Research Topics
Genomes and Genes | Yan WuSummaryCountry: China Publications
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Publications
Botulinum toxin type A for the treatment of glabellar lines in Chinese: a double-blind, randomized, placebo-controlled studyYan Wu
Department of Dermatology, Peking University First Hospital, Beijing, China
Dermatol Surg 36:102-8. 2010..This is the first well-controlled study of the use of botulinum toxin type A (BoNTA) for glabellar lines in China...- Efficient delivery of antitumor drug to the nuclei of tumor cells by amphiphilic biodegradable poly(L-aspartic acid-co-lactic acid)/DPPE co-polymer nanoparticlesSiyuan Han
CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Small 8:1596-606. 2012..These results demonstrate the feasibility of the application of the amphiphilic polyaspartic acid derivative, poly(AA-co-LA)/DPPE, as a nanocarrier for cell nuclear delivery of potent antitumor drugs... 
Split-face study of topical 23.8% L-ascorbic acid serum in treating photo-aged skinTian Hua Xu
Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, China
J Drugs Dermatol 11:51-6. 2012..L-ascorbic acid has been widely used to treat photo-aged skin. However, its aqueous formula is prone to oxidation. Therefore, a new formula that contains 23.8% L-ascorbic acid and a chemical penetration enhancer was developed...- Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticlesQing Xu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Biomaterials 33:1627-39. 2012..Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy... - Inhibition of invasion and up-regulation of E-cadherin expression in human malignant melanoma cell line A375 by (-)-epigallocatechin-3-gallateYan Wu
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
J Huazhong Univ Sci Technolog Med Sci 28:356-9. 2008..It was suggested that EGCG strongly inhibited invasion of A375 cells, and the inhibition mechanism was possibly associated with the up-regulation of E-cadherin expression... - Sustained release of insulin through skin by intradermal microdelivery systemYan Wu
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China
Biomed Microdevices 12:665-71. 2010..The extent of blood glucose lowering was in proportion to the area of microneedle treatment... - Split-face comparison of ultrapulse-mode and superpulse-mode fractionated carbon dioxide lasers on photoaged skinYao Jia Luo
Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, Liaoning, China
J Drugs Dermatol 11:1310-4. 2012..Both ultrapulse-mode and superpulse-mode fractional CO2 lasers (UPCO2 and SPCO2) could be successfully used in treating photoaged skin... - Immunohistological evaluation of skin responses after treatment using a fractional ultrapulse carbon dioxide laser on back skinXue Gang Xu
Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, China
Dermatol Surg 37:1141-9. 2011..Although plenty of clinical data have demonstrated the efficacy of the FP laser, only limited histologic studies have been available to observe serial short- to long-term skin responses... - [Expression of neutral endopeptidase and motility-related protein-1 in cutaneous malignant melanoma]Yan Wu
Department of Dermatology, The Affiliated Xiehe Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Bing Li Xue Za Zhi 36:466-9. 2007..To study the expression of neutral endopeptidase (CD10) and motility-related protein-1 (CD9) in malignant melanoma and their clinical significance... - The expression of interleukin-22 and S100A7, A8, A9 mRNA in patients with psoriasis vulgarisHoujun Liu
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Huazhong Univ Sci Technolog Med Sci 27:605-7. 2007..543, r (2)=0.774, r(3)=0.621, P<0.01). It was concluded that IL-22 and S100A7, A8, A9 might play important roles in the occurrence and progression of psoriasis... - Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes managementGuangjiong Qin
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, Peoples Republic of China
Nanomedicine 8:221-7. 2012..This new method is has the potentials to replace insulin pumps by offering a cost effective alternative with less inconvenience and improved compliance... - A Chinese experience of fractional ultrapulsed CO₂laser for skin rejuvenationYuan Hong Li
Department of Dermatology, The First Hospital of China Medical University, Shenyang, China
J Cosmet Laser Ther 12:250-5. 2010..However, its application in Asian skin has not been widely reported. The purpose of this study is to observe the efficacy and safety of the protocol 'ActiveFX' for photodamaged facial skin in Chinese patients... - Immunolocalization of NR1, NR2A, and PSD-95 in rat hippocampal subregions during postnatal developmentWei Ling
