Yu Quan Wei

Summary

Country: China

Publications

  1. ncbi Enhanced antitumor effect of curcumin liposomes with local hyperthermia in the LL/2 model
    Jian Cai Tang
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Asian Pac J Cancer Prev 14:2307-10. 2013
  2. ncbi The pigment epithelial-derived factor gene loaded in PLGA nanoparticles for therapy of colon carcinoma
    Feng Yu Cui
    School of Life Science, Sichuan University, Chengdu, PR China
    Oncol Rep 24:661-8. 2010
  3. doi RNA interference-mediated silencing of focal adhesion kinase inhibits growth of human malignant glioma xenograft in nude mice
    Guan Jie Wang
    State Key Laboratory of Biotherapy, West China Hospital and West China Medical School, Sichuan University, Chengdu, Sichuan, Peoples Republic of China
    Cell Biol Int 35:841-8. 2011
  4. pmc AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model
    Qin Jie Wu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, P R China
    BMC Cancer 12:129. 2012
  5. doi Enhanced gemcitabine-mediated cell killing of human lung adenocarcinoma by vector-based RNA interference against PLK1
    Xin Yu Zhao
    State Key Laboratory of Biotherapy and Cancer Centre, West China Hospital, Sichuan University, Chengdu, China
    Biomed Pharmacother 66:597-602. 2012
  6. ncbi Induction of tumor inhibition and apoptosis by a candidate tumor suppressor gene DRR1 on 3p21.1
    Quan Liu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Oncol Rep 22:1069-75. 2009
  7. doi Acute toxicity evaluation of biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PEG-PCL-PEG hydrogel
    Chang Yang Gong
    State Key Laboratory of Biotherapy, West China Hospital, and School of Life Science, Sichuan University, Chengdu 610041, China
    J Biomed Mater Res B Appl Biomater 91:26-36. 2009
  8. pmc Enhancement of cisplatin sensitivity in Lewis Lung carcinoma by liposome-mediated delivery of a survivin mutant
    Dan Dan Yu
    West China Hospital, Sichuan University, Chengdu, China
    J Exp Clin Cancer Res 29:46. 2010
  9. pmc NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin
    Chao Lin
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, High Technological Development Zone, Chengdu, China
    PLoS ONE 7:e36722. 2012
  10. pmc Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model
    Xian ping Liu
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, China
    J Exp Clin Cancer Res 29:76. 2010

Collaborators

  • Xia Zhao
  • Li Yang
  • Sheng Yong Yang
  • Yong Qiu Mao
  • Yong Sheng Wang
  • Jiong Li
  • Yang Yang
  • Zhi Yong Li
  • Lei Liu
  • Wei Wang
  • Chun Ting Wang
  • Xiang Chen
  • Chang Yang Gong
  • Shuai Shi
  • Hua Shan Shi
  • Hong Xin Deng
  • Li Juan Chen
  • Shuang Zhang
  • Pan Ji
  • Qin Jie Wu
  • Ren Lin Zheng
  • Zhu Yuan
  • Xian Huo Wang
  • Zhi Yong Qian
  • Yuan Wen
  • Bo Mu
  • Xiang Rong Song
  • Xikun Zhou
  • Lei Li
  • Chao Lin
  • Jiao Yang
  • Qiong Wen Zhang
  • Lei Zhong
  • Shan Feng
  • Lin Li Li
  • Zhi Xing Cao
  • Chun Lai Nie
  • Wen jing Xu
  • Ying Lan Zhao
  • Fei Leng
  • Feng Luo
  • Dong Mei Zhang
  • Han Shuo Yang
  • Yan jun Wen
  • Sha Sha He
  • Kang Cao
  • Yong Xu
  • Yang Wan
  • Qing Wei Li
  • Zhi zhi Chen
  • Luo Ting Yu
  • Hao Zheng
  • Na Zhang
  • Tian Tai Ma
  • Guan Jie Wang
  • Xiu Hong Wang
  • Ke Men
  • Li Pan
  • Tao Yi
  • Dan Dan Yu
  • Li Na Zhou
  • Xiu Xiu Zeng
  • Feng Yu Cui
  • Gang Guo
  • Zhi Yao He
  • Xing Chen Peng
  • Bing Kan
