Lichun Xu

Summary

Country: China

Publications

  1. Wang Q, Wang H, Shen J, Zhang R, Hong J, Li Z, et al. The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells. Ecotoxicol Environ Saf. 2019;177:58-65 pubmed publisher
    ..This study provides a novel insight into the CYP-induced reproductive toxicity. ..
  2. Yu H, Wu Y, Ju P, Wang B, Yang X, Wang H, et al. eNOS-JNK1-AR signaling pathway mediates deltamethrin-induced germ cells apoptosis in testes of adult rats. Environ Toxicol Pharmacol. 2014;38:733-41 pubmed publisher
    ..Histamine and quercetagetin were also examined to have a further confirmation. It is suggested DM-induced germ cells apoptosis and reduction of sperm production were mediated by eNOS-JNK1-AR signaling pathway. ..
  3. Wang Q, Xu L, Zhou J, Zhou X, Wang H, Ju Q, et al. Antagonism effects of cypermethrin on interleukin-6-induced androgen receptor activation. Environ Toxicol Pharmacol. 2015;40:172-4 pubmed publisher
    ..Cypermethrin exhibits inhibitory effects on IL-6-induced ligand-independent AR signaling. We provide a novel insight into cypermethrin-mediated antagonism of the IL-6-mediated ligand-independent activation of the AR. ..
  4. Liu Y, Xu L, Wang Q, Zhou X, Zhou J, Pan C, et al. Identification of susceptibility genes in non-syndromic cleft lip with or without cleft palate using whole-exome sequencing. Med Oral Patol Oral Cir Bucal. 2015;20:e763-70 pubmed
    ..The susceptibility genes identified in this study will not only be useful in revealing the etiology of NSCL/P but also in diagnosis and treatment of the patients with NSCL/P. ..
  5. Chen G, Li M, Wang H, Hong J, Shen J, Wang Q, et al. Identification of key genes in cleft lip with or without cleft palate regulated by miR-199a-5p. Int J Pediatr Otorhinolaryngol. 2018;111:128-137 pubmed publisher
    ..MiR-199a-5p may mediate CL/P by regulating key target gene TGFA. The study may contribute to a better understanding of the etiology of CL/P. ..
  6. Wang Q, Zhou J, Wang H, Ju Q, Ding Z, Zhou X, et al. Inhibition effect of cypermethrin mediated by co-regulators SRC-1 and SMRT in interleukin-6-induced androgen receptor activation. Chemosphere. 2016;158:24-9 pubmed publisher
    ..Inhibition of the interactions of AR-SRC-1 and AR-SMRT mediated by IL-6 contributes to the AR antagonism induced by cypermethrin. ..
  7. Wang H, Ding Z, Shi Q, Ge X, Wang H, Li M, et al. Anti-androgenic mechanisms of Bisphenol A involve androgen receptor signaling pathway. Toxicology. 2017;387:10-16 pubmed publisher
    ..The data uncover novel anti-androgenic mechanisms by which BPA antagonizes AR signaling, contributing to Sertoli cell proliferation suppression and male reproductive toxicology. ..
  8. Chen Y, Fu R, Xu M, Huang Y, Sun G, Xu L. N-methyl-N-nitro-N-nitrosoguanidine-mediated ING4 downregulation contributed to the angiogenesis of transformed human gastric epithelial cells. Life Sci. 2018;199:179-187 pubmed publisher
    ..Our findings provided a significant mechanistic insight into angiogenesis of MNNG-transformed human gastric epithelial cell and supported the concept that ING4 may be a relevant therapeutic target for gastric cancer. ..