Department of Anatomy, Capital Medical University, Beijing, China
Acta Histochem 114:285-95. 2012..Discovering the alteration of the relationship between PSD-95 and NMDAR subunits expression may be helpful for understanding mechanisms and therapy of neurodegenerative diseases... - A Pilot Study of Intense Pulsed Light in the Treatment of Riehl's MelanosisYuan Hong Li
Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, China Sheftel Associates Dermatology, Tucson, Arizona Department of Dermatology, General Hospital of the Air Force, Beijing, China Department of Dermatology, Mount Sinai Medical Center, New York, New York
Dermatol Surg 37:119-22. 2011..The authors have indicated no significant interest with commercial supporters... - Expression of apoptosis related protein in skin lesions of lichen planus and its implicationXu e Chen
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
J Huazhong Univ Sci Technolog Med Sci 28:349-51. 2008..05). Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus... - Treatment of infraorbital dark circles using a low-fluence Q-switched 1,064-nm laserTian Hua Xu
Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, China
Dermatol Surg 37:797-803. 2011..To evaluate the efficacy and safety of the low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminium garnet (QSNY) laser in treating infraorbital dark circles... 
Molecular and microscopic analysis of bacteria and viruses in exhaled breath collected using a simple impaction and condensing methodZhenqiang Xu
State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, China
PLoS ONE 7:e41137. 2012..Nonetheless, the reported work is a proof-of-concept demonstration, and its performance in non-invasive disease diagnosis such as bacterimia and virus infections needs to be further validated including effects of its influencing matrix...- Expression of phosphorylated-STAT3 and osteopontin and their correlation in melanomaYan Wu
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
J Huazhong Univ Sci Technolog Med Sci 29:246-50. 2009..It is concluded that p-STAT3 and osteopontin may play important roles in the pathogenesis of malignant melanoma... - Local expression of vaginal Th1 and Th2 cytokines in murine vaginal candidiasis under different immunity conditionsShanjuan Chen
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
J Huazhong Univ Sci Technolog Med Sci 28:476-9. 2008..albicans), and its expression suppressed leading to decreased clearance of mucosal C. albican in immuno-suppression. The over-expression of IL-4 and IL-10 could significantly enhance the susceptibility to C. albicans infection in mice... - Olmsted syndrome: a case report and review of literatureJuan Tao
Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Int J Dermatol 47:432-7. 2008..We review the literature and present a summary of all reported cases to date... - Inhibitory effect of live-attenuated Listeria monocytogenes-based vaccines expressing MIA gene on malignant melanomaYue Qian
Department of Dermatology, Huazhong University of Science and Technology, Wuhan 430022, China
J Huazhong Univ Sci Technolog Med Sci 32:591-7. 2012..This study implicates attenuated LM may be a safer and more effective vector for immunotherapy of melanoma... - EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translationYing Yang
Key Laboratory of Neurological Disease, Ministry of Education, China, and Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Neuron 73:774-88. 2012..Thus, EPAC proteins control miR-124 transcription in the brain for processing spatial learning and social interactions... - Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agentsQinghua Miao
National Center for Nanoscience and Technology of China, Beijing, China
Biomaterials 31:7364-75. 2010..These results demonstrate a feasible application of the amphiphilic hyper-branched co-polymer, HPAE-co-PLA, as nanocarriers for intracellular delivery of potent anti-tumor agents... - Expression of MMP-9 and TIMP-1 in lesions of systemic sclerosis and its implicationsChi Meng
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science Technology, Wuhan 430022, China
J Huazhong Univ Sci Technolog Med Sci 28:480-2. 2008..05). It was suggested that the expression of MMP-9 and TIMP-1 might play an important role in the development of systemic sclerosis... - Histochemical mapping of hnRNP A2/B1 in rat brain after ischemia-reperfusion insultsYichen Liu
Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing, China
