Jia Qu

Summary

Affiliation: Wenzhou Medical College
Country: China

Publications

  1. pmc Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy
    Haiyan Jiang
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, 270 Xueyuan Road, Wenzhou, Zhejiang 325003, P R China
    J Neuroinflammation 8:119. 2011
  2. pmc Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 51:4906-12. 2010
  3. pmc Low penetrance of Leber's hereditary optic neuropathy in ten Han Chinese families carrying the ND6 T11484C mutation
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325003, China
    Biochim Biophys Acta 1800:305-12. 2010
  4. doi request reprint The development of the refractive status and ocular growth in C57BL/6 mice
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 49:5208-14. 2008
  5. pmc Extremely low penetrance of Leber's hereditary optic neuropathy in 8 Han Chinese families carrying the ND4 G11778A mutation
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Ophthalmology 116:558-564.e3. 2009
  6. doi request reprint Leber's hereditary optic neuropathy is associated with the T12338C mutation in mitochondrial ND5 gene in six Han Chinese families
    Xiao Ling Liu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Ophthalmology 118:978-85. 2011
  7. pmc Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs
    Feng Dong
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 17:2824-34. 2011
  8. pmc Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosis
    Xia Li
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 52:7-15. 2011
  9. pmc Very low penetrance of Leber's hereditary optic neuropathy in five Han Chinese families carrying the ND1 G3460A mutation
    Yi Tong
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Genet Metab 99:417-24. 2010
  10. pmc Very high penetrance and occurrence of Leber's hereditary optic neuropathy in a large Han Chinese pedigree carrying the ND4 G11778A mutation
    Xiangtian Zhou
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Genet Metab 100:379-84. 2010

Collaborators

Detail Information

Publications84

  1. pmc Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy
    Haiyan Jiang
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, 270 Xueyuan Road, Wenzhou, Zhejiang 325003, P R China
    J Neuroinflammation 8:119. 2011
    ..We tested possibility that SR and its product, D-serine, were altered in a rat model of DR...
  2. pmc Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 51:4906-12. 2010
    ..The purpose of this study was to investigate the role of modifier factors in the expression of Leber's hereditary optic neuropathy (LHON)...
  3. pmc Low penetrance of Leber's hereditary optic neuropathy in ten Han Chinese families carrying the ND6 T11484C mutation
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325003, China
    Biochim Biophys Acta 1800:305-12. 2010
    ..The purpose of this investigation is to understand the role of mitochondrial haplotypes in the development of LHON associated with ND6 T14484C mutation in Chinese families...
  4. doi request reprint The development of the refractive status and ocular growth in C57BL/6 mice
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 49:5208-14. 2008
    ..To investigate refraction, corneal curvature, axial components, and the correlations between the refraction and ocular growth during the emmetropization in the C57BL/6 mouse...
  5. pmc Extremely low penetrance of Leber's hereditary optic neuropathy in 8 Han Chinese families carrying the ND4 G11778A mutation
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Ophthalmology 116:558-564.e3. 2009
    ..To investigate the role of mitochondrial haplotypes in the development of Leber's hereditary optic neuropathy (LHON) associated with the ND4 G11778A mutation in Chinese families...
  6. doi request reprint Leber's hereditary optic neuropathy is associated with the T12338C mutation in mitochondrial ND5 gene in six Han Chinese families
    Xiao Ling Liu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Ophthalmology 118:978-85. 2011
    ..To investigate the molecular pathogenesis of Leber's hereditary optic neuropathy (LHON) in Chinese families...
  7. pmc Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs
    Feng Dong
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 17:2824-34. 2011
    ..This study evaluated effects of a non-selective DA receptor agonist, apomorphine (APO) on refractive development in guinea pigs treated with form deprivation or hyperopic defocus...
  8. pmc Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosis
    Xia Li
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 52:7-15. 2011
    ..A prior study showed that AAV-mediated RPE65 expression can prevent early cone degeneration. The present study was conducted to test whether the remaining cones in older rd12 mice can be rescued...
