Zhiwei Wang


Affiliation: Wuhan University
Country: China


  1. Li B, Wang Z, Chen R, Hong J, Wu Q, Hu J, et al. Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways. Life Sci. 2019;224:51-57 pubmed publisher
    ..Conclusively, upregulation of Iars regulates the phenotypic switching and apoptosis of VSMCs. Targeting Iars may be a promising strategy to prevent abdominal aortic aneurysm. ..
  2. Hong J, Hu Z, Wu Q, Tang C, Hu J, Chen R, et al. The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration. Biosci Rep. 2019;39: pubmed publisher
    ..b>Conclusions: STIM1 is indispensable in ASMCs. Interfering with STIM1 exaggerated the AMD process by modulating the expression of contractile proteins, inducing ER stress in ASMCs. ..
  3. Jiang W, Hu X, Hu Z, Tang Z, Wu H, Chen L, et al. Morbidity and Mortality of Nosocomial Infection after Cardiovascular Surgery: A Report of 1606 Cases. Curr Med Sci. 2018;38:329-335 pubmed publisher
    ..08, 95% CI=1.79-9.29). Greater attention should be paid toward compliance with ventilator and catheter regulations in order to decrease NI morbidity and mortality following cardiovascular procedures. ..
  4. Li L, Wang Z, Xu P, Ruan Y, Jiang W, Wu Z. Cardiac Mass, Aortic Intramural Hematoma, and IgG4-related Disease: A Case Report. Ann Vasc Surg. 2016;35:208.e5-8 pubmed publisher
    ..Corticosteroids were administered postoperatively. This case shows that the heart itself can also be a potential site for IgG4-related disease. ..
  5. Li L, Wang Z, Hu X, Wan T, Wu H, Jiang W, et al. Human aortic smooth muscle cell-derived exosomal miR-221/222 inhibits autophagy via a PTEN/Akt signaling pathway in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2016;479:343-350 pubmed publisher
    ..This phenomenon can be reversed by the transfection of miR-221/222 inhibitors. These data suggested that miR-221/222 from HAoSMC-derived exosomes inhibited autophagy in HUVECs by modulating PTEN/Akt signaling pathway. ..
  6. Li B, Hu X, Wang Z. The neurologic protection of unilateral versus bilateral antegrade cerebral perfusion in aortic arch surgery with deep hypothermic circulatory arrest: A study of 77 cases. Int J Surg. 2017;40:8-13 pubmed publisher
    ..Due to the high variations in circle of Willis as well as increased safety, simplicity, and efficiency, the bilateral ACP approach is preferred over the unilateral technique. ..
  7. Huang J, Wang Z, Hu Z, Jiang W, Li B. Association between blood vitamin D and myocardial infarction: A meta-analysis including observational studies. Clin Chim Acta. 2017;471:270-275 pubmed publisher
    ..Present study suggested that the levels of blood 25(OH)D were significant lower in MI patients, especially in America and Asia, and sufficient blood vitamin D levels might protect against the occurrence of MI. ..
  8. Hu R, Wang Z, Ren Z, Liu M. Autonomic remodeling may be responsible for decreased incidence of aortic dissection in STZ-induced diabetic rats via down-regulation of matrix metalloprotease 2. BMC Cardiovasc Disord. 2016;16:200 pubmed
    ..001). STZ-induced diabetic rats have a lower incidence of AD after URAS and BAPN treatment, this protective effect could be possibly attributed to autonomic innervation modification and possible related down-regulation of MMP2. ..
  9. Li B, Wang Z, Hu Z, Zhang M, Ren Z, Zhou Z, et al. P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. Ann Vasc Surg. 2017;40:262-273 pubmed publisher
    ..Ang II could regulate the expression of miR143/145 gene cluster and the phenotypic switching of VSMCs via the p38 MAPK signaling pathway. This may play an important role in the pathogenesis of AD. ..

More Information


  1. Liu H, Wang Z, Xia J, Hu R, Wu Z, Hu X, et al. Evaluation of Different Minimally Invasive Techniques in Surgical Treatment for Ventricular Septal Defect. Heart Lung Circ. 2018;27:365-370 pubmed publisher
    ..001). Both the LMS and RLT approach can be performed with favourable cosmetic and acceptable clinical results for closing VSD. They are the promising alternatives to standard median sternotomy and merit further study. ..