Bing Xia

Summary

Country: China

Publications

  1. pmc CD4⁺T cells: differentiation and functions
    Rishi Vishal Luckheeram
    Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, China
    Clin Dev Immunol 2012:925135. 2012
  2. pmc MICB0106 gene polymorphism is associated with ulcerative colitis in central China
    Yi Li
    Department of Gastroenterology and Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, People s Republic of China
    Int J Colorectal Dis 25:153-9. 2010
  3. pmc Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China
    Min Chen
    INSERM, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Nancy Universite, Nancy Vandoeuvre, France
    BMC Med Genet 9:78. 2008
  4. pmc Association of diminished expression of RASSF1A with promoter methylation in primary gastric cancer from patients of central China
    Mei Ye
    Department of Internal Medicine and Geriatrics, Research Centre of Digestive Diseases, Zhongnan Hospital, Wuhan University, PR China
    BMC Cancer 7:120. 2007
  5. doi Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China
    Yi Jiang
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, Clinical Research Center for Intestinal and Colorectal Diseases of Hubei Province, Wuhan, China
    J Gastroenterol Hepatol 25:1157-61. 2010
  6. ncbi Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice
    Hong Cheng
    Department of Internal Medicine and Geriatrics, Zhongnan Hospital, Research Center of Digestive Diseases, Wuhan University School of Medicine, Wuhan 430071, PR China
    Int Immunopharmacol 7:604-11. 2007
  7. ncbi [An association between MICB 0106 allele and ulcerative colitis in Chinese Han in Hubei province]
    Yi Li
    Research Center of Digestive Diseases, Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 47:213-6. 2008
  8. ncbi [Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis]
    Feng Zhou
    Department of Internal Medicine, Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 45:478-81. 2006
  9. doi Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients
    Jie Zhao
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, Wuhan, China
    J Gastroenterol Hepatol 26:593-8. 2011
  10. pmc High intestinal and systemic levels of interleukin-23/T-helper 17 pathway in Chinese patients with inflammatory bowel disease
    Lu Song
    Department of Gastroenterology Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
    Mediators Inflamm 2013:425915. 2013

Collaborators

Detail Information

Publications65

  1. pmc CD4⁺T cells: differentiation and functions
    Rishi Vishal Luckheeram
    Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, China
    Clin Dev Immunol 2012:925135. 2012
    ..This paper will focus on the cytokine-signaling and the network of transcription factors responsible for the differentiation of naive CD4⁺T cells...
  2. pmc MICB0106 gene polymorphism is associated with ulcerative colitis in central China
    Yi Li
    Department of Gastroenterology and Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, People s Republic of China
    Int J Colorectal Dis 25:153-9. 2010
    ..MICA and MICB gene polymorphisms and expressions are associated with autoimmune diseases but not known in ulcerative colitis (UC)...
  3. pmc Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China
    Min Chen
    INSERM, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Nancy Universite, Nancy Vandoeuvre, France
    BMC Med Genet 9:78. 2008
    ..We evaluated the association of the polymorphisms of MTHFR, MTR, MTRR and TCN2 genes with ulcerative colitis in Central China...
  4. pmc Association of diminished expression of RASSF1A with promoter methylation in primary gastric cancer from patients of central China
    Mei Ye
    Department of Internal Medicine and Geriatrics, Research Centre of Digestive Diseases, Zhongnan Hospital, Wuhan University, PR China
    BMC Cancer 7:120. 2007
    ....
  5. doi Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China
    Yi Jiang
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, Clinical Research Center for Intestinal and Colorectal Diseases of Hubei Province, Wuhan, China
    J Gastroenterol Hepatol 25:1157-61. 2010
    ....
  6. ncbi Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice
    Hong Cheng
    Department of Internal Medicine and Geriatrics, Zhongnan Hospital, Research Center of Digestive Diseases, Wuhan University School of Medicine, Wuhan 430071, PR China
    Int Immunopharmacol 7:604-11. 2007
    ..Our findings suggest that sinomenine attenuates TNBS-induced colitis in mice and the therapeutic mechanism might be related to the reduction of up-regulated colonic TNF-alpha and IFN-gamma production caused by TNBS...
