Research Topics
| Xinbing YuSummaryCountry: China Publications
| Collaborators
|
Detail Information
Publications
The draft genome of the carcinogenic human liver fluke Clonorchis sinensisXiaoyun Wang
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan 2nd Road, Guangzhou, 510080, PR China
Genome Biol 12:R107. 2011..Experimental and epidemiological studies have shown a strong association between the incidence of cholangiocarcinoma and the infection rate of C. sinensis. To aid research into this organism, we have sequenced its genome...- Molecular identification of Clonorchis sinensis and discrimination with other opisthorchid liver fluke species using multiple Ligation-depended Probe Amplification (MLPA)Jiufeng Sun
Department of Parasitology, Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control, Ministry of Education, Sun Yat Sen University, Guangzhou, Guangdong, China
Parasit Vectors 4:98. 2011..felineus cause severe health problems globally, particularly in Southeast Asia. Early identification of the infection is essential to provide timely and appropriate chemotherapy to patients... 
Clonorchis sinensis: expression, characterization, immunolocalization and serological reactivity of one excretory/secretory antigen-LPAP homologueFengyu Hu
Department of Parasitology, Preclinical School of Sun Yat sen University, Guangzhou 510089, PR China
Exp Parasitol 117:157-64. 2007..14%) and specificity (85.86%) than the crude worm antigen by enzyme-linked immunosorbent assay (ELISA), a result which suggested that the recombinant antigen might be valuable in the serodiagnosis of human clonorchiasis...
Identification and molecular characterization of a novel signaling molecule 14-3-3 epsilon in Clonorchis sinensis excretory/secretory productsXiaoyun Wang
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
Parasitol Res 110:1411-20. 2012..Recombinant Cs14-3-3 conferred effective protection both in worm reduction rate and egg reduction rate, suggesting that the signaling molecule Cs14-3-3 was a promising vaccine candidate against C. sinensis infection...- Expression and immune response analysis of Schistosoma japonicum VAL-1, a homologue of vespid venom allergensJingfang Chen
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, 74 2nd Zhongshan Road, Guangzhou, 510089, China
Parasitol Res 106:1413-8. 2010..Its role as a potential modulator of immune function or as a pathogenic factor of granuloma formation in schistosomiasis needs further study... - Molecular cloning and identification of a novel Clonorchis sinensis gene encoding a tegumental proteinZhenwen Zhou
Department of Parasitology, Medicine School of Sun Yat Sen University, 74 Zhongshan 2nd Road, Guangzhou 510089, People s Republic of China
Parasitol Res 101:737-42. 2007..The sensitivity was 68%, and the specificity was 84%. The antigen was less useful for the serodiagnosis of clonorchiasis with IgG... - Molecular characterization of cathepsin B from Clonorchis sinensis excretory/secretory products and assessment of its potential for serodiagnosis of clonorchiasisWenjun Chen
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
Parasit Vectors 4:149. 2011..The purpose of this study was to identify a cathepsin B of Clonorchis sinensis (CsCB) and to investigate its diagnostic value for human helminthiases... - Stage and tissue specific differences in SjBMI1, a Polycomb protein in Schistosoma japonicumDong Hu
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
Parasitol Res 106:677-82. 2010..The study reveals the SjBMI1 expression profile in developmental stages and localization characteristic and provides a clue that it may be associated with reproductive development of S. japonicum... - Molecular characterization and serodiagnosis analysis of a novel lysophospholipase from Clonorchis sinensisChangling Ma
Department of Parasitology, Zhongshan School of Medicine, SunYat sen University, Guangzhou, 510080, People s Republic of China
Parasitol Res 101:419-25. 2007..The results suggested that the recombinant lysophospholipase protein was not a satisfactory candidate for diagnosis of clonorchiasis, although it might be an excretory/secretory protein... - Molecular expression and characterization of a novel protein phosphatase 2A gene from Clonorchis sinensisChuanhuan Deng
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong, 510080, China
Parasitol Res 110:1951-7. 2012..Collectively, the results of this study suggested that CsPP2A may be involved in the development of adult and metacercaria of C. sinensis... - Molecular cloning and characterization of a novel ras-related protein (rap2) from Clonorchis sinensisWenjun Chen
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan 2nd Road, Guangzhou, 510080, People s Republic of China