J Histochem Cytochem 58:695-705. 2010.... - Childhood psoriasis: a study of 137 cases from central ChinaYan Wu
Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
World J Pediatr 6:260-4. 2010..This study was undertaken to evaluate the epidemiological and clinical findings in children with psoriasis treated in a 9-year period and to compare the data with those from other studies... - [Clinicopathologic study of 8 cases of poorly differentiated cutaneous angiosarcoma of scalp]Si Yuan Chen
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Bing Li Xue Za Zhi 37:313-5. 2008..To study the clinical and pathologic characteristics of poorly differentiated cutaneous angiosarcoma of scalp... - Depigmentation of melanocytes by the treatment of extracts from traditional Chinese herbs: a cell culture assayShaomin Zhong
Department of Dermatology, Peking University First Hospital, Beijing, China
Biol Pharm Bull 29:1947-51. 2006..Among them, water extract of Galla Chinensis and ethanol extract of Radix Clematidis exhibited higher depigmentation activity and caused lower tyrosinase activity in cell culture assays and are worthy to be further studied... - Expression and functional roles of Smad1 and BMPR-IB in glioma developmentShuang Liu
Department of Brain Protection and Plasticity Research, Beijing Institute of Basic Medical Sciences, Beijing, China
Cancer Invest 27:734-40. 2009..The effects could be blocked by cotransfection of Smad6. These results might provide new molecular marker and target for glioma diagnosis and therapy... - Two new compounds from the dried tender stems of Cinnamomum cassiaChao Liu
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
J Asian Nat Prod Res 11:845-9. 2009..7 microM. Compounds 3-8 were isolated from the title plant for the first time... - Expression of IRF-4 and IBP in skin lesions of patients with psoriasis vulgarisAnhong Ni
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
J Huazhong Univ Sci Technolog Med Sci 32:287-90. 2012..05). Both IRF-4 and IBP might be involved in the pathogenesis of psoriasis vulgaris... - Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapyYan Wu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Nanomedicine 7:945-54. 2011..FROM THE CLINICAL EDITOR: In this paper, the development of novel amphiphilic copolymer nanoparticles is discussed with the goal of establishing high encapsulation efficiency for chemotherapy drugs... - A novel chitosan-poly(lactide) copolymer and its submicron particles as imidacloprid carriersMin Li
Key Laboratory of Pesticide Chemistry and Application, MOA, Institute of Plant Protection, CAAS, Beijing, China
Pest Manag Sci 67:831-6. 2011..These copolymeric submicron particle systems are expected to be potential candidates for applications in pesticide delivery... - Epirubicin-encapsulated long-circulating thermosensitive liposome improves pharmacokinetics and antitumor therapeutic efficacy in animalsYan Wu
Department of Pharmacy, General Hospital of the Air Force, Beijing, China
J Liposome Res 21:221-8. 2011..The mean tumor inhibitory rate for EPI-LTSL, EPI-NTSL, and EPI-solution were 61.1, 39.6, and 43.1%, respectively... - A novel homozygous point mutation in the COL17A1 gene in a Chinese family with generalized atrophic benign epidermolysis bullosaYan Wu
Department of Dermatology, Peking University First Hospital, Beijing, People s Republic of China
J Dermatol Sci 28:181-6. 2002..In addition, we found a novel polymorphic substitution of C-to-G at nucleotide position 798 in exon 10 of the COL17A1 gene, which results in an I233M change in BPAG2 and is a common polymorphic allele in a limited Chinese population... - Multicellular tumor spheroids as an in vivo-like tumor model for three-dimensional imaging of chemotherapeutic and nano material cellular penetrationHui Li Ma
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China
Mol Imaging 11:487-98. 2012..The development of this image-based, reproducible, and quantifiable in vitro HeLa spheroid screening tool will greatly aid future exploration of chemotherapeutics and nanoparticle delivery into solid tumors... - DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxiaLei Xiong
Department of Cognitive Sciences, Institute of Basic Medical Sciences, Beijing, China College of Life Science, Wuhan University, Wuhan, China
FEBS J 279:4318-26. 2012..Specifically, the expression of DNMT3b decreased significantly after exposure to 0.3% O(2) . Thus, these results demonstrate that DNA demethylation regulates miR-210 expression in NPCs under both normoxia and hypoxia... - Inactivation and magnetic separation of bacteria from liquid suspensions using electrosprayed and nonelectrosprayed nZVI particles: observations and mechanismsQi Chen
