Lang Chong He

Summary

Affiliation: Xi'an Jiaotong University
Country: China

Publications

  1. ncbi Pharmacokinetic behavior and tissue distribution of verapamil and its enantiomers in rats by HPLC
    Langchong He
    College of Pharmacy, Xi an Jiaotong University, Xi an 710061, P R China
    Arch Pharm Res 26:763-7. 2003
  2. ncbi Studies on differences of pharmacokinetic behavior and tissue distribution of nimodipine and its two enantiomers in rats using achiral and chiral liquid chromatography
    Lang Chong He
    College of Pharmacy, Xi an Jiaotong University, Xi an 710061, China
    Yao Xue Xue Bao 38:603-8. 2003
  3. doi A novel taspine derivative, HMQ1611, inhibits breast cancer cell growth via estrogen receptor α and EGF receptor signaling pathways
    YingZhuan Zhan
    School of Medicine, Xi an Jiaotong University, Shaanxi Province, PR China
    Cancer Prev Res (Phila) 5:864-73. 2012
  4. ncbi Facile synthesis and biological evaluation of novel symmetrical biphenyls as antitumor agents
    Jie Zhang
    School of Medicine, Xi an Jiaotong University, No 76, Yanta West Road, Xi an, Shaanxi Province, 710061, P R, China
    Med Chem 8:145-50. 2012
  5. ncbi Recent advances in antiangiogenic agents with VEGFR as target
    J Zhang
    School of Medicine, Xi an Jiaotong University, Xi an, Shaanxi Province, P R China
    Mini Rev Med Chem 11:920-46. 2011
  6. ncbi Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release
    Yong xiao Cao
    Department of Pharmacology, Xi an Jiaotong University School of Medicine, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an, Shaanxi, PR China
    Vascul Pharmacol 45:171-6. 2006
  7. ncbi [Pharmacokinetics and tissue distribution of atractylenolide III in rats]
    Cui qin Li
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Zhong Yao Cai 29:807-9. 2006
  8. doi Role of store-operated calcium entry in imperatorin-induced vasodilatation of rat small mesenteric artery
    Yan Zhang
    School of Medicine, Xi an Jiaotong University, Xi an, PR China
    Eur J Pharmacol 647:126-31. 2010
  9. ncbi [Effect of taspine derivatives on human liver cancer SMMC7721]
    Yan Min Zhang
    School of Medcine, Xi an Jiaotong University, Xi an 710061, China
    Zhong Yao Cai 34:1094-7. 2011
  10. ncbi [Inhibitory effect of taspine on mouse S180 sarcoma and its mechanism]
    Yan Min Zhang
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Zhongguo Zhong Yao Za Zhi 32:953-6. 2007