Parasitol Res 108:1021-6. 2011..sinensis. This fundamental study might contribute to further researches in signaling systems that are related to growth control and development of C. sinensis and other parasites... - Clonorchis sinensis enolase: identification and biochemical characterization of a glycolytic enzyme from excretory/secretory productsXiaoyun Wang
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, PR China
Mol Biochem Parasitol 177:135-42. 2011..In conclusion, Csenolase is an important glycolytic enzyme required for the development of C. sinensis, and may be a potential vaccine candidate and drug target against C. sinensis infection... - Molecular characterization and expression of the MYND-ZF gene from Clonorchis sinensisLexun Wang
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, 74 2nd Zhongshan Road, Guangzhou 510089, China
Parasitol Res 107:1249-55. 2010..sinensis using anti-recombinant CsMYND-ZF serum. These findings may contribute to the development of a reliable diagnostic method... - Gene/protein expression level, immunolocalization and binding characteristics of fatty acid binding protein from Clonorchis sinensis (CsFABP)Lisi Huang
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
Mol Cell Biochem 363:367-76. 2012..sinensis resided in the infected Sprague-Dawley rat was also strongly labeled, implying that CsFABP may possibly mediate direct interactions with host cells as a component of excretory/secretory products... - Molecular cloning, expression, and immunolocalization of the NAD(+)-dependent glycerol 3-phosphate dehydrogenase (GPD) from Clonorchis sinensisYongxiu Fan
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
Parasitol Res 109:621-6. 2011..Our current study has paved the way for the further researches about the biological functions involved in the growth of C. sinensis... - Clonorchis sinensis: molecular cloning and functional expression of novel cytosolic malate dehydrogenaseNancai Zheng
Department of Parasitology, Preclinical School of Sun Yat-sen University, Guangzhou 510089, PR China
Exp Parasitol 109:220-7. 2005..The recombinant cMDH showed high MDH activity of 241 U mg(-1), without lactate dehydrogenase and NADP(H) selectivity. It provides a model for the structure, function analysis, and drug screening on cMDH... - Molecular cloning and analysis of stage and tissue-specific expression of Cathepsin L-like protease from Clonorchis sinensisYanwen Li
Department of Parasitology, Zhongshan School of Medicine, SunYat sen University, Guangzhou, 510080, People s Republic of China
Parasitol Res 105:447-52. 2009.... - Immunogenicity of self-adjuvanticity oral vaccine candidate based on use of Bacillus subtilis spore displaying Schistosoma japonicum 26 KDa GST proteinLi Li
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, 510080, China
Parasitol Res 105:1643-51. 2009..subtilis WB600 spores showed good immunogenicity, and B. subtilis spores could be used as potential mucosal delivery vehicles to provide more effective vaccination strategies for parasite prevention and control in the future... - Clonorchis sinensis: molecular cloning and functional expression of a novel cytosolic glutathione transferaseZhongluan Wu
Department of Parasitology, School of Pre clinical Medicine, Sun Yat Sen University, Guangzhou, China
Parasitol Res 100:227-32. 2007..1 and 265.4 muM, respectively. The nucleotide sequence reported in this paper was submitted to the GenBank Database with accession number DQ342327... - Molecular cloning and characterization of cDNA encoding a novel cytosolic glutathione transferase from Clonorchis sinensisZhongluan Wu
Department of Parasitology, School of Pre-clinical Medicine, Sun Yat-sen University, Guangzhou, 510089, China
Parasitol Res 98:534-8. 2006..1 and 247.1 microM. It provides a model for the structure and physiological function analysis on CsGST. The nucleotide sequence reported in this paper has been submitted to the GenBank Database with accession number DQ179264... - Reverse vaccinology approach identify an Echinococcus granulosus tegumental membrane protein enolase as vaccine candidateWenjia Gan
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University Guangzhou, Guangzhou, Guangdong, China
Parasitol Res 106:873-82. 2010..granulosus. Reverse vaccinology process identified E. granulosus tegumental membrane protein enolase as vaccine candidate... - Molecular characterization of a novel Clonorchis sinensis secretory phospholipase A(2) and investigation of its potential contribution to hepatic fibrosisFengyu Hu
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, PR China
Mol Biochem Parasitol 167:127-34. 2009..Our results suggest that CsGIIIsPLA(2) might play an important role in the initiation and development of hepatic fibrosis caused by C. sinensis... - Molecular cloning, expression, and characterization of cyclophilin A from Clonorchis sinensisWeihua Wu
Zhongshan School of Medicine, Department of Parasitology, Sun Yat Sen University, Guangzhou, People s Republic of China