  7. ncbi [An association between MICB 0106 allele and ulcerative colitis in Chinese Han in Hubei province]
    Yi Li
    Research Center of Digestive Diseases, Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 47:213-6. 2008
    ..To investigate the association between the exon 2, 3, 4 of MHC class I chain-related gene-B (MICB) and ulcerative colitis (UC) in Chinese Han...
  8. ncbi [Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis]
    Feng Zhou
    Department of Internal Medicine, Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 45:478-81. 2006
    ..The aim of the present study is to investigate the association between CTLA-4 promoter -1722 (T/C), -1661 (A/G) polymorphisms and ulcerative colitis (UC) in Han Chinese, in Hubei province of central China...
  9. doi Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients
    Jie Zhao
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, Wuhan, China
    J Gastroenterol Hepatol 26:593-8. 2011
    ..The aim of the present study was to evaluate the contribution of the dimorphism (MICA-129 val and met) to the genetic susceptibility and functions of ulcerative colitis (UC) in patients in central China...
  10. pmc High intestinal and systemic levels of interleukin-23/T-helper 17 pathway in Chinese patients with inflammatory bowel disease
    Lu Song
    Department of Gastroenterology Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
    Mediators Inflamm 2013:425915. 2013
    ..Taken together, our results provided evidence that IL-23/Th17 pathway genes may represent important biomarkers of active stage of IBD and serve as novel therapeutic targets for IBD in Chinese population. ..
  11. doi Cytotoxic T lymphocyte antigen-4 promoter -658CT gene polymorphism is associated with ulcerative colitis in Chinese patients
    Yan Luo
    Key Laboratory of Allergy and Immune Related Diseases, School of Medicine, Wuhan University, Wuhan, Hubei Province, People s Republic of China
    Int J Colorectal Dis 24:489-93. 2009
    ..The present study aimed to examine an association between the CTLA-4 gene polymorphisms and ulcerative colitis (UC) in the Han Chinese in central China...
  12. doi Distribution of peroxisome proliferator-activated receptor-gamma polymorphisms in Chinese and Dutch patients with inflammatory bowel disease
    Umid Kumar Shrestha
    Department of Gastroenterology, Wuhan University, Zhongnan Hospital, Wuhan, People s Republic of China
    Inflamm Bowel Dis 16:312-9. 2010
    ..The aims of the present study were to determine the distribution of PPAR-gamma polymorphisms Pro12Ala and C161T and to explore the association between the PPAR-gamma genotypes and phenotypes of IBD patients...
  13. doi Association of cytotoxic T lymphocyte associated antigen-4 gene (rs60872763) polymorphism with Crohn's disease and high levels of serum sCTLA-4 in Crohn's disease
    Zhitao Chen
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, Clinical Research Center for Intestinal and Colorectal Diseases of Hubei Province, Wuhan, China
    J Gastroenterol Hepatol 26:924-30. 2011
    ..Our aim was to evaluate cytotoxic T lymphocyte associated antigen-4 (CTLA-4) gene polymorphisms in Crohn's disease (CD) and explore soluble CTLA-4 (sCTLA-4) levels in serum of CD patients in central China...
  14. ncbi Distribution of signal transducer and activator of transcription 6 gene G2964A polymorphism in Chinese patients with ulcerative colitis
    Jianbo Zhu
    Department of Internal Medicine and Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan, China
    J Gastroenterol Hepatol 21:1854-7. 2006
    ..The aim of the present study was to determine distribution of the STAT6 gene polymorphism in Chinese patients with ulcerative colitis...
  15. ncbi Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients
    Yi Jiang
    Department of Internal Medicine and Geriatrics, Research Center of Digestive Diseases, Zhongnan Hospital, Key Laboratory of Allergy and Immune Related Diseases, Wuhan University School of Medicine, Wuhan, China
    Inflamm Bowel Dis 12:369-73. 2006
    ..The longer alleles of the CTLA-4 gene microsatellite polymorphism were strongly associated with UC in Chinese patients...