Collaborators

Detail Information

Publications31

  1. ncbi Pharmacokinetic behavior and tissue distribution of verapamil and its enantiomers in rats by HPLC
    Langchong He
    College of Pharmacy, Xi an Jiaotong University, Xi an 710061, P R China
    Arch Pharm Res 26:763-7. 2003
    ..At 1.3 h after oral administration of racemic verapamil, however, there were no significant differences between enantiomers for the distributions in major tissues such as heart, cerebrum, cerebellum, liver, spleen and kidney...
  2. ncbi Studies on differences of pharmacokinetic behavior and tissue distribution of nimodipine and its two enantiomers in rats using achiral and chiral liquid chromatography
    Lang Chong He
    College of Pharmacy, Xi an Jiaotong University, Xi an 710061, China
    Yao Xue Xue Bao 38:603-8. 2003
    ..To investigate the differences of pharmacokinetic behavior and tissue distribution of nimodipine and its two enantiomers in rats...
  3. doi A novel taspine derivative, HMQ1611, inhibits breast cancer cell growth via estrogen receptor α and EGF receptor signaling pathways
    YingZhuan Zhan
    School of Medicine, Xi an Jiaotong University, Shaanxi Province, PR China
    Cancer Prev Res (Phila) 5:864-73. 2012
    ..These results showed that the novel compound HMQ1611 had anticancer effects, and partially via ERα and/or EGFR signaling pathways, suggesting that HMQ1611 may be a potential novel candidate for human breast cancer intervention...
  4. ncbi Facile synthesis and biological evaluation of novel symmetrical biphenyls as antitumor agents
    Jie Zhang
    School of Medicine, Xi an Jiaotong University, No 76, Yanta West Road, Xi an, Shaanxi Province, 710061, P R, China
    Med Chem 8:145-50. 2012
    ..The highly active compound (2) also exhibited potent growth inhibition against cancer cell lines in vivo. Our findings demonstrated that these symmetrical biphenyl derivatives would be a promising candidate as novel anticancer agents...
  5. ncbi Recent advances in antiangiogenic agents with VEGFR as target
    J Zhang
    School of Medicine, Xi an Jiaotong University, Xi an, Shaanxi Province, P R China
    Mini Rev Med Chem 11:920-46. 2011
    ..We attempt to cover all essential publications on the medicinal chemistry in terms of chemical structure, pharmacological profile and structure-activity relationships...
  6. ncbi Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release
    Yong xiao Cao
    Department of Pharmacology, Xi an Jiaotong University School of Medicine, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an, Shaanxi, PR China
    Vascul Pharmacol 45:171-6. 2006
    ..Our results suggest that ligustilide induces vasodilatation in rat mesenteric artery by inhibiting the VDCC and ROCC, and receptor-mediated Ca(2+) influx and release...
  7. ncbi [Pharmacokinetics and tissue distribution of atractylenolide III in rats]
    Cui qin Li
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Zhong Yao Cai 29:807-9. 2006
    ..corrected] To establish an HPLC method for the analysis of pharmacokinetics and tissue distribution of atractylenolide III in rats...
  8. doi Role of store-operated calcium entry in imperatorin-induced vasodilatation of rat small mesenteric artery
    Yan Zhang
    School of Medicine, Xi an Jiaotong University, Xi an, PR China
    Eur J Pharmacol 647:126-31. 2010
    ..Our results exclude SOCE mechanism of vasodilatation by imperatorin. But imperatorin is partly similar with nifedipine in vasorelaxation effect...
  9. ncbi [Effect of taspine derivatives on human liver cancer SMMC7721]
    Yan Min Zhang
    School of Medcine, Xi an Jiaotong University, Xi an 710061, China
    Zhong Yao Cai 34:1094-7. 2011
    ..To analyse the inhibition effect of taspine derivatives on human Liver cancer SMMC7721 cell and its mechanism...
  10. ncbi [Inhibitory effect of taspine on mouse S180 sarcoma and its mechanism]
    Yan Min Zhang
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Zhongguo Zhong Yao Za Zhi 32:953-6. 2007
    ..To study the inhibition effect of taspine on mouse S180 sarcoma and its mechanism...
  11. ncbi [Study on the extraction of the total alkaloids from Caulopyhllum robustum]
    Yi Ping Li
    Faculty of Pharmacy, School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Zhong Yao Cai 30:220-3. 2007
    ..To study the technological parameters of the extraction process of the total alkaloids from Caulopyhllum robstum...
  12. doi Effects of caulophine on caffeine-induced cellular injury and calcium homeostasis in rat cardiomyocytes
    Kai Wei Si
    Department of Pharmacology, Xi an Jiaotong University School of Medicine, Xi an, China
    Basic Clin Pharmacol Toxicol 107:976-81. 2010
    ..This finding provides a basis for further study and development of caulophine as a new calcium antagonist for treating ischaemic cardiovascular diseases...
  13. ncbi [Study on thaspine in inducing apoptosis of A549 cell]
    Yan Min Zhang
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Zhong Yao Cai 30:429-32. 2007
    ..To investigate the effect of thaspine on the cellular proliferation, apoptosis and cell cycle in A549 cell line...
  14. ncbi Atractylenolide I and atractylenolide III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages
    Cui qin Li
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Phytother Res 21:347-53. 2007
    ..So, atractylenolide I could be a candidate for the development of new drugs to treat inflammatory diseases accompanied by the overproduction of TNF-alpha and NO...
  15. ncbi [Concentration and determination of strychnine alkaloid in biological fluids]
    Jing Zhang
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Fa Yi Xue Za Zhi 21:36-8. 2005
    ..To establish a new method for determination of strychnine alkaloid in biological fluids based on molecularly imprinted polymers...
  16. ncbi Inhibitory effects of ligustilide and butylidenephthalide on bFGF-stimulated proliferation of rat smooth muscle cells
    Ming jin Liang
    Faculty of Pharmacy, School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Yao Xue Xue Bao 41:161-5. 2006
    ..To investigate the bio-affinities of ligustilide and butylidenephthalide to rat aortic smooth muscle cells and the inhibitory effects of them on bFGF-stimulated proliferation of rat vascular smooth muscle cell (VSMC)...
