Ruichuan Chen

Summary

Affiliation: Xiamen University
Country: China

Publications

  1. Hu X, Lu X, Liu R, Ai N, Cao Z, Li Y, et al. Histone cross-talk connects protein phosphatase 1? (PP1?) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression. J Biol Chem. 2014;289:23154-67 pubmed publisher
    ..Combined with previous studies on the regulation of P-TEFb activation, the intricate signaling network for the tight control of transcription elongation is established. ..
  2. Lu X, Zhu X, Li Y, Liu M, Yu B, Wang Y, et al. Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II. Nucleic Acids Res. 2016;44:6853-67 pubmed publisher
    ..Therefore, our studies reveal a co-regulatory mechanism of Brd4 and SEC in modulating the transcriptional pause release by recruiting multiple P-TEFbs via a Mediator- and Paf1c-coordinated recruitment network. ..
  3. Shi S, Liu K, Chen Y, Zhang S, Lin J, Gong C, et al. Competitive Inhibition of Lysine Acetyltransferase 2B by a Small Motif of the Adenoviral Oncoprotein E1A. J Biol Chem. 2016;291:14363-72 pubmed publisher
  4. Chen R, Liu M, Li H, Xue Y, Ramey W, He N, et al. PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev. 2008;22:1356-68 pubmed publisher
    ..Thus, through cooperatively dephosphorylating Cdk9 in response to Ca2+ signaling, PP2B and PP1alpha alter the P-TEFb functional equilibrium through releasing P-TEFb from 7SK snRNP for transcription. ..