  16. ncbi [Association of IL-10 gene polymorphisms with gastroduodenal diseases in Hubei Han population]
    Hui Xiao
    Department of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, 430071 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:423-6. 2009
    ..To study the distribution of IL-10 gene polymorphisms in patients with gastroduodenal diseases in Hubei Han population and their association with helicobacter pylori (Hp) infection...
  17. doi Utility of in vitro interferon-γ release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease
    Yuan Lei
    Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, Hubei Province, China
    J Dig Dis 14:68-75. 2013
    ..To evaluate the diagnostic utility of interferon-γ release assay (T-SPOT.TB) for the differential diagnosis between Crohn's disease (CD) and intestinal tuberculosis (ITB)...
  18. ncbi CTLA-4 gene polymorphisms in Chinese patients with ulcerative colitis
    Wei Hou
    Department of Internal Medicine and Research Center of Digestive Diseases, Wuhan University Zhongnan Hospital, Wuhan, China
    Inflamm Bowel Dis 11:653-6. 2005
    ..The aim of this study was to investigate CTLA-4 gene polymorphisms in patients with UC in a Chinese population with Han nationality...
  19. pmc MHC class I chain-related gene A-A5.1 allele is associated with ulcerative colitis in Chinese population
    Yijuan Ding
    Department of Gastroenterology, Renmin Hospital, Wuhan, Peoples Republic of China
    Clin Exp Immunol 142:193-8. 2005
    ..Therefore, the MICA-A5.1 homozygous genotype and A5.1 allele were closely associated with UC and the MICA-A5.1 allele was positively associated with the female UC patients in Chinese population...
  20. ncbi [Association of cytotoxic T lymphocyte antigen-4 promoter C-658T polymorphism with ulcerative colitis in Chinese]
    Yan Luo
    Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, Hubei, 430071 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:431-4. 2009
    ..To investigate the association of gene polymorphism of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) with ulcerative colitis (UC) in Chinese...
  21. ncbi Association between interleukin-1 gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in a Chinese population
    Chun Li
    Department of Internal Medicine and Geriatrics, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, China
    J Gastroenterol Hepatol 22:234-9. 2007
    ..pylori-induced gastric inflammation. The present study aimed to determine polymorphisms of IL-1B and IL-1 receptor antagonist (IL-1RN) genes and their association with H. pylori infection and gastroduodenal diseases in Chinese patients...
  22. ncbi Retrospective survey of 452 patients with inflammatory bowel disease in Wuhan city, central China
    Li Jiang
    Department of Internal Medicine, Zhongnan Hospital, and Key Laboratory of Allergy and Immune related Diseases, Wuhan City, People s Republic of China
    Inflamm Bowel Dis 12:212-7. 2006
    ....
  23. ncbi [The relationship between major histocompatibility complex class I chain-related antigens A (MICA)-129 gene polymorphism, soluble MICA level and ulcerative colitis]
    Jie Zhao
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 50:311-5. 2011
    ..To investigate the association of the major histocompatibility complex class I chain-related antigens A (MICA)-129 gene polymorphism and soluble MICA (sMICA) levels with ulcerative colitis (UC) in Hubei Han nationality...
  24. ncbi The prevalence and diagnostic value of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease in mainland China
    Feng Zhou
    Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, People s Republic of China
    Clin Chim Acta 411:1461-5. 2010
    ..We determined the prevalence of pANCA and ASCA in the mainland Chinese population and the ability of pANCA and ASCA to discriminate between ulcerative colitis (UC) and Crohn's disease (CD)...
  25. doi Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected]
    Yi Jiang
    Department of Gastroenterology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, People s Republic of China
    Cell Biochem Biophys 62:203-10. 2012
    ..In conclusion, our data highlight a prevention strategy for moderation of HHcy and supplementation with folate and vitamine B(12) in patients with UC from Southeast China...
  26. ncbi [The relationship among IL-10, TNF gene polymorphisms, Helicobacter pylori infection and gastroduodenal diseases in Hubei Han ethnic]
    Hui Xiao
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 48:552-6. 2009
    ..To study the distribution of IL-10 and TNF gene polymorphisms in patients with gastroduodenal diseases in Hubei Han ethnic and their association with Helicobacter pylori (Hp) infection...