  • Xing Yi Li
  • Ping Chen
  • Jian Cai Tang
  • Yinbing Zhang
  • Zhongwen Chen
  • Nongyu Huang
  • Ji Qiu
  • Zhen Wang
  • Jun Zou
  • Lian Lu
  • Bi Lan Wang
  • Jing jing Liu
  • Youli Pan
  • Shun Tao Luo
  • Yu Wei Zhao
  • Xuan Hong Shi
  • Xue Lei Ma
  • Xin Yu Liu
  • Hui Qiong Huang
  • Li Jiao Wang
  • Wei Wei Li
  • Yi Li
  • Chun Hui Zhang

Detail Information

Publications62

  1. ncbi Enhanced antitumor effect of curcumin liposomes with local hyperthermia in the LL/2 model
    Jian Cai Tang
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Asian Pac J Cancer Prev 14:2307-10. 2013
    ..Furthermore, combination therapy reduced angiogenesis and increased tumor apoptosis. Our findings suggest that the combination therapy exerted synergistic antitumor effects, providing a new perspective fpr clinical tumor therapy...
  2. ncbi The pigment epithelial-derived factor gene loaded in PLGA nanoparticles for therapy of colon carcinoma
    Feng Yu Cui
    School of Life Science, Sichuan University, Chengdu, PR China
    Oncol Rep 24:661-8. 2010
    ..Our present study demonstrates the inhibitory effect of PEDF-PLGANPs on the growth of CT26s in vitro and in vivo for the first time. PLGANP-mediated PEDF gene could provide an innovative strategy for the therapy of colon carcinoma...
  3. doi RNA interference-mediated silencing of focal adhesion kinase inhibits growth of human malignant glioma xenograft in nude mice
    Guan Jie Wang
    State Key Laboratory of Biotherapy, West China Hospital and West China Medical School, Sichuan University, Chengdu, Sichuan, Peoples Republic of China
    Cell Biol Int 35:841-8. 2011
    ..05) and apoptosis induction (P<0.05). Taken together, our results demonstrated that shRNA-mediated silencing of FAK might be a potential therapeutic approach against human malignant glioma...
  4. pmc AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model
    Qin Jie Wu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, P R China
    BMC Cancer 12:129. 2012
    ..The objective of this work was to evaluate the ability of AAV-mediated human PEDF (hPEDF) as a potent tumor suppressor and a potential candidate for cancer gene therapy...
  5. doi Enhanced gemcitabine-mediated cell killing of human lung adenocarcinoma by vector-based RNA interference against PLK1
    Xin Yu Zhao
    State Key Laboratory of Biotherapy and Cancer Centre, West China Hospital, Sichuan University, Chengdu, China
    Biomed Pharmacother 66:597-602. 2012
    ..These results indicated a feasible bio-chemotherapeutic strategy for cancer...
  6. ncbi Induction of tumor inhibition and apoptosis by a candidate tumor suppressor gene DRR1 on 3p21.1
    Quan Liu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Oncol Rep 22:1069-75. 2009
    ..DRR1 is a potent growth suppressor of NSCLC, acting through apoptosis pathway in vivo and it may be a potential therapeutic gene for human lung cancer...
  7. doi Acute toxicity evaluation of biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PEG-PCL-PEG hydrogel
    Chang Yang Gong
    State Key Laboratory of Biotherapy, West China Hospital, and School of Life Science, Sichuan University, Chengdu 610041, China
    J Biomed Mater Res B Appl Biomater 91:26-36. 2009
    ..The results indicated that the prepared PECE hydrogel was nontoxic after intrapleural, intraperitoneal, or subcutaneous administration, and it could be a safe candidate for in situ gel-forming controlled drug delivery system...
