Qingyong Ma

Summary

Affiliation: Xi'an Jiaotong University
Country: China

Publications

  1. pmc Immune sculpting of norepinephrine on MHC-I, B7-1, IDO and B7-H1 expression and regulation of proliferation and invasion in pancreatic carcinoma cells
    Liancai Wang
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, Shaanxi Province, China
    PLoS ONE 7:e45491. 2012
  2. ncbi request reprint Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer
    Wei Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, China
    Curr Cancer Drug Targets 14:348-56. 2014
  3. pmc High glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFR
    Liang Han
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    PLoS ONE 6:e27074. 2011
  4. pmc Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway
    Z Wang
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    Br J Cancer 99:1695-703. 2008
  5. pmc Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells
    Liang Han
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi, China
    Curr Med Chem 20:4142-52. 2013
  6. ncbi request reprint Vitamin D - pivotal nutraceutical in the regulation of cancer metastasis and angiogenesis
    Jun Xu
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, China
    Curr Med Chem 20:4109-20. 2013
  7. ncbi request reprint The mechanism of calcitriol in cancer prevention and treatment
    Jiguang Ma
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi, China
    Curr Med Chem 20:4121-30. 2013
  8. pmc Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway
    Wei Li
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi, China
    Curr Med Chem 20:4185-94. 2013
  9. ncbi request reprint 1, 25(OH)₂D₃ inhibits hepatocellular carcinoma development through reducing secretion of inflammatory cytokines from immunocytes
    Jian Guo
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, China
    Curr Med Chem 20:4131-41. 2013
  10. ncbi request reprint Aspirin: a potential therapeutic approach in pancreatic cancer
    Xin Shen
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi, China
    Curr Med Chem 20:4153-62. 2013

Collaborators

Detail Information

Publications59

  1. pmc Immune sculpting of norepinephrine on MHC-I, B7-1, IDO and B7-H1 expression and regulation of proliferation and invasion in pancreatic carcinoma cells
    Liancai Wang
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, Shaanxi Province, China
    PLoS ONE 7:e45491. 2012
    ..This study aims to investigate the role of NE in modulating the immune phenotype and allowing pancreatic carcinoma (PC) cells to escape the immune response...
  2. ncbi request reprint Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer
    Wei Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, China
    Curr Cancer Drug Targets 14:348-56. 2014
    ..Taken together, these results indicate that hyperglycemia-induced TXNIP expression is involved in diabetes-mediated oxidative stress in pancreatic cancer via p38 MAPK and ERK pathways. ..
  3. pmc High glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFR
    Liang Han
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    PLoS ONE 6:e27074. 2011
    ....
  4. pmc Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway
    Z Wang
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    Br J Cancer 99:1695-703. 2008
    ..Collectively, these data reported here demonstrate CXCR4 could modulate the canonical Wnt pathway and perhaps be a promising therapeutic target for pancreatic cancer progression...
  5. pmc Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells
    Liang Han
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi, China
    Curr Med Chem 20:4142-52. 2013
    ..Our findings indicate that indometacin could be used as a novel therapeutic strategy to treat PC patients who simultaneously suffer from diabetes or HG. ..
  6. ncbi request reprint Vitamin D - pivotal nutraceutical in the regulation of cancer metastasis and angiogenesis
    Jun Xu
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, China
    Curr Med Chem 20:4109-20. 2013
    ..Here, we present a systematic summary of the effects of vitamin D in the chemoprevention and chemotherapy of cancer, especially anti-metastatic and anti-angiogenic actions. ..
  7. ncbi request reprint The mechanism of calcitriol in cancer prevention and treatment
    Jiguang Ma
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi, China
    Curr Med Chem 20:4121-30. 2013
    ..This review summarizes the role of calcitriol in anticancer therapy and the progress in understanding its mechanism. ..
