Yun Wu Zhang

Summary

Affiliation: Xiamen University
Country: China

Publications

  1. doi request reprint Trafficking regulation of proteins in Alzheimer's disease
    Shangtong Jiang
    Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China
    Mol Neurodegener 9:6. 2014
  2. pmc Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
    Yun Wu Zhang
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:10613-8. 2007
  3. pmc Meeting report: 2009 international conference on molecular neurodegeneration May 18-20, 2009, Xiamen, China
    Yunwu Zhang
    Departments of Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine, St, Louis, Missouri, USA
    Mol Neurodegener 4:43. 2009
  4. ncbi request reprint Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia
    Ruishan Wang
    Laboratory of Molecular and Cellular Neuroscience, School of Life Sciences, Xiamen University, Xiamen, China
    FASEB J 20:1275-7. 2006
  5. pmc Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
    Yun Wu Zhang
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:17020-6. 2005
  6. pmc A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation
    Yun Wu Zhang
    Institute for Biomedical Research, Xiamen University, Xiamen, China
    Neuron 64:328-40. 2009
  7. pmc Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid
    Yaomin Chen
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    J Neurosci 32:11390-5. 2012
  8. pmc The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation
    Xiumei Huang
    Institute for Biomedical Research and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Xiamen University, Xiamen 361005, China
    Hum Mol Genet 19:3835-43. 2010
  9. pmc Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration
    Han Zhang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research and Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    J Neurosci 32:15565-76. 2012
  10. ncbi request reprint Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease
    Huaxi Xu
    Center for Neurosciences and Aging, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1089:324-42. 2006