State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, China
Environ Sci Technol 46:2360-7. 2012..Our data together with optical adsorption analysis suggested that the inactivation and magnetic separation mainly depend on Fe(0)/Fe(3)O(4) shell compositions, the type of bacteria (aerobic and anaerobic) and their concentrations... - Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibitionChristopher J Vavricka
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
PLoS Pathog 7:e1002249. 2011.... - The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008Xiaojuan Tan
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
PLoS ONE 6:e25662. 2011..Nonetheless, long-term antigenic and genetic surveillance is still necessary for further understanding... - Expression of p63 and cyclooxygenase-2 and their correlation in skin tumorsYan Wu
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Huazhong Univ Sci Technolog Med Sci 27:206-8. 2007..The increased expression of cox-2 and p63 may play an important role in the development of skin tumors and work synergetically in malignant skin tumors... - Onsite infectious agents and toxins monitoring in 12 May Sichuan earthquake affected areasMaosheng Yao
State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China
J Environ Monit 11:1993-2001. 2009..The total bacterial concentrations were found to range from 250 to 2.5 x 10(5) DNA copies/L. Aspergillus fumigatus (Asp f 1) and dust mite allergens (Der p 1 and Der f 1) were also found below their detection limits... - Efficacy and safety of intense pulsed light in treatment of melasma in Chinese patientsYuan Hong Li
Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, China
Dermatol Surg 34:693-700; discussion 700-1. 2008..Melasma is commonly seen in the Asian population. Traditional therapies are less effective and may cause adverse effects... - Enhanced bioavailability of L-carnitine after painless intradermal delivery vs. oral administration in ratsSuohui Zhang
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China
Pharm Res 28:117-23. 2011..In vitro and in vivo permeation studies were conducted to evaluate the characteristic of percutaneous administration of high hydrophilic drug L-carnitine (LC) by Functional MicroArray (FMA) painless intradermal delivery system... - Comparison of the effects of three different anti-fungus drugs on Candida albicans of murine vaginal mucosaShanjuan Chen
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Huazhong Univ Sci Technolog Med Sci 27:209-12. 2007..05). Itraconazole or fluconazole, but not terbinafine, is very effective for the treatment of fungal vaginitis caused by C. albicans in mice... - Restoration of the expression of transports associated with antigen processing in human malignant melanoma increases tumor-specific immunityJuan Tao
Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Invest Dermatol 128:1991-6. 2008.... - Amyloid-β induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptorsJinping Liu
Department of Anatomy, Capital Medical University, Beijing, China
J Alzheimers Dis 22:541-56. 2010..The identified novel mechanism through which Aβ initiates synaptic dysfunction suggests that selective enhancement of NR2A activity and/or reduction of NR2B activity can halt the manifestation of a key early-stage event in AD... - Inhibitory effect of safflor yellow on pulmonary fibrosisLin Wang
Department of Pharmacology, Beijing Institute of Heart Lung and Blood Vessel Disease Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Biol Pharm Bull 34:511-6. 2011..SY had anti-fibrotic effect in experiment and might be employed as a therapeutic candidate agent for attenuating pulmonary fibrosis... - [Research advances of genodermatosis in China]Yong Yang
Department of Dermatology, Peking University First Hospital, Beijing 100034, China
Beijing Da Xue Xue Bao 36:544-6. 2004..Different gene mutations involved in more than twenty kinds of genodermatosises have been detected. This review will synthesize recent findings of the genodermatosises in China... - Paraneoplastic pemphigus associated with Castleman tumor: a commonly reported subtype of paraneoplastic pemphigus in ChinaJing Wang
Department of Dermatology, Peking University First Hospital, Beijing, China
Arch Dermatol 141:1285-93. 2005..Early detection and removal of the Castleman tumor are crucial for the treatment of this tumor-associated autoimmune disease...