  8. pmc Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway
    Wei Li
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi, China
    Curr Med Chem 20:4185-94. 2013
    ..This study suggests that resveratrol may be a potential anticancer agent for pancreatic cancer. ..
  9. ncbi request reprint 1, 25(OH)₂D₃ inhibits hepatocellular carcinoma development through reducing secretion of inflammatory cytokines from immunocytes
    Jian Guo
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, China
    Curr Med Chem 20:4131-41. 2013
    ..Collectively, 1,25(OH)₂D₃ inhibits HCC development through up-regulating the expression of p27(kip1) in immune cell and reducing inflammatory cytokine production...
  10. ncbi request reprint Aspirin: a potential therapeutic approach in pancreatic cancer
    Xin Shen
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi, China
    Curr Med Chem 20:4153-62. 2013
    ..The COX-dependent and COX-independent mechanisms will be described in this review. In addition, we will discuss future research directions on the risks and benefits of the use of aspirin to treat PC and the potential cellular/molecular. ..
  11. ncbi request reprint Aberrant expression of CXCR4 and β-catenin in pancreatic cancer
    Zheng Wang
    Department of Hepatobiliary Surgery, The First Affiliated Hospital, Medical College of Xi an Jiaotong University, Xi an 710061, Shaanxi, P R China or
    Anticancer Res 33:4103-10. 2013
    ..The aim of this study was to investigate the expression of CXCR4 and β-catenin in pancreatic cancer...
  12. ncbi request reprint L-arginine reduces cell proliferation and ornithine decarboxylase activity in patients with colorectal adenoma and adenocarcinoma
    Qingyong Ma
    Departments of General Surgery, The First Hospital of Xi An Jiaotong University, Xi an, PR China
    Clin Cancer Res 13:7407-12. 2007
    ..We suppose that L-arginine may inhibit the process of carcinogenesis from colorectal adenoma to adenocarcinoma. The aim of this study was to investigate the effects of L-arginine on the formation and development of colorectal tumors...
  13. doi request reprint The beneficial effect of resveratrol on severe acute pancreatitis
    Qingyong Ma
    Department of Hepatobiliary and Pancreas Surgery, First Affiliated Hospital of Xi an Jiaotong University, China
    Ann N Y Acad Sci 1215:96-102. 2011
    ..We propose that resveratrol has a potentially therapeutic effect on the progression of SAP...
  14. ncbi request reprint Targeting the L-arginine-nitric oxide pathway for cancer treatment
    Qingyong Ma
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    Curr Pharm Des 16:392-410. 2010
    ..Members of this pathway have been reported to be promising therapeutic molecules in tumor therapy. This review article summarizes research data on the roles of the L-arginine/NO pathway in cancer biology and cancer therapy...
  15. ncbi request reprint Hyperglycemia as a mechanism of pancreatic cancer metastasis
    Wei Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi Province, China
    Front Biosci (Landmark Ed) 17:1761-74. 2012
    ..A deep understanding of metastasis mechanisms will identify novel targets for therapeutic intervention...
  16. doi request reprint Upregulated miR-106a plays an oncogenic role in pancreatic cancer
    Pei Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi an Jiaotong University, Xi an, Shaanxi 710061, China
    FEBS Lett 588:705-12. 2014
    ..MiR-106a could be a critical therapeutic target in pancreatic cancer. ..
  17. pmc SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway
    Xuqi Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi an Jiaotong University, Shaanxi, China
    Cancer Lett 322:169-76. 2012
    ..Taken together, SDF-1/CXCR4 axis may represent a promising therapeutic target to prevent pancreatic cancer progression...
  18. pmc Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells
    Xuqi Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, Shaanxi, China
    Mol Cancer Res 11:294-302. 2013
    ..Our results suggest that SP plays an important role in the development of pancreatic cancer metastasis and PNI, and blocking the SP/NK-1R signaling system is a novel strategy for the treatment of pancreatic cancer...