  8. pmc Enhancement of cisplatin sensitivity in Lewis Lung carcinoma by liposome-mediated delivery of a survivin mutant
    Dan Dan Yu
    West China Hospital, Sichuan University, Chengdu, China
    J Exp Clin Cancer Res 29:46. 2010
    ..The aim of this study was to determine whether a dominant-negative mouse survivin mutant could enhance the anti-tumor activity of CDDP...
  9. pmc NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin
    Chao Lin
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, High Technological Development Zone, Chengdu, China
    PLoS ONE 7:e36722. 2012
    ..Taken together, our findings show that NOXA is potentially useful as a chemosensitizer in ovarian cancer therapy...
  10. pmc Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model
    Xian ping Liu
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, China
    J Exp Clin Cancer Res 29:76. 2010
    ..But the clinical application is largely hampered by its extreme water insolubility and unpredictable side effect. It is essential to establish an efficient and safe protocol for the administration of CPT versus melanoma...
  11. doi Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model
    Yuan Wen
    State Key Laboratory of Biotherapy, West China Hospital and School of Life Science, Sichuan University Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, China
    Cancer Sci 101:2325-32. 2010
    ..5-fold increase in lifespan and no significant pathology. These results suggest that FAP, a product preferentially expressed by TAF, could function as an effective tumor rejection antigen...
  12. doi Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery
    Zhi Yao He
    West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, PR China
    Int J Pharm 397:147-54. 2010
    ..In conclusion, GA-PEG-CLs containing 5% GA-PEG-Chol might be one of the most potential gene vectors as hepatoma targeting therapy...
  13. ncbi Preparation of N-trimethyl chitosan-protein nanoparticles intended for vaccine delivery
    Xing Yi Li
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Nanosci Nanotechnol 10:4850-8. 2010
    ..SDS-polyacrylamide gel electrophoresis (SDS-PAGE) assay showed that alginate modification could effectively improve the stability of TMC nanoparticles and protect BSA from degradation or hydrolysis in acidic condition for at least 2 h...
  14. doi Antitumor effect of mSurvivinThr34→Ala in murine colon carcinoma when administered intravenously
    Hong Xia Li
    Department of Gynecology and Obstetrics, Second West China Hospital, Sichuan University, Chengdu, 610041, People s Republic of China
    Med Oncol 27:1156-63. 2010
    ..Our observations may have potential implications for the further exploration of the treatment of human colorectal cancer by intravenous delivery of dominant-negative mutant Survivin T34A...
  15. doi SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo
    Zhi Xing Cao
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, 1 Keyuan Road 4 Gaopeng Street, Chengdu, China
    Cell Physiol Biochem 27:565-74. 2011
    ..Its potential to be a candidate of anticancer agent is worth being further investigated...
  16. pmc AAV-mediated gene transfer of human pigment epithelium-derived factor inhibits Lewis lung carcinoma growth in mice
    Sha Sha He
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China
    Oncol Rep 27:1142-8. 2012
    ....
  17. doi Hyperthermia increases the therapeutic efficacy of survivinT34A in mouse tumor models
    Zhi Mian Li
    Sichuan University, Chengdu, China
    Cancer Biol Ther 12:523-30. 2011
    ..Our findings suggest that the antitumor efficacy of survivin disruption can be enhanced by hyperthermia, which might be a new feasible approach for cancer therapy...
  18. doi Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer
    Pei Du Jiang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, No 1 Keyuan Road 4, Gaopeng Street, High Technological Development Zone, Chengdu, Sichuan 610041, People s Republic of China
    Biomed Pharmacother 64:609-14. 2010
    ..These data suggested that chloroquine diphosphate might have chemotherapeutic efficacy against breast cancer including inhibition of metastasis...
  19. doi Vector-based miR-15a/16-1 plasmid inhibits colon cancer growth in vivo
    Lixia Dai
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Cell Biol Int 36:765-70. 2012
    ..These findings suggest that systemic delivery of vector-based miR-15a/16-1 expression plasmid can be an approach to colon cancer therapy...
