Wang G, Zhang T, Sun W, Wang H, Yin F, Wang Z, et al
. Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma. Free Radic Biol Med. 2017;106:24-37 pubmed publisher
..Arsenic sulfide may be a potential clinical antitumor drugs targeting osteosarcoma. ..
Fu Z, Deng B, Liao Y, Shan L, Yin F, Wang Z, et al
. The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis. BMC Cancer. 2013;13:580 pubmed publisher
..Osteosarcoma is the most frequent primary malignant bone tumor, notorious for its lung metastasis. Shikonin, an effective constituent extracted from Chinese medicinal herb, was demonstrated to induce necroptosis in some cancers...