Parasitol Res 109:345-51. 2011..sinensis adult in biliary ducts could release CsCyPA without signal peptide through nonclassical secretory pathway into the liver and might play a role in inflammation and biliary epithelium proliferation and adenomatoid hyperplasia... - Molecular cloning, characterization, and immunolocalization of two lactate dehydrogenase homologous genes from Taenia soliumWuying Du
Department of Parasitology, Guiyang Medical College, Guiyang, China
Parasitol Res 109:567-74. 2011..The results suggested that the two LDH homologues are similar in the characteristics of LDH family, and they are not specific antigens for immunodiagnosis... - Molecular cloning and characterization of a novel serpin gene of Clonorchis sinensis, highly expressed in the stage of metacercariaYabo Yang
Department of Parasitology, Key Laboratory for Tropical Diseases Control, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
Parasitol Res 106:221-5. 2009..sinensis metacercaria. Although we are not much clear about the detailed function of this serpin protein, the study that proteinase initiates metacercaria excystment gives a clue that it may participate in the encystment of cercaria... - Cloning and expression of 21.1-kDa tegumental protein of Clonorchis sinensis and human antibody response to it as a trematode-nematode pan-specific serodiagnosis antigenJiajia Chen
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
Parasitol Res 108:161-8. 2011..This study demonstrated that CsTP21.1 is a trematode-nematode pan-specific antigen that is valuable in the development of a universal immunodiagnostic kit for human trematode and nematode infections... - Identification, expression, characterization, and immunolocalization of lactate dehydrogenase from Taenia asiaticaJiang Huang
Department of Parasitology, Guiyang Medical College, Guiyang, China
Parasitol Res 104:287-93. 2009..asiatica adult and embryonic membrane of oncosphere. Our study suggested that TaLDH is a potential drug target and candidate antigen for immunodiagnosis and vaccine for taeniasis and viscero-cysticercosis caused by T. asiatica... - Molecular characterization and expression of a cysteine protease from Clonorchis sinensis and its application for serodiagnosis of clonorchiasisXiaoli Lv
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, 510080, China
Parasitol Res 110:2211-9. 2012..96%) and specificity (70.42%). These results revealed that CsCP may play an important role in the biology of C. sinensis and could be a diagnostic candidate for clonorchiasis... - Recognition and characterization of TGF-beta receptor interacting protein 1 (TRIP-1) containing WD40 repeats from Clonorchis sinensis by bioinformatics, cloning, and expression in Escherichia coliXuchu Hu
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, China
Parasitol Res 103:1151-8. 2008..CsTRIP-1 will aid to explore interaction between host and the parasite as well as the mechanism by which TGF-beta controls the development of C. sinensis and participates in the pathogenesis... - Experimental model in rats for study on transmission dynamics and evaluation of Clonorchis sinensis infection immunologically, morphologically, and pathologicallyXiaoyun Wang
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, People s Republic of China
Parasitol Res 106:15-21. 2009..sinensis was frequency-dependent and dose-related. Humoral immunity played a prevalent role in resisting to C . sinensis based on the rat models. C . sinensis infection played an undoubted role in biliary and hepatic diseases... - 41.5-kDa Cathepsin L protease from Clonorchis sinensis: expression, characterization, and serological reactivity of one excretory-secretory antigenYanwen Li
Department of Parasitology, Guangxi Medical University, Nanning 530021, China
Parasitol Res 111:673-80. 2012..It was concluded that there were differences in biological function, efficiency of serodiagnosis, and characterization of immune reactivity between CsCL41.5 and other CPs of C. sinensis, combining with previous studies... - Molecular cloning and characterization of a novel adenylate kinase 3 gene from Clonorchis sinensisGuang Yang
Department of Parasitology, Medical School, Sun Yat Sen University, 74 Zhongshan 2 Road, 510089, Guangzhou, P R China
Parasitol Res 95:406-12. 2005..The Km of the CsAK3 for AMP and GTP are 118 microM and 359 microM, respectively. CsAK3 is inhibited by Ap5A (>70% inhibition by 2.0 mM AP5A). Ap5A may be a potential lead compound acting on C. sinensis in which AK3 as a drug target... - Proteomic analysis of excretory secretory products from Clonorchis sinensis adult worms: molecular characterization and serological reactivity of a excretory-secretory antigen-fructose-1,6-bisphosphataseMinghui Zheng
