Yi X, Han Z, Zhou Q, Lin J, Liu P. 20-Hydroxyeicosatetraenoic Acid as a Predictor of Neurological Deterioration in Acute Minor Ischemic Stroke. Stroke. 2016;47:3045-3047 pubmed
..ND is fairly common in acute minor ischemic stroke and is associated with poor prognosis. Elevated plasma level of 20-HETE may be a predictor for ND in acute minor ischemic stroke. ..
Wang C, Yi X, Zhang B, Liao D, Lin J, Chi L. Clopidogrel plus aspirin prevents early neurologic deterioration and improves 6-month outcome in patients with acute large artery atherosclerosis stroke. Clin Appl Thromb Hemost. 2015;21:453-61 pubmed publisher
..Clopidogrel plus aspirin is superior to aspirin alone for reducing END and RIS within 30 days and improves outcomes in certain subgroups at 6 months. ..
Yi X, Zhang B, Wang C, Liao D, Lin J, Chi L. Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients. J Stroke Cerebrovasc Dis. 2015;24:521-9 pubmed publisher
..921; 95% CI, 1.118-7.012; P = .008). The interaction between rs10507391 and rs776746 increases the susceptibility to ischemic stroke and is associated with atherothrombotic events in stroke patients. ..
Yi X, Zhang B, Wang C, Liao D, Lin J, Chi L. CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke. Gene. 2015;565:85-9 pubmed publisher
..The combinational analysis used in this study may be helpful in the elucidation of genetic risk factors for common and complex diseases such as IS. ..
Lin J, Han Z, Wang C, Yi X, Chai Z, Zhou Q, et al
. Dual therapy with clopidogrel and aspirin prevents early neurological deterioration in ischemic stroke patients carrying CYP2C19*2 reduced-function alleles. Eur J Clin Pharmacol. 2018;74:1131-1140 pubmed publisher
..Genetic testing may be useful to guide personalized and precise antiplatelet therapy. The study described here is registered at http://www.chictr.org / (unique Identifier: ChiCTR-OCH-14004724). ..
Yi X, Lin J, Zhou Q, Wu L, Cheng W, Wang C. Clopidogrel Resistance Increases Rate of Recurrent Stroke and Other Vascular Events in Chinese Population. J Stroke Cerebrovasc Dis. 2016;25:1222-1228 pubmed publisher
..The incidence of CR in IS patients taking clopidogrel is relatively high in the Chinese population. CR is associated with ischemic vascular events, including RIS, and poor neurological recovery. ..
Yi X, Wang C, Liu P, Fu C, Lin J, Chen Y. Antiplatelet drug resistance is associated with early neurological deterioration in acute minor ischemic stroke in the Chinese population. J Neurol. 2016;263:1612-9 pubmed publisher
..http://www.chictr.org/ . Unique Identifier: ChiCTR-OCH-14004724. ..
Yi X, Cheng W, Lin J, Zhou Q, Wang C. Interaction between COX-1 and COX-2 Variants Associated with Aspirin Resistance in Chinese Stroke Patients. J Stroke Cerebrovasc Dis. 2016;25:2136-44 pubmed publisher
..The interactions of rs3842787 and rs20417 were associated with AR. The combinational analysis used in this study may provide further insight into the complex genetic risk of AR. ..
Yi X, Zhou Q, Wang C, Lin J, Cheng W, Chi L. Concomitant Use of Proton Pump Inhibitors and Clopidogrel Is Not Associated with Adverse Outcomes after Ischemic Stroke in Chinese Population. J Stroke Cerebrovasc Dis. 2016;25:2859-2867 pubmed publisher
..Further well-designed randomized controlled studies are necessary to confirm our current results. ..