  27. ncbi Risk factors for ulcerative colitis in a Chinese population: an age-matched and sex-matched case-control study
    Li Jiang
    Department of Internal Medicine and Geriatrics of Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, PR China
    J Clin Gastroenterol 41:280-4. 2007
    ..We conducted a case-control study to examine associations between previously reported environmental risk factors and development of ulcerative colitis (UC) in Wuhan city, central China...
  28. doi Upregulated mRNA expression of major histocompatibility complex class I chain-related gene A in colon and activated natural killer cells of Chinese patients with ulcerative colitis
    Liu Qing Ge
    Department of Gastroenterology and Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China
    J Dig Dis 12:82-9. 2011
    ....
  29. ncbi Elevated risk of opportunistic viral infection in patients with Crohn's disease during biological therapies: a meta analysis of randomized controlled trials
    Xiaobing Wang
    Department of Gastroenterology Hepatology, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, 430071, People s Republic of China
    Eur J Clin Pharmacol 69:1891-9. 2013
    ..These drugs carry the risk of excessive immunosuppression, indicating possible opportunistic infections including opportunistic viral infections, but no meta analysis has ever focused on this issue...
  30. ncbi Deletion of N-glycosylation sites of hepatitis C virus envelope protein E1 enhances specific cellular and humoral immune responses
    Min Liu
    Department of Immunology, State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Medicine, Wuhan 430071, China
    Vaccine 25:6572-80. 2007
    ....
  31. doi First prospective, population-based inflammatory bowel disease incidence study in mainland of China: the emergence of "western" disease
    Jie Zhao
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China
    Inflamm Bowel Dis 19:1839-45. 2013
    ..However, its true incidence is unknown. The incidence of IBD in Wuhan, a major city in central China, was investigated using population-based methods...
  32. pmc The prevalence and risk factors of cytomegalovirus infection in inflammatory bowel disease in Wuhan, Central China
    Fengming Yi
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University School of Medicine, Donghu Road 169, Wuhan 430071, PR of China
    Virol J 10:43. 2013
    ..The etiologic link between IBD and CMV infection needs to be studied. The objective of the present study is to investigate the prevalence and risk factors of CMV in a cohort of IBD patients from Central China...
  33. doi [CTLA-4 gene polymorphism regulates CTLA-4 mRNA stability and protein level in patients with ulcerative colitis]
    Zhi tao Chen
    Department of Gastroenterology, Wuhan University Zhongnan Hospital Clinical Research Center for Intestinal and Colorectal Diseases of Hubei Province and Key Laboratory of Allergy and Immune related Diseases, Wuhan, Hubei, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:603-9. 2010
    ....
  34. pmc Effects of sinomenine on the expression of microRNA-155 in 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice
    Qiao Yu
    Department of Gastroenterology Hepatology, Zhongnan Hospital of Wuhan University School of Medicine, Wuhan, P R of China The Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, P R of China
    PLoS ONE 8:e73757. 2013
    ..MicroRNAs (miRNAs) are gradually being recognized as critical mediators of disease pathogenesis via coordinated regulation of molecular effector pathways...
  35. ncbi The utility of platelet, mean platelet volume, and red cell distribution width in the diagnosis of active Crohn's disease and intestinal tuberculosis
    Sha Huang
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University School of Medicine, Wuhan, China
    Saudi Med J 34:1161-6. 2013
    ..To evaluate the diagnostic utility of platelet count (PLT), mean platelet volume (MPV), and red cell distribution width (RDW) in patients with active Crohn's disease (CD) and intestinal tuberculosis (ITB)...
  36. pmc CCL25/CCR9 Interactions Regulate the Function of iNKT Cells in Oxazolone-Induced Colitis in Mice
    Siying Zhu
    Department of Gastroenterology Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P R China The Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, Hubei, P R China
    PLoS ONE 9:e100167. 2014
    ..The interaction of chemokine ligand 25 (CCL25) with chemokine receptor 9 (CCR9) is involved in gut-specific migration of leukocytes and induces regulatory T cells (Tregs) to migrate to the intestine in chronic ileitis...
