Affiliation: Xiamen University
Cao L, Zhou J, Zhang J, Wu S, Yang X, Zhao X, et al
. Cyclin-dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Clin Cancer Res. 2015;21:1419-28 pubmed publisher
..Our results suggest that low CDK5 expression is associated with poor overall survival in patients with gastric cancer, and nuclear accumulation of CDK5 inhibits the proliferation and tumorigenicity of human gastric cancer cells. ..
Chow H, Guo D, Zhou J, Zhang G, Li H, Herrup K, et al
. CDK5 activator protein p25 preferentially binds and activates GSK3Î². Proc Natl Acad Sci U S A. 2014;111:E4887-95 pubmed publisher
..We propose that the effects of p25, although normally attributed to activate CDK5, may be mediated in part by elevated GSK3Î² activity. ..
Zhou J, Li H, Li X, Zhang G, Niu Y, Yuan Z, et al
. The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death. J Neurosci. 2015;35:2624-35 pubmed publisher
Leng L, Zhuang K, Liu Z, Huang C, Gao Y, Chen G, et al
. Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron. 2018;100:551-563.e7 pubmed publisher
..Our results reveal a distinct astroglial role for menin in regulating neuroinflammation in depression, indicating that menin may be an attractive therapeutic target in MDD. ..
Guo D, Xie W, Xiong P, Li H, Wang S, Chen G, et al
. Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. Cell Death Dis. 2018;9:951 pubmed publisher
..Targeting CLIC4 in neurons may therefore provide a therapeutic approach for managing progressive neurodegenerative diseases that arise from neuronal apoptosis. ..
Zhuang K, Huang C, Leng L, Zheng H, Gao Y, Chen G, et al
. Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression. Cell Rep. 2018;24:701-712 pubmed publisher
..These results reveal a critical role for menin in synaptic and cognitive function by modulating the p35-Cdk5 pathway. ..
Zhang J, Li H, Zhou T, Zhou J, Herrup K. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. J Biol Chem. 2012;287:25985-94 pubmed publisher
..The data suggest an unsuspected role for Cdk5 during the progression of a normal cell cycle and offer new pharmaceutical targets for regulating neuronal cell cycling and cell death. ..