  17. ncbi [Effect of taspine hydrochloride on skin wound healing in rats and its mechanism]
    Ya Lin Dong
    Department of Pharmacy, School of Medicine, Xi an Jiaotong University, Xi an, Shaanxi Province 710061, China
    Zhong Xi Yi Jie He Xue Bao 3:386-90. 2005
    ..To study the effect of taspine hydrochloride (TA/HCl) on skin wound healing in rats and its mechanism...
  18. doi The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice
    Wen Lu
    School of Medicine, Xi an Jiaotong University, No 76 Western Yanta Road, Xi an 710061, PR China
    Int J Biol Macromol 43:320-4. 2008
    ..These results suggested that SLN tended to be preferentially delivered to the liver and Ta-G2SLN may further enhance liver targeting...
  19. ncbi HPLC method for the pharmacokinetics and tissue distribution of taspine solution and taspine liposome after intravenous administrations to mice
    Wen Lu
    School of Medicine, Xi an Jiaotong University, Xi an 710061, PR China
    J Pharm Biomed Anal 46:170-6. 2008
    ..It can thus be concluded that incorporation into liposomes prolonged taspine retention within the systemic circulation, increased its distribution to the spleen and liver but reduced its distribution to the heart and brain...
  20. ncbi [Effects of Bai-Chuan capsule on left ventricular hypertrophy and correlative indexes]
    Yan Zhang
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Zhong Yao Cai 33:1290-2. 2010
    ..To investigate the effects of Bai-Chuan capsule (BC) on the left ventricular hypertrophy in spontaneously hypertensive rats (SHR)...
  21. ncbi [Protecting effect of brevifolin and 8,9-single-epoxy brevifolin of Phyllanthus simplex on rat liver injury]
    Xiao Feng Niu
    Department of Pharmacy, Medical School of Xi an Jiaotong University, Xi an 710061, China
    Zhongguo Zhong Yao Za Zhi 31:1529-32. 2006
    ..To investigate the effect of protecting liver of brevifolin and 8,9-single-epoxy brevifolin of Phyllanthus simplex...
  22. ncbi Evaluation of drug-muscarinic receptor affinities using cell membrane chromatography and radioligand binding assay in guinea pig jejunum membrane
    Bing Xiang Yuan
    Department of Pharmacology Pharmacy College, Xi an Jiaotong University, Xi an 710061, China
    Acta Pharmacol Sin 26:113-6. 2005
    ..To study if cell membrane chromatography (CMC) could reflect drug-receptor interaction and evaluate the affinity and competitive binding to muscarinic acetylcholine receptor (mAChR)...
  23. ncbi [A method for improving the accuracy and sensitivity of cell membrane chromatography]
    Yu Wang
    Xi an Jiaotong University College of Medicine, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2362-6. 2009
    ..To improve the accuracy and sensitivity of cell membrane chromatography (CMC) and evaluate the feasibility of CMC in the study of subtype receptors...
  24. ncbi Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz
    Cui qin Li
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    J Ethnopharmacol 114:212-7. 2007
    ..Atractylenolide I and 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol were the main components of Atractylodes macrocephala that were effective as anti-inflammatory agents...
  25. ncbi Determination of three bile acids in artificial Calculus Bovis and its medicinal preparations by micellar electrokinetic capillary electrophoresis
    Zhen Hu
    School of Medicine, Xi an Jiaotong University, No 205, ZhuQue Street, Xi an, Shannxi 710061, China
    J Chromatogr B Analyt Technol Biomed Life Sci 837:11-7. 2006
    ..S.D.s were less than 5% for the analytes. This method, due to its convenience, high accuracy and good reproducibility can be employed in quality control of artificial Calculus Bovis and its medicinal preparations...
  26. doi Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats
    Yan Jun Cao
    School of Medicine, Xi an Jiaotong University, Xi an 710061, PR China
    Phytomedicine 20:1048-54. 2013
    ..IMP showed antihypertensive and antioxidant effects in the renal injury of renovascular hypertensive rats, suggesting that IMP could be of therapeutic use in preventing renal injury related hypertension. ..
  27. ncbi [Analysis of supercritical fluid extracts of Radix caulophylli with gas chromatography-mass spectrometry]
    Si Cen Wang
    School of Medicine, Xi an Jiaotong University, Xi an 710061, China
    Yao Xue Xue Bao 42:525-8. 2007
    ..23%), 10-undecenal (3.22%), octadecanoic acid (2.25%), and caulophylline (1.76%) etc. The results will provide important foundation for understanding the constituents and further exploitation of Radix caulophylli...
  28. ncbi Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release
    Jian Yu He
    Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, 710061, PR China
    Eur J Pharmacol 573:170-5. 2007
    ..Opening calcium-activated potassium channel and competitive antagonism of 5-HT receptors may also contribute to this vasodilatation effect...
  29. ncbi Synthesis and cytotoxic evaluation of novel symmetrical taspine derivatives as anticancer agents
    Jie Zhang
    College of Medicine, Xi an Jiaotong University, No 76 Yanta West Road, Xi an, Shaanxi, Province 710061, P R China
    Med Chem 7:286-94. 2011
    ..Our findings provide a good starting point for further development of symmetrical biphenyl derivatives as potential novel anticancer agents...
  30. ncbi Screening, analysis and in vitro vasodilatation of effective components from Ligusticum Chuanxiong
    Ming jin Liang
    Department of Pharmacy, School of Medicine, Xi an Jiaotong University, No 76, Yanta Weststreet, 120, Xi an, Shaanxi Province 710061, PR China
    Life Sci 78:128-33. 2005
    ..Ligustilide and butylidenephthalide seem to be the two main effective components of Ligusticum Chuanxiong as a traditional Chinese medicine for treating blood vessel diseases...
  31. ncbi Enhanced transcription of contractile 5-hydroxytryptamine 2A receptors via extracellular signal-regulated kinase 1/2 after organ culture of rat mesenteric artery
    Yong xiao Cao
    Division of Experimental Vascular Research, Department of Medicine, Lund University, Sweden
    Basic Clin Pharmacol Toxicol 96:282-8. 2005
    ..These data reveal a role of ERK1/2 in up-regulation of 5-HT2A receptors and suggest a possibility to inhibit the enhanced responses to 5-HT by inhibition of the ERK1/2 pathway...