Research Topics
Genomes and Genes | Y C WongSummaryCountry: China Publications
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Publications
Id-1 expression and cell survivalY C Wong
Department of Anatomy, Cancer Biology Lab, Faculty of Medicine, and Central Laboratory of Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
Apoptosis 9:279-89. 2004..Finally, the therapeutic implications through inactivation of Id-1 in the treatment of human cancer will also be addressed...- Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancerH F Yuen
Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
Histopathology 50:648-58. 2007..The present study aimed to investigate the prognostic significance of TWIST and to correlate TWIST and E-cadherin expression in prostatic cancer specimens... - Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble ratX S Ouyang
Department of Anatomy, Faculty of Medicine, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
Carcinogenesis 22:965-73. 2001..Our results provide the first evidence of up-regulation of TRPM-2, MMP-7 and Id-1 during sex hormone-induced prostate carcinogenesis and strongly suggest their association with the development of prostate cancer... - The prostate gland and prostate carcinogenesisY C Wong
Department of Anatomy, Faculty of Medicine, The University of Hong Kong, SAR, China
Ital J Anat Embryol 103:237-52. 1998.... 
Role of MEK/ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cellsM K L Fung
Cancer Biology Group, Department of Anatomy, Laboratory Block, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
Br J Cancer 95:475-84. 2006..Our results also suggest that downregulation of MAD2 may be an indicator for identification of TGCT cancer cells that are potentially resistant to cisplatin-based therapy...- Evidence of a novel biomarker, alphas1-Casein, a milk protein, in benign prostate hyperplasiaK Xu
Department of Anatomy, Laboratory Block, Faculty of Medicine, The University of Hong Kong, Hong Kong, HKSAR, China
Prostate Cancer Prostatic Dis 9:293-7. 2006..Our results suggest that alphas1-Casein may be a potential biomarker for early identification of BPH patients... - Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading framesC K Choo
Department of Pathology, University of Hong Kong, Hong Kong, China
Prostate 40:150-8. 1999..Here, we report our work on the immortalization of a human prostate epithelial cell line and show that it can be used as a model to study prostate tumorigenesis... - Sex hormone-induced prostatic carcinogenesis in the noble rat: the role of insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in the development of prostate cancerY Z Wang
Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
Prostate 35:165-77. 1998.... - Mechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cellsX Wang
Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pok Fu Lam Road, Hong Kong
Anticancer Res 21:403-8. 2001..Our results suggest that upregulation of Bax is associated with the sensitivity of these NPC cells to cisplatin... - The role of androgens in mammary carcinogenesisY C Wong
Department of Anatomy, Faculty of Medicine, The University of Hong Kong, HKSAR, China
Ital J Anat Embryol 106:111-25. 2001..These findings highlight that the effect of androgens on the stroma, may be through a paracrine action of epithelial cells. The changes in the stroma may, in turn, promote mammary carcinogeneis in a reciprocal manner... - Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cellsM T Ling
Department of Anatomy, Faculty of Medicine, 5 F, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
Biochim Biophys Acta 1570:145-52. 2002..Our results provide evidence for the first time that TGF beta 1 may be one of the upstream regulators of Id-1... - MAD2DeltaC induces aneuploidy and promotes anchorage-independent growth in human prostate epithelial cellsK W To-Ho
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Oncogene 27:347-57. 2008..The evidence presented here provides a link between MAD2 inactivation and malignant transformation of epithelial cells... - Evidence of increased Id-1 expression and its role in cell proliferation in nasopharyngeal carcinoma cellsXianghong Wang
Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
Mol Carcinog 35:42-9. 2002.... - Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasionYi Ding
Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, PR China
Int J Oncol 28:847-54. 2006..Inactivation of Id-1 may be a potential therapeutic target to inhibit the invasion by bladder cancer cells... - Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathwayXiaomeng Zhang
Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
Int J Cancer 118:2072-81. 2006.... - Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cellsH M Li
Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China
Oncogene 23:4488-94. 2004..Induction of Id1 by LMP1 may facilitate clonal expansion of premalignant nasopharyngeal epithelial cells infected with EBV and may promote their malignant transformation... - Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancerS Yu
Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Oncogene 27:3313-28. 2008..Taken together, our findings indicate that ERRbeta performs a tumor suppressing function in prostate cancer cells, and targeting ERRbeta could be a potential therapeutic strategy for prostate cancer... - Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growthMing-Tat Ling
Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
Oncogene 21:8498-505. 2002..Our results suggest for the first time that the function of Id-1 is associated with MAPK signaling pathway activation and indicate a possible novel mechanism in which Id-1 regulates prostate cancer cell growth and tumorigenesis... - Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cellsHiu Wing Cheung
Cancer Biology Group, Department of Anatomy, The University of Hong Kong, Hong Kong
Carcinogenesis 25:881-7. 2004..Our evidence also indicates a novel treatment strategy to increase anticancer drug-induced apoptosis through inactivation of the Id-1 protein... 
Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruptionX Wang
Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
Oncogene 27:4456-66. 2008..These results demonstrate a novel function of Id-1 in promoting chromosomal instability through modification of APC/C activity during mitosis and provide a novel molecular mechanism accounted for the function of Id-1 as an oncogene...- Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylationHiu Wing Cheung
Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
Mol Carcinog 43:237-45. 2005..1% (22 out of 36) of primary NPC tumors while it was absent in non-malignant tissues. These findings suggest that downregulation of CHFR is a common event in NPC cells which may be due to hypermethylation of the gene promoter region... - Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1H F Yuen
Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
Br J Cancer 102:332-41. 2010..Id-1 is overexpressed in and correlated with metastatic potential of prostate cancer. The role of Id-1 in this metastatic process was further analysed... - Id-I stimulates cell proliferation through activation of EGFR in ovarian cancer cellsX Zhang
Cancer Biology Group, Department of Anatomy, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
Br J Cancer 91:2042-7. 2004..Our findings also implicate that Id-1 may be a potential target for the development of novel strategies in the treatment of ovarian cancer... - Anti-apoptotic role of BARF1 in gastric cancer cellsQi Wang
Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Laboratory Block, 1/F, 21 Sassoon Road, Hong Kong, SAR, China
Cancer Lett 238:90-103. 2006..Our results suggest that BARF1 expression in gastric cancer cells may provide a protective role against apoptosis through an increased Bcl-2 to Bax ratio, thus promoting cancer cell survival... - The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cellsS W Tsao
Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
Eur J Cancer 39:524-31. 2003..Our results also suggest that reducing the methylation of the E-cad gene may be a potential therapeutic strategy for NPC... - Identification of downstream target genes of latent membrane protein 1 in nasopharyngeal carcinoma cells by suppression subtractive hybridizationA Kwok Fung Lo
Department of Anatomy, Faculty of Medicine, University of Hong Kong, PR China
Biochim Biophys Acta 1520:131-40. 2001..The expression profiles of differentially expressed genes identified in this study suggest a role of LMP1 in promotion of cell survival and facilitation of tumor invasion... - Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenesS W Tsao
Department of Anatomy, Faculty of Medicine, University of Hong Kong, SAR, Hong Kong, China
Cancer Genet Cytogenet 130:141-9. 2001..Identification of nonrandom chromosomal imbalance in immortalized HOSE cells may facilitate the identification of specific chromosomes harboring genes involved in the immortalization of human ovarian surface epithelial cells... - Sex hormone-induced mammary carcinogenesis in female Noble rats: detection of differentially expressed genesG Leung
Department of Anatomy, Faculty of Medicine, University of Hong Kong, New Medical Complex, Pokfulam, Hong Kong, China
Breast Cancer Res Treat 77:49-63. 2003..The result of the present study provides some information on the molecular basis of this sex hormone-induced mammary carcinogenesis and the role of these proteins in tumor progression... - Ultrastructural and cytochemical studies of the effects of prolactin on the lateral prostate and the seminal vesicle of the castrated guinea pigC C Tam
Department of Anatomy, Faculty of Medicine, University of Hong Kong
Cell Tissue Res 270:105-12. 1992..The results from radioimmunoassay indicated that the action of prolactin on these glands could be a direct effect and not mediated through testosterone... - Changes in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble ratY C Wong
Department of Anatomy, Faculty of Medicine, University of Hong Kong, SAR, People s Republic of China
Tumour Biol 21:328-36. 2000..It is suggested that tissue zinc content may be used as a marker for prostatic lesions, including hyperplasia, dysplasia and carcinoma, while serum zinc levels may be a useful indicator for abnormal prostatic growth... - Expression study of three secretory proteins (prostatic secretory protein of 94 amino acids, probasin, and seminal vesicle secretion II) in dysplastic and neoplastic rat prostatesJoseph Kwong
Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Prostate 56:81-97. 2003.... - Effect of p53 on centrosome amplification in prostate cancer cellsX Ouyang
Department od Anatomy, Faculty of Medicine, University of Hong Kong, SAR, PR China
Biochim Biophys Acta 1541:212-20. 2001..Our results indicate that p53 may play a role in the regulation of centrosome amplification and loss of p53 may be one of the mechanisms involving CIN in prostate cancer cells... - Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathwayXue Song Ouyang
Department of Anatomy, Faculty of Medicine, 5 F, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
Carcinogenesis 23:721-5. 2002..Given the fact that both Id-1 over-expression and inactivation of p16(INK4a)/pRB are common events in prostate cancer, our results provide a possible mechanism on the molecular basis of prostate carcinogenesis... - Significance of scheduling on the cytotoxicity of radiation and cisplatin combination treatment in nasopharyngeal carcinoma cellsXianghong Wang
Department of Anatomy, University of Hong Kong, SAR, China
Anticancer Drugs 13:957-64. 2002..The differential cytotoxicity was partially explained by the alterations in cell cycle distribution. Our results indicate the importance of scheduling the radiation and cisplatin combination regimens on the survival of NPC cells... - No effect of a high-fat diet on promotion of sex hormone-induced prostate and mammary carcinogenesis in the Noble rat modelG Leung
Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
Br J Nutr 88:399-409. 2002.... - Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenesSai Wah Tsao
Department of Anatomy, Faculty of Medicine, University of Hong Kong, New Medical Complex, 1st Floor, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China
Biochim Biophys Acta 1590:150-8. 2002..The immortalized NP cell lines are non-tumorigenic and exhibit anchorage-dependent growth. These cell lines may provide a possible cell model system for studying the mechanisms involved in the tumorigenesis of NPC... - Prostate development and carcinogenesisY C Wong
Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, HKSAR, China
Int Rev Cytol 227:65-130. 2003..Finally, environmental and genetic factors that lead to prostate carcinogenesis including activation of oncogenes and mutations of tumor suppressor genes are also discussed... - E-cadherin upregulation as a therapeutic goal in cancer treatmentE W Howard
Department of Anatomy, Laboratory Block, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
Mini Rev Med Chem 8:496-518. 2008..These pathways will likely provide significant future treatment breakthroughs against cancer metastasis... - Evaluation of testing capabilities for the determination of melamine in milk through an interlaboratory proficiency test programme during the melamine crisisM Chan
Analytical and Advisory Services Division, Hong Kong Government Laboratory, Hong Kong, China
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:1450-8. 2009..In summary, eight participants (or 62%) demonstrated their competence for all the four test samples... - Over expression of ID-1 in prostate cancerX S Ouyang
Cancer Biology Lab, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
J Urol 167:2598-602. 2002..CONCLUSIONS: Our results suggest that over expression of Id-1 may have important roles in the development of prostate cancer. The potential use of Id-1 protein as a marker for prostate cancer should be further explored... - Prognostic significance of Id-1 and its association with EGFR in renal cell cancerX Li
Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
Histopathology 50:484-90. 2007..The aim of this study was to investigate the significance of Id-1 expression in renal cell cancer and to study its relationship with EGFR... - Co-expression of vascular endothelial growth factor (VEGF) and its receptors (flk-1 and flt-1) in hormone-induced mammary cancer in the Noble ratB Xie
Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
Br J Cancer 81:1335-43. 1999..The present study is the first report showing that VEGF may act as a growth stimulator for mammary cancer cells... - Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinomaH F Yuen
Department of Pathology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
Br J Cancer 97:1409-15. 2007..Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients... - Dedifferentiation of stromal smooth muscle as a factor in prostate carcinogenesisY C Wong
Cancer Biology Lab, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
Differentiation 70:633-45. 2002..Consequently, a loss of differentiation in both epithelium and stromal SMCs may be critically involved in hormone-induced prostate carcinogenesis... - Thiamine pyrophosphatase activity in secretory cells of the lateral prostate and seminal vesicle of normal and castrated guinea pigs and castrates treated with oestradiolC C Tam
Department of Anatomy, Faculty of Medicine, University of Hong Kong
Histochem J 25:77-85. 1993..However, almost all cisternae of the smaller Golgi complexes were TPPase-positive.(ABSTRACT TRUNCATED AT 250 WORDS).. - Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stressPing Huang
Institute of Molecular Biology, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
Exp Eye Res 83:939-48. 2006..Together, these data suggest that increased PLD2 activity in the lens under hyperglycemic condition might impair its osmoregulatory mechanism and reduce its ability to cope with the osmotic stress triggered by sorbitol accumulation... - Inflammatory myofibroblastic tumor of the nasal cavityV Lai
Department of Diagnostic Radiology, Tuen Mun Hospital, Tuen Mun, Hong Kong, China
AJNR Am J Neuroradiol 28:135-7. 2007..We also demonstrate the hypervascular nature of this disease on angiography and the contribution of preoperative embolization in assisting surgical excision and minimizing the potential uncontrolled intraoperative bleeding... - Radiation-induced peripheral nerve neurofibromata in a patient receiving hypofractionated radiation therapyV Lai
Department of Radiology, Tuen Mun Hospital, Tuen Mun, Hong Kong, China
AJNR Am J Neuroradiol 29:1995-7. 2008..The toxicity of high-dose radiation in a hypofractionated regime is also stressed... - Performance assessment for determining malachite green and leucomalachite green in swamp eel (Monopterus albus) muscle using assigned reference values in a proficiency testY C Wong
Analytical and Advisory Services Division, Government Laboratory, Hong Kong, China
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:1472-81. 2009..With the provision of reference values, the programme served to establish an external quality control mechanism for assessing the measurement capabilities of participating laboratories in the determination of MG and LMG in eel samples... - The effect of flutamide and tamoxifen on sex hormone-induced mammary carcinogenesis and pituitary adenomaG Leung
Department of Anatomy, Faculty of Medicine, University of Hong Kong, China
Breast Cancer Res Treat 72:153-62. 2002..The animal model, in addition to mammary carcinogenesis, may be useful for investigation of anti-estrogen therapy in pituitary adenomas...