  19. pmc α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion
    Jianjun Lei
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, Shaanxi Province, China
    Cancer Lett 347:129-38. 2014
    ..Increased generation of hypoxic ROS is responsible for HIF-1α stabilization and GLI1 upregulation. Therefore, α-mangostin may be beneficial in preventing hypoxia-induced pancreatic cancer progression. ..
  20. pmc Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia
    Junhui Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, Shaanxi, China
    PLoS ONE 6:e17385. 2011
    ..The goal of the current study was to examine the neural alterations in pancreatic cancer patients with hyperglycemia and to identify the relationship between the neural alterations and perineural invasion...
  21. pmc Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
    Jianjun Lei
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061Shaanxi Province, China
    Mol Cancer 12:66. 2013
    ..However, it is not quite clear how hypoxia may contribute to these events. Here we investigate the role of Hedgehog (Hh) signaling in hypoxia induced pancreatic cancer EMT and invasion...
  22. doi request reprint Protective effect of resveratrol in severe acute pancreatitis-induced brain injury
    Rajiv Kumar Jha
    Department of Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, People s Republic of China
    Pancreas 38:947-53. 2009
    ..The aim of this study was to study the effects of resveratrol on severe acute pancreatitis (SAP)-induced brain injury...
  23. ncbi request reprint Resveratrol suppresses microcirculatory disturbance in a rat model of severe acute pancreatitis
    Huanchen Sha
    Department of Surgery, First Affiliated Hospital of Xi an Jiaotong University, 277 West Yanta Road, Xi an, 710061, People s Republic of China
    Cell Biochem Biophys 67:1059-65. 2013
    ..05) attenuated changes of both histopathologic and biochemical markers induced by SAP. In conclusion, this study provides evidence that RES treatment is a promising therapeutic approach to suppress microcirculatory disturbance in SAP...
  24. doi request reprint Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1α under normoxic condition
    Min Zhang
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an 710061, China
    Cancer Lett 303:108-17. 2011
    ..Therefore, our results suggest that the inhibition of both c-kit and HIF-1α may be an effective strategy for pancreatic cancer therapy...
  25. ncbi request reprint Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol
    Kun Guo
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College of Xi an Jiaotong University, Xi an 710061, P R China
    Oncol Rep 22:825-30. 2009
    ..This study also provides experimental evidence for the use of beta-blockers in the chemoprevention of pancreatic cancer metastasis...
  26. doi request reprint Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling
    Kun Guo
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, People s Republic of China
    Mol Cancer Ther 12:264-73. 2013
    ..Inhibition of the activity of sympathetic nerves or STAT3 may be potential strategies for pancreatic cancer PNI therapy...
  27. doi request reprint Hyperglycemia enhances the invasive and migratory activity of pancreatic cancer cells via hydrogen peroxide
    Wei Li
    Department of Hepatobiliary and Pancreas Surgery, First Affiliated Hospital, Xi an Jiaotong University, 277 West Yanta Road, Xi an 710061, PR China
    Oncol Rep 25:1279-87. 2011
    ..These results suggest that the association between hyperglycemia and poor prognosis in pancreatic cancer can be attributed to the alterations of the migratory and invasive ability of the cells through the production of hydrogen peroxide...
  28. ncbi request reprint Resveratrol ameliorates hepatic injury via the mitochondrial pathway in rats with severe acute pancreatitis
    Huanchen Sha
    Department of Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, 710061, China
    Eur J Pharmacol 601:136-42. 2008
    ....
  29. doi request reprint Inactivation of p27kip1 promotes chemical hepatocarcinogenesis through enhancing inflammatory cytokine secretion and STAT3 signaling activation
    Jian Guo
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi an Jiaotong University, Xi an, Shaanxi, PR, China
    J Cell Physiol 228:1967-76. 2013
    ....
  30. ncbi request reprint Effects of resveratrol on calcium regulation in rats with severe acute pancreatitis
    Liancai Wang
    Department of Hepatobiliary Surgery, First Hospital of Xi an Jiaotong University, 1 Jiankang Road, Xi an, 710061, Shaanxi Province, China
    Eur J Pharmacol 580:271-6. 2008
    ....