  9. pmc Very low penetrance of Leber's hereditary optic neuropathy in five Han Chinese families carrying the ND1 G3460A mutation
    Yi Tong
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Genet Metab 99:417-24. 2010
    ..However, nuclear modifier genes, epigenetic and environmental factors appear to be modifier factors for the phenotypic manifestation of the G3640A mutation in these Chinese families...
  10. pmc Very high penetrance and occurrence of Leber's hereditary optic neuropathy in a large Han Chinese pedigree carrying the ND4 G11778A mutation
    Xiangtian Zhou
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Genet Metab 100:379-84. 2010
    ..Therefore, nuclear modifier gene(s) may be responsible for very high penetrance and occurrence of optic neuropathy in this Chinese pedigree...
  11. pmc Cosegregation of the ND4 G11696A mutation with the LHON-associated ND4 G11778A mutation in a four generation Chinese family
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325003, China
    Mitochondrion 7:140-6. 2007
    ..These imply that the G11696A mutation may act in synergy with the primary LHON-associated G11778A mutation in this Chinese pedigree...
  12. doi request reprint MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met
    Dongsheng Yan
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, People s Republic of China
    Invest Ophthalmol Vis Sci 50:1559-65. 2009
    ..MicroRNA-34a (miR-34a), a potential key effector of the p53 tumor-suppressor gene, was studied as a potential tumor suppressor in uveal melanoma...
  13. ncbi request reprint The mitochondrial tRNA(Glu) A14693G mutation may influence the phenotypic manifestation of ND1 G3460A mutation in a Chinese family with Leber's hereditary optic neuropathy
    Yi Tong
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325003, China
    Biochem Biophys Res Commun 357:524-30. 2007
    ..Therefore, the tRNA(Glu) A14693G mutation may have a potential modifier role in the phenotypic manifestation of the primary LHON-associated G3460A mutation in this Chinese family...
  14. pmc Self-complementary AAV5 vector facilitates quicker transgene expression in photoreceptor and retinal pigment epithelial cells of normal mouse
    Fansheng Kong
    Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou 325027, China
    Exp Eye Res 90:546-54. 2010
    ....
  15. doi request reprint Diurnal variation of ocular hysteresis, corneal thickness, and intraocular pressure
    Meixiao Shen
    School of Optometry and Ophthalmology, Eye Hospital, Wenzhou Medical College, Key Laboratory of Vision Science, Ministry of Health PR China, Wenzhou, Zhejiang, China
    Optom Vis Sci 85:1185-92. 2008
    ....
  16. ncbi request reprint [Leber's hereditary optic neuropathy may be associated with the mitochondrial tRNAGlu A14693G mutation in three Chinese families]
    Yong Mei Zhang
    Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, China
    Yi Chuan 32:353-9. 2010
    ..However, none of other variants showed the evolutionary conservation and functional significance. These observations suggested that the tRNAGlu A14693G mutation may be involved in the pathogenesis of optic neuropathy in these families...
  17. doi request reprint Comparison of fresh corneal tissue versus glycerin-cryopreserved corneal tissue in deep anterior lamellar keratoplasty
    Wei Chen
    School of Ophthalmology and Optometry, Wenzhou Medical College, Zhejiang, China
    Invest Ophthalmol Vis Sci 51:775-81. 2010
    ..To compare the microstructural differences in fresh corneal tissue (FCT) with glycerin-cryopreserved corneal tissue (GCCT) used during deep anterior lamellar keratoplasty (DALK)...
  18. pmc Changes in protein profiles of guinea pig sclera during development of form deprivation myopia and recovery
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 16:2163-74. 2010
    ..To investigate changes in protein profiles of posterior sclera in guinea pigs during development of form deprivation myopia and recovery...
  19. ncbi request reprint The novel A4435G mutation in the mitochondrial tRNAMet may modulate the phenotypic expression of the LHON-associated ND4 G11778A mutation
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Zhejiang, China
    Invest Ophthalmol Vis Sci 47:475-83. 2006
    ..To investigating the role of mitochondrial haplotypes in the development of Leber's hereditary optic neuropathy (LHON) associated with the ND4 G11778A mutation in Chinese families...