  20. doi Preparation and characterization of a porous scaffold based on poly(D,L-lactide) and N-hydroxyapatite by phase separation
    Xiu Hong Wang
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    J Biomater Sci Polym Ed 22:1917-29. 2011
    ..The immortalized rat osteoblastic ROS 17/2.8 cell line was used in this research to study the cell adhesion and proliferation behavior, and the results indicated that composite membranes had great cell affinity and good biocompatibility...
  21. doi Down-regulation of Pkd2 by siRNAs suppresses cell-cell adhesion in the mouse melanoma cells
    Guo Hui Bian
    Core Facility of Gene Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Keyuan the Fourth Road, The District of Hi and Tech, 610041 Chengdu, People s Republic of China
    Mol Biol Rep 37:2387-95. 2010
    ..Collectively, these findings for the first time showed that PC-2 may mediate cell-cell adhesion, at least partially, through E-cadherin...
  22. pmc Treating acute cystitis with biodegradable micelle-encapsulated quercetin
    Bi Lan Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, People s Republic of China
    Int J Nanomedicine 7:2239-47. 2012
    ..These data suggested that MPEG-PCL micelle was a candidate intravesical drug carrier, and QU/MPEG-PCL micelles may have potential application in acute cystitis therapy...
  23. ncbi An N-, C-terminally truncated basic fibroblast growth factor and LPD (liposome-polycation-DNA) complexes elicits a protective immune response against murine colon carcinoma
    Xiao ping Zhang
    State Key Laboratory of Biotherapy and Cancer Center, Second West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Cancer Biol Ther 10:276-81. 2010
    ..These results suggest that anti-angiogenesis treatment induced by a bFGF-specific CTLs against microvascular endothelial cells may be a useful method for cancer therapy...
  24. doi Efficient inhibition of human colorectal carcinoma growth by RNA interference targeting polo-like kinase 1 in vitro and in vivo
    Wen jing Xu
    State Key Laboratory of Biotherapy, West China Hospital and West China Medical School, Sichuan University, Ke yuan Road 4, No 1 Gao peng Street, Chengdu, Sichuan, The People s Republic of China
    Cancer Biother Radiopharm 26:427-36. 2011
    ..001). Our study showed that knockdown of PLK1 by shRNA might be the potential therapeutic approach against human colorectal carcinoma...
  25. doi Therapeutic effects of survivin dominant negative mutant in a mouse model of prostate cancer
    Li Pan
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Keyuan Road 4, Chengdu, Sichuan, People s Republic of China
    J Cancer Res Clin Oncol 137:19-28. 2011
    ..This study was designed to determine whether mS-T34A plasmid encapsuled by DOTAP-chol liposome (Lip-mS) has the anti-tumor activity against prostate cancer, if so, to further investigate the possible mechanisms...
  26. doi Improved solubility and pharmacokinetics of PEGylated liposomal honokiol and human plasma protein binding ability of honokiol
    Xian Huo Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Pharm 410:169-74. 2011
    ..Besides, the percent of protein bound of honokiol in human plasma was between 60% and 65%...
  27. doi Neighbor communities in drug combination networks characterize synergistic effect
    Jun Zou
    Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China
    Mol Biosyst 8:3185-96. 2012
    ..The results suggested that this method provides a means to explore promising drug combinations at an earlier stage of the drug development process...
  28. pmc The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1
    Zhu Yuan
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Mol Med 17:1262-74. 2011
    ..Taken together, our findings indicate that PUMA is an important modulator of therapeutic responses of ovarian cancer cells and is potentially useful as a chemosensitizer in ovarian cancer therapy...
  29. doi Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration
    Xiangjun Chen
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China
    Drug Deliv 17:385-90. 2010
    ..Retinoic acid pre-treatment can increase the efficiency of transfection. This finding indicates that one can more effectively and much less expensively make use of genes therapy to treat diseases of the hair and skin...
