Yun Wu Zhang


Affiliation: Xiamen University
Country: China


  1. Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, et al. RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits. Biol Psychiatry. 2018;: pubmed publisher
    ..This demonstrates that RPS23RG1-mediated pathways show good therapeutic potential in AD intervention. ..
  2. Hu J, Lin T, Xu J, Ding R, Wang G, Shen R, et al. Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway. Bioorg Med Chem Lett. 2016;26:505-511 pubmed publisher
    ..These results suggest that VTT extracts may be beneficial for AD prevention and treatment. ..
  3. Zhan Y, Zheng H, Wang C, Rong Z, Xiao N, Ma Q, et al. A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease. Neurobiol Aging. 2017;50:168.e1-168.e4 pubmed publisher
    ..Our results identify a novel pathogenic PS1 F388L mutation in a Chinese FAD family. ..
  4. Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, et al. MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy. Mol Neurobiol. 2016;53:1-7 pubmed publisher
  5. Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, et al. Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation. Neurobiol Aging. 2015;36:1310-5 pubmed publisher
    ..Together, our results reveal a reciprocal modulation of copper and CUTA and suggest that both regulate Aβ generation through different mechanisms, although Aβ mutually affects copper and CUTA levels. ..
  6. Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, et al. SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Mol Neurobiol. 2016;53:3690-3701 pubmed publisher
    ..Together, our results suggest that SNX15 regulates the recycling of APP to cell surface and, thus, its processing for Aβ generation. ..
  7. Zhang Y, Wang R, Liu Q, Zhang H, Liao F, Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A. 2007;104:10613-8 pubmed
    ..Our results indicate an important role of PS/gamma-secretase-generated APP metabolite AICD in gene transcription and in EGFR-mediated tumorigenesis. ..
  8. Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, et al. Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. J Cell Sci. 2016;129:994-1002 pubmed publisher
    ..Together, our results demonstrate that appoptosin can interact with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. ..
  9. Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, et al. The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death. Mol Neurobiol. 2017;54:4189-4200 pubmed publisher
    ..Together, our study indicates that TMEM59L is a pro-apoptotic neuronal protein involved in animal behaviors such as anxiety, depression, and memory, and that TMEM59L downregulation protects neurons against oxidative stress. ..

More Information


  1. Wang C, Niu M, Zhou Z, Zheng X, Zhang L, Tian Y, et al. VPS35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiol Aging. 2016;46:22-31 pubmed publisher