Affiliation: Wuhan University
Wang Z, Hu Y, Xiao D, Wang J, Liu C, Xu Y, et al
. Stabilization of Notch1 by the Hsp90 Chaperone Is Crucial for T-Cell Leukemogenesis. Clin Cancer Res. 2017;23:3834-3846 pubmed publisher
..i>Clin Cancer Res; 23(14); 3834-46. ©2017 AACR. ..
Xiao D, Yue M, Su H, Ren P, Jiang J, Li F, et al
. Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival. Mol Cell. 2016;64:493-506 pubmed publisher
..These findings reveal a PLK1-Fbw7-Myc signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 antagonists, as potential effective therapeutics for MYC-overexpressing cancers. ..
Yue M, Jiang J, Gao P, Liu H, Qing G. Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis. Cell Rep. 2017;21:3819-3832 pubmed publisher
..These findings thus reveal a MYC-SLC7A5/SLC43A1 signaling circuit that underlies EAA metabolism, MYC deregulation, and tumorigenesis. ..