Jin Yang

Summary

Country: China

Publications

  1. doi request reprint Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers
    Jin Yang
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People s Republic of China
    Clin Ther 31:311-20. 2009
  2. doi request reprint Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers
    Qing Hua Zhang
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P R China
    Arzneimittelforschung 60:640-4. 2010
  3. pmc A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    PLoS ONE 9:e114049. 2014
  4. doi request reprint Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica 44:541-6. 2014
  5. doi request reprint Prediction of warfarin maintenance dose in Han Chinese patients using a mechanistic model based on genetic and non-genetic factors
    Yuan Lu
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, No 24 Tongjiaxiang, Nanjing, 210009, China
    Clin Pharmacokinet 52:567-81. 2013
  6. pmc Acarbose bioequivalence: exploration of new pharmacodynamic parameters
    Min Zhang
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China
    AAPS J 14:345-51. 2012
  7. doi request reprint Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Biopharm Drug Dispos 33:235-45. 2012

Collaborators

  • Min Zhang
  • Qian Wang
  • Ruijuan Xu
  • Xiaoquan Liu
  • Yuan Lu
  • Andrew K Davey
  • Qing Hua Zhang
  • Jing Zhang
  • Min Zang
  • Haiyan Zhang
  • Xueying Zhang
  • Jiping Wang
  • Ji Ping Wang
  • Fang Liu
  • Ying He

Detail Information

Publications7

  1. doi request reprint Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers
    Jin Yang
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People s Republic of China
    Clin Ther 31:311-20. 2009
    ..Despite being widely used as a dietary supplement with claimed benefits for numerous conditions, there is little information about the pharmacokinetic properties of exogenous SAMe...
  2. doi request reprint Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers
    Qing Hua Zhang
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P R China
    Arzneimittelforschung 60:640-4. 2010
    ..The aim of the present study was to assess the effect of food on the pharmacokinetics of entecavir (CAS 142217-69-4) from dispersible tablets...
  3. pmc A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    PLoS ONE 9:e114049. 2014
    ..The critical value of the dose limit was found to be 101 mg with a probability of 3.07%. ..
  4. doi request reprint Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica 44:541-6. 2014
    ..3. Our results suggest that Mrp2 inhibitor GL should be discouraged with NAC to treat APAP hepatotoxicity. Such PK drug-drug interactions should be considered in the treatment of APAP-induced liver injury...
  5. doi request reprint Prediction of warfarin maintenance dose in Han Chinese patients using a mechanistic model based on genetic and non-genetic factors
    Yuan Lu
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, No 24 Tongjiaxiang, Nanjing, 210009, China
    Clin Pharmacokinet 52:567-81. 2013
    ..The model incorporates demographic factors [sex, age, body weight (BW)] and the genetic polymorphisms of cytochrome P450 (CYP) 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1)...
  6. pmc Acarbose bioequivalence: exploration of new pharmacodynamic parameters
    Min Zhang
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China
    AAPS J 14:345-51. 2012
    ..The acarbose test formulation can be initially considered to be bioequivalent to Glucobay®...
  7. doi request reprint Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Biopharm Drug Dispos 33:235-45. 2012
    ..9% in the 20 µm GL group and by 60.5% in the 2 µm GL group. In conclusion, glycyrrhizin increases hepatic glutathione content possibly through inhibition of Mrp2 which then reduces the biliary excretion of glutathione...