Department of Parasitology, Key Laboratory for Tropical Diseases Control, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
Parasitol Res 109:737-44. 2011..sinensis adult worms and suggest that FBPase may be an important antigen present in the ESP of C. sinensis and may lay the foundation for additional studies on the development of clonorchiasis-associated hepatic fibrosis... - Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectorsWeiqiang Li
Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou, Guangdong, PR China
Cell Transplant 19:1181-93. 2010..This approach will provide a useful tool for both gene function studies and in vivo cell tracking of stem cells... - Characterization of a profilin-like protein from Schistosoma japonicum, a potential new vaccine candidateShuang min Zhang
Key Laboratory for Tropical Diseases Control, Sun Yat Sen University, Ministry of Education, Guangzhou, China
Parasitol Res 102:1367-74. 2008..Immunohistochemical analysis localized the protein to the tegument and underlying tissue of the S. japonicum adult worm. The rSj15 could induce the expressions of IL-12 in the cultured mouse dendritic cell... - A novel tegumental protein 31.8 kDa of Clonorchis sinensis: sequence analysis, expression, and immunolocalizationYan Huang
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, 74th, Zhongshan Road 2, Guangzhou, 510089, People s Republic of China
Parasitol Res 102:77-81. 2007..Recombinant CsTP31.8 was expressed and purified from Escherichia coli BL21 (DE3). CsTP31.8 was immunolocalized at the tegument of adult C. sinensis by using antirecombinant CsTP31.8 sera... - Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigenYanwen Li
Department of Parasitology, Guangxi Medical University, Nanning, 530021, China
Parasitol Res 110:2197-203. 2012..In addition, specific IgG4 detection can be used to valuate infected degree and therapeutic effect of clonorchiasis patients... - Identification and characterization of paramyosin from cyst wall of metacercariae implicated protective efficacy against Clonorchis sinensis infectionXiaoyun Wang
Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
PLoS ONE 7:e33703. 2012..Taken together, CsPmy could be a promising vaccine candidate in the prevention of C. sinensis regarding its high immunogenicity and surface localization... - Immunological cross-reactivity analysis on recombinant histamine-releasing factors from Schistosoma japonicum, Clonorchis sinensis, and Wistar ratXiaoxiang Chen
Department of Parasitology, Medical College, Sun Yat Sen University, 74 Zhongshan 2nd Road, 510080, Guangzhou, China
Parasitol Res 100:749-54. 2007..Based on their detected cross-reactivities, a hypothesis was put forward that the anti-parasitic HRFs antibodies could inhibit the effects of host HRF and those of parasitic HRFs and thus decreased the host sensitivities to allergens... - Expression and characterization of lactate dehydrogenase from Schistosoma japonicumGang Lu
Department of Parasitology, Medical College, Sun Yat-sen University, Guangzhou, 74 Zhongshan 2nd Road, 510089 Guangdong, China
Parasitol Res 99:593-6. 2006..Characterization such as Michaelis constant (K (m)) and maximum velocity (V (max)), optimum pH, and temperature of the protein were assayed. It provides a model for drug screening on SjLDH... - The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in miceLinlin Du
Department of General Internal Medicine, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
Dig Dis Sci 56:2810-7. 2011..Helminth infection has been proven to reduce the severity of experimental inflammatory bowel disease (IBD). The excretory-secretory proteins of helminths play an important role in the process of immunomodulation... - A novel biomimetic composite scaffold hybridized with mesenchymal stem cells in repair of rat bone defects modelsCaixia Xu
Center for Stem Cell Biology and Tissue Engineering, SunYat sen University, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Guangzhou, Guangdong 510080, People s Republic of China
J Biomed Mater Res A 95:495-503. 2010..The results demonstrated that the BG-COL-HYA-PS scaffold was biocompatible and osteoconductive and the transplanted MSCs with the scaffold enhanced the healing of the bone defect... - Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell testRui Chen
Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong PR China 510080
Toxicol Mech Methods 20:112-8. 2010..These results may provide a valuable attempt to expand the application of EST to the cosmetics field... - Molecular cloning and characterization of cDNA encoding a ubiquitin-conjugating enzyme from Clonorchis sinensisLinxia Song
Department of Parasitology, Medical School, Sun Yat-sen University, 510089, Guangzhou, PR China
Parasitol Res 94:227-32. 2004..The nucleotide sequence reported in this paper has been submitted to the Genbank Database with accession number AY632078...