Qin Z, Li S, Yao Z, Hong X, Wu B, Krausz K, et al
. Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins . Food Funct. 2018;9:1410-1423 pubmed publisher
..7% for MRP1; 35.1% for MRP3; 63.1% for MRP4). In conclusion, chemical inhibition and gene silencing results suggested that BCRP, MRP1, MRP3 and MRP4 were significant contributors to excretion of wushanicaritin glucuronides. ..
Hu L, Yao Z, Qin Z, Liu L, Song X, Dai Y, et al
. In vivo metabolic profiles of Bu-Zhong-Yi-Qi-Tang, a famous traditional Chinese medicine prescription, in rats by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. J Pharm Biomed Anal. 2019;171:81-98 pubmed publisher
Liu L, Hu L, Yao Z, Qin Z, Idehara M, Dai Y, et al
. Mucosal immunomodulatory evaluation and chemical profile elucidation of a classical traditional Chinese formula, Bu-Zhong-Yi-Qi-Tang. J Ethnopharmacol. 2019;228:188-199 pubmed publisher
Li S, Xu J, Yao Z, Hu L, Qin Z, Gao H, et al
. The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells. Chem Biol Interact. 2018;296:45-56 pubmed publisher
..Meanwhile, the UGT1A1 modified HeLa cells were a simple and practical tool to study UGT1A1-mediated glucuronidation and to characterize BCRP and MRPs-mediated glucuronide transport at a cellular level. ..
Qin Z, Li S, Yao Z, Hong X, Xu J, Lin P, et al
. Metabolic profiling of corylin in vivo and in vitro. J Pharm Biomed Anal. 2018;155:157-168 pubmed publisher
..Finally, the proposed metabolic pathway of corylin involed CYP and UGT isoforms were summarized, which could help to understand the metabolic fate of corylin in vivo. ..
Lin P, Qin Z, Yao Z, Wang L, Zhang W, Yu Y, et al
. Metabolites profile of Gualou Xiebai Baijiu decoction (a classical traditional Chinese medicine prescription) in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1085:72-88 pubmed publisher
..Taken altogether, this study would be helpful for the further pharmacokinetics, pharmacological evaluation and quality control of GLXB. ..
Xu J, Li M, Yao Z, Zhang Y, Li S, Hu L, et al
. In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP-glucuronosyltransferase enzymes by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. J Pharm Biomed Anal. 2018;158:351-360 pubmed publisher