X, Ma C, Bai T, Sun X, et al. The Value of CBCT-based Tumor Density and Volume Variations in Prediction of Early Response to Chemoradiation Therapy in Advanced NSCLC. Sci Rep. 2017;7:14650 pubmed publisher
    ..The changes in CTN and TV obtained from CBCT images have the potential capability to predict an early response of NSCLC. ..
  13. Puliga E, Min Q, Tao J, Zhang R, Pradhan Sundd T, Poddar M, et al. Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin-Driven Hepatocellular Cancer. Am J Pathol. 2017;187:2473-2485 pubmed publisher
    ..GC-1 does not promote β-catenin activation in HCC. Thus, GC-1 may be safe for use in inducing regeneration during chronic hepatic insufficiency. ..
  14. Shi M, Ma F, Liu J, Xing H, Zhu H, Yu J, et al. A functional BRCA1 coding sequence genetic variant contributes to prognosis of triple-negative breast cancer, especially after radiotherapy. Breast Cancer Res Treat. 2017;166:109-116 pubmed publisher
    ..Our study also highlights the clinical potential of this polymorphism in the screening of high-risk TNBC patients for recurrence and the possibility of patient-tailored decisions especially during radiotherapy. ..
  15. Xue S, Hu M, Iyer V, Yu J. Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy. J Hematol Oncol. 2017;10:81 pubmed publisher
    ..Potential treatment strategies and the challenges that may occur during the clinical development of these agents for gliomas are also reviewed. ..