  37. doi The trend in newly diagnosed Crohn's disease and extraintestinal manifestations of Crohn's disease in central China: a retrospective study of a single center
    Fengming Yi
    Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, People s Republic of China
    Eur J Gastroenterol Hepatol 24:1424-9. 2012
    ..Data on extraintestinal manifestations (EIMs) in CD are rare, especially in Asians. We aimed to evaluate the trend of newly diagnosed CD and the prevalence and risk factors of EIMs in a clinical center in central China...
  38. pmc Increased proportions of bifidobacterium and the lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease
    Wei Wang
    Department of Gastroenterology Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, People s Republic of China
    J Clin Microbiol 52:398-406. 2014
    ..Butyrate-producing bacteria might be important to gut homeostasis. ..
  39. doi Effect of cytotoxic T lymphocyte-associated molecule 4 1661 gene polymorphism on its expression and transcription in ulcerative colitis
    Ting Jiang
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China
    J Dig Dis 11:369-75. 2010
    ..Our aim was to investigate the expression of cytotoxic T lymphocyte-associated molecule 4 (CTLA-4) in ulcerative colitis (UC) and to evaluate the effect of CTLA-4 gene -1661A/G polymorphism on CTLA-4 expression and transcription...
  40. pmc Exome Sequencing Identifies DLG1 as a Novel Gene for Potential Susceptibility to Crohn's Disease in a Chinese Family Study
    Shufang Xu
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University School of Medicine, Wuhan, People s Republic of China
    PLoS ONE 9:e99807. 2014
    ..The aim of this study, which focuses on a Han Chinese CD family, is to identify high-risk variants and potentially novel loci using whole exome sequencing technique...
  41. ncbi Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis
    Zhitao Chen
    Department of Gastroenterology and Central Laboratory, The Central Hospital of Wuhan, Sheng Li Street 26, Wuhan, 430014, Hubei Province, People s Republic of China
    Int J Colorectal Dis 28:1351-8. 2013
    ..Our aims were to evaluate protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms in ulcerative colitis (UC) and explore PTPN22 mRNA levels in colonic biopsies of UC patients in central China...
  42. doi Increased proportions of bifidobacterium and the lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease
    Wei Wang
    Department of Gastroenterology Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, People s Republic of China
    J Clin Microbiol 52:398-406. 2014
    ..Butyrate-producing bacteria might be important to gut homeostasis. ..
  43. doi Effects of recombinant human intestinal trefoil factor on trinitrobenzene sulphonic acid induced colitis in rats
    Jin Li
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Hubei provincial center of clinical study for intestinal and colonrectal disease, Donghu Road 169, Wuhan 430071, Hubei Province, People s Republic of China
    Mol Biol Rep 38:4787-92. 2011
    ..It was possibly related to suppression of neutrophil infiltration, down-regulation expression of NF-κB and up-regulation expression of EGF...
  44. ncbi Association of Fas-670 gene polymorphism with inflammatory bowel disease in Chinese patients
    Bing Xia
    Department of Internal Medicine, Zhongnan Hospital, Medical School of Wuhan University, Wuhan 430071, Hubei Province, China
    World J Gastroenterol 11:415-7. 2005
    ..The aim of this study was to determine whether the Fas gene promoter polymorphism at position-670 was associated with IBD in Chinese patients...
  45. ncbi Meta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis
    Fengming Yi
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University School of Medicine, China
    Intern Med 51:523-30. 2012
    ..In addition, enteral nutrition treatment methods have developed; early enteral nutrition has already been highlighted for severe acute pancreatitis, but the therapeutic risks versus benefits need to be studied...
  46. doi Epigenetic regulation of death-associated protein kinase expression in primary gastric cancers from Chinese patients
    Mei Ye
    Department of Gastroenterology, Hubei Clinical Centre and Key Laboratory of Intestinal and Colorectal Diseases, Zhongnan Hospital of Wuhan University School of Medicine, Wuhan, Hubei Province, People s Republic of China
    Eur J Cancer Prev 21:241-6. 2012
    ..04). DAPK protein and mRNA expression was reduced in GC tissues of Chinese patients. Diminished expression of DAPK was associated with promoter methylation...
