Yun Wu Zhang

Summary

Affiliation: Xiamen University
Country: China

Publications

  1. ncbi Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
    Yonghao Zhao
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, People s Republic of China
    Mol Neurodegener 7:30. 2012
  2. ncbi Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
    Yun Wu Zhang
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:10613-8. 2007
  3. ncbi Meeting report: 2009 international conference on molecular neurodegeneration May 18-20, 2009, Xiamen, China
    Yunwu Zhang
    Departments of Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine, St, Louis, Missouri, USA
    Mol Neurodegener 4:43. 2009
  4. ncbi Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
    Yun Wu Zhang
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:17020-6. 2005
  5. ncbi Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation
    Ping Han
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Neurosci 25:11542-52. 2005
  6. ncbi A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation
    Yun Wu Zhang
    Institute for Biomedical Research, Xiamen University, Xiamen, China
    Neuron 64:328-40. 2009
  7. ncbi Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease
    Huaxi Xu
    Center for Neurosciences and Aging, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1089:324-42. 2006
  8. ncbi Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1
    Yun Liu
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 284:12145-52. 2009
  9. ncbi CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-site APP cleaving protein 1 (BACE1)
    Yingjun Zhao
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    J Biol Chem 287:11141-50. 2012
  10. ncbi Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway
    Xiumei Huang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian, China
    Neurobiol Aging 33:1007.e9-17. 2012

Collaborators

Detail Information

Publications16

  1. ncbi Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
    Yonghao Zhao
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, People s Republic of China
    Mol Neurodegener 7:30. 2012
    ....
  2. ncbi Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
    Yun Wu Zhang
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:10613-8. 2007
    ..Our results indicate an important role of PS/gamma-secretase-generated APP metabolite AICD in gene transcription and in EGFR-mediated tumorigenesis...
  3. ncbi Meeting report: 2009 international conference on molecular neurodegeneration May 18-20, 2009, Xiamen, China
    Yunwu Zhang
    Departments of Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine, St, Louis, Missouri, USA
    Mol Neurodegener 4:43. 2009
    ..About 100 investigators presented their recent discoveries with a wide range of scopes of neurodegeneration research, including new genes, molecular pathways, animal models, and potential therapeutics...
  4. ncbi Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
    Yun Wu Zhang
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:17020-6. 2005
    ....
  5. ncbi Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation
    Ping Han
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Neurosci 25:11542-52. 2005
    ..We suggest that CDK5 activation, through a calcium/calpain/p25 pathway, plays a key role in neuronal excitotoxicity and represents an underlying mechanism for the physiological functions of APP...
  6. ncbi A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation
    Yun Wu Zhang
    Institute for Biomedical Research, Xiamen University, Xiamen, China
    Neuron 64:328-40. 2009
    ..Our studies reveal a new target/pathway for regulating AD pathologies and uncover a retrogene and its role in regulating protein kinase pathways...
  7. ncbi Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease
    Huaxi Xu
    Center for Neurosciences and Aging, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1089:324-42. 2006
    ....
  8. ncbi Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1
    Yun Liu
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 284:12145-52. 2009
    ..Our results clearly elucidate a physiological function of APP in regulating protein trafficking and suggest that intracellular trafficking of PS1/gamma-secretase is regulated by multiple factors, including APP and PLD1...
  9. ncbi CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-site APP cleaving protein 1 (BACE1)
    Yingjun Zhao
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    J Biol Chem 287:11141-50. 2012
    ..Our results identify the H component of CUTA as a novel BACE1-interacting protein that mediates the intracellular trafficking of BACE1 and the processing of APP to Aβ...
  10. ncbi Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway
    Xiumei Huang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian, China
    Neurobiol Aging 33:1007.e9-17. 2012
    ..This study also suggests that modulation of Aβ-induced NF-κB activation could be a potential therapeutic strategy for Alzheimer's disease...
  11. ncbi Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis
    Ping Lin
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92037, USA
    J Neurochem 100:1505-14. 2007
    ..Our results suggest a novel function of calnuc in modulating the levels of APP and its proteolytic metabolites, which may further affect the patho/physiological functions of APP including AD pathogenesis...
  12. ncbi Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid
    Xiaoqing You
    Institute for Biomedical Research and School of Life Sciences, Xiamen University, Xiamen, China
    J Neurochem 111:142-9. 2009
    ..Together, these results suggest that RXRalpha can regulate Abeta generation and is also required for (R)-flurbiprofen-mediated Abeta generation...
  13. ncbi M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation
    Shangtong Jiang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, People s Republic of China
    Neurosci Lett 515:125-30. 2012
    ..These findings point to a novel coupling of BACE1 and M1 mAChR in AD and possibly schizophrenia...
  14. ncbi APP processing in Alzheimer's disease
    Yun Wu Zhang
    Institute for Biomedical Research, Xiamen University, 422 SiMingNanLu, Xiamen 361005, Fujian, PR China
    Mol Brain 4:3. 2011
    ..Therefore, understanding the metabolism/processing of APP is crucial for AD therapeutics. Here we review current knowledge of APP processing regulation as well as the patho/physiological functions of APP and its metabolites...
  15. ncbi Proteolytic processing of Alzheimer's β-amyloid precursor protein
    Han Zhang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian, China
    J Neurochem 120:9-21. 2012
    ..In this review, we describe the mechanisms involved in APP metabolism and the likely functions of its various proteolytic products to give a better understanding of the patho/physiological functions of APP...
  16. ncbi Differential regulation of BACE1 expression by oxidative and nitrosative signals
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 6:17. 2011
    ..abstract:..