  20. ncbi request reprint Leber's hereditary optic neuropathy is associated with the mitochondrial ND4 G11696A mutation in five Chinese families
    Xiangtian Zhou
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325003, China
    Biochem Biophys Res Commun 340:69-75. 2006
    ..Therefore, nuclear modifier gene(s) or environmental factor(s) may play a role in the phenotypic expression of the LHON-associated G11696A mutation in these Chinese pedigrees...
  21. ncbi request reprint Normal development of refractive state and ocular dimensions in guinea pigs
    Xiangtian Zhou
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, 82 Xueyuan Road, Wenzhou, Zhejiang 325003, China
    Vision Res 46:2815-23. 2006
    ..This study investigated changes in refraction, corneal curvature, axial components and weight of posterior sclera in guinea pig eyes during the normal development from birth...
  22. pmc Leber's hereditary optic neuropathy is associated with the T3866C mutation in mitochondrial ND1 gene in three Han Chinese Families
    Xiangtian Zhou
    School of Ophthalmology and Optometry, Wenzhou Medical College, Zhejiang, China
    Invest Ophthalmol Vis Sci 53:4586-94. 2012
    ..To investigate the pathophysiology of Leber's hereditary optic neuropathy (LHON)...
  23. pmc Assessment of exonic single nucleotide polymorphisms in the adenosine A2A receptor gene to high myopia susceptibility in Chinese subjects
    Xiaoyan Chen
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Zhejiang, China
    Mol Vis 17:486-91. 2011
    ..We aimed to determine if single nucleotide polymorphisms (SNPs) in A(2A)R exons associates with high myopia found in Chinese subjects...
  24. pmc MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development
    Dongsheng Yan
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang 325003, China
    J Biol Chem 284:29596-604. 2009
    ..Inhibition of miR-1/206 function could contribute to aberrant cell proliferation and migration, leading to rhabdomyosarcoma development...
  25. doi request reprint Correlation between myopia and major biometric parameters of the eye: a retrospective clinical study
    Ruozhong Xie
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Optom Vis Sci 86:E503-8. 2009
    ..To investigate the relationship between myopia and changes in ocular biometry and macular thickness in young adults...
  26. pmc Genetic deletion of the adenosine A2A receptor confers postnatal development of relative myopia in mice
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, China
    Invest Ophthalmol Vis Sci 51:4362-70. 2010
    ..To critically evaluate whether the adenosine A2A receptor (A2AR) plays a role in postnatal refractive development in mice...
  27. doi request reprint Biometric measurement of the mouse eye using optical coherence tomography with focal plane advancement
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325003, China
    Vision Res 48:1137-43. 2008
    ..To demonstrate that high-resolution biometry is possible in mouse eyes in vivo, using real-time OCT with focal plane advancement by a stepper motor...
  28. pmc Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2
    Dongsheng Yan
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    PLoS ONE 7:e40967. 2012
    ..Our results demonstrated that miR-182, a p53 dependent miRNA, suppressed the expression of MITF, BCL2, cyclin D2 and functioned as a potent tumor suppressor in uveal melanoma cells...
  29. doi request reprint Further characterization of ocular safety profile of commercially available preserved and preservative-free triamcinolone acetonide
    Yuli Li
    Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Retina 32:364-74. 2012
    ..To characterize the safety profile of triamcinolone acetonide (TA) for intraocular application...
  30. doi request reprint [The mitochondrial tRNA(Thr) A15951G mutation may be associated with Leber's hereditary optic neuropathy in two Chinese families]
    Yu Zhang
    Giuseppe Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou, Zhejiang, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:501-6. 2011
    ..To explore clinical, genetic and molecular features of two Chinese Han families with Leber's hereditary optic neuropathy (LHON)...