  47. pmc Prevalence and risk factors of fatty liver disease in the Shuiguohu district of Wuhan city, central China
    Zhongli Wang
    Department of Internal Medicine and Geriatrics, Wuhan University School of Medicine, Zhongnan Hospital, Wuhan, PR China
    Postgrad Med J 83:192-5. 2007
    ..Fatty liver disease (FLD) is highly prevalent in Western countries, but recent data have shown that FLD is also emerging in China...
  48. ncbi Defects of FA/BRCA pathway in lymphoma cell lines
    Hui Xiao
    Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People s Republic of China
    Int J Hematol 88:543-50. 2008
    ..In conclusion, this mutation maybe the reason which caused FANCN protein expression absent or made the protein very unstable and lose its function in HT and JEKO-1 cell lines...
  49. ncbi Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice
    Hong Cheng
    Department of Internal Medicine and Geriatrics, Zhongnan Hospital, Research Center of Digestive Diseases, Wuhan University School of Medicine, Wuhan 430071, PR China
    Pharmacol Res 53:202-8. 2006
    ..Our findings suggest that matrine improves TNBS-induced colitis in mice and the therapeutic mechanism might be related to the reduction of up-regulated colonic TNF-alpha production caused by TNBS...
  50. pmc Multicenter case-control study of the risk factors for ulcerative colitis in China
    Yu Fang Wang
    Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 19:1827-33. 2013
    ..To evaluate potential risk factors in the development of ulcerative colitis (UC) in China...
  51. ncbi [The influence of promoter methylation of RASSF1A on RASSF1A mRNA and protein expression in gastric cancer tissues]
    Mei Ye
    Department of Internal Medicine and Geriatrics, Zhongnan Hospital, China
    Zhonghua Nei Ke Za Zhi 45:1008-12. 2006
    ..To investigate RASSF1A expression in tissue of primary gastric cancer (GC) at mRNA and protein levels and analyze the relationship between DNA methylation status and RASSF1A expression in GC...
  52. ncbi Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients
    Qiusha Guo
    Department of Internal Medicine, Research Center of Digestive Diseases, Wuhan University Zhongnan Hospital, Wuhan, China
    J Gastroenterol Hepatol 21:92-7. 2006
    ..Toll-like receptor 4 and CD14 are components of the lipopolysaccharide receptor complex. Our study aimed to investigate an association between TLR4 Asp299Gly and CD14-260 polymorphisms in Chinese patients with colorectal cancer...
  53. doi Herpes zoster in Crohn's disease during treatment with infliximab
    Xiaobing Wang
    aDepartment of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine bThe Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, People s Republic of China
    Eur J Gastroenterol Hepatol 26:237-9. 2014
    ..We hope to increase the gastroenterologists' awareness of this potential infection in CD patients during treatment with infliximab. ..
  54. doi Total glucosides of peony attenuates 2,4,6-trinitrobenzene sulfonic acid/ethanol-induced colitis in rats through adjustment of TH1/TH2 cytokines polarization
    Yabing Zhang
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University School of Medicine, Donghu Road 169, Wuhan, 430071, Hubei, People s Republic of China
    Cell Biochem Biophys 68:83-95. 2014
    ....
  55. pmc Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in Salmonella enterica Serovar Typhi elicits full immune response by intranasal vaccination
    Fengling Luo
    Department of Immunology, Hubei Province Key Laboratory of Allergy and Immune related Diseases, The State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan 430071, People s Republic of China
    Clin Vaccine Immunol 14:990-7. 2007
    ..Our work also indicates that the type IVB pilus operon promoter controlling foreign gene expression in Salmonella can elicit full immune responses by intranasal vaccination...
  56. ncbi Interleukin-18 and -12 synergistically enhance cytotoxic functions of tumor-infiltrating lymphocytes
    Zhi Fen Chen
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
    Chin Med J (Engl) 125:4245-8. 2012
    ..This study aimed to investigate the effects of interleukin (IL)-18 and -12 on cytotoxic functions of TILs...
  57. ncbi Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population
    Bao ying Fei
    Department of Gastroenterology, Zhejiang Provincial People s Hospital, Hanzhou 310014, Zhejiang Province, China
    World J Gastroenterol 10:1256-61. 2004
    ..To investigate the association of TNF polymorphisms with chronic atrophic gastritis (CAG) and gastric adenocarcinoma in Chinese Han patients...