  30. ncbi [RNA interference targeting focal adhesion kinase inhibited the growth of human hepatocellular carcinoma sk-hep-1]
    Wen jing Xu
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 42:455-60. 2011
    ..To test the impact of silencing focal adhesion kinase (FAK) gene on human hepatocellular carcinoma cell line sk-hep-1 using RNA interference (RNAi) in vitro, and its therapeutic effect on human hepatocellular carcinoma xenograft in vivo...
  31. doi Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice
    Hua Shan Shi
    Department of Thoracic Oncology, Sichuan University, Chengdu, China
    Cancer Sci 101:1447-53. 2010
    ..Our findings suggest that targeting tumor glycolysis can increase the efficacy of chemotherapy. In particular, the targeting of PKM2 could, to some extent, be a new way of reversing chemotherapy resistance to cancer therapy...
  32. doi Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity
    Chang Yang Gong
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu, 610041, P R China
    Growth Factors 27:377-83. 2009
    ..Strong humoral immunity created by bFGF-hydrogel was maintained for more than 14 weeks. Therefore, the prepared bFGF loaded PECE hydrogel might have great potential as a novel vaccine adjuvant for protein antigen...
  33. doi TP-58, a novel thienopyridine derivative, protects mice from concanavalinA-induced hepatitis by suppressing inflammation
    Yi Li
    Laboratory of Ethnopharmacology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
    Cell Physiol Biochem 29:31-40. 2012
    ..These results indicate that TP-58 protects against liver injury by inhibition of the NF-κB-mediated inflammation and suggest a potential role of TP-58 against acute liver injury and other inflammatory diseases...
  34. doi Suppression of human MDA-MB-435S tumor by U6 promoter-driven short hairpin RNAs targeting focal adhesion kinase
    An liang Huang
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
    J Cancer Res Clin Oncol 136:1229-42. 2010
    ..In the present study, we took advantage of a cationic liposome as gene carrier and targeted FAK function through both in vitro and in vivo approaches...
  35. doi SKLB1206, a novel orally available multikinase inhibitor targeting EGFR activating and T790M mutants, ErbB2, ErbB4, and VEGFR2, displays potent antitumor activity both in vitro and in vivo
    Youli Pan
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, China
    Mol Cancer Ther 11:952-62. 2012
    ..SKLB1206 also showed a very good oral bioavailability (50.1%). Collectively, these preclinical evaluations may support clinical development of SKLB1206 for cancers with EGFR-activating/resistance mutations or EGFR/ErbB2 overexpressed...
  36. doi Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations
    Jiao Yang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, China
    J Med Chem 55:10685-99. 2012
    ..In vivo, oral administration of compound 9e at a dose of 5 mg/kg caused rapid and complete tumor regression in a HCC827 xenograft model, and an oral dose of 50 mg/kg initiated a considerable antitumor effect in an H1975 xenograft model...
  37. ncbi A novel drug and gene co-delivery system based on Poly(epsilon-caprolactone)-Poly(ethylene glycol)-Poly(epsilon-caprolactone) grafted polyethyleneimine micelle
    Ke Men
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    J Nanosci Nanotechnol 10:7958-64. 2010
    ..This study demonstrated a novel DNA and hydrophobic chemotherapeutic drug co-delivery system...
  38. ncbi Lentiviral vector-mediated doxycycline-inducible iASPP gene targeted RNA interference in hepatocellular carcinoma
    Ming Shu Pang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China
    Chin J Cancer 29:796-801. 2010
    ..This study was to construct an efficient doxycycline-regulated, lentiviral vector-mediated knockdown system for iASPP that will allow for inducible down-regulation of iASPP gene expression and preliminary functional analysis...
  39. ncbi Prognostic role of microRNA-21 in non-small cell lung cancer: a meta-analysis
    Xue Lei Ma
    Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, Chengdu, China
    Asian Pac J Cancer Prev 13:2329-34. 2012
    ..The aim of this study was to summarize the evidence for a prognostic role of miR-21...