  31. doi request reprint β2-adrenoceptor blocker synergizes with gemcitabine to inhibit the proliferation of pancreatic cancer cells via apoptosis induction
    Tao Shan
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Shaanxi Province, China
    Eur J Pharmacol 665:1-7. 2011
    ..Our study implies that this combination may be an effective therapeutic strategy for pancreatic cancer...
  32. doi request reprint Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist's anticancer effect in pancreatic cancer cell
    Dong Zhang
    Department of Hepatobiliary and Pancreas Surgery, First Affiliated Hospital, Xi an Jiaotong University, Xi an, China
    Pancreas 38:94-100. 2009
    ..Propranolol inhibited pancreatic cancer cell proliferation by blocking signaling through the beta-adrenoceptor. We hypothesized that propranolol may suppress pancreatic cancer cell growth through induction of apoptosis...
  33. pmc Therapeutic potential of perineural invasion, hypoxia and desmoplasia in pancreatic cancer
    Han Liu
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, Shaanxi, China
    Curr Pharm Des 18:2395-403. 2012
    ..This review describes the main players in perineural invasion, hypoxia and desmoplasia and the molecular mechanisms of these pathophysiological processes...
  34. pmc Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a systematic review and meta-analysis
    Jiangbo Liu
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College of Xi an Jiaotong University, Xi an, China
    Eur J Cancer 48:2328-38. 2012
    ..This systematic review and meta-analysis aimed to provide comprehensive evidence on the association of p53 alterations with recurrence-free survival (RFS) and overall survival (OS) in HCC patients...
  35. pmc Targeting the cancer-stroma interaction: a potential approach for pancreatic cancer treatment
    Xuqi Li
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, Shaanxi, China
    Curr Pharm Des 18:2404-15. 2012
    ..Novel therapies that target on the pancreatic tumor microenvironment should become one of the more effective treatments for pancreatic cancer...
  36. ncbi request reprint Paracrine sonic hedgehog signaling derived from tumor epithelial cells: a key regulator in the pancreatic tumor microenvironment
    Xuqi Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an 710061, Shaanxi, China
    Crit Rev Eukaryot Gene Expr 22:97-108. 2012
    ..Taken together, these findings are of valuable implications for the use of Hh pathway inhibitors currently in development and inhibition of the Hh pathway paracrine loop in pancreatic cancer...
  37. pmc α-Mangostin suppresses the viability and epithelial-mesenchymal transition of pancreatic cancer cells by downregulating the PI3K/Akt pathway
    Qinhong Xu
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, Shaanxi 710061, China
    Biomed Res Int 2014:546353. 2014
    ..Our results suggest that α -mangostin may be potentially used as a novel adjuvant therapy or complementary alternative medicine for the management of pancreatic cancers. ..
  38. doi request reprint Relationship of fibronectin and CD44v6 expression with invasive growth and metastasis of liver cancer
    Rajiv K Jha
    Department of Surgery, First Hospital of Xi an Jiaotong University, Xi an, China
    Cancer Invest 27:324-8. 2009
    ..5% of liver cancers. Increased CD44v6 expression was more common with poor clinical tumor characteristics. FN and CD44v6 are potential markers for determining liver cancer invasion and metastasis...
  39. ncbi request reprint hSSTR2 expression and octreotide treatment reverses multidrug resistance of BxPC-3 human pancreatic cancer cells
    Chenguang Sui
    Department of Oncology, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, PR China
    Oncol Rep 22:1391-6. 2009
    ..01). These data suggested that the down-regulation of MDR genes is responsible for the improvement in the chemotherapeutic sensitivity of hSSTR2-expressing pancreatic cancer cells, when these cells are subjected to octreotide treatment...
