Genomes and Genes


Shengyuan Yu


Affiliation: Chinese PLA General Hospital
Location: Beijing, China


  1. Chen Z, Chen X, Liu M, Liu S, Ma L, Yu S. Nonspecific periaqueductal gray lesions on T2WI in episodic migraine. J Headache Pain. 2016;17:101 pubmed
    ..003). HIL of PAG may be the direct evidence of the EM genesis, and the further structural and functional study should be performed to elucidate the neuromechanism of migraine pathogenesis. ..
  2. Chen Z, Chen X, Chen Z, Liu M, He H, Ma L, et al. Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimentional texture analysis. J Headache Pain. 2017;18:112 pubmed publisher
    ..Texture analysis using VGLCM is a sensitive and efficient method to detect subtle gray matter changes in MOH. ..
  3. Liu Y, Yu S. Recent Approaches and Development of Acupuncture on Chronic Daily Headache. Curr Pain Headache Rep. 2016;20:4 pubmed publisher
    ..Although acupuncture has been shown to have potential effects on CDH, it requires much deeper researches on the optimized usage and underlying mechanisms. ..
  4. Chen Y, Xing X, Zhang J, Wang R, Zhao W, Tan Q, et al. Autoimmune encephalitis mimicking sporadic Creutzfeldt-Jakob disease: A retrospective study. J Neuroimmunol. 2016;295-296:1-8 pubmed publisher
    ..Fluoroscope-positron emission tomography (PET) of patients with AE revealed variable metabolism and normative and long-term immunosuppression were less likely to relapse. ..
  5. Wang M, Zhang M, Wu L, Dong Z, Yu S. Leukoencephalopathy with cerebral calcification and cysts: Cases report and literature review. J Neurol Sci. 2016;370:173-179 pubmed publisher
    ..Therefore, we propose a diagnostic flow chart for neuroimaging in leukoencephalopathy, cerebral calcifications and cysts. ..
  6. Fan Z, Hou L, Wan D, Ao R, Zhao D, Yu S. Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. J Headache Pain. 2018;19:1 pubmed publisher
    ..Association between HCRTR2, ADH4,CLOCK gene polymorphisms and CH was not significant in the present study, however, haplotype analysis indicated H1-GTGGGG was linked to a reduced CH risk. ..
  7. Hu G, Zhang M, Su M, Zhang Q, Wu H, Wang X, et al. Wider range of allodynia in a rat model of repeated dural nociception compared with infraorbital nerve chronic constriction injury. Neurosci Lett. 2018;666:120-126 pubmed publisher
    ..The IS group exhibited a wider range of allodynia than the IoN-CCI group, but further studies are necessary to determine underlying mechanisms. ..
  8. Chen Z, Chen X, Liu M, Liu S, Shu S, Ma L, et al. Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study. J Headache Pain. 2016;17:89 pubmed
    ..This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation. ..
  9. He M, Yu S, Liu R, Yang X, Zhao G, Qiao X, et al. Familial occurrence of headache disorders: A population-based study in mainland China. Clin Neurol Neurosurg. 2016;149:143-6 pubmed publisher
    ..There are important implications in this for public health and education. ..