  40. doi Antitumor and anti-angiogenesis immunity induced by CR-SEREX-identified Xenopus RHAMM
    Han Shuo Yang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Cancer Sci 101:862-8. 2010
    ..Thus, a xenogenic vaccine based on xRHAMM induced an effective immunity against B16 melanoma cells and endothelial cells...
  41. pmc (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione protects rats from carbon tetrachloride-induced liver injury and fibrogenesis
    Zhi zhi Chen
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 18:654-61. 2012
    ..To evaluate the hepatoprotective roles of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione (SKLB010) against carbon tetrachloride (CCl₄)-induced acute and chronic liver injury and its underlying mechanisms of action...
  42. doi Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo
    Wei Wei Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, China
    J Med Chem 55:3852-66. 2012
    ..Western blot and immunohistochemical analysis were carried out to illustrate the mechanism of action of 20c...
  43. doi Novel thienopyridine derivatives as specific anti-hepatocellular carcinoma (HCC) agents: synthesis, preliminary structure-activity relationships, and in vitro biological evaluation
    Xiu Xiu Zeng
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medicinal School, Sichuan University, Chengdu 610041, Sichuan, China
    Bioorg Med Chem Lett 20:6282-5. 2010
    ..These results, especially the HCC-specific anticancer activity of 1g, suggest their potential in targeted chemotherapy for HCC...
  44. ncbi [Construction and identification of eukaryotic co-expression plasmid carrying FUS1 and recombinant human IL-12 genes and its effection on apoptosis of A549 cells]
    Dong Mei Zhang
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:569-74. 2009
    ..To construct a eukaryotic co-expression plasmid containing FUS1 and IL-12, and to investigate the influence of the recombinant plasmid on the cultured human lung cancer cell line A549...
  45. doi Combination of vesicular stomatitis virus matrix protein gene therapy with low-dose cisplatin improves therapeutic efficacy against murine melonoma
    Shan Luo
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Cancer Sci 101:1219-25. 2010
    ..Our findings may prove useful in further explorations of the application of these combinational approaches to the treatment of malignant melanoma...
  46. doi Comparative proteomic analysis suggests that mitochondria are involved in autosomal recessive polycystic kidney disease
    Qing Wei Li
    Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Sichuan, People s Republic of China
    Proteomics 12:2556-70. 2012
    ..In conclusion, our findings depicted a global understanding of ARPKD progression and provided a promising resource of targeting protein, and shed some light further investigation of ARPKD...
  47. doi hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells
    Lei Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, 1 Keyuan Road 4, Gaopeng Street, High Technological Development Zone, Chengdu 610041, China
    Apoptosis 18:467-79. 2013
    ..To our knowledge, we provide the first molecular evidence for the potential application of hPNAS-4 as a novel target in ovarian cancer gene therapy...
  48. doi In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin
    Xikun Zhou
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, No 1 Keyuan Road 4th, Chengdu, Sichuan 610041, People s Republic of China
    J Cancer Res Clin Oncol 138:1081-90. 2012
    ..This study was designed to determine whether an anti-EGFR immunotoxin has anti-tumor activity against NSCLC, and if so, to further investigate the possible mechanisms of cytotoxicity...
  49. pmc Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature
    Qiong Wen Zhang
    Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China
    PLoS ONE 7:e50946. 2012
    ..Tumor associated macrophages (TAMs) are considered with the capacity to have both negative and positive effects on tumor growth. The prognostic value of TAM for survival in patients with solid tumor remains controversial...
  50. doi A novel vaccine delivery system: biodegradable nanoparticles in thermosensitive hydrogel
    Qin Jie Wu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu, People s Republic of China
    Growth Factors 29:290-7. 2011
    ..Thus, the NPs/hydrogel composite may have great potential application as a novel vaccine delivery system...
  51. pmc Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers
    Jian Ping Zhou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People s Republic of China
    PLoS ONE 6:e28930. 2011
    ....
  52. pmc Cellular Immunotherapy for Carcinoma Using Genetically Modified EGFR-Specific T Lymphocytes
    Xikun Zhou
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
    Neoplasia 15:544-53. 2013
    ..Taken together, our study provided the experimental basis for clinical application of genetically engineered lymphocytes; moreover, we also evaluate a new and interesting cell therapy protocol...