  40. doi request reprint Role of glial cell line-derived neurotrophic factor in perineural invasion of pancreatic cancer
    Han Liu
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an 710061, Shaanxi Province, China
    Biochim Biophys Acta 1826:112-20. 2012
    ..Finally, we also review some potential inhibitors for GDNF-targeted therapy...
  41. pmc β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway
    Dong Zhang
    Department of Hepatobiliary and Pancreas Surgery, First Affiliated Hospital, Xi an Jiaotong University, Xi an 710061, China
    Mol Cancer 10:146. 2011
    ..To clarify the mechanism of apoptosis induced by β2-adrenergic antagonist, we hypothesize that blockage of the β2-adrenoceptor could induce G1/S phase arrest and apoptosis and Ras may be a key player in PanCa cells...
  42. doi request reprint Resveratrol ameliorates the deleterious effect of severe acute pancreatitis
    Rajiv K Jha
    Department of Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an 710061, China
    Cell Biochem Biophys 62:397-402. 2012
    ..In conclusion, this study confirmed the anti-inflammatory properties of RES and demonstrated the prevention of injury to the intestinal barrier in the rat SAP model...
  43. doi request reprint Clinical significance of B7-H1 and B7-1 expressions in pancreatic carcinoma
    Liancai Wang
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, 277 West Yanta Road, Xi an, 710061, Shaanxi Province, China
    World J Surg 34:1059-65. 2010
    ..Aberrant B7-H1 and B7-1 expressions may help pancreatic carcinoma (PC) cells escape immune attack; these molecules can be considered as prognostic markers for patients with PC who have undergone radical resection...
  44. pmc Hyperglycemia, a neglected factor during cancer progression
    Wanxing Duan
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi an Jiaotong University, 277 West Yanta Road, Xi an, Shaanxi 710061, China
    Biomed Res Int 2014:461917. 2014
    ..Therefore, controlling hyperglycemia may have important therapeutic implications in cancer patients. ..
  45. ncbi request reprint Predictors of systemic chemotherapy contraindication in pancreatic cancer patients with distant metastasis
    Yong Zhang
    Department of Hepatobiliary Surgery, The First Hospital of Xi An Jiaotong University, Xi an, China
    Hepatogastroenterology 54:254-9. 2007
    ..To investigate predictors of systemic chemotherapy contraindication in pancreatic cancer patients with distant metastasis...
  46. ncbi request reprint Pleiotrophin expression in human pancreatic cancer and its correlation with clinicopathological features, perineural invasion, and prognosis
    Jun Yao
    Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, 710061, China
    Dig Dis Sci 54:895-901. 2009
    ..0% versus 20.8%, respectively; P = 0.001). We conclude that high expression of PTN combined with N-syndecan may contribute to the increased perineural invasion and poor prognosis of pancreatic cancer...
  47. doi request reprint High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells
    Han Liu
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, 227 West Yan ta Road, Xi an, 710061, China
    Mol Cell Biochem 347:95-101. 2011
    ..Up-regulation of GDNF and RET ligand-receptor interaction might participate in the glucose-induced cancer progression...
  48. ncbi request reprint Beta-catenin is a promising key factor in the SDF-1/CXCR4 axis on metastasis of pancreatic cancer
    Zheng Wang
    Department of Hepatobillary Surgery, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, Shaanxi, 710061, PR China
    Med Hypotheses 69:816-20. 2007
    ..Through the observation of this crosstalk, it is possible to understand more clearly about the pancreatic cancer specific metastasis and to make some contributions on gene therapy of pancreatic cancer...
  49. doi request reprint Resveratrol ameliorates lung injury via inhibition of apoptosis in rats with severe acute pancreatitis
    Huanchen Sha
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    Exp Lung Res 35:344-58. 2009
    ..Apoptosis is involved in lung injury associated with severe acute pancreatitis, and resveratrol can ameliorate this injury, thus protecting lung function in rats with severe acute pancreatitis...
