Affiliation: Xiamen University
Hu X, Lu X, Liu R, Ai N, Cao Z, Li Y, et al
. Histone cross-talk connects protein phosphatase 1? (PP1?) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression. J Biol Chem. 2014;289:23154-67 pubmed publisher
..Combined with previous studies on the regulation of P-TEFb activation, the intricate signaling network for the tight control of transcription elongation is established. ..
Lu X, Zhu X, Li Y, Liu M, Yu B, Wang Y, et al
. Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II. Nucleic Acids Res. 2016;44:6853-67 pubmed publisher
..Therefore, our studies reveal a co-regulatory mechanism of Brd4 and SEC in modulating the transcriptional pause release by recruiting multiple P-TEFbs via a Mediator- and Paf1c-coordinated recruitment network. ..
Shi S, Liu K, Chen Y, Zhang S, Lin J, Gong C, et al
. Competitive Inhibition of Lysine Acetyltransferase 2B by a Small Motif of the Adenoviral Oncoprotein E1A. J Biol Chem. 2016;291:14363-72 pubmed publisher
Chen R, Liu M, Li H, Xue Y, Ramey W, He N, et al
. PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev. 2008;22:1356-68 pubmed publisher
..Thus, through cooperatively dephosphorylating Cdk9 in response to Ca2+ signaling, PP2B and PP1alpha alter the P-TEFb functional equilibrium through releasing P-TEFb from 7SK snRNP for transcription. ..