Zhi Qing David Xu
Wang P, Li H, Barde S, Zhang M, Sun J, Wang T, et al
. Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray. Proc Natl Acad Sci U S A. 2016;113:E4726-35 pubmed publisher
..Thus, the depression-like behavior in rats exposed to CMS is likely related to an elevated expression of Galr1 in the vPAG, suggesting that a GALR1 antagonist could have antidepressant effects. ..
Yang Y, Cui J, Xue F, Overstreet A, Zhan Y, Shan D, et al
. Resveratrol Represses Pokemon Expression in Human Glioma Cells. Mol Neurobiol. 2016;53:1266-78 pubmed publisher
..In addition, we found that RSV could increase the recruitment of HDAC1, but decreased p300 to the Pokemon promoter. Taken together, all these results extended our understanding on the anti-cancer mechanism of RSV in glioma cells. ..
Jing B, Liu B, Li H, Lei J, Wang Z, Yang Y, et al
. Within-subject test-retest reliability of the atlas-based cortical volume measurement in the rat brain: A voxel-based morphometry study. J Neurosci Methods. 2018;307:46-52 pubmed publisher
..Atlas-based cortical volume of the rat brain can be reliably estimated using the VBM-DARTEL method in most subregions. However, findings in subregions with lower reliability must be interpreted with caution. ..
Bai Y, Ma H, Liu L, Li H, Li X, Yang Y, et al
. Activation of galanin receptor 1 inhibits locus coeruleus neurons via GIRK channels. Biochem Biophys Res Commun. 2018;503:79-85 pubmed publisher
..Taken together, the inhibitory effect of GAL on LC neurons is mediated by GALR1 via PTX-sensitive Gi/o proteins, which activate GIRK channels. ..
Yang Y, Liu L, Luo H, Li Y, Li H, Xu Z. Characterization of the Rat GAL2R Promoter: Positive Role of ETS-1 in Regulation of the Rat GAL2R Gene in PC12 Cells. Mol Neurobiol. 2017;54:4421-4431 pubmed publisher
..These data indicate a role for ETS-1 in the control of the GAL2R gene expression and provide a basis for understanding the transcriptional regulation of the GAL2R gene. ..
Yang Y, Cui J, Xue F, Zhang C, Mei Z, Wang Y, et al
. Pokemon (FBI-1) interacts with Smad4 to repress TGF-Î²-induced transcriptional responses. Biochim Biophys Acta. 2015;1849:270-81 pubmed publisher
..Taken together, all these data suggest that Pokemon is a new partner of Smad4 and plays a negative role in TGF-Î² pathway. ..
Pan N, Bai Y, Yang Y, Hokfelt T, Xu Z. Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells. Biochem Biophys Res Commun. 2014;446:316-21 pubmed publisher
..Taken together, activation of GalR2 leads to elevation of intracellular Ca(2+) is due to Ca(2+) efflux from ER through IP3R sequentially opening BK channels. ..
Wang T, Shi C, Li X, Zhang P, Liu B, Wang H, et al
. Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model. Behav Brain Res. 2018;336:236-243 pubmed publisher
..Moreover, injection of OXT also reversed GRS-induced increase of TrkB in PVN of PPD rats. All those data suggest that OXT plays an antidepressant role by, at least in part, modulating HPA axis via TrkB in PVN of PPD rats. ..