Detail Information


  1. Wang Y, Xie J, Yang F, Wu S, Wang H, Zhang X, et al. Comorbidity of poor sleep and primary headaches among nursing staff in north China. J Headache Pain. 2015;16:88 pubmed publisher
    ..72, 95 % CI: 1.14-2.57). Comorbidity of poor sleep and primary headaches among nursing staff is common. Therefore, sleep quality should be carefully evaluated in nurses with primary headaches. ..
  2. Chen Z, Chen X, Liu M, Dong Z, Ma L, Yu S. Altered functional connectivity of amygdala underlying the neuromechanism of migraine pathogenesis. J Headache Pain. 2017;18:7 pubmed publisher
    ..The altered functional connectivity of amygdala demonstrated that neurolimbic pain network contribute in the EM pathogenesis and CM chronicization. ..
  3. Wang J, Su H, Xie W, Yu S. Mobile Phone Use and The Risk of Headache: A Systematic Review and Meta-analysis of Cross-sectional Studies. Sci Rep. 2017;7:12595 pubmed publisher;2 calls: OR, 2.52; 95% CI, 1.78-3.58, p?<?0.001). Our data indicate that MP use is significantly associated with headache, further epidemiologic and experimental studies are required to affirm and understand this association...
  4. Yu S, Liu R, Yang X, Zhao G, Qiao X, Feng J, et al. Body mass index and migraine: a survey of the Chinese adult population. J Headache Pain. 2012;13:531-6 pubmed publisher
    ..0. No association was found between obesity and migraine severity, frequency, or disability. Morbid obesity was associated with twofold increased odds of migraine in this Chinese men and women cohort of predominantly reproductive age. ..
  5. Zhang M, Liu Y, Zhao M, Tang W, Wang X, Dong Z, et al. Depression and anxiety behaviour in a rat model of chronic migraine. J Headache Pain. 2017;18:27 pubmed publisher
    ..Most of the chronic migraine rats were present depression and anxiety like behaviors. The new scales we created are expected to use in the future studies to find out the potential mechanism of affective disorders' ?comorbidity. ..
  6. Chen Z, Chen X, Liu M, Dong Z, Ma L, Yu S. Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI. J Headache Pain. 2017;18:25 pubmed publisher
    ..These results provided evidence that MOH and EM suffered from altered intrinsic functional connectivity architecture, and the current study presented a new perspective for understanding the neuromechanism of MOH and EM pathogenesis. ..
  7. Chen Z, Chen X, Liu M, Liu S, Ma L, Yu S. Volume expansion of periaqueductal gray in episodic migraine: a pilot MRI structural imaging study. J Headache Pain. 2017;18:83 pubmed publisher
    ..833) and EM vs. CM (AUC, 0.618; Sensitivity, 0.813; Specificity, 0.556). PAG volume expansion may be the direct impairment evidence on the brain in EM, and could be considered as a diagnostic and evaluated imaging biomarker in migraine. ..
  8. Chen Z, Jia Z, Chen X, Liu M, Liu S, Ma L, et al. Volumetric abnormalities of thalamic subnuclei in medication-overuse headache. J Headache Pain. 2017;18:82 pubmed publisher
    ..These structural changes in the thalamus may also be influenced by mood disturbances related to the MOH. ..
  9. Jia Z, Tang W, Zhao D, Yu S. Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache. Sci Rep. 2017;7:3960 pubmed publisher
  10. Liu Y, Dong Z, Wang R, Ao R, Han X, Tang W, et al. Migraine Prevention Using Different Frequencies of Transcutaneous Occipital Nerve Stimulation: A Randomized Controlled Trial. J Pain. 2017;18:1006-1015 pubmed publisher
    ..It shows tONS is well tolerated and could be considered as a promising treatment for patients who prefer to nonpharmacological therapy. ..
  11. Chen Z, Chen X, Liu M, Liu S, Ma L, Yu S. Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine. J Headache Pain. 2017;18:36 pubmed publisher
    ..The present study suggested that the dysfunction of bilateral vlPAG and left dlPAG presented in EM, and functional evaluation of PAG subregions may be help for the diagnosis and understanding of EM pathogenesis. ..
  12. Wang X, Huang D, Huang X, Zhang J, Ran Y, Lou X, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report. J Neuroimmunol. 2017;305:68-71 pubmed publisher
    ..Here, we report a 51-year-old woman who was diagnosed with CLIPPERS but progressed to primary CNS lymphomatoid granulomatosis, which supports that CLIPPERS is not just an inflammatory CNS disorder. ..
  13. Ran Y, Wang L, Zhang F, Ao R, Dong Z, Yu S. Anti-NMDAR encephalitis followed by seropositive neuromyelitis optica spectrum disorder: A case report and literature review. Clin Neurol Neurosurg. 2017;155:75-82 pubmed publisher
    ..Details of the 34 patients identified are summarized and compared. There may be a connection between anti-NMDAR encephalitis and NMOSD. ..
  14. Chen Z, Chen X, Liu M, Liu S, Ma L, Yu S. Texture features of periaqueductal gray in the patients with medication-overuse headache. J Headache Pain. 2017;18:14 pubmed publisher
    ..434, P?=?0.003). Texture Contrast could be used to identify the altered MR imaging characteristics in MOH in understanding the MOH pathogenesis, and it could also be considered as imaging biomarker in for MOH diagnosis. ..
  15. Chen Z, Chen X, Liu M, Liu S, Ma L, Yu S. Volume gain of periaqueductal gray in medication-overuse headache. J Headache Pain. 2017;18:12 pubmed publisher
    ..6%. The present study demonstrated that the PAG volume gain was confirmed in MOH patients, and the automated individual PAG volume measure may be considered as a simple and effective imaging biomarker in MOH diagnosis. ..
  16. Wan D, Hou L, Zhang X, Han X, Chen M, Tang W, et al. DNA methylation of RAMP1 gene in migraine: an exploratory analysis. J Headache Pain. 2015;16:90 pubmed publisher
    ..Lower methlytion level at (+89, +94, +96) CpG unit may be a risk of migraine in females. ..
  17. Zhang X, Zhou Z, Steiner T, Zhang W, Liu R, Dong Z, et al. Validation of ICHD-3 beta diagnostic criteria for 13.7 Tolosa-Hunt syndrome: Analysis of 77 cases of painful ophthalmoplegia. Cephalalgia. 2014;34:624-32 pubmed publisher
    ..It may be helpful to understand and master the entity of THS for researchers and clinicians to adjust the gradation and ranking of the diagnostic criteria. ..
  18. Yu S, Steiner T. Lifting the burden of headache in China: managing migraine in a SMART way. J Headache Pain. 2017;18:79 pubmed publisher
    ..In future, as we promote SMART in CME, we can use the database of our computerized clinical decision support systems to evaluate the impact on treatment outcomes. ..