  53. doi Orlistat, a novel potent antitumor agent for ovarian cancer: proteomic analysis of ovarian cancer cells treated with Orlistat
    Hui Qiong Huang
    Department of Gynecology and Obstetrics, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Int J Oncol 41:523-32. 2012
    ..These changes confirmed our hypothesis that Orlistat is a potential inhibitor of ovarian cancer and can be used as a novel adjuvant antitumor agent...
  54. pmc Chitosan-alginate sponge: preparation and application in curcumin delivery for dermal wound healing in rat
    Mei Dai
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Biomed Biotechnol 2009:595126. 2009
    ..An in vivo animal test using SD rat showed that sponge had better effect than cotton gauze, and adding curcumin into the sponge enhanced the therapeutic healing effect...
  55. doi A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats
    Xin Wei
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China
    Biochem Biophys Res Commun 397:311-7. 2010
    ..These findings also suggest that PI3Kgamma may be a useful target in treating inflammation diseases and AS605240 may represent a promising novel agent for the future therapy of pulmonary fibrosis...
  56. pmc Polyclonal rabbit anti-murine plasmacytoma cell globulins induce myeloma cells apoptosis and inhibit tumour growth in mice
    Bo Mu
    State Key Laboratory of Biotherapy, West China Hospital and School of Lifesciences, Sichuan University, Keyuan Road 4, Chengdu, Sichuan, People s Republic of China
    Apoptosis 16:370-81. 2011
    ..05) compared to control treatments. We conclude that PAb is an effective agent for in vitro and in vivo induction of apoptosis in multiple myeloma and that exploratory clinical trials may be warranted...
  57. ncbi [Inhibition of tumour cells with hepatitis B virus x (HBx) gene adenoviral vector in vivo]
    Hui Min Lu
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:803-6. 2009
    ..To investigate the inhibitory effects of the hepatitis B virus x protein (HBx protein) on tumor in vivo...
  58. doi Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma
    Xiang Rong Song
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China
    J Pharm Sci 99:4874-9. 2010
    ..Therefore, we speculate that CVn might be the most effective preparation in the treatment of drug-resistant human HCC in vivo...
  59. ncbi RNA interference-mediated silencing of focal adhesion kinase inhibits growth of human colon carcinoma xenograft in nude mice
    Ke Lei
    State Key Laboratory of Biotherapy, West China Hospital and College of Life Science, Sichuan University, Chengdu, Sichuan 610041, China
    J Biomed Nanotechnol 6:272-8. 2010
    ..05) and apoptosis induction (p < 0.05). Taken together, our data demonstrated that shRNA-mediated silencing of FAK might be a potential therapeutic approach against human colon carcinoma...
  60. ncbi Matrix metalloproteinase-9 as a prognostic factor in gastric cancer: a meta-analysis
    Qiong Wen Zhang
    Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
    Asian Pac J Cancer Prev 13:2903-8. 2012
    ..However, its prognostic value for survival in patients with gastric cancer remains controversial...
  61. doi Discovery of novel Pim-1 kinase inhibitors by a hierarchical multistage virtual screening approach based on SVM model, pharmacophore, and molecular docking
    Ji Xia Ren
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China
    J Chem Inf Model 51:1364-75. 2011
    ..In particular, four of them were found to have new scaffolds which have potential for the chemical development of Pim-1 inhibitors...
  62. doi Synthesis and biological evaluation of novel benzothiazole-2-thiol derivatives as potential anticancer agents
    Xuan Hong Shi
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Molecules 17:3933-44. 2012
    ..Compound 7e displayed the most potent anticancer activity on SKRB-3 (IC(50) = 1.2 nM), SW620 (IC(50) = 4.3 nM), A549 (IC(50) = 44 nM) and HepG2 (IC(50) = 48 nM) and was found to induce apoptosis in HepG2 cancer cells...