Feng Zhang

Summary

Affiliation: Xi'an Jiaotong University
Country: China

Publications

  1. ncbi request reprint Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    Hum Genet 133:793-9. 2014
  2. pmc Expression profile analysis of mycotoxin-related genes in cartilage with endemic osteochondropathy Kashin-Beck Disease
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China, 710061
    BMC Musculoskelet Disord 13:130. 2012
  3. pmc Multilocus association testing of quantitative traits based on partial least-squares analysis
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 6:e16739. 2011
  4. doi request reprint Confounding from cryptic relatedness in haplotype-based association studies
    Feng Zhang
    College of Medicine, Xi an Jiaotong University, 710061 Xi an, People s Republic of China
    Genetica 138:945-50. 2010
  5. pmc Genome-wide gene expression analysis suggests an important role of hypoxia in the pathogenesis of endemic osteochondropathy Kashin-Beck disease
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 6:e22983. 2011
  6. pmc Genome-wide pathway association studies of multiple correlated quantitative phenotypes using principle component analyses
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, China
    PLoS ONE 7:e53320. 2012
  7. pmc Genome-wide association study identified CNP12587 region underlying height variation in Chinese females
    Yin Ping Zhang
    Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, College of Medicine, Xi an Jiaotong University, Xi an, PR China
    PLoS ONE 7:e44292. 2012
  8. pmc A PCA-based method for ancestral informative markers selection in structured populations
    Feng Zhang
    Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, 710049, China
    Sci China C Life Sci 52:972-6. 2009
  9. pmc Correcting for cryptic relatedness in population-based association studies of continuous traits
    Feng Zhang
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, PR China
    Hum Hered 69:28-33. 2010
  10. doi request reprint Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis
    Shi xun Wu
    Faculty of Public Health, College of Medicine of Xi an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases, Ministry of Health, Xi an 710061, China Department of Orthopedics Surgery, The First Affiliated Hospital, College of Medicine of Xi an Jiaotong University, Xi an 710061, China
    Gene 535:124-30. 2014