  58. ncbi [Probiotic therapy using live combined bifidobacterium, lactobacillus and enterococcus for experimental colitis in rats model]
    Yue meng Wan
    Department of Gastroenterology, Zhongnan Hospital, Medical School of Wuhan University, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 49:418-21. 2010
    ..To evaluate the effect of live combined bifidobacterium, lactobacillus and enterococcus capsules for colitis in rats induced by trinitrobenzenesulfonic acid (TNBS), so as to explore a new therapy for inflammatory bowel diseases (IBD)...
  59. ncbi [Association between the cytotoxic T lymphocyte antigen-4 gene microsatellite polymorphism and inflammatory bowel diseases in the Chinese]
    Yi Jiang
    Department of Internal Medicine, Wuhan University Zhongnan Hospital, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 43:191-4. 2004
    ..Polymorphisms in the CTLA-4 gene are known to be associated with several autoimmune diseases, but no studies related to IBD. The aim of the study is to investigate an association between CTLA-4 gene microsatellite polymorphisms and IBD...
  60. ncbi Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation
    Hua Zhang
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China
    J BUON 19:372-6. 2014
    ..Conclusions: Madecassic acid inhibits in vivo CT26 cell-induced tumor growth by facilitating cell apoptosis and increasing immune defense mechanisms. ..
  61. ncbi [Serum screening of celiac disease in Chinese adults with diarrhea-predominant irritable bowel syndrome in Hubei, China]
    Hong Ling Wang
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University School of Medicine, Wuhan, China
    Zhonghua Nei Ke Za Zhi 52:38-41. 2013
    ..To screen the prevalence of celiac disease with serologic markers in the central Chinese population, specifically in patients with chronic diarrhea-predominant irritable bowel syndrome (D-IBS)...
  62. ncbi [The relationship of methylenetetrahydrofolate reductase G1793A gene polymorphism, hyperhomocysteinaemia and ulcerative colitis]
    Yi Jiang
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, Wuhan 430071, China
    Zhonghua Nei Ke Za Zhi 49:675-9. 2010
    ....
  63. ncbi NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Han nationality
    Qiu sha Guo
    Department of Internal Medicine, Zhongnan Hospital, Medical School of Wuhan University, Wuhan 430071, Hubei Province, China
    World J Gastroenterol 10:1069-71. 2004
    ..The present study aimed to genotype NOD2/CARD15 gene 3020insC frameshift mutation in Chinese patients with inflammatory bowel disease...
  64. doi Impact of ethnicity, geography, and disease on the microbiota in health and inflammatory bowel disease
    Lani Prideaux
    1Department of Gastroenterology, St Vincent s Hospital Melbourne, Australia 2Department of Medicine, The University of Melbourne, Parkville, Australia 3Preventative Health National Research Flagship Program, Commonwealth Scientific and Industrial Research Organisation CSIRO, Australia 4Enteric Virus Group, Murdoch Childrens Research Institute, Parkville, Australia 5Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China 6Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, China 7Department of Gastroenterology, Box Hill Hospital, Melbourne, Australia 8Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China 9The Ohio State University, Columbus, Ohio 10Department of Microbiology, La Trobe University, Bundoora, Australia and 11Department of Immunology, Imperial College, London, United Kingdom
    Inflamm Bowel Dis 19:2906-18. 2013
    ..The gut microbiota is central to health and disorders such as inflammatory bowel disease. Differences in microbiota related to geography and ethnicity may hold the key to recent changes in the incidence of microbiota-related disorders...
  65. doi Unsedated versus sedated gastrointestinal endoscopy: a questionnaire investigation in Wuhan, central China
    Hong Ling Wang
    Department of Gastroenterology, the Research Center for Clinical Study of Intestinal and Colorectal Diseases of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China
    J Huazhong Univ Sci Technolog Med Sci 33:857-61. 2013
    ..With the rapid improvement of people's living standard and the reliability of sedation technology, we expect sedated GI endoscopy will be gradually accepted by more patients. ..