  31. pmc Leber's hereditary optic neuropathy is associated with mitochondrial ND1 T3394C mutation
    Min Liang
    Wenzhou Medical College, Zhejiang, China
    Biochem Biophys Res Commun 383:286-92. 2009
    ..Therefore, nuclear modifier gene(s) or environmental factor(s) may play a role in the phenotypic expression of the LHON-associated T3394C mutation...
  32. doi request reprint Axial myopia induced by hyperopic defocus in guinea pigs: A detailed assessment on susceptibility and recovery
    Fan Lu
    School of Optometry and Ophthalmology, Eye Hospital, Wenzhou Medical College, 270 Xueyuan Road, Wenzhou, Zhejiang, China
    Exp Eye Res 89:101-8. 2009
    ..Guinea pigs aged 3 weeks can still develop negative lens induced myopia and this myopia is reversible after removal of the lens. The myopia and recovery are mainly due to changes in vitreous length and choroidal thickness...
  33. doi request reprint Mitochondrial variants may influence the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation
    Wanshi Cai
    Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, China
    J Genet Genomics 35:649-55. 2008
    ..The results imply that the G6480A, T12811C and A15395G variants might have a potential modifier role in increasing the penetrance and expressivity of the primary LHON-associated G11778A mutation in this Chinese family...
  34. ncbi request reprint Recovery from axial myopia induced by a monocularly deprived facemask in adolescent (7-week-old) guinea pigs
    Xiangtian Zhou
    School of Optometry and Ophthalmology, Eye Hospital, Wenzhou Medical College, 270 Xueyuan Road, Wenzhou, Zhejiang 325003, China
    Vision Res 47:1103-11. 2007
    ..Infant guinea pigs are susceptible to recovery from myopia within 2 weeks of form deprivation. This study investigated whether adolescent guinea pigs are susceptible to recovery from myopia after a longer period of form deprivation...
  35. ncbi request reprint Only male matrilineal relatives with Leber's hereditary optic neuropathy in a large Chinese family carrying the mitochondrial DNA G11778A mutation
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325003, China
    Biochem Biophys Res Commun 328:1139-45. 2005
    ..Thus, nuclear modifier gene(s) or environmental factor(s) seem to account for the penetrance and phenotypic variability of LHON in this Chinese family carrying the G11778A mutation...
  36. pmc Differential proteomics and functional research following gene therapy in a mouse model of Leber congenital amaurosis
    Qinxiang Zheng
    Eye Hospital, Wenzhou Medical College, Wenzhou, China
    PLoS ONE 7:e44855. 2012
    ..Our findings support the feasibility of gene therapy in LCA2 patients and support a role for alpha A crystallin, heat shock protein 70 and peroxiredoxin 6 in the pathogenetic mechanisms involved in LCA2 disease process...
  37. doi request reprint The effect of temporal and spatial stimuli on the refractive status of guinea pigs following natural emmetropization
    Zhina Zhi
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 54:890-7. 2013
    ..To understand the visual information essential for maintaining stable refraction after emmetropization, we investigated the effects of spatial and temporal stimuli on the refractive status of guinea pigs...
  38. pmc Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 18:1312-24. 2012
    ....
  39. pmc Association analysis of retinoic acid receptor beta (RARbeta) gene with high myopia in Chinese subjects
    Yang Ding
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, P R China
    Mol Vis 16:855-61. 2010
    ..The purpose of this study was to determine if high myopia is associated with single nucleotide polymorphism (SNP) variants in the retinoic acid receptor beta (RARbeta) gene in Chinese subjects...
  40. ncbi request reprint [Leber's hereditary optic neuropathy and limbs abnormity claudication may be associated with the mitochondrial ND1 T3866C mutation]
    Yan Liu
    Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, China
    Yi Chuan 32:141-7. 2010
    ..Therefore, the T3866C mutation is likely associated with LHON and limbs abnormity claudication...