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    Hum Genet 133:793-9. 2014
    ..Gene expression analysis also found that ABI3BP was up-regulated in KBD patients compared to healthy controls. Our results suggest that ABI3BP was a novel susceptibility gene for KBD...
  2. pmc Expression profile analysis of mycotoxin-related genes in cartilage with endemic osteochondropathy Kashin-Beck Disease
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China, 710061
    BMC Musculoskelet Disord 13:130. 2012
    ..To identify key genes involved in the mycotoxin-induced cartilage lesions, we compared the expression profiles of mycotoxin-related genes (MRG) between KBD cartilage and healthy cartilage...
  3. pmc Multilocus association testing of quantitative traits based on partial least-squares analysis
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 6:e16739. 2011
    ..We aim to provide an effective and powerful MLAS approach, which may help to overcome the limitations of SLAS in disease genes mapping...
  4. doi request reprint Confounding from cryptic relatedness in haplotype-based association studies
    Feng Zhang
    College of Medicine, Xi an Jiaotong University, 710061 Xi an, People s Republic of China
    Genetica 138:945-50. 2010
    ..We observed significant negative effect of cryptic relatedness on the performance of HFAT and HSAT. Ignoring cryptic relatedness may increase spurious association results in haplotype-based PBAS...
  5. pmc Genome-wide gene expression analysis suggests an important role of hypoxia in the pathogenesis of endemic osteochondropathy Kashin-Beck disease
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 6:e22983. 2011
    ..Our efforts may help to understand the pathogenesis of KBD as well as other osteoarthrosis with similar articular cartilage lesions...
  6. pmc Genome-wide pathway association studies of multiple correlated quantitative phenotypes using principle component analyses
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, China
    PLoS ONE 7:e53320. 2012
    ..We aim to provide a applicable MPPAS approach, which may help to gain deep understanding the potential biological mechanism of association results for complex diseases...
  7. pmc Genome-wide association study identified CNP12587 region underlying height variation in Chinese females
    Yin Ping Zhang
    Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, College of Medicine, Xi an Jiaotong University, Xi an, PR China
    PLoS ONE 7:e44292. 2012
    ..We aim to identify sequence variants associated with adult height by a genome-wide association study of copy number variants (CNVs) in Chinese...
  8. pmc A PCA-based method for ancestral informative markers selection in structured populations
    Feng Zhang
    Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, 710049, China
    Sci China C Life Sci 52:972-6. 2009
    ....
  9. pmc Correcting for cryptic relatedness in population-based association studies of continuous traits
    Feng Zhang
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, PR China
    Hum Hered 69:28-33. 2010
    ..Ignoring cryptic relatedness may increase spurious association results in PBAS. Our ELRT provides a novel approach to control cryptic relatedness in PBAS of human continuous traits...
  10. doi request reprint Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis
    Shi xun Wu
    Faculty of Public Health, College of Medicine of Xi an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases, Ministry of Health, Xi an 710061, China Department of Orthopedics Surgery, The First Affiliated Hospital, College of Medicine of Xi an Jiaotong University, Xi an 710061, China
    Gene 535:124-30. 2014
    ....
  11. pmc Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures
    Yin Ping Zhang
    The Key Laboratory of Environment and Genes Related to Diseases, Xi an Jiaotong University College of Medicine, Ministry of Education, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 6:e21835. 2011
    ..This study aims to verify the potential association between hip OF and TRAIL pathway...
  12. doi request reprint Regulatory gene networks and signaling pathways from primary osteoarthritis and Kashin-Beck disease, an endemic osteoarthritis, identified by three analysis software
    Sen Wang
    Faculty of Public Health, Medical College of Xi an Jiaotong University, Xi an, Shaanxi, PR China
    Gene 512:89-96. 2013
    ....
  13. doi request reprint Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China
    Chunyan Li
    Faculty of Public Health, Medical College of Xi an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, Xi an 710061, China
    Sci China Life Sci 55:1057-63. 2012
    ..Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease...
  14. pmc Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis
    Yan Guo
    Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, People s Republic of China
    PLoS Genet 6:e1000806. 2010
    ..ALDH7A1 degrades and detoxifies acetaldehyde, which inhibits osteoblast proliferation and results in decreased bone formation. Our findings may provide new insights into the pathogenesis of osteoporosis...
  15. pmc Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromas
    Feng Zhang
    Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, China
    PLoS ONE 8:e72316. 2013
    ..The novel c.1457insG deleterious mutation of EXT1 gene reported in this study expands the causal mutation spectrum of MO, and may be helpful for prenatal genetic screening and early diagnosis of MO. ..
  16. pmc Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry
    Yuan Chen
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi 710049, PR China
    Bone 46:129-36. 2010
    ..Overall, these results suggest the significant genetic contribution of EphrinA-EphR pathway to femoral neck bone geometry...
  17. doi request reprint Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy
    Shu lan He
    Key Laboratory of Environment and Gene Related Diseases, Xi an Jiaotong University, Ministry Education, No 76 Yanta West Road, Xi an, Shaanxi 710061, PR China Key Laboratory of Trace elements and Endemic Diseases, Xi an Jiaotong University, Ministry of Health, No 76 Yanta West Road, Xi an, Shaanxi 710061, PR China
    Exp Cell Res 319:2604-16. 2013
    ..Our results may lead to the identification of potential diagnostic biomarkers for KD in PBMCs, and may help to understand the pathogenesis of KD...
  18. pmc Comparison of population-based association study methods correcting for population stratification
    Feng Zhang
    Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi, China
    PLoS ONE 3:e3392. 2008
    ..Our study intends to provide a practical guideline for researchers to select proper study methods and make appropriate inference of the results in population-based association studies...
  19. ncbi request reprint Gender differences on osteoporosis health beliefs and related behaviors in non-academic community Chinese
    Yin Ping Zhang
    Department of Nursing, College of Medicine, Xi an Jiaotong University, No 76, West Yanta Road, Xi an, Shaanxi, 710061, People s Republic of China
    J Community Health 39:545-51. 2014
    ..019). The findings from the study suggest an increased awareness of this major public health problem in non-academic Chinese and the scope for enhancing osteoporosis intervention considering the gender difference...
  20. doi request reprint Fabrication and in vitro evaluation of the collagen/hyaluronic acid PEM coating crosslinked with functionalized RGD peptide on titanium
    Ying Huang
    Department of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, People s Republic of China
    Acta Biomater 8:866-77. 2012
    ..These results indicate that the strategy employed herein may function as an effective way to construct stable, RGD-containing bioactive coatings on Ti...
  21. doi request reprint Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells
    Feng Zhang
    Department of Oncology, Tangdu Hospital, The Fourth Military Medical University, Xi an, People s Republic of China
    J Med Virol 82:920-8. 2010
    ..Thus, we conclude that HBx upregulate Capn4 through NF-kappaB/p65 to promote migration of hepatoma cells...