Collaborators

Detail Information

Publications31

  1. doi request reprint Trafficking regulation of proteins in Alzheimer's disease
    Shangtong Jiang
    Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China
    Mol Neurodegener 9:6. 2014
    ..Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD. ..
  2. pmc Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
    Yun Wu Zhang
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:10613-8. 2007
    ..Our results indicate an important role of PS/gamma-secretase-generated APP metabolite AICD in gene transcription and in EGFR-mediated tumorigenesis...
  3. pmc Meeting report: 2009 international conference on molecular neurodegeneration May 18-20, 2009, Xiamen, China
    Yunwu Zhang
    Departments of Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine, St, Louis, Missouri, USA
    Mol Neurodegener 4:43. 2009
    ..About 100 investigators presented their recent discoveries with a wide range of scopes of neurodegeneration research, including new genes, molecular pathways, animal models, and potential therapeutics...
  4. ncbi request reprint Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia
    Ruishan Wang
    Laboratory of Molecular and Cellular Neuroscience, School of Life Sciences, Xiamen University, Xiamen, China
    FASEB J 20:1275-7. 2006
    ....
  5. pmc Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
    Yun Wu Zhang
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:17020-6. 2005
    ....
  6. pmc A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation
    Yun Wu Zhang
    Institute for Biomedical Research, Xiamen University, Xiamen, China
    Neuron 64:328-40. 2009
    ..Our studies reveal a new target/pathway for regulating AD pathologies and uncover a retrogene and its role in regulating protein kinase pathways...
  7. pmc Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid
    Yaomin Chen
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    J Neurosci 32:11390-5. 2012
    ....
  8. pmc The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation
    Xiumei Huang
    Institute for Biomedical Research and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Xiamen University, Xiamen 361005, China
    Hum Mol Genet 19:3835-43. 2010
    ..Together, our results present a new gene family, whose products and associated signaling pathways might prevent mice from developing AD-like pathologies...
  9. pmc Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration
    Han Zhang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research and Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    J Neurosci 32:15565-76. 2012
    ..Our study identifies appoptosin as a crucial player in apoptosis and a novel pro-apoptotic protein involved in neuronal cell death, providing a possible new therapeutic target for neurodegenerative disorders...
  10. ncbi request reprint Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease
    Huaxi Xu
    Center for Neurosciences and Aging, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1089:324-42. 2006
    ....
  11. ncbi request reprint Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation
    Ping Han
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Neurosci 25:11542-52. 2005
    ..We suggest that CDK5 activation, through a calcium/calpain/p25 pathway, plays a key role in neuronal excitotoxicity and represents an underlying mechanism for the physiological functions of APP...
  12. ncbi request reprint Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules
    Xue Zhang
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    FASEB J 20:1272-4. 2006
    ..These findings suggest a link between malfunction of PTEN and tauopathy, and imply PTEN as a therapeutic target for tauopathy...
  13. ncbi request reprint Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis
    Ping Lin
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92037, USA
    J Neurochem 100:1505-14. 2007
    ..Our results suggest a novel function of calnuc in modulating the levels of APP and its proteolytic metabolites, which may further affect the patho/physiological functions of APP including AD pathogenesis...
  14. ncbi request reprint Presenilins regulate the cellular level of the tumor suppressor PTEN
    Han Zhang
    Institute for Biomedical Research and School of Life Sciences, Xiamen University, 361005 Xiamen, China
    Neurobiol Aging 29:653-60. 2008
    ..Our data suggest an important role for PS in signaling pathways involving PI3K/Akt and PTEN that are crucial for physiological functions and the pathogenesis of multiple diseases...
  15. pmc Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway
    Xiumei Huang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian, China
    Neurobiol Aging 33:1007.e9-17. 2012
    ..This study also suggests that modulation of Aβ-induced NF-κB activation could be a potential therapeutic strategy for Alzheimer's disease...
  16. pmc CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-site APP cleaving protein 1 (BACE1)
    Yingjun Zhao
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    J Biol Chem 287:11141-50. 2012
    ..Our results identify the H component of CUTA as a novel BACE1-interacting protein that mediates the intracellular trafficking of BACE1 and the processing of APP to Aβ...
  17. ncbi request reprint Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation
    Xian Zhang
    Institute for Biomedical Research and School of Life Sciences, Xiamen University, Xiamen 361005, China
    J Biol Chem 282:10873-80. 2007
    ..Our results demonstrate an important role for hypoxia/HIF-1alpha in modulating the amyloidogenic processing of APP and provide a molecular mechanism for increased incidence of AD following cerebral ischemic and stroke injuries...
  18. pmc Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
    Yonghao Zhao
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, People s Republic of China
    Mol Neurodegener 7:30. 2012
    ....
  19. pmc Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1
    Yun Liu
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 284:12145-52. 2009
    ..Our results clearly elucidate a physiological function of APP in regulating protein trafficking and suggest that intracellular trafficking of PS1/gamma-secretase is regulated by multiple factors, including APP and PLD1...
  20. ncbi request reprint Alteration of beta-secretase traffic by the receptor tyrosine kinase signaling pathway - a new mechanism for regulating Alzheimer's beta-amyloid production
    Yun Wu Zhang
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Cell Res 17:385-6. 2007
  21. pmc Ferritin light chain interacts with PEN-2 and affects γ-secretase activity
    Xinxin Li
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, People s Republic of China
    Neurosci Lett 548:90-4. 2013
    ....
  22. pmc APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival
    Yun Wu Zhang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research and Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, China Neurodegenerative Disease Research Program, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 8:e80571. 2013
    ..Together, our results suggest that APP mediates endocytosis of NGF receptors through direct interaction, thereby regulating endocytosis of NGF and NGF-induced downstream signaling pathways for neuronal survival and differentiation...
  23. ncbi request reprint Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism
    Yun Wu Zhang
    Institute for Biomedical Research, Xiamen University, China
    Curr Mol Med 7:687-96. 2007
    ....
  24. doi request reprint M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation
    Shangtong Jiang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian 361005, People s Republic of China
    Neurosci Lett 515:125-30. 2012
    ..These findings point to a novel coupling of BACE1 and M1 mAChR in AD and possibly schizophrenia...
  25. doi request reprint Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation
    Liangwu Sun
    Neurodegenerative Disease Research Program, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Mol Brain 6:52. 2013
    ..Patients with PMM2-CDG exhibit a significantly reduced number of cerebellar Purkinje cells and granule cells. The molecular mechanism underlying the specific cerebellar neurodegeneration in PMM2-CDG, however, remains elusive...
  26. pmc Proteolytic processing of Alzheimer's β-amyloid precursor protein
    Han Zhang
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Xiamen, Fujian, China
    J Neurochem 120:9-21. 2012
    ..In this review, we describe the mechanisms involved in APP metabolism and the likely functions of its various proteolytic products to give a better understanding of the patho/physiological functions of APP...
  27. pmc Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid
    Xiaoqing You
    Institute for Biomedical Research and School of Life Sciences, Xiamen University, Xiamen, China
    J Neurochem 111:142-9. 2009
    ..Together, these results suggest that RXRalpha can regulate Abeta generation and is also required for (R)-flurbiprofen-mediated Abeta generation...
  28. doi request reprint Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome
    Xin Wang
    Center for Neuroscience, Aging and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Nat Med 19:473-80. 2013
    ..Upregulating SNX27 in the hippocampus of Down's syndrome mice rescues synaptic and cognitive deficits. Our identification of the role of SNX27 in synaptic function establishes a new molecular mechanism of Down's syndrome pathogenesis...
  29. pmc Differential regulation of BACE1 expression by oxidative and nitrosative signals
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 6:17. 2011
    ..abstract:..
  30. pmc APP processing in Alzheimer's disease
    Yun Wu Zhang
    Institute for Biomedical Research, Xiamen University, 422 SiMingNanLu, Xiamen 361005, Fujian, PR China
    Mol Brain 4:3. 2011
    ..Therefore, understanding the metabolism/processing of APP is crucial for AD therapeutics. Here we review current knowledge of APP processing regulation as well as the patho/physiological functions of APP and its metabolites...
  31. pmc Transcriptional regulation and its misregulation in Alzheimer's disease
    Xiao Fen Chen
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, 361102 Xiamen, Fujian, People s Republic of China
    Mol Brain 6:44. 2013
    ..In this review, we describe the mechanisms of transcriptional regulation for the known AD genes and the misregualtion that leads to AD susceptibility. ..