  41. ncbi request reprint Wavefront aberration and its association with intraocular pressure and central corneal thickness in myopic eyes
    Jia Qu
    Wenzhou Medical College, Wenzhou, Zhejiang, China
    J Cataract Refract Surg 33:1447-54. 2007
    ..To investigate the association between intraocular pressure (IOP), central corneal thickness (CCT), or both and wavefront aberrations in the anterior cornea and the whole eye in myopia...
  42. doi request reprint Relative axial myopia induced by prolonged light exposure in C57BL/6 mice
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College Xueyuan Road, Wenzhou, Zhejiang, China
    Photochem Photobiol 86:131-7. 2010
    ..This model, which uses mice with similar genetic backgrounds, provides an alternative to the currently available models and therefore is useful for evaluation of refractive errors caused by changes in environmental illumination...
  43. pmc Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population
    Fuxin Zhao
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 16:1920-7. 2010
    ..The purpose of this study was to determine if BLID and LOC399959 are associated with high myopia in Chinese Han subjects...
  44. ncbi request reprint [Leber's hereditary optic neuropathy is associated with the mitochondrial G11696A mutation in two Chinese families]
    Fu xin Zhao
    Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, 325035 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:556-9. 2007
    ..To report the clinical, genetic, and molecular characterization of two Chinese families with Leber's hereditary optic neuropathy (LHON)...
  45. pmc Leber's hereditary optic neuropathy is associated with mitochondrial ND6 T14502C mutation
    Fuxin Zhao
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Biochem Biophys Res Commun 389:466-72. 2009
    ..Furthermore, nuclear modifier gene(s) or environmental factor(s) may play a role in the phenotypic manifestation of the LHON-associated T14502C mutation in these Chinese families...
  46. pmc A comparative transcriptomic analysis of uveal melanoma and normal uveal melanocyte
    Jianhong An
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, China
    PLoS ONE 6:e16516. 2011
    ....
  47. doi request reprint Disruption of emmetropization and high susceptibility to deprivation myopia in albino guinea pigs
    Liqin Jiang
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 52:6124-32. 2011
    ..To compare emmetropization in albino and pigmented guinea pigs...
  48. ncbi request reprint [Expression of muscarinic acetylcholine receptor-1 in human scleral fibroblasts]
    Xiang Tian Zhou
    School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou 325003, China
    Zhonghua Yan Ke Za Zhi 41:995-9. 2005
    ..The aim of this study was to identify the presence of muscarinic acetylcholine receptors-1 (mAChRs-1) in human sclera in order to determine whether the sclera is a potential site of action for mAChR antagonists...
  49. doi request reprint Mitochondrial haplotypes may modulate the phenotypic manifestation of the LHON-associated m.14484T>C (MT-ND6) mutation in Chinese families
    Juanjuan Zhang
    Department of Genetics, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mitochondrion 13:772-81. 2013
    ..These data provided the direct evidence that mitochondrial modifiers modulate the variable penetrance and expressivity of optic neuropathy among Chinese pedigrees carrying the m.14484T>C mutation...
  50. doi request reprint Microphthalmia-associated transcription factor acts through PEDF to regulate RPE cell migration
    Xiaoyin Ma
    Developmental Cell Biology and Disease Program, School of Ophthalmology and Optometry and Eye hospital, Wenzhou Medical College, Wenzhou 325003, China
    Exp Cell Res 318:251-61. 2012
    ..We suggest that MITF has a novel and important role in maintaining RPE cells as a stable monolayer and the down-regulation of PEDF that may contribute to retinal degenerative diseases...
  51. ncbi request reprint [Refractive and biometric changes in adolescent guinea pig eyes in development and recover stages of form-deprivation myopia]
    Ke li Long
    Eye Hospital, Wenzhou Medical College, Wenzhou, China
    Zhonghua Yan Ke Za Zhi 46:550-5. 2010
    ..To investigate changes in refraction and vitreous length during form-deprivation and visual re-exposure in guinea pig eyes...
  52. doi request reprint Changes in ocular response analyzer parameters after LASIK
    Shihao Chen
    Wenzhou Medical College, Wenzhou, Zhejiang, China
    J Refract Surg 26:279-88. 2010
    ..To investigate changes in Ocular Response Analyzer parameters after myopic LASIK...