  50. doi request reprint Early manifestations of pancreatic cancer: the effect of cancer-nerve interaction
    Junhui Li
    Department of General Surgery, Second Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    Med Hypotheses 81:180-2. 2013
    ..The combination of the so-called common gastrointestinal symptoms and diabetes may represent early typical symptoms of PanCa that can be used to improve early diagnosis. ..
  51. pmc The bidirectional interation between pancreatic cancer and diabetes
    Junhui Li
    Department of General Surgery, Second Affiliated Hospital, School of Medicine, Xi an Jiaotong University, 157 West 5th Road, Xi an 710004, People s Republic of China
    World J Surg Oncol 10:171. 2012
    ....
  52. doi request reprint Hyperglycemia promotes the perineural invasion in pancreatic cancer
    Junhui Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, China
    Med Hypotheses 71:386-9. 2008
    ..The above two mechanisms can promote the perineural invasion in pancreatic cancer. Controlling hyperglycemia might reduce the perineural invasion in pancreatic cancer...
  53. doi request reprint NS5ATP9 gene regulated by NF-kappaB signal pathway
    Kang Li
    The First Hospital of Xi An Jiaotong University, Xi an, PR China
    Arch Biochem Biophys 479:15-9. 2008
    ..Our results suggest that NF-kappaB could participate in the regulation of NS5ATP9 gene expression in carcinogenesis...
  54. ncbi request reprint Acute pancreatitis: a literature review
    Rajiv K Jha
    Department of Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    Med Sci Monit 15:RA147-56. 2009
    ..Drugs such as resveratrol and rosiglitazone are being investigated as potential candidates for the treatment of AP...
  55. doi request reprint Reversal effect of resveratrol on multidrug resistance in KBv200 cell line
    Fang Quan
    Department of ENT and Head and Neck Surgery, The First Affiliated Hospital, Medical College of Xi an Jiaotong University, No 277 West Yanta Road, Xi an 710061, PR China
    Biomed Pharmacother 62:622-9. 2008
    ..Resveratrol can efficiently reverse multidrug resistance in KBv200 cells. The potential mechanism may be via inhibiting the multidrug-resistant gene expressions and/or promoting cell apoptosis...
  56. doi request reprint Trypsin is the culprit of multiple organ injury with severe acute pancreatitis
    Huanchen Sha
    Department of Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an 710061, China
    Med Hypotheses 72:180-2. 2009
    ..These mysteries can be explained by this hypothesis and might help us to understand more clearly about the mechanism of SAP-associated MODS...
  57. ncbi request reprint Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer
    Chengxue Dang
    Department of Surgical Oncology, First Hospital of Xi an Jiaotong University, Xi an, China
    J Gastroenterol Hepatol 21:850-8. 2006
    ..The aim of the present study was to investigate the prognostic value of the two types of nerve growth factor receptors (NGFR), namely high-affinity receptor TrkA and low-affinity receptor p75NGFR, in pancreatic cancer...
  58. ncbi request reprint Factors influencing the prevalence of gallstones in liver cirrhosis
    Yong Zhang
    Department of Hepatobiliary Surgery, First Hospital of Xi an Jiaotong University, Xi an, China
    J Gastroenterol Hepatol 21:1455-8. 2006
    ..To investigate the prevalence of gallstone disease in Chinese patients with liver cirrhosis and to identify risk factors for cholelithiasis...
  59. ncbi request reprint Optimizing drug delivery for enhancing therapeutic efficacy of recombinant human endostatin in cancer treatment
    Fuguo Xu
    Department of Surgery, First Affiliated Hospital of Xi an Jiaotong University, Xi an 710061, China
    Crit Rev Ther Drug Carrier Syst 24:445-92. 2007
    ..Thus, we suggest that the combination of rhEndostatin with chemotherapy, radiotherapy, and biotherapy (i.e., fusion protein, molecular-targeted therapy on cancers, etc.) might provide an optimal strategy for cancer treatment...