Shixia Xu


Country: China


  1. Tian R, Wang Z, Niu X, Zhou K, Xu S, Yang G. Evolutionary Genetics of Hypoxia Tolerance in Cetaceans during Diving. Genome Biol Evol. 2016;8:827-39 pubmed publisher
    ..In summary, positive selection, divergent selective pressures, and parallel evolution at the molecular level provided some new insights into the genetic adaptation of hypoxia tolerance. ..
  2. Xu S, Tian R, Lin Y, Yu Z, Zhang Z, Niu X, et al. Widespread positive selection on cetacean TLR extracellular domain. Mol Immunol. 2018;106:135-142 pubmed publisher
  3. Li L, Rong X, Li G, Wang Y, Chen B, Ren W, et al. Genomic organization and adaptive evolution of IGHC genes in marine mammals. Mol Immunol. 2018;99:75-81 pubmed publisher
  4. Tian R, Chen M, Chai S, Rong X, Chen B, Ren W, et al. Divergent Selection of Pattern Recognition Receptors in Mammals with Different Ecological Characteristics. J Mol Evol. 2018;86:138-149 pubmed publisher
    ..This study provides a comprehensive look at the evolutionary patterns and implications of mammalian PRRs, and highlights the importance of ecological influences in molecular adaptation. ..
  5. Zhu K, Zhou X, Xu S, Sun D, Ren W, Zhou K, et al. The loss of taste genes in cetaceans. BMC Evol Biol. 2014;14:218 pubmed publisher
    ..The integrity of the candidate salt taste receptor genes in all the cetaceans examined may be because of their function in Na(+) reabsorption, which is key to osmoregulation and aquatic adaptation. ..
  6. Xu S, Sun X, Niu X, Zhang Z, Tian R, Ren W, et al. Genetic basis of brain size evolution in cetaceans: insights from adaptive evolution of seven primary microcephaly (MCPH) genes. BMC Evol Biol. 2017;17:206 pubmed publisher
  7. Shen T, Xu S, Wang X, Yu W, Zhou K, Yang G. Adaptive evolution and functional constraint at TLR4 during the secondary aquatic adaptation and diversification of cetaceans. BMC Evol Biol. 2012;12:39 pubmed publisher
  8. Xiong Y, Brandley M, Xu S, Zhou K, Yang G. Seven new dolphin mitochondrial genomes and a time-calibrated phylogeny of whales. BMC Evol Biol. 2009;9:20 pubmed publisher
    ..Moreover, we incorporate a newly-developed "relaxed" molecular clock to model heterogenous rates of evolution among cetacean lineages...
  9. Chen Z, Wang Z, Xu S, Zhou K, Yang G. Characterization of hairless (Hr) and FGF5 genes provides insights into the molecular basis of hair loss in cetaceans. BMC Evol Biol. 2013;13:34 pubmed publisher
    ..Consequently, the hair follicle cycle was disrupted and the hair was lost completely due to the loss of the Hr gene function in cetaceans. This suggests that cetaceans have evolved an effective and complex mechanism for hair loss...

More Information


  1. Chen Z, Xu S, Zhou K, Yang G. Whale phylogeny and rapid radiation events revealed using novel retroposed elements and their flanking sequences. BMC Evol Biol. 2011;11:314 pubmed publisher