  53. doi request reprint Spontaneous axial myopia and emmetropization in a strain of wild-type guinea pig (Cavia porcellus)
    Liqin Jiang
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 50:1013-9. 2009
    ..Such a strain is of interest because it may permit the exploration of defective emmetropization and mapping of the underlying quantitative trait loci...
  54. doi request reprint On the compensation of horizontal coma aberrations in young human eyes
    Fan Lu
    Wenzhou Medical College, Wenzhou, China
    Ophthalmic Physiol Opt 28:277-82. 2008
    ....
  55. ncbi request reprint Feasibility of two-dimensional gel electrophoresis used for proteomic analysis of human scleral fibroblasts
    Fan Lu
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Curr Eye Res 32:319-29. 2007
    ..In addition, differences in the presence and amount of proteins from fibroblasts isolated from the anterior or posterior sclera were analyzed...
  56. doi request reprint Interocular evaluation of axial length and retinal thickness in people with myopic anisometropia
    Zipei Jiang
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Eye Contact Lens 39:277-82. 2013
    ..To investigate the changes in axial length and retinal thickness and their relationships with myopia in highly myopic anisometropia...
  57. doi request reprint Three-dimensional B,N-doped graphene foam as a metal-free catalyst for oxygen reduction reaction
    Yuhua Xue
    Institute of Advanced Materials for Nano Bio Applications, School of Ophthalmology and Optometry, Wenzhou Medical College, 270 Xueyuan Xi Road, Wenzhou, Zhejiang 325027, China
    Phys Chem Chem Phys 15:12220-6. 2013
    ....
  58. ncbi request reprint [The analysis of Leber's hereditary optic neuropathy associated with mitochondrial tRNAAla C5601T mutation in seven Han Chinese families]
    Hui Hui Zhou
    Giuseppe Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou, China
    Yi Chuan 34:1031-42. 2012
    ..Therefore, nuclear backgrounds and environmental factors seem to be modifying factors for the phenotypic manifestation of the tRNAAla C5601T mutation in the seven Chinese families...
  59. ncbi request reprint A comparative gene expression profile of the whole eye from human, mouse, and guinea pig
    Xiangtian Zhou
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 13:2214-21. 2007
    ..To characterize and compare gene expression patterns of the whole eyeball among human, mouse, and guinea pig based on expressed sequence tags (ESTs)...
  60. doi request reprint Lower volumes of tear menisci in contact lens wearers with dry eye symptoms
    Qi Chen
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 50:3159-63. 2009
    ..To investigate tear meniscus volumes during short-term lens wear by soft contact lens (SCL) wearers with dryness symptoms...
  61. doi request reprint Endoscopically controlled goniosynechialysis in managing synechial angle-closure glaucoma
    Ai Wu Fang
    Department of Ophthalmology, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, People s Republic of China
    J Glaucoma 19:19-23. 2010
    ..To propose a new surgical technique for optimized visualization of the chamber angle using ophthalmic microendoscope in goniosynechialysis (GSL)...
  62. ncbi request reprint [Measurement of grating acuity in guinea pigs by a customized automated optomotor device]
    Li Qin Jiang
    School of Optometry and Ophthalmology, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang 325027, China
    Zhonghua Yan Ke Za Zhi 46:725-30. 2010
    ..The guinea pig becomes an important model for studies on myopia, but little is known about its visual performance. In this study, grating acuity was measured using a custom-built automated device to track optomotor responses...
  63. doi request reprint Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis
    Wei Chen
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, 270 Xue Yuan West Road, Wenzhou, Zhejiang 325027, China
    Exp Eye Res 89:311-8. 2009
    ..Trehalose produces some of the same responses as serum upon topical application and can maintain corneal health...
  64. doi request reprint Mitochondrial ND6 T14502C variant may modulate the phenotypic expression of LHON-associated G11778A mutation in four Chinese families
    Juanjuan Zhang
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Biochem Biophys Res Commun 399:647-53. 2010
    ..These data suggested that the T14502C variant may modulate the phenotypic manifestation of the G11778A mutation in these Chinese pedigrees...
  65. ncbi request reprint The presence of m1 to m5 receptors in human sclera: evidence of the sclera as a potential site of action for muscarinic receptor antagonists
    Jia Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Key Laboratory of Vision Science, Ministry of Health PR China, Wenzhou, Zhejiang, China
    Curr Eye Res 31:587-97. 2006
    ..The aim of this study was to identify the presence of muscarinic acetylcholine receptors (mAChRs) in human sclera in order to determine whether the sclera is a potential site of action for mAChR antagonists...
  66. doi request reprint Changes in corneal wavefront aberrations in microincision and small-incision cataract surgery
    NuXia Tong
    School of Optometry and Ophthalmology, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    J Cataract Refract Surg 34:2085-90. 2008
    ..To study the effect of incision size on the optical quality of the anterior cornea by comparing the changes in corneal wavefront aberrations between microincision cataract surgery (MICS) and small-incision cataract surgery (SICS)...
  67. doi request reprint Intraocular and systemic pharmacokinetics of triamcinolone acetonide after a single 40-mg posterior subtenon application
    Lijun Shen
    Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Ophthalmology 117:2365-71. 2010
    ..To characterize the pharmacokinetics of triamcinolone acetonide (TA) in aqueous, vitreous, and systemic circulation after a single subtenon injection...
  68. ncbi request reprint [The mitochondrial ND5 T12338C mutation may be associated with Leber's hereditary optic neuropathy in two Chinese families]
    Yan Chun Ji
    Giuseppe Attardi Institute of Mitochondrial Biomedicine and Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, China
    Yi Chuan 33:322-8. 2011
    ..It suggests that other factors, such as nuclear modifier gene(s) or environmental factor(s), may play a role in the phenotypic expression of the LHON-associated ND4 G11696A and ND5 T12338C mutation...
  69. ncbi request reprint [Expression of dopamine receptor D2 and adenosine receptor A2A in human retinal pigment epithelium]
    Feng Dong
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou 325003, China
    Zhonghua Yan Ke Za Zhi 43:1110-3. 2007
    ..The aim of this study was to identify the presence of dopamine receptor D2 and adenosine receptor A2A in human retinal pigment epithelium (RPE) in order to determine whether the RPE is a potential site of action for these two receptors...
  70. doi request reprint GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development
    Chang Jin
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Invest Ophthalmol Vis Sci 49:4245-53. 2008
    ..In this study, the authors attempted to clarify the role of GPR48 in eyelid development and the molecular mechanisms leading to the EOB phenotype...
  71. ncbi request reprint Bimanual technique in proliferative diabetic retinopathy using an optical fiber-free intravitreal surgery system: a case control study
    Li jun Shen
    The School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang China
    Eur J Ophthalmol 19:273-9. 2009
    ..To evaluate the results of bimanual membrane peeling technique with an optical fiber-free intravitreal surgery system (OFFISS) in eyes with fibrovascular proliferation due to diabetic retinopathy...
  72. ncbi request reprint Expression of toll-like receptors in the healthy and herpes simplex virus-infected cornea
    Xiuming Jin
    Department of Ophthalmology, Zhejing University School of Medicine, Hangzhou, Zhejiang, China
    Cornea 26:847-52. 2007
    ..To study the expression of toll-like receptors (TLRs) in healthy corneas and corneas with active or nonactive herpetic stromal keratitis (HSK)...
  73. pmc Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye
    Wensheng Li
    Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou, China
    Mol Vis 15:267-75. 2009
    ....
  74. ncbi request reprint [Expression of retinoid acid receptors in human scleral fibroblasts and regulation of growth of fibroblasts by retinoic acid]
    Dong sheng Yan
    School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou 325003, China
    Zhonghua Yan Ke Za Zhi 43:750-3. 2007
    ..The aim of this study was to identify the presence of retinoid acid receptors in cultured human scleral fibroblasts and the effect of retinoic acid (RA) on the regulation of cell growth...
  75. doi request reprint Diurnal variation of upper and lower tear menisci
    Meixiao Shen
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Am J Ophthalmol 145:801-6. 2008
    ..To determine diurnal variation of tear menisci around upper and lower eyelids in normal subjects...
  76. doi request reprint Area dependent expression of ZNF312 in human fetal cerebral cortex
    Hua Zhu
    Key Laboratory of Visual Science, National Ministry of Health, and School of Optometry and Ophthalmology, Wenzhou Medical College, PR China
    Neurosci Res 68:73-6. 2010
    ..Our results indicate that ZNF312 and other layer markers have area dependent expressions in the human fetal cortex...
  77. ncbi request reprint [Study of corrected visual performance and vision quality]
    Jia Qu
    School of Optometry and Ophthalmology, Wenzhou Medical College, 325003 Zhejiang, China
    Zhonghua Yan Ke Za Zhi 39:325-7. 2003
    ....
  78. ncbi request reprint [The influence of mitochondrial haplogroup on Leber's hereditary optic neuropathy]
    Yi jian Mao
    School of Life Sciences, Wenzhou Medical College, Wenzhou, Zhejiang, 325035 People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:45-9. 2008
    ..In particular, the mitochondrial haplotypes may play a synergic role in the development of vision loss in the families carrying the LHON-associated primary mtDNA mutation(s)...
  79. ncbi request reprint [Preliminary clinical results of optical lamellar keratoplasty assisted by homemade-microkeratome]
    Wei Chen
    The Affiliated Eye Hospital of Wenzhou Medical College, Zhejiang 325003, China
    Zhonghua Yan Ke Za Zhi 39:14-8. 2003
    ..To evaluate the efficacy and safety of optical lamellar keratoplasty assisted by homemade-microkeratome in treating corneal opacification for optical indications...
  80. ncbi request reprint [Effects after orthokeratology on corneal topography and monochromic wavefront aberration]
    Xin Jie Mao
    The Affiliated Eye Hospital, Wenzhou Medical College, Wenzhou 325027, China
    Zhonghua Yan Ke Za Zhi 40:471-3. 2004
    ..To assess the corneal topography and monochromatic wavefront aberration among subjects using orthokeratology. Changes of ocular optical quality and related visual functions induced by corneal topography were studied...
  81. ncbi request reprint Automated lamellar keratoplasty for recurrent granular corneal dystrophy after phototherapeutic keratectomy
    Wei Chen
    Affiliated Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    J Refract Surg 21:288-93. 2005
    ..To evaluate the safety and efficacy of automated lamellar keratoplasty for the treatment of recurrent granular corneal dystrophy after phototherapeutic keratectomy (PTK)...
  82. ncbi request reprint [Selection of Chinese visual targets by fourier frequency spectrum analysis]
    Chen Xiao Wang
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, China
    Zhonghua Yan Ke Za Zhi 44:587-90. 2008
    ..To select Chinese characters for Chinese visual acuity chart by using the method of Fourier frequency spectrum analysis...
  83. ncbi request reprint [Vitrectomy for severe proliferative diabetic retinopathy: a comparison of optical fiber free intravitreal surgery system with traditional vitrectomy]
    Li jun Shen
    Hospital of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou 325027, China
    Zhonghua Yan Ke Za Zhi 42:600-5. 2006
    ..To compare the optical fiber free intravitreal surgery system with traditional vitrectomy in eyes with severe proliferative diabetic retinopathy (PDR)...
  84. ncbi request reprint [Culture and study on melanogenesis of mongolian uveal melanocytes in vitro]
    Xiang Tian Zhou
    School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou 325000, China
    Zhonghua Yan Ke Za Zhi 40:104-7. 2004
    ..To establish cell lines of Mongolian uveal melanocytes from adult donor eyes, and to